Characterization of EHop-016, Novel Small Molecule Inhibitor of Rac GTPase

Rac GTPases in Human Diseases

(2013) Sung-Yun Pai et al.   DISEASE MARKERS

mTORC1 and mTORC2 Regulate EMT, Motility, and Metastasis of Colorectal Cancer via RhoA and Rac1 Signaling Pathways

(2011) P. Gulhati et al.   CANCER RESEARCH

The diverse roles of Rac signaling in tumorigenesis

(2011) Natalie A. Mack et al.   CELL CYCLE

Rho GTPase Effector Functions in Tumor Cell Invasion and Metastasis

(2011) Somesh Baranwal et al.   CURRENT DRUG TARGETS

Rac1 Regulates the Activity of mTORC1 and mTORC2 and Controls Cellular Size

(2011) Abdelhafid Saci et al.   MOLECULAR CELL

Development of small-molecule inhibitors of the group I p21-activated kinases, emerging therapeutic targets in cancer

(2010) Chunling Yi et al.   BIOCHEMICAL PHARMACOLOGY

Rac and Rho GTPases in cancer cell motility control

(2010) Matteo Parri et al.   Cell Communication and Signaling

Guanine nucleotide exchange factors for RhoGTPases: Good therapeutic targets for cancer therapy?

(2010) Galit Lazer et al.   CELLULAR SIGNALLING

Inhibition of the Rho GTPase, Rac1, decreases estrogen receptor levels and is a novel therapeutic strategy in breast cancer

(2010) A. E. Rosenblatt et al.   ENDOCRINE-RELATED CANCER

PAK1 as a therapeutic target

(2010) Julia V Kichina et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Signalling to cancer cell invasion through PAK family kinases

(2010) Andrew Whale   Frontiers in Bioscience-Landmark

Focal-adhesion targeting links caveolin-1 to a Rac1-degradation pathway

(2010) M. Nethe et al.   JOURNAL OF CELL SCIENCE

G   Signaling Promotes Breast Cancer Cell Migration and Invasion

(2010) J. K. Kirui et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Blockade of Rac1 Activity Induces G1 Cell Cycle Arrest or Apoptosis in Breast Cancer Cells through Downregulation of Cyclin D1, Survivin, and X-Linked Inhibitor of Apoptosis Protein

(2010) T. Yoshida et al.   MOLECULAR CANCER THERAPEUTICS

Identification of the Rac-GEF P-Rex1 as an Essential Mediator of ErbB Signaling in Breast Cancer

(2010) Maria Soledad Sosa et al.   MOLECULAR CELL

P-Rex1 participates in Neuregulin-ErbB signal transduction and its expression correlates with patient outcome in breast cancer

(2010) J C Montero et al.   ONCOGENE

Structure–activity relationship of isoform selective inhibitors of Rac1/1b GTPase nucleotide binding

(2009) Eric Beausoleil et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Rho GTPases in hematopoiesis and hemopathies

(2009) J. C. Mulloy et al.   BLOOD

Pak protein kinases and their role in cancer

(2009) Bettina Dummler et al.   CANCER AND METASTASIS REVIEWS

A Cell Active Chemical GEF Inhibitor Selectively Targets the Trio/RhoG/Rac1 Signaling Pathway

(2009) Nathalie Bouquier et al.   CHEMISTRY & BIOLOGY

Distinct Roles for RhoVersusRac/Cdc42 GTPases Downstream of Vav2 in Regulating Mammary Epithelial Acinar Architecture

(2009) Lei Duan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Virtual Screening Approach for the Identification of New Rac1 Inhibitors

(2009) Nicola Ferri et al.   JOURNAL OF MEDICINAL CHEMISTRY

Host Deficiency in Vav2/3 Guanine Nucleotide Exchange Factors Impairs Tumor Growth, Survival, and Angiogenesis In vivo

(2009) D. M. Brantley-Sieders et al.   MOLECULAR CANCER RESEARCH

Rac1 contributes to trastuzumab resistance of breast cancer cells: Rac1 as a potential therapeutic target for the treatment of trastuzumab-resistant breast cancer

(2009) M. Dokmanovic et al.   MOLECULAR CANCER THERAPEUTICS

Phospholipase C 1 Is Required for Metastasis Development and Progression

(2008) G. Sala et al.   CANCER RESEARCH

Crucial structural role for the PH and C1 domains of the Vav1 exchange factor

(2008) Jonathan Rapley et al.   EMBO REPORTS

Inhibition of Rac1 decreases the severity of pancreatitis and pancreatitis-associated lung injury in mice

(2008) Marcelo G. Binker et al.   EXPERIMENTAL PHYSIOLOGY

Rho GTPases in cancer cell biology

(2008) Francisco M. Vega et al.   FEBS LETTERS

Structural Basis of Guanine Nucleotide Exchange Mediated by the T-Cell Essential Vav1

(2008) Jill E. Chrencik et al.   JOURNAL OF MOLECULAR BIOLOGY

Increased Rac1b Expression Sustains Colorectal Tumor Cell Survival

(2008) P. Matos et al.   MOLECULAR CANCER RESEARCH

Role of Rho GTPases in breast cancer

(2007) Yong Tang   Frontiers in Bioscience-Landmark