标题
U.S. FDA Approved Drugs from 2015–June 2020: A Perspective
作者
关键词
-
出版物
JOURNAL OF MEDICINAL CHEMISTRY
Volume 64, Issue 5, Pages 2339-2381
出版商
American Chemical Society (ACS)
发表日期
2021-02-23
DOI
10.1021/acs.jmedchem.0c01786
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Lemborexant: First Approval
- (2020) Lesley J. Scott DRUGS
- The Pharmaceutical Industry in 2019. An Analysis of FDA Drug Approvals from the Perspective of Molecules
- (2020) Beatriz G. de la Torre et al. MOLECULES
- Fluorine-containing drugs approved by the FDA in 2019
- (2020) Haibo Mei et al. CHINESE CHEMICAL LETTERS
- Frailty and Co-Prescribing of Potentially Interacting Drugs in New Users of Warfarin
- (2020) Milka Hauta-aho et al. DRUGS & AGING
- Invited commentary— WHO Classification of Tumours: How should tumors be classified? Expert consensus, systematic reviews or both?
- (2020) Lesley Uttley et al. INTERNATIONAL JOURNAL OF CANCER
- Metabolic and Pharmaceutical Aspects of Fluorinated Compounds
- (2020) Benjamin M. Johnson et al. JOURNAL OF MEDICINAL CHEMISTRY
- Naldemedine: A New Option for OIBD
- (2020) Flaminia Coluzzi et al. Journal of Pain Research
- Advancing structured decision‐making in drug regulation at the FDA and EMA
- (2020) Aris Angelis et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Spirocyclic Scaffolds in Medicinal Chemistry
- (2020) Kerstin Hiesinger et al. JOURNAL OF MEDICINAL CHEMISTRY
- Applications of deuterium in medicinal chemistry
- (2019) Tracey Pirali et al. JOURNAL OF MEDICINAL CHEMISTRY
- Drug pipeline: 4Q18
- (2019) Laura DeFrancesco NATURE BIOTECHNOLOGY
- The Pharmaceutical Industry in 2018. An Analysis of FDA Drug Approvals from the Perspective of Molecules
- (2019) Beatriz G. de la Torre et al. MOLECULES
- Design of N-Benzoxaborole Benzofuran GSK8175—Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor
- (2019) Pek Y. Chong et al. JOURNAL OF MEDICINAL CHEMISTRY
- Drug Approved for Rare Muscle Weakening Syndrome
- (2019) Rebecca Voelker JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Mycobacterium tuberculosis infection of host cells in space and time
- (2019) Claudio Bussi et al. FEMS MICROBIOLOGY REVIEWS
- Ravulizumab: First Global Approval
- (2019) Kate McKeage DRUGS
- Clinical Studies on Drug‐Drug Interactions Involving Metabolism and Transport: Methodology, Pitfalls and Interpretation
- (2019) Aleksi Tornio et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association
- (2019) Emelia J. Benjamin et al. CIRCULATION
- Vestronidase Alfa: A Review in Mucopolysaccharidosis VII
- (2019) Emma H. McCafferty et al. BIODRUGS
- Cannabinoid therapy in epilepsy
- (2019) Santoshi Billakota et al. CURRENT OPINION IN NEUROLOGY
- A comparison of EMA and FDA decisions for new drug marketing applications 2014‐2016: concordance, discordance and why
- (2019) Mwango Kashoki et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Will morphing boron-based inhibitors beat the β-lactamases?
- (2019) Alen Krajnc et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- 2018 in review: FDA approvals of new molecular entities
- (2019) Michael S. Kinch et al. DRUG DISCOVERY TODAY
- Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165
- (2019) Stephen T. Wrobleski et al. JOURNAL OF MEDICINAL CHEMISTRY
- Hepatitis C virus infection in children and adolescents
- (2019) Giuseppe Indolfi et al. Lancet Gastroenterology & Hepatology
- Cystic fibrosis lung disease and bronchiectasis
- (2019) James D Chalmers Lancet Respiratory Medicine
- Association Between the Respiratory Microbiome and Susceptibility to Influenza Virus Infection
- (2019) Tim K Tsang et al. CLINICAL INFECTIOUS DISEASES
- Pretomanid: First Approval
- (2019) Susan J. Keam DRUGS
- Upadacitinib: First Approval
- (2019) Sean Duggan et al. DRUGS
- Boron in drug design: Recent advances in the development of new therapeutic agents
- (2019) Guilherme Felipe Santos Fernandes et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Role of sulphur-heterocycles in medicinal chemistry: An update
- (2019) Shelly Pathania et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Secnidazole for treatment of bacterial vaginosis: a systematic review
- (2019) Mohamed A. Abd El Aziz et al. BMC Womens Health
- The global burden of neurological disorders: translating evidence into policy
- (2019) Valery L Feigin et al. LANCET NEUROLOGY
- Editorial: Recent Trends in Anticancer Drug Development: Challenges and Opportunities
- (2018) Ira-Ida Skvortsova et al. CURRENT MEDICINAL CHEMISTRY
- Latanoprostene Bunod Ophthalmic Solution 0.024%: A Review in Open-Angle Glaucoma and Ocular Hypertension
- (2018) Sheridan M. Hoy DRUGS
- Fostamatinib: First Global Approval
- (2018) Anthony Markham DRUGS
- Update on FXR Biology: Promising Therapeutic Target?
