Emerging Interrelationship Between the Gut Microbiome and Cellular Senescence in the Context of Aging and Disease: Perspectives and Therapeutic Opportunities

Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19

(2021) Yun Kit Yeoh et al.   GUT

Senolytic combination of Dasatinib and Quercetin alleviates intestinal senescence and inflammation and modulates the gut microbiome in aged mice

(2021) Tatiana Dandolini Saccon et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Age-dependent remodeling of gut microbiome and host serum metabolome in mice

(2021) Chia-Shan Wu et al.   Aging-US

Marine phycocompound screening reveals a potential source of novel senotherapeutics

(2021) Rahagir Salekeen et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Alterations in the gut bacterial microbiome in people with type 2 diabetes mellitus and diabetic retinopathy

(2021) Taraprasad Das et al.   Scientific Reports

The aging gut microbiome and its impact on host immunity

(2021) Nabil Bosco et al.   GENES AND IMMUNITY

An aged immune system drives senescence and ageing of solid organs

(2021) Matthew J. Yousefzadeh et al.   NATURE

Senescence in tissue samples of humans with age-related diseases: A systematic review

(2021) Camilla S.L. Tuttle et al.   AGEING RESEARCH REVIEWS

Ageing of the gut microbiome: Potential influences on immune senescence and inflammageing

(2021) Jessica Conway et al.   AGEING RESEARCH REVIEWS

Perspectives on the dynamic implications of cellular senescence and immunosenescence on macrophage aging biology

(2021) Rohit Sharma   BIOGERONTOLOGY

Gut Microbiota Predicts Healthy Late-Life Aging in Male Mice

(2021) Shanlin Ke et al.   Nutrients

Bioactive food components for managing cellular senescence in aging and disease: A critical appraisal and perspectives

(2021) Rohit Sharma   PharmaNutrition

Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice

(2020) Matthew J. Yousefzadeh et al.   AGING CELL

Gut microbiota alterations affect glioma growth and innate immune cells involved in tumor immunosurveillance in mice

(2020) Giuseppina D'Alessandro et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Plant Polyphenols Based Second Generation Synbiotics: Emerging Concepts, Challenges and Opportunities

(2020) Rohit Sharma et al.   NUTRITION

Gut Microbiome Profiles Are Associated With Type 2 Diabetes in Urban Africans

(2020) Ayo P. Doumatey et al.   Frontiers in Cellular and Infection Microbiology

Role of gut microbiota in type 2 diabetes pathophysiology

(2020) Manoj Gurung et al.   EBioMedicine

Faecal microbiota transplantation as a home therapy to frail older people

(2020) Simon Mark Dahl Jørgensen et al.   AGE AND AGEING

Survey of senescent cell markers with age in human tissues

(2020) M. Laura Idda et al.   Aging-US

Age-related shifts in gut microbiota contribute to cognitive decline in aged rats

(2020) Yanli Li et al.   Aging-US

Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice

(2020) Yusheng Cai et al.   CELL RESEARCH

Early signs of gut microbiome aging: biomarkers of inflammation, metabolism, and macromolecular damage in young adulthood

(2020) Audrey Renson et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Microbiome analyses of blood and tissues suggest cancer diagnostic approach

(2020) Gregory D. Poore et al.   NATURE

Perspectives of the potential implications of polyphenols in influencing the interrelationship between oxi-inflammatory stress, cellular senescence and immunosenescence during aging

(2020) Rohit Sharma et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Implication of the gut microbiome composition of type 2 diabetic patients from northern China

(2020) Qian Li et al.   Scientific Reports

Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases

(2020) Ping Song et al.   Cells

Age-related compositional changes and correlations of gut microbiome, serum metabolome, and immune factor in rats

(2020) Xia Zhang et al.   GeroScience

Metabolic and Lipidomic Profiling of Vegetable Juices Fermented with Various Probiotics

(2020) Hyuk-Jin Chung et al.   Biomolecules

Senolytic activity of small molecular polyphenols from olive restores chondrocyte redifferentiation and promotes a pro-regenerative environment in osteoarthritis

(2020) Marta Varela-Eirín et al.   Aging-US

Differences in the gut Firmicutes to Bacteroidetes ratio across age groups in healthy Ukrainian population

(2020) Alexander Vaiserman et al.   BMC MICROBIOLOGY

Microbiota-Derived Metabolites in Tumor Progression and Metastasis

(2020) Tania Rossi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Senolytic drugs: from discovery to translation

(2020) J. L. Kirkland et al.   JOURNAL OF INTERNAL MEDICINE

A Senescence-Centric View of Aging: Implications for Longevity and Disease

(2020) M. Borghesan et al.   TRENDS IN CELL BIOLOGY

Human Gut Microbiome Aging Clock Based on Taxonomic Profiling and Deep Learning

(2020) Fedor Galkin et al.   iScience

Microbial Stimulation Reverses the Age-Related Decline in M Cells in Aged Mice

(2020) David S. Donaldson et al.   iScience

An intact gut microbiome protects genetically predisposed mice against leukemia

(2020) Carolina Vicente Dueñas et al.   BLOOD

Abiraterone acetate preferentially enriches for the gut commensal Akkermansia muciniphila in castrate-resistant prostate cancer patients

(2020) Brendan A. Daisley et al.   Nature Communications

Age-dependent decline in stress response capacity revealed by proteins dynamics analysis

(2020) Kaiyue Chen et al.   Scientific Reports

Alterations of Gut Microbiota in Type 2 Diabetes Individuals and the Confounding Effect of Antidiabetic Agents

(2020) Babiker Saad Almugadam et al.   Journal of Diabetes Research

Faecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients

(2020) Alfonsina D’Amato et al.   Microbiome

Gut Microbiota and Metabolome Alterations Associated with Parkinson’s Disease

(2020) Sarah Vascellari et al.   mSystems

Young versus aged microbiota transplants to germ-free mice: increased short-chain fatty acids and improved cognitive performance

(2020) Juneyoung Lee et al.   Gut Microbes

Aging, Frailty, and the Microbiome—How Dysbiosis Influences Human Aging and Disease

(2020) John P. Haran et al.   GASTROENTEROLOGY

Gut microbiota-derived metabolites as central regulators in metabolic disorders

(2020) Allison Agus et al.   GUT

The gut microbiota is associated with immune cell dynamics in humans

(2020) Jonas Schluter et al.   NATURE

Fisetin Regulates Gut Microbiota and Exerts Neuroprotective Effect on Mouse Model of Parkinson’s Disease

(2020) Tian-Jiao Chen et al.   Frontiers in Neuroscience

Diet supplemented with phytochemical epigallocatechin gallate and probiotic Lactobacillus fermentum confers second generation synbiotic effects by modulating cellular immune responses and antioxidant capacity in aging mice

(2019) Rohit Sharma et al.   EUROPEAN JOURNAL OF NUTRITION

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

(2019) Jamie N. Justice et al.   EBioMedicine

Dysbiosis of the Gut Microbiome in Lung Cancer

(2019) He Zhuang et al.   Frontiers in Cellular and Infection Microbiology

Dietary Quercetin Increases Colonic Microbial Diversity and Attenuates Colitis Severity in Citrobacter rodentium-Infected Mice

(2019) Rui Lin et al.   Frontiers in Microbiology

Attenuation of negative effects of senescence in human skin using an extract from Shingomonas hydrophobicum : development of new skin care solution

(2019) Sandie Gervason et al.   INTERNATIONAL JOURNAL OF COSMETIC SCIENCE

Multi-Omic Analysis of the Microbiome and Metabolome in Healthy Subjects Reveals Microbiome-Dependent Relationships Between Diet and Metabolites

(2019) Zheng-Zheng Tang et al.   Frontiers in Genetics

Intestinal stem cells acquire premature senescence and senescence associated secretory phenotype concurrent with persistent DNA damage after heavy ion radiation in mice

(2019) Santosh Kumar et al.   Aging-US

Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition

(2019) Branca I. Pereira et al.   Nature Communications

An untargeted fecal and urine metabolomics analysis of the interplay between the gut microbiome, diet and human metabolism in Indian and Chinese adults

(2019) Abhishek Jain et al.   Scientific Reports

Macronutrient metabolism by the human gut microbiome: major fermentation by-products and their impact on host health

(2019) Kaitlyn Oliphant et al.   Microbiome

Cell-Free Culture Supernatant of Probiotic Lactobacillus fermentum Protects Against H2O2-Induced Premature Senescence by Suppressing ROS-Akt-mTOR Axis in Murine Preadipocytes

(2019) Ravi Kumar et al.   Probiotics and Antimicrobial Proteins

Senescence‐associated tissue microenvironment promotes colon cancer formation through the secretory factor GDF15

(2019) Yuna Guo et al.   AGING CELL

The Microbiome and Aging

(2019) Bianca Bana et al.   Annual Review of Genetics

Anti-tumor potential of cell free culture supernatant of Lactobacillus rhamnosus strains isolated from human breast milk

(2019) Muhammad Shahid Riaz Rajoka et al.   FOOD RESEARCH INTERNATIONAL

Effects of Quercetin and Resveratrol on in vitro Properties Related to the Functionality of Potentially Probiotic Lactobacillus Strains

(2019) Aldeir Sabino dos Santos et al.   Frontiers in Microbiology

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

(2019) LaTonya J. Hickson et al.   EBioMedicine

Functional microbiome deficits associated with ageing: Chronological age threshold

(2019) Susana Ruiz‐Ruiz et al.   AGING CELL

The gut microbiota is a major regulator of androgen metabolism in intestinal contents

(2019) Hannah Colldén et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Colorectal cancer-associated microbiota contributes to oncogenic epigenetic signatures

(2019) Iradj Sobhani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurogenesis and prolongevity signaling in young germ-free mice transplanted with the gut microbiota of old mice

(2019) Parag Kundu et al.   Science Translational Medicine

Suppression of gut dysbiosis by Bifidobacterium longum alleviates cognitive decline in 5XFAD transgenic and aged mice

(2019) Hae-Ji Lee et al.   Scientific Reports

Fecal microbiome signatures of pancreatic cancer patients

(2019) Elizabeth Half et al.   Scientific Reports

Cellular senescence and chronological age in various human tissues: A systematic review and meta‐analysis

(2019) Camilla S. L. Tuttle et al.   AGING CELL

Probiotic bacteria as modulators of cellular senescence: emerging concepts and opportunities

(2019) Rohit Sharma et al.   Gut Microbes

Cellular senescence: Immunosurveillance and future immunotherapy

(2018) Dominick G.A. Burton et al.   AGEING RESEARCH REVIEWS

Multiscale Evolutionary Dynamics of Host-Associated Microbiomes

(2018) Aura Ferreiro et al.   CELL

Probiotic Cell-Free Supernatants Exhibited Anti-Inflammatory and Antioxidant Activity on Human Gut Epithelial Cells and Macrophages Stimulated with LPS

(2018) Stefania De Marco et al.   Evidence-based Complementary and Alternative Medicine

Mechanisms and functions of cellular senescence

(2018) Nicolás Herranz et al.   JOURNAL OF CLINICAL INVESTIGATION

Lactic acid bacteria-fermented product of green tea and Houttuynia cordata leaves exerts anti-adipogenic and anti-obesity effects

(2018) Li-Chun Wang et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

Stress, cell senescence and organismal ageing

(2018) João Pedro de Magalhães et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The fecal metabolome as a functional readout of the gut microbiome

(2018) Jonas Zierer et al.   NATURE GENETICS

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Possible correlation between gut microbiota and immunity among healthy middle-aged and elderly people in southwest China

(2018) Xi Shen et al.   Gut Pathogens

Metagenomic and metabolomic analyses unveil dysbiosis of gut microbiota in chronic heart failure patients

(2018) Xiao Cui et al.   Scientific Reports

Dysbiosis signatures of gut microbiota in coronary artery disease

(2018) Qi Zhu et al.   PHYSIOLOGICAL GENOMICS

Analysis of the Gut Microbiome of Rural and Urban Healthy Indians Living in Sea Level and High Altitude Areas

(2018) Bhabatosh Das et al.   Scientific Reports

Rebuilding the Gut Microbiota Ecosystem

(2018) Antonella Gagliardi et al.   International Journal of Environmental Research and Public Health

Epigallocatechin gallate suppresses premature senescence of preadipocytes by inhibition of PI3K/Akt/mTOR pathway and induces senescent cell death by regulation of Bax/Bcl-2 pathway

(2018) Ravi Kumar et al.   BIOGERONTOLOGY

Microbiota-Derived Lactate Activates Production of Reactive Oxygen Species by the Intestinal NADPH Oxidase Nox and Shortens Drosophila Lifespan

(2018) Igor Iatsenko et al.   IMMUNITY

Impaired immune surveillance accelerates accumulation of senescent cells and aging

(2018) Yossi Ovadya et al.   Nature Communications

Gastric microbial community profiling reveals a dysbiotic cancer-associated microbiota

(2017) Rui M Ferreira et al.   GUT

Biological Aging and the Human Gut Microbiota

(2017) Vincent J Maffei et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The gut microbiome in atherosclerotic cardiovascular disease

(2017) Zhuye Jie et al.   Nature Communications

Regulation of life span by the gut microbiota in the short-lived African turquoise killifish

(2017) Patrick Smith et al.   eLife

Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice

(2017) Floris Fransen et al.   Frontiers in Immunology

(Dis)Trust your gut: the gut microbiome in age-related inflammation, health, and disease

(2017) Thomas W. Buford   Microbiome

A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1−/ − mice is correlated to increased cellular senescence

(2017) Yiqiang Zhang et al.   Redox Biology

Dysbiosis and compositional alterations with aging in the gut microbiota of patients with heart failure

(2017) Takehiro Kamo et al.   PLoS One

The effect of age on the intestinal mucus thickness, microbiota composition and immunity in relation to sex in mice

(2017) Marlies Elderman et al.   PLoS One

Gut microbiota signatures of longevity

(2016) Fanli Kong et al.   CURRENT BIOLOGY

Current Understanding of Dysbiosis in Disease in Human and Animal Models

(2016) Arianna K. DeGruttola et al.   INFLAMMATORY BOWEL DISEASES

Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice

(2016) Ming Xu et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Butyrate production from high-fiber diet protects against lymphoma tumor

(2016) Wei Wei et al.   LEUKEMIA & LYMPHOMA

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Cross-species comparisons of host genetic associations with the microbiome

(2016) Julia K. Goodrich et al.   SCIENCE

Functional Redundancy-Induced Stability of Gut Microbiota Subjected to Disturbance

(2016) Andrés Moya et al.   TRENDS IN MICROBIOLOGY

Anti-inflammaging effects of Lactobacillus brevis OW38 in aged mice

(2016) J.-J. Jeong et al.   Beneficial Microbes

Revised Estimates for the Number of Human and Bacteria Cells in the Body

(2016) Ron Sender et al.   PLOS BIOLOGY

Cellular Senescence as the Causal Nexus of Aging

(2016) Naina Bhatia-Dey et al.   Frontiers in Genetics

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

The probiotic mixture IRT5 ameliorates age-dependent colitis in rats

(2015) Jin-Ju Jeong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Investigation of the Association Between the Fecal Microbiota and Breast Cancer in Postmenopausal Women: a Population-Based Case-Control Pilot Study

(2015) James J. Goedert et al.   JNCI-Journal of the National Cancer Institute

Neutrophil ageing is regulated by the microbiome

(2015) Dachuan Zhang et al.   NATURE

The tantalizing links between gut microbes and the brain

(2015) Peter Andrey Smith   NATURE

Gut mucosal microbiome across stages of colorectal carcinogenesis

(2015) Geicho Nakatsu et al.   Nature Communications

Investigation of the Association Between the Fecal Microbiota and Breast Cancer in Postmenopausal Women: a Population-Based Case-Control Pilot Study

(2015) James J. Goedert et al.   JNCI-Journal of the National Cancer Institute

Orally Administrated Lactobacillus pentosus var. plantarum C29 Ameliorates Age-Dependent Colitis by Inhibiting the Nuclear Factor-Kappa B Signaling Pathway via the Regulation of Lipopolysaccharide Production by Gut Microbiota

(2015) Jin-Ju Jeong et al.   PLoS One

Improvement in Th1/Th2 immune homeostasis, antioxidative status and resistance to pathogenic E. coli on consumption of probiotic Lactobacillus rhamnosus fermented milk in aging mice

(2014) Rohit Sharma et al.   AGE

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Senescence and apoptosis: dueling or complementary cell fates?

(2014) B. G. Childs et al.   EMBO REPORTS

Prognostic Value of Elevated Levels of Intestinal Microbe-Generated Metabolite Trimethylamine-N-Oxide in Patients With Heart Failure

(2014) W.H. Wilson Tang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Minireview: Gut Microbiota: The Neglected Endocrine Organ

(2014) Gerard Clarke et al.   MOLECULAR ENDOCRINOLOGY

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

(2014) Pamela V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fecal microbial metabolism of polyphenols and its effects on human gut microbiota

(2013) Shanthi G. Parkar et al.   ANAEROBE

Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model

(2013) Christin E. Burd et al.   CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Programmed Cell Senescence during Mammalian Embryonic Development

(2013) Daniel Muñoz-Espín et al.   CELL

Fermentation in vitro of EGCG, GCG and EGCG3"Me isolated from Oolong tea by human intestinal microbiota

(2013) Xin Zhang et al.   FOOD RESEARCH INTERNATIONAL

Age-Associated Remodeling of the Intestinal Epithelial Barrier

(2013) L. Tran et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

(2013) Shin Yoshimoto et al.   NATURE

The abundance and variety of carbohydrate-active enzymes in the human gut microbiota

(2013) Abdessamad El Kaoutari et al.   NATURE REVIEWS MICROBIOLOGY

A senescent cell bystander effect: senescence-induced senescence

(2012) Glyn Nelson et al.   AGING CELL

Genetics of Longevity in Model Organisms: Debates and Paradigm Shifts

(2012) David Gems et al.   Annual Review of Physiology

Gut Microbiota Composition and Activity in Relation to Host Metabolic Phenotype and Disease Risk

(2012) Elaine Holmes et al.   Cell Metabolism

Symptomatic atherosclerosis is associated with an altered gut metagenome

(2012) Fredrik H. Karlsson et al.   Nature Communications

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

(2011) Ariel C. Bulua et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Composition, variability, and temporal stability of the intestinal microbiota of the elderly

(2010) M. J. Claesson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns

(2010) M. G. Dominguez-Bello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression ofp16INK4ain peripheral blood T-cells is a biomarker of human aging

(2009) Yan Liu et al.   AGING CELL

Doxorubicin induces senescence or apoptosis in rat neonatal cardiomyocytes by regulating the expression levels of the telomere binding factors 1 and 2

(2009) Paolo Spallarossa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age

(2009) D Mariat et al.   BMC MICROBIOLOGY

GPR109A Is a G-protein-Coupled Receptor for the Bacterial Fermentation Product Butyrate and Functions as a Tumor Suppressor in Colon

(2009) M. Thangaraju et al.   CANCER RESEARCH

An Update of the Oxidation-Inflammation Theory of Aging: The Involvement of the Immune System in Oxi-Inflamm-Aging

(2009) Monica Fuente et al.   CURRENT PHARMACEUTICAL DESIGN

Gut microbiota: Changes throughout the lifespan from infancy to elderly

(2009) Paul W. O'Toole et al.   INTERNATIONAL DAIRY JOURNAL

Microbial community gene expression in ocean surface waters

(2008) J. Frias-Lopez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA