Selective electrophilic di- and monofluorinations for the synthesis of 4-difluoromethyl and 4-fluoromethyl quinazolin(thi)ones by a Selectfluor-triggered multi-component reaction

A fluorine turns a medicinal benzodiazepine into NPS: the case of flualprazolam

(2021) Panagoula-Stamatina A. Ntoupa et al.   Forensic Toxicology

U.S. FDA Approved Drugs from 2015–June 2020: A Perspective

(2021) Priyadeep Bhutani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Applications of fluorine to the construction of bioisosteric elements for the purposes of novel drug discovery

(2021) Paul Richardson   Expert Opinion on Drug Discovery

Environmentally Benign Synthesis of Quinoline–Spiroquinazolinones by Iron-Catalyzed Dehydrogenative [4 + 2] Cycloaddition of Secondary/Tertiary Anilines and 4-Methylene-quinazolinones

(2021) Yuxin Ding et al.   JOURNAL OF ORGANIC CHEMISTRY

Iodine‐Catalyzed Double [4+2] Oxidative Annulations for the Synthesis of Bipyrazines from Ketones and Diamines by a Domino Strategy

(2021) Yuxin Ding et al.   ADVANCED SYNTHESIS & CATALYSIS

Aryl Quinazolinone Derivatives as Novel Therapeutic Agents against Brain-Eating Amoebae

(2020) Mohammad Ridwane Mungroo et al.   ACS Chemical Neuroscience

A practical synthesis of α-bromo/iodo/chloroketones from olefins under visible-light irradiation conditions

(2020) Zhihui Wang et al.   CHINESE CHEMICAL LETTERS

Exploration of the Structural Space in 4(3H)-Quinazolinone Antibacterials

(2020) Yuanyuan Qian et al.   JOURNAL OF MEDICINAL CHEMISTRY

Visible-light-induced photoredox-catalyzed synthesis of benzimidazo[2,1-a]iso-quinoline-6(5H)-ones

(2020) Bin Wang et al.   CHINESE CHEMICAL LETTERS

Palladium‐Catalyzed Regio‐, Diastereo‐, and Enantioselective 1,2‐Arylfluorination of Internal Enamides

(2020) Yang Xi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Importance of Fluorine in Benzazole Compounds

(2020) Thuraya Al-Harthy et al.   MOLECULES

Structure-guided optimization and mechanistic study of a class of quinazolinone-threonine hybrids as antibacterial ThrRS inhibitors

(2020) Junsong Guo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Expeditious Approach to Indoloquinazolinones via Double Annulations of o-Aminoacetophenones and Isocyanates

(2020) Yuxin Ding et al.   JOURNAL OF ORGANIC CHEMISTRY

Cink4T, a quinazolinone-based dual inhibitor of Cdk4 and tubulin polymerization, identified via ligand-based virtual screening, for efficient anticancer therapy

(2019) Vinay Sonawane et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Anticancer and DNA binding studies of potential amino acids based quinazolinone analogs: Synthesis, SAR and molecular docking

(2019) K.P. Rakesh et al.   BIOORGANIC CHEMISTRY

4(3H)-Quinazolinone derivatives: Promising antibacterial drug leads

(2019) Srikanth Gatadi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, in-silico studies and biological screening of quinazolinone analogues as potential antibacterial agents against MRSA

(2019) Shahnawaz I. Qureshi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, Molecular Docking, and Biological Evaluation of the New Hybrids of 4-Thiazolidinone and 4(3H)-Quinazolinone Against Streptozotocin Induced Diabetic Rats

(2019) S. S. Jangam et al.   RUSSIAN JOURNAL OF GENERAL CHEMISTRY

A Simple Metal-Free Cyclization for the Synthesis of 4-Methylene-3-Substituted Quinazolinone and Quinazolinthione Derivatives: Experiment and Theory

(2019) Huihui Yan et al.   Frontiers in Chemistry

Applications of fluorine-containing amino acids for drug design

(2019) Haibo Mei et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Direct and Chemoselective Synthesis of Tertiary Difluoroketones via Weinreb Amide Homologation with a CHF2-Carbene Equivalent

(2019) Margherita Miele et al.   ORGANIC LETTERS

Modern Approaches for Asymmetric Construction of Carbon–Fluorine Quaternary Stereogenic Centers: Synthetic Challenges and Pharmaceutical Needs

(2018) Yi Zhu et al.   CHEMICAL REVIEWS

Expedient chemoselective and catalyst-free synthesis of 3,3-difluorochroman-4-ones from o -hydroxyarylenaminones and Selectfluor

(2018) Jian Xu et al.   CHINESE CHEMICAL LETTERS

Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure

(2018) Wolfgang Dohle et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, spectroscopic characterization, antimicrobial evaluation and molecular docking study of novel triazine-quinazolinone based hybrids

(2018) Mohammad Dinari et al.   JOURNAL OF MOLECULAR STRUCTURE

Design, synthesis, molecular modeling, and biological evaluation of novel α-aminophosphonates based quinazolinone moiety as potential anticancer agents: DFT, NBO and vibrational studies

(2018) Mohamed K. Awad et al.   JOURNAL OF MOLECULAR STRUCTURE

A Coupling Approach for the Generation of α,α-Bis(enolate) Equivalents: Regioselective Synthesis of gem-Difunctionalized Ketones

(2018) Carmelo E. Iacono et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Difluorination–Hydroxylation, Trifluorination, and C(sp2)–H Fluorination of Enamides

(2018) Socrates B. Munoz et al.   ORGANIC LETTERS

Synthesis and anticancer activity of novel quinazolinone and benzamide derivatives

(2018) Maher Abd El-Aziz Mahmoud El-Hashash et al.   RESEARCH ON CHEMICAL INTERMEDIATES

Fullerene quinazolinone conjugates targeting Mycobacterium tuberculosis: a combined molecular docking, QSAR, and ONIOM approach

(2018) Ali Mirchi et al.   STRUCTURAL CHEMISTRY

Antitumor Activity of Quinazolinone Alkaloids Inspired by Marine Natural Products

(2018) Solida Long et al.   Marine Drugs

Design and synthesis of novel quinazolinone-1,2,3-triazole hybrids as new anti-diabetic agents: In vitro α-glucosidase inhibition, kinetic, and docking study

(2018) Mina Saeedi et al.   BIOORGANIC CHEMISTRY

Pharmaceutical prospects of naturally occurring quinazolinone and its derivatives

(2017) Dan He et al.   FITOTERAPIA

Novel quinazolinone-based 2,4-thiazolidinedione-3-acetic acid derivatives as potent aldose reductase inhibitors

(2017) Kamel Metwally et al.   Future Medicinal Chemistry

Quinazolinone Derivatives as a Potential Class of Compounds in Malaria Drug Discovery

(2017) Mohammed Hussen Bule et al.   International Journal of Pharmacology

Difluorination of Furonaphthoquinones

(2017) Jie Li et al.   JOURNAL OF ORGANIC CHEMISTRY

Application of Fluorine in Drug Design During 2010-2015 Years: A Mini-Review

(2017) Bao-Cheng Wang et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Me3SiCF2Br-Self-Assisted Domino Reaction: Catalytic Synthesis of α,α-Difluorocyclopentanones from Methylvinylketones

(2017) Jian Chang et al.   ORGANIC LETTERS

The unique fluorine effects in organic reactions: recent facts and insights into fluoroalkylations

(2016) Chuanfa Ni et al.   CHEMICAL SOCIETY REVIEWS

Fluorination methods for drug discovery and development

(2016) Paul Richardson   Expert Opinion on Drug Discovery

Synthesis, crystal structure and biological evaluation of substituted quinazolinone benzoates as novel antituberculosis agents targeting acetohydroxyacid synthase

(2015) Wei Lu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthetic approaches, functionalization and therapeutic potential of quinazoline and quinazolinone skeletons: The advances continue

(2015) Imtiaz Khan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Applications of Fluorine in Medicinal Chemistry

(2015) Eric P. Gillis et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Highly Regio- and Stereoselective Synthesis of α-Fluorinated Imides via Fluorination of Chiral Enamides

(2015) Yan-Shuang Xu et al.   ORGANIC LETTERS

Difluorohomologation of Ketones

(2015) Mikhail D. Kosobokov et al.   ORGANIC LETTERS

Nickel-Catalyzed Cross-Coupling of Functionalized Difluoromethyl Bromides and Chlorides with Aryl Boronic Acids: A General Method for Difluoroalkylated Arenes

(2014) Yu-Lan Xiao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorinated Compounds in Medicinal Chemistry: Recent Applications, Synthetic Advances and Matched-Pair Analyses

(2014) David Barnes-Seeman et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Trifluoromethyl Ethers and –Thioethers as Tools for Medicinal Chemistry and Drug Discovery

(2014) Gregory Landelle et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Recent Progress in Asymmetric Fluorination and Trifluoromethylation Reactions

(2014) Vincent Bizet et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Recent advances in the structural library of functionalized quinazoline and quinazolinone scaffolds: Synthetic approaches and multifarious applications

(2014) Imtiaz Khan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Direct Synthesis of Fluorinated Heteroarylether Bioisosteres

(2013) Qianghui Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Introduction of Fluorine and Fluorine-Containing Functional Groups

(2013) Theresa Liang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

Discovery of a New Class of Natural Product-Inspired Quinazolinone Hybrid as Potent Antileishmanial agents

(2013) Moni Sharma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of cationic fullerene quinazolinone conjugates and their binding mode with modeled Mycobacterium tuberculosis hypoxanthine-guanine phosphoribosyltransferase enzyme

(2013) Manishkumar B. Patel et al.   JOURNAL OF MOLECULAR MODELING

Palladium-catalyzed asymmetric hydrogenation of fluorinated quinazolinones

(2013) Ying Duan et al.   TETRAHEDRON LETTERS

A Doubly Axially Chiral Phosphoric Acid Catalyst for the Asymmetric Tandem Oxyfluorination of Enamides

(2012) Takashi Honjo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Fluorination of Enamides: Access to α-Fluoroimines Using an Anionic Chiral Phase-Transfer Catalyst

(2012) Robert J. Phipps et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis and antitubercular activity of novel pyrazole–quinazolinone hybrid analogs

(2012) Unnat Pandit et al.   MEDICINAL CHEMISTRY RESEARCH

Tricomponent Catalytic α,α-Difluorination of Acid Chlorides

(2011) Steven Bloom et al.   ORGANIC LETTERS

An Efficient Difluorohydroxylation of Indoles Using Selectfluor as a Fluorinating Reagent

(2011) Riyuan Lin et al.   ORGANIC LETTERS

Synthesis and evaluation of 4-quinazolinone compounds as potential antimalarial agents

(2010) Shuren Zhu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Fluorocyanation of Enamines

(2010) Alexander D. Dilman et al.   JOURNAL OF ORGANIC CHEMISTRY