- (2018) Chang Han INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design
- (2018) Nicholas A. Meanwell JOURNAL OF MEDICINAL CHEMISTRY
- From Oxiranes to Oligomers: Architectures of US FDA Approved Pharmaceuticals Containing Oxygen Heterocycles
- (2018) Michael D. Delost et al. JOURNAL OF MEDICINAL CHEMISTRY
- The Lancet Commission on malaria eradication
- (2018) Ingrid Chen et al. LANCET
- Chronic idiopathic constipation in adults: epidemiology, pathophysiology, diagnosis and clinical management
- (2018) Christopher J Black et al. MEDICAL JOURNAL OF AUSTRALIA
- The Pharmaceutical Industry in 2017. An Analysis of FDA Drug Approvals from the Perspective of Molecules
- (2018) Beatriz de la Torre et al. MOLECULES
- The expanding role of prodrugs in contemporary drug design and development
- (2018) Jarkko Rautio et al. NATURE REVIEWS DRUG DISCOVERY
- Targeted 5-HT1F Therapies for Migraine
- (2018) Marta Vila-Pueyo Neurotherapeutics
- Adenosine deaminase deficiency: a review
- (2018) Aisling M. Flinn et al. Orphanet Journal of Rare Diseases
- Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers
- (2018) Janeta Popovici-Muller et al. ACS Medicinal Chemistry Letters
- Delafloxacin: A New Anti-MRSA Fluoroquinolone
- (2018) Louis D Saravolatz et al. CLINICAL INFECTIOUS DISEASES
- Elagolix: First Global Approval
- (2018) Yvette N. Lamb DRUGS
- Tecovirimat: First Global Approval
- (2018) Sheridan M. Hoy DRUGS
- Testing Fluorescence Lifetime Standards using Two-Photon Excitation and Time-Domain Instrumentation: Fluorescein, Quinine Sulfate and Green Fluorescent Protein
- (2018) Arne S. Kristoffersen et al. JOURNAL OF FLUORESCENCE
- Designed for life: biocompatible de novo designed proteins and components
- (2018) Katie J. Grayson et al. Journal of the Royal Society Interface
- The burden of chronic respiratory diseases and their heterogeneity across the states of India: the Global Burden of Disease Study 1990–2016
- (2018) Sundeep Salvi et al. Lancet Global Health
- Angiotensin II: a new therapeutic option for vasodilatory shock
- (2018) Rachel Bussard et al. Therapeutics and Clinical Risk Management
- Comparing biologicals and small molecule drug therapies for chronic respiratory diseases: An EAACI Taskforce on Immunopharmacology position paper
- (2018) Franziska Roth-Walter et al. ALLERGY
- Revefenacin: First Global Approval
- (2018) Young-A Heo DRUGS
- A Survey of the Structures of US FDA Approved Combination Drugs
- (2018) Pradipta Das et al. JOURNAL OF MEDICINAL CHEMISTRY
- Nitro-Group-Containing Drugs
- (2018) Kunal Nepali et al. JOURNAL OF MEDICINAL CHEMISTRY
- Epidemiology and treatment patterns of rheumatoid arthritis in a large cohort of Arab patients
- (2018) Soha R. Dargham et al. PLoS One
- Triplet CFTR modulators: future prospects for treatment of cystic fibrosis
- (2018) Nauman Chaudary Therapeutics and Clinical Risk Management
- Heterozygous Mutation in Adenosine Deaminase Gene in a Patient With Severe Lymphopenia Following Corticosteroid Treatment of Autoimmune Hemolytic Anemia
- (2018) Serena I. Tripodi et al. Frontiers in Pediatrics
- A Comprehensive Map of FDA-Approved Pharmaceutical Products
- (2018) Hao Zhong et al. Pharmaceutics
- Lipid Lowering Therapy and Circulating PCSK9 Concentration
- (2017) Tsuyoshi Nozue Journal of Atherosclerosis and Thrombosis
- Platform for Unified Molecular Analysis: PUMA
- (2017) Mariana González-Medina et al. Journal of Chemical Information and Modeling
- Toward an Understanding of Structural Insights of Xanthine and Aldehyde Oxidases: An Overview of their Inhibitors and Role in Various Diseases
- (2017) Raj Kumar et al. MEDICINAL RESEARCH REVIEWS
- Therapeutic Potential of Targeting the Th17/Treg Axis in Autoimmune Disorders
- (2017) Patrizia Fasching et al. MOLECULES
- JAK inhibition as a therapeutic strategy for immune and inflammatory diseases
- (2017) Daniella M. Schwartz et al. NATURE REVIEWS DRUG DISCOVERY
- Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection
- (2017) Mark H. Wilcox et al. NEW ENGLAND JOURNAL OF MEDICINE
- DrugBank 5.0: a major update to the DrugBank database for 2018
- (2017) David S Wishart et al. NUCLEIC ACIDS RESEARCH
- Profile of sarilumab and its potential in the treatment of rheumatoid arthritis
- (2017) Maria Gabriella Raimondo et al. Drug Design Development and Therapy
- Transthyretin Cardiac Amyloidosis
- (2017) Anit K. Mankad et al. Current Cardiology Reports
- THROMBOCYTOPENIA IN PATIENTS WITH CHRONIC HEPATITIS C VIRUS INFECTION
- (2017) Sumit Dahal et al. Mediterranean Journal of Hematology and Infectious Diseases
- When barriers ignore the “rule-of-five”
- (2016) Stefanie D. Krämer et al. ADVANCED DRUG DELIVERY REVIEWS
- Combined Angiotensin Receptor Antagonism and Neprilysin Inhibition
- (2016) Scott A. Hubers et al. CIRCULATION
- An analysis of FDA-approved drugs for cardiovascular diseases
- (2016) Michael S. Kinch et al. DRUG DISCOVERY TODAY
- Migalastat: First Global Approval
- (2016) Anthony Markham DRUGS
- Venetoclax: First Global Approval
- (2016) Emma D. Deeks DRUGS
- Lesinurad: First Global Approval
- (2016) Sheridan M. Hoy DRUGS
- Ixazomib: First Global Approval
- (2016) Matt Shirley DRUGS
- Obeticholic Acid: First Global Approval
- (2016) A. Markham et al. DRUGS
- Natpara for the treatment of hypoparathyroidism
- (2016) Gemma Marcucci et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Drug–diagnostic co-development: challenges and issues
- (2016) Rumiko Shimazawa et al. EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
- Challenges and Opportunities for the Application of Boron Clusters in Drug Design
- (2016) Zbigniew J. Leśnikowski JOURNAL OF MEDICINAL CHEMISTRY
- Fluorescent Polymer Nanoparticles Based on Dyes: Seeking Brighter Tools for Bioimaging
- (2016) Andreas Reisch et al. Small
- Are the physicochemical properties of antibacterial compounds really different from other drugs?
- (2016) Jean-Paul Ebejer et al. Journal of Cheminformatics
- Chemotherapy-Induced Constipation and Diarrhea: Pathophysiology, Current and Emerging Treatments
- (2016) Rachel M. McQuade et al. Frontiers in Pharmacology
- Drug-drug interactions and QT prolongation as a commonly assessed cardiac effect - comprehensive overview of clinical trials
- (2016) Barbara Wiśniowska et al. BMC Pharmacology & Toxicology
- Discovery, Understanding, and Bioapplication of Organic Fluorophore: A Case Study with an Indolizine-Based Novel Fluorophore, Seoul-Fluor
- (2015) Eunha Kim et al. ACCOUNTS OF CHEMICAL RESEARCH
- Toxicophore exploration as a screening technology for drug design and discovery: techniques, scope and limitations
- (2015) Pankaj Kumar Singh et al. ARCHIVES OF TOXICOLOGY
- Pharmacological profile of opicapone, a third-generation nitrocatechol catechol-O-methyl transferase inhibitor, in the rat
- (2015) M J Bonifácio et al. BRITISH JOURNAL OF PHARMACOLOGY
- The differential expression of IL-4 and IL-13 and its impact on type-2 immunity
- (2015) Katherine Bao et al. CYTOKINE
- An analysis of FDA-approved drugs for metabolic diseases
- (2015) Michael S. Kinch et al. DRUG DISCOVERY TODAY
- An analysis of FDA-approved drugs for neurological disorders
- (2015) Michael S. Kinch DRUG DISCOVERY TODAY
- An analysis of FDA-approved drugs for inflammation and autoimmune diseases
- (2015) Michael S. Kinch et al. DRUG DISCOVERY TODAY
- Eluxadoline: First Global Approval
- (2015) Karly P. Garnock-Jones DRUGS
- Evaluation of Flibanserin
- (2015) Walid F. Gellad et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Discovery and Characterization of (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one (BMN 673, Talazoparib), a Novel, Highly Potent, and Orally Efficacious Poly(ADP-ribose) Polymerase-1/2 Inhibitor, as an Anticancer Agent
- (2015) Bing Wang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Applications of Fluorine in Medicinal Chemistry
- (2015) Eric P. Gillis et al. JOURNAL OF MEDICINAL CHEMISTRY
- A Survey of the Role of Noncovalent Sulfur Interactions in Drug Design
- (2015) Brett R. Beno et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases
- (2015) Scott J. Hecker et al. JOURNAL