Review
Biochemistry & Molecular Biology
Xiao-jie Liang, Xin-yu Song, Jia-lin Wu, Dan Liu, Bing-yu Lin, Hong-sheng Zhou, Liang Wang
Summary: This article provides an overview of the research advances in DLBCL prognostic biomarkers using a multi-omics approach. It emphasizes the urgent need for highly specific and sensitive biomarkers to predict the therapeutic response of DLBCL and assess patient benefit from systemic chemotherapy. The use of systems biology in DLBCL research is highlighted for its comprehensive quantification and identification of biomarkers and its potential to address major biological problems with high accuracy and sensitivity.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Oncology
Allison Barraclough, Eliza Hawkes, Laurie H. Sehn, Sonali M. Smith
Summary: Large B-cell lymphoma is the most common lymphoma and has the highest burden of lymphoma-related deaths. Treatment has aimed to achieve a cure with CHOP and rituximab plus CHOP, but not all patients are cured due to the heterogeneity of the disease.
HEMATOLOGICAL ONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Cong Xu, Ting Liang, Jing Liu, Yunfeng Fu
Summary: This study reveals that RAB39B is overexpressed in DLBCL and is associated with drug resistance and poor overall survival. It may be involved in immune infiltration, m6A modification, and regulation by multiple non-coding RNAs. RAB39B could serve as an effective biomarker for the diagnosis and treatment of DLBCL.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Liang Wang, Lin-Rong Li
Summary: This review discusses the mechanisms of resistance in diffuse large B-cell lymphoma (DLBCL), including biological, epigenetic, and abnormal signaling pathways. By analyzing various aspects of DLBCL in depth, a more detailed classification and personalized treatment may improve the prognosis of DLBCL patients.
CHINESE MEDICAL JOURNAL
(2021)
Review
Pharmacology & Pharmacy
Manfei Pi, Huixian Kuang, Chunyan Yue, Qixuan Yang, Anqin Wu, Yuhua Li, Yehuda G. Assaraf, Dong-Hua Yang, Shaojie Wu
Summary: Cancer cell metabolism plays a crucial role in cancer progression and drug resistance. Various signal transduction pathways regulate tumor metabolism, and targeting these pathways could be a promising therapeutic strategy for cancer treatment.
DRUG RESISTANCE UPDATES
(2022)
Article
Oncology
Javier Melchor, Marcos Garcia-Lacarte, Sara C. Grijalba, Adrian Arnaiz-Leche, Marien Pascual, Carlos Panizo, Oscar Blanco, Victor Segura, Francisco J. Novo, Juan Garcia Valero, Patricia Perez-Galan, Jose A. Martinez-Climent, Sergio Roa
Summary: This study demonstrates that venetoclax can selectively kill MYC+/BCL2(+) lymphoma cells and enhance the infiltration of antigen-activated effector CD8 T cells in the tumor microenvironment, improving the therapeutic response. The combination of anti-CD20-based immunotherapy and BCL2 inhibition shows cooperative immunomodulatory effects and offers promising therapeutic opportunities for DEL-DLBCL patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Oncology
Maria Huguet, Jose-Tomas Navarro, Jose Molto, Josep-Maria Ribera, Gustavo Tapia
Summary: Non-Hodgkin lymphoma (NHL) is a common HIV-related neoplasm, with diffuse large B-cell lymphoma (DLBCL) being the most common subtype. DLBCL in people with HIV presents with aggressive characteristics. The introduction of combined antiretroviral therapy (cART) and the use of cART with chemotherapy have significantly improved the prognosis for people with HIV and DLBCL, approaching that of the general population.
Article
Radiology, Nuclear Medicine & Medical Imaging
Lars Kurch, Andreas Huettmann, Thomas W. Georgi, Jan Rekowski, Osama Sabri, Christine Schmitz, Regine Kluge, Ulrich Duehrsen, Dirk Hasenclever
Summary: In diffuse large B-cell lymphoma, continuous scales such as qPET and Delta SUVmax are more suitable for predicting treatment outcomes based on interim PET scans compared to the ordinal Deauville scale. The positive predictive value curves for qPET and Delta SUVmax were found to be similar, with both methods identifying less than 15% of patients as poor responders. The study suggests that continuous scales offer more accurate outcome predictions in this context.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Medicine, General & Internal
Herve Tilly, Franck Morschhauser, Laurie H. Sehn, Jonathan W. Friedberg, M. Trneny, Jeff P. Sharman, Charles Herbaux, John M. Burke, Matthew Matasar, Shinya Rai, Koji Izutsu, Neha Mehta-Shah, Lucie Oberic, Adrien Chauchet, Wojciech Jurczak, Yuqin Song, Richard Greil, Larysa Mykhalska, Juan M. Bergua-Burgues, Matthew C. Cheung, Antonio Pinto, Ho-Jin Shin, Greg Hapgood, Eduardo Munhoz, Pau Abrisqueta, Jyh-Pyng Gau, Jamie Hirata, Yanwen Jiang, Mark Yan, Calvin Lee, Christopher R. Flowers, Gilles Salles
Summary: In untreated intermediate-risk or high-risk DLBCL patients, those who received pola-R-CHP had a lower risk of disease progression, relapse, or death compared to those who received R-CHOP. Overall survival and safety profiles were similar between the two groups.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Genetics & Heredity
Rajib Roychowdhury, Soumya Prakash Das, Amber Gupta, Parul Parihar, Kottakota Chandrasekhar, Umakanta Sarker, Ajay Kumar, Devade Pandurang Ramrao, Chinta Sudhakar
Summary: Global warming and climate change have negative effects on plants by imposing environmental stresses and disease pressure. Multi-omics approaches, including genomics, transcriptomics, proteomics, metabolomics, etc., have become useful tools to understand plant responses to abiotic stress and develop climate-smart crops.
Review
Immunology
Massimiliano Gambella, Simona Carlomagno, Anna Maria Raiola, Livia Giannoni, Chiara Ghiggi, Chiara Setti, Chiara Giordano, Silvia Luchetti, Alberto Serio, Alessandra Bo, Michela Falco, Mariella Della Chiesa, Emanuele Angelucci, Simona Sivori
Summary: Surgical resection, chemotherapy, and radiotherapy have been the primary cancer treatments for a long time. Recently, immune checkpoint inhibitors and adoptive cell therapies have emerged as promising alternatives. These therapies aim to activate and utilize the patient's immune system to fight against cancer cells, and have shown remarkable results.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Chanjuan Jin, Di Zhou, Jun Li, Lintao Bi, Lisha Li
Summary: The evolution of lymphoma is a complex process that results in genetic mutations and variations, leading to heterogeneity. Single-cell assays and multi-omics analyses are shedding light on the mechanisms of lymphoma evolution, drug resistance, and potential therapeutic approaches. These advancements allow for personalized treatment and the discovery of novel lymphoma biomarkers.
Article
Biochemistry & Molecular Biology
Shan-Ju Yeh, Tsun-Yung Yeh, Bor-Sen Chen
Summary: This study aims to understand the pathogenesis of DLBCL ABC and DLBCL GCB by constructing a candidate genome-wide genetic and epigenetic network. By identifying core signaling pathways and investigating pathogenic mechanisms, potential drug targets and drug combinations are proposed for the treatment of DLBCL ABC and DLBCL GCB.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Sotirios G. Papageorgiou, Thomas P. Thomopoulos, Athanasios Liaskas, Theodoros P. Vassilakopoulos
Summary: Diffuse large B-cell lymphoma (DLBCL) is the most common high-grade NHL. The standard frontline treatment combines rituximab with chemotherapy. However, many patients experience poor results in relapse. Recent research on novel agents for DLBCL has raised hope for these patients.
Article
Cell Biology
Eva A. M. Hesius, Lidia van Laar, Margriet Oosterveld, Annemiek B. van Spriel, Blanca Scheijen, Jan Willem Leeuwis, Henri A. M. Marres, Patricia J. T. A. Groenen, Wendy B. C. Stevens, Ellen van Der Spek, Adriaan J. C. van den Brule, Brigiet M. Hoevenaars, Konnie M. Hebeda, Michiel van den Brand
Summary: LBCL-IRF4 is a newly identified subtype of large B cell lymphoma in the 2017 revised WHO classification, initially reported in children. This study aimed to assess the frequency of IRF4 rearrangements in adult DLBCLs that need to be reclassified as LBCL-IRF4 using FISH. Among 238 DLBCL patients, six (including the index patient) were found to have IRF4 rearrangements, and their immunohistochemical profile was consistent with LBCL-IRF4. This study highlights the importance of considering LBCL-IRF4 in older patients and at different anatomical sites.
Article
Immunology
Jeromine Klingler, Nicodeme Paul, Geraldine Laumond, Sylvie Schmidt, Luzia M. Mayr, Thomas Decoville, Olivier Lambotte, Brigitte Autran, Seiamak Bahram, Christiane Moog
Summary: The study found that HIV-1 controllers have a unique HIV-specific antibody profile that may contribute to the control of HIV replication. This emphasizes the importance of analyzing multifunctional antibody responses in vaccine research.
Article
Clinical Neurology
Amjad Khan, Anne Molitor, Sylvain Mayeur, Gaoqun Zhang, Bruno Rinaldi, Beatrice Lannes, Benoit Lhermitte, Muhammad Umair, Stefan T. Arold, Sylvie Friant, Sepand Rastegar, Mathieu Anheim, Seiamak Bahram, Raphael Carapito
Summary: A novel missense variant in the PPP1R1B gene was identified in a consanguineous family with generalized dystonia. The expression of PPP1R1B protein in movement control regions suggests its involvement in abnormal movements, making it a potential gene to be sequenced in patients with unexplained movement disorders.
MOVEMENT DISORDERS
(2022)
Article
Hematology
David Marx, Arnaud Dupuis, Anita Eckly, Anne Molitor, Jerome Olagne, Guy Touchard, Sihem Kaaki, Cecile Ory, Anne-Laure Faller, Benedicte Gerard, Melanie Cotter, Lisa Westerberg, Marton Keszei, Bruno Moulin, Christian Gachet, Sophie Caillard, Seiamak Bahram, Raphael Carapito
Summary: This study reports a gain-of-function variant in the WAS gene associated with both the hematological phenotype of X-linked neutropenia (neutropenia, macrothrombocytopenia) and renal disease (proteinuria, renal failure).
Article
Genetics & Heredity
Maimuna S. Paul, Anna R. Duncan, Casie A. Genetti, Hongling Pan, Adam Jackson, Patricia E. Grant, Jiahai Shi, Michele Pinelli, Nicola Brunetti-Pierri, Alexandra Garza-Flores, Dave Shahani, Russell P. Saneto, Giuseppe Zampino, Chiara Leoni, Emanuele Agolini, Antonio Novelli, Ulrike Bluemlein, Tobias B. Haack, Wolfram Heinritz, Eva Matzker, Bader Alhaddad, Rami Abou Jamra, Tobias Bartolomaeus, Saber AlHamdan, Raphael Carapito, Bertrand Isidor, Seiamak Bahram, Alyssa Ritter, Kosuke Izumi, Ben Pode Shakked, Ortal Barel, Bruria Ben Zeev, Amber Begtrup, Deanna Alexis Carere, Sureni Mullegama, Timothy Blake Palculict, Daniel G. Calame, Katharina Schwan, Alicia R. P. Aycinena, Rasa Traberg, Sofia Douzgou, Harrison Pirt, Naila Ismayilova, Siddharth Banka, Hsiao-Tuan Chao, Pankaj B. Agrawal
Summary: Variants in the EIF4A2 gene cause a genetic neurodevelopmental syndrome characterized by global developmental delay, intellectual disability, hypotonia, epilepsy, and structural brain anomalies. These variants disrupt protein structure and result in both loss of function and gain of function mechanisms.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Charlotte M. Fonta, Thomas Loustau, Chengbei Li, Suchithra Poilil Surendran, Uwe Hansen, Devadarssen Murdamoothoo, Mario C. Benn, Ines Velazquez-Quesada, Raphael Carapito, Gertraud Orend, Viola Vogel
Summary: Immunostainings of mouse breast tumors reveal that tumor matrix tracks, with immunosuppressive functions, are surrounded by an endothelial-like basement membrane and contain collagen and fibronectin fibers. These tracks form in early-stage tumors and mature over time, and their maturation depends on host-derived tenascin-C (TNC). Tumor infiltrating leukocytes, mainly M2 macrophages and CD8+ T cells, are retained in early-stage tumor tracks but reduce in number after track maturation.
Review
Microbiology
Marie-Pierre Ledoux, Raoul Herbrecht
Summary: Cases of invasive pulmonary aspergillosis are increasing due to new risk factors and a wider range of patients at risk. The diagnosis of this disease has become more complex and relies on various imaging and laboratory techniques. Treatment options have improved, but there is still a need for new antifungal drugs.
Letter
Allergy
Virginie Doyen, Anh Poirot, Myriam Maumy-Bertrand, Frederic Bertrand, Naji Khayath, Nathalie Domis, Frederic de Blay
Article
Biochemistry & Molecular Biology
Martha Gschwandtner, Anis N. Gammage, Claire Deligne, Linda F. M. Mies, Alissa Domaingo, Devardarssen Murdamoothoo, Thomas Loustau, Anja Schwenzer, Rupert Derler, Raphael Carapito, Manuel Koch, Matthias Moergelin, Gertraud Orend, Andreas J. Kungl, Kim S. Midwood
Summary: Bidirectional dialogue between cellular and non-cellular components of the tumor microenvironment (TME) drives cancer survival. The interplay between the matrix molecule tenascin-C (TNC) and chemokine CCL2 in HER2+ breast cancer was studied, revealing their distinct roles in subverting anti-tumoral immunity. TNC supported sustained CCL2 synthesis and facilitated an immune suppressive macrophage phenotype, while CCL2 did not impact macrophage survival/activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Daniela Matuozzo, Estelle Talouarn, Astrid Marchal, Peng Zhang, Jeremy Manry, Yoann Seeleuthner, Yu Zhang, Alexandre Bolze, Matthieu Chaldebas, Baptiste Milisavljevic, Adrian Gervais, Paul Bastard, Takaki Asano, Lucy Bizien, Federica Barzaghi, Hassan Abolhassani, Ahmad Abou Tayoun, Alessandro Aiuti, Ilad Alavi Darazam, Luis M. Allende, Rebeca Alonso-Arias, Andres Augusto Arias, Gokhan Aytekin, Peter Bergman, Simone Bondesan, Yenan T. Bryceson, Ingrid G. Bustos, Oscar Cabrera-Marante, Sheila Carcel, Paola Carrera, Giorgio Casari, Khalil Chaibi, Roger Colobran, Antonio Condino-Neto, Laura E. Covill, Ottavia M. Delmonte, Loubna El Zein, Carlos Flores, Peter K. Gregersen, Marta Gut, Filomeen Haerynck, Rabih Halwani, Selda Hancerli, Lennart Hammarstroem, Nevin Hatipoglu, Adem Karbuz, Sevgi Keles, Christele Kyheng, Rafael Leon-Lopez, Jose Luis Franco, Davood Mansouri, Javier Martinez-Picado, Ozge Metin Akcan, Isabelle Migeotte, Pierre-Emmanuel Morange, Guillaume Morelle, Andrea Martin-Nalda, Giuseppe Novelli, Antonio Novelli, Tayfun Ozcelik, Figen Palabiyik, Qiang Pan-Hammarstroem, Rebeca Perez de Diego, Laura Planas-Serra, Daniel E. Pleguezuelo, Carolina Prando, Aurora Pujol, Luis Felipe Reyes, Jacques G. Riviere, Carlos Rodriguez-Gallego, Julian Rojas, Patrizia Rovere-Querini, Agatha Schlueter, Mohammad Shahrooei, Ali Sobh, Pere Soler-Palacin, Yacine Tandjaoui-Lambiotte, Imran Tipu, Cristina Tresoldi, Jesus Troya, Diederik van de Beek, Mayana Zatz, Pawel Zawadzki, Saleh Zaid Al-Muhsen, Mohammed Faraj Alosaimi, Fahad M. Alsohime, Hagit Baris-Feldman, Manish J. Butte, Stefan N. Constantinescu, Megan A. Cooper, Clifton L. Dalgard, Jacques Fellay, James R. Heath, Yu-Lung Lau, Richard P. Lifton, Tom Maniatis, Trine H. Mogensen, Horst von Bernuth, Alban Lermine, Michel Vidaud, Anne Boland, Jean-Francois Deleuze, Robert Nussbaum, Amanda Kahn-Kirby, France Mentre, Sarah Tubiana, Guy Gorochov, Florence Tubach, Pierre Hausfater, C. O. V. I. D. Human Genetic Effort, Isabelle Meyts, Shen-Ying Zhang, Anne Puel, Luigi D. Notarangelo, Stephanie Boisson-Dupuis, Helen C. Su, Bertrand Boisson, Emmanuelle Jouanguy, Jean-Laurent Casanova, Qian Zhang, Laurent Abel, Aurelie Cobat
Summary: Through a genome-wide rare variant burden association analysis, it was found that there is an association between at-risk variants in the TLR7 gene and rare loss-of-function variants in TLR3-dependent type I interferon immunity genes. These findings suggest that rare variants in TLR3- and TLR7-dependent type I interferon immunity genes may underlie life-threatening COVID-19 in patients under 60 years old.
Article
Medicine, Research & Experimental
Sylvain Mayeur, Benoit Lhermitte, Justine Gantzer, Anne Molitor, Tristan Stemmelen, Sebastien Meyer, Aline Kolmer, Jean-Emmanuel Kurtz, Seiamak Bahram, Raphael Carapito
Summary: Exome sequencing of a patient with postchemotherapy thymic teratoma revealed 19 shared somatic mutations among the mature teratoma, melanocytic neuroectodermal tumor (MNT), and metastatic anaplastic MNT components. Enrichment analysis indicated the involvement of known cancer-related genes such as KRAS, TP53, ERBB4, and KDR in the development of anaplastic MNT transformation. This study provides valuable insights into the molecular characteristics of MNT and highlights the importance of understanding these tumors for improved therapeutics.
COLD SPRING HARBOR MOLECULAR CASE STUDIES
(2023)
Article
Computer Science, Artificial Intelligence
Steve de Rose, Philippe Meyer, Frederic Bertrand
Summary: This paper uses topological data analysis to study human body shapes. It shows that relevant information about shapes can be extracted by persistent homology. Anomalies of scans are detected using clustering algorithms and a discrimination index accurately separates gender. Ward-linkage hierarchical clusterings are used to define male and female morphotypes based on weight classes and ratios between circumferences. The techniques used in this work allow for direct classification of human bodies and detection of scan anomalies on the full human body point clouds.
Article
Biochemistry & Molecular Biology
Benjamin Mary, Nandini Asokan, Katerina Jerabkova-Roda, Annabel Larnicol, Ignacio Busnelli, Tristan Stemmelen, Angelique Pichot, Anne Molitor, Raphael Carapito, Olivier Lefebvre, Jacky G. Goetz, Vincent Hyenne
Summary: Hemodynamics affect the function of circulating tEVs. Under low flow conditions, tEVs are mainly internalized by venous endothelial cells and rerouted towards non-degradative compartments, promoting their pro-tumoral function.
Article
Immunology
Quentin Philippot, Masato Ogishi, Jonathan Bohlen, Julia Puchan, Andres Augusto Arias, Tina Nguyen, Marta Martin-Fernandez, Clement Conil, Darawan Rinchai, Mana Momenilandi, Seyed Alireza Mandaviani, Mohammad Keramatipour, Jeremie Rosain, Rui Yang, Taushif Khan, Anna-Lena Neehus, Marie Materna, Ji Eun Han, Jessica Peel, Federico Mele, Marc Weisshaar, Sandra Jovic, Paul Bastard, Romain Levy, Tom Le Voyer, Peng Zhang, Majistor Raj Luxman Maglorius Renkilaraj, Carlos A. Arango-Franco, Simon Pelham, Yoann Seeleuthner, Mathieu Pochon, Manar Mahmoud Ahmad Ata, Fatima Al Ali, Melanie Migaud, Camille Soudee, Tatiana Kochetkov, Anne Molitor, Raphael Carapito, Seiamak Bahram, Bertrand Boisson, Claire Fieschi, Davood Mansouri, Nico Marr, Satoshi Okada, Mohammad Shahrooei, Nima Parvaneh, Zahra Chavoshzadeh, Aurelie Cobat, Dusan Bogunovic, Laurent Abel, Stuart G. Tangye, Cindy S. Ma, Vivien Beziat, Federica Sallusto, Stephanie Boisson-Dupuis, Jacinta Bustamante, Jean-Laurent Casanova, Anne Puel
Summary: Patients with IL-23R deficiency may suffer from Mendelian susceptibility to mycobacterial disease and chronic mucocutaneous candidiasis. IL-23 is essential for the production of IL-17A in MATT cells and for the production of IFN-y in both V62+ y6 T cells and MATT cells.
SCIENCE IMMUNOLOGY
(2023)
Review
Genetics & Heredity
Li-Yun Lin, Raphael Carapito, Bin Su, Christiane Moog
Summary: The development of an effective HIV vaccine is urgently needed, but reproducing and improving identified antibody parameters and additional factors that influence the protective effect are difficult. Future vaccine designs should consider multifaceted antibody functions and demographic attributes.
GENES AND IMMUNITY
(2022)
