标题
Fluorination methods for drug discovery and development
作者
关键词
-
出版物
Expert Opinion on Drug Discovery
Volume 11, Issue 10, Pages 983-999
出版商
Informa UK Limited
发表日期
2016-08-22
DOI
10.1080/17460441.2016.1223037
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- 18F-Labeling of Arenes and Heteroarenes for Applications in Positron Emission Tomography
- (2016) Sean Preshlock et al. CHEMICAL REVIEWS
- Concerted nucleophilic aromatic substitution with 19F− and 18F−
- (2016) Constanze N. Neumann et al. NATURE
- A Transmetalation Reaction Enables the Synthesis of [18F]5-Fluorouracil from [18F]Fluoride for Human PET Imaging
- (2016) Andrew J. Hoover et al. ORGANOMETALLICS
- Moving Metal-Mediated 18F-Fluorination from Concept to Clinic
- (2016) Melanie S. Sanford et al. ACS Central Science
- Late-Stage Fluorination: Fancy Novelty or Useful Tool?
- (2015) Constanze N. Neumann et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Monofluorination of Organic Compounds: 10 Years of Innovation
- (2015) Pier Alexandre Champagne et al. CHEMICAL REVIEWS
- Organofluorine chemistry: applications, sources and sustainability
- (2015) Antal Harsanyi et al. GREEN CHEMISTRY
- Anhydrous Tetramethylammonium Fluoride for Room-Temperature SNAr Fluorination
- (2015) Sydonie D. Schimler et al. JOURNAL OF ORGANIC CHEMISTRY
- PyFluor: A Low-Cost, Stable, and Selective Deoxyfluorination Reagent
- (2015) Matthew K. Nielsen et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Dosage delivery of sensitive reagents enables glove-box-free synthesis
- (2015) Aaron C. Sather et al. NATURE
- Acyl Azolium Fluorides for Room Temperature Nucleophilic Aromatic Fluorination of Chloro- and Nitroarenes
- (2015) Sarah J. Ryan et al. ORGANIC LETTERS
- PhenoFluorMix: Practical Chemoselective Deoxyfluorination of Phenols
- (2015) Teppei Fujimoto et al. ORGANIC LETTERS
- Synthesis of [18F]Arenes via the Copper-Mediated [18F]Fluorination of Boronic Acids
- (2015) Andrew V. Mossine et al. ORGANIC LETTERS
- Modern Carbon–Fluorine Bond Forming Reactions for Aryl Fluoride Synthesis
- (2014) Michael G. Campbell et al. CHEMICAL REVIEWS
- Mild Fluorination of Chloropyridines with in Situ Generated Anhydrous Tetrabutylammonium Fluoride
- (2014) Laura J. Allen et al. JOURNAL OF ORGANIC CHEMISTRY
- Pd-Catalyzed Nucleophilic Fluorination of Aryl Bromides
- (2014) Hong Geun Lee et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Synthesis and Late-Stage Functionalization of Complex Molecules through C–H Fluorination and Nucleophilic Aromatic Substitution
- (2014) Patrick S. Fier et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Copper-Catalyzed [18F]Fluorination of (Mesityl)(aryl)iodonium Salts
- (2014) Naoko Ichiishi et al. ORGANIC LETTERS
- Late-Stage Fluorination: From Fundamentals to Application
- (2014) Michael G. Campbell et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Process Development for Scale-Up of a Novel 3,5-Substituted Thiazolidine-2,4-dione Compound as a Potent Inhibitor for Estrogen-Related Receptor 1
- (2014) Xun Li et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- A One-Pot Diazotation–Fluorodediazoniation Reaction and Fluorine Gas for the Production of Fluoronaphthyridines
- (2014) Stefan Abele et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- PhenoFluor: Practical Synthesis, New Formulation, and Deoxyfluorination of Heteroaromatics
- (2014) Teppei Fujimoto et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Silver-mediated fluorination of potassium aryltrifluoroborates with Selectfluor®
- (2014) Srinivas Reddy Dubbaka et al. TETRAHEDRON
- Late-stage [18F]fluorination: new solutions to old problems
- (2014) Allen F. Brooks et al. Chemical Science
- Introduction of Fluorine and Fluorine-Containing Functional Groups
- (2013) Theresa Liang et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Flow microreactor synthesis in organo-fluorine chemistry
- (2013) Hideki Amii et al. Beilstein Journal of Organic Chemistry
- Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
- (2013) Jiang Wang et al. CHEMICAL REVIEWS
- Synthesis of Functionalized Aryl Fluorides Using Organolithium Reagents in Flow Microreactors
- (2013) Aiichiro Nagaki et al. Chemistry-An Asian Journal
- Late-Stage Deoxyfluorination of Alcohols with PhenoFluor
- (2013) Filippo Sladojevich et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Palladium(III)-Catalyzed Fluorination of Arylboronic Acid Derivatives
- (2013) Anthony R. Mazzotti et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Mild Copper-Mediated Fluorination of Aryl Stannanes and Aryl Trifluoroborates
- (2013) Yingda Ye et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Copper-Mediated Fluorination of Arylboronate Esters. Identification of a Copper(III) Fluoride Complex
- (2013) Patrick S. Fier et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Cu(OTf)2-Mediated Fluorination of Aryltrifluoroborates with Potassium Fluoride
- (2013) Yingda Ye et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- An Improved Catalyst System for the Pd-Catalyzed Fluorination of (Hetero)Aryl Triflates
- (2013) Hong Geun Lee et al. ORGANIC LETTERS
- Application of Palladium-Mediated 18F-Fluorination to PET Radiotracer Development: Overcoming Hurdles to Translation
- (2013) Adam S. Kamlet et al. PLoS One
- Investigating the Dearomative Rearrangement of Biaryl Phosphine-Ligated Pd(II) Complexes
- (2012) Phillip J. Milner et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Selective Continuous Flow Processes Using Fluorine Gas
- (2012) Christopher B. McPake et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- A New Route to Roflumilast via Copper-Catalyzed Hydroxylation
- (2012) Jianqi Li et al. SYNTHESIS-STUTTGART
- Palladium(II)-Catalyzed Selective Monofluorination of Benzoic Acids Using a Practical Auxiliary: A Weak-Coordination Approach
- (2011) Kelvin S. L. Chan et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Accelerating Palladium-Catalyzed CF Bond Formation: Use of a Microflow Packed-Bed Reactor
- (2011) Timothy Noël et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- 4-Fluoropyrrolidine-2-carbonyl Fluorides: Useful Synthons and Their Facile Preparation with 4-tert-Butyl-2,6-dimethylphenylsulfur Trifluoride
- (2011) Rajendra P. Singh et al. JOURNAL OF ORGANIC CHEMISTRY
- Deoxyfluorination of Phenols
- (2011) Pingping Tang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Evidence for in Situ Catalyst Modification during the Pd-Catalyzed Conversion of Aryl Triflates to Aryl Fluorides
- (2011) Thomas J. Maimone et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Silver-mediated fluorination of aryl silanes
- (2011) Pingping Tang et al. TETRAHEDRON
- Convenient Electrophilic Fluorination of Functionalized Aryl and Heteroaryl Magnesium Reagents
- (2010) Shigeyuki Yamada et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- A New and Practical Grignard-Coupling-Fluorination Sequence: Synthesis of 2-Aryl Fluoroarenes
- (2010) Pazhamalai Anbarasan et al. Chemistry-An Asian Journal
- Probing Fluorine Interactions in a Polyhydroxylated Environment: Conservation of a C-F···H-C Recognition Motif in Presence of O-H···O Hydrogen Bonds
- (2010) Goverdhan Mehta et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Aminodifluorosulfinium Salts: Selective Fluorination Reagents with Enhanced Thermal Stability and Ease of Handling†,‡
- (2010) Alexandre L’Heureux et al. JOURNAL OF ORGANIC CHEMISTRY
- Discovery of 4-tert-Butyl-2,6-dimethylphenylsulfur Trifluoride as a Deoxofluorinating Agent with High Thermal Stability as Well as Unusual Resistance to Aqueous Hydrolysis, and Its Diverse Fluorination Capabilities Including Deoxofluoro-Arylsulfinylation with High Stereoselectivity
- (2010) Teruo Umemoto et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Transition-Metal-Mediated Reactions for Csp2F Bond Construction: The State of Play
- (2009) John M. Brown et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Efficient Synthesis of Aryl Fluorides
- (2009) Pazhamalai Anbarasan et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Fluorine in medicinal chemistry: a century of progress and a 60-year retrospective of selected highlights
- (2009) Robert Filler et al. Future Medicinal Chemistry
- Silver-Mediated Fluorination of Functionalized Aryl Stannanes
- (2009) Takeru Furuya et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Aminodifluorosulfinium Tetrafluoroborate Salts as Stable and Crystalline Deoxofluorinating Reagents
- (2009) Francis Beaulieu et al. ORGANIC LETTERS
- Fluorination of Boronic Acids Mediated by Silver(I) Triflate
- (2009) Takeru Furuya et al. ORGANIC LETTERS
- Formation of ArF from LPdAr(F): Catalytic Conversion of Aryl Triflates to Aryl Fluorides
- (2009) D. A. Watson et al. SCIENCE
- Development of fluorination methods using continuous-flow microreactors
- (2009) Marcus Baumann et al. TETRAHEDRON
- Metal-free electrophilic fluorination of alkyl trifluoroborates and boronic acids
- (2009) Clément Cazorla et al. TETRAHEDRON LETTERS
- Palladium-Mediated Fluorination of Arylboronic Acids
- (2008) Takeru Furuya et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Fluorination reactions in microreactors
- (2008) Tomas Gustafsson et al. CHEMICAL COMMUNICATIONS
- The Many Roles for Fluorine in Medicinal Chemistry
- (2008) William K. Hagmann JOURNAL OF MEDICINAL CHEMISTRY
- Development of a Bulk Enabling Route to Maraviroc (UK-427,857), a CCR-5 Receptor Antagonist
- (2008) Sarah J. Haycock-Lewandowski et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Fluorination in Medicinal Chemistry: Methods, Strategies, and Recent Developments
- (2008) Kenneth L. Kirk ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Understanding organofluorine chemistry. An introduction to the C–F bond
- (2007) David O'Hagan CHEMICAL SOCIETY REVIEWS
- Fluorine in medicinal chemistry
- (2007) Sophie Purser et al. CHEMICAL SOCIETY REVIEWS
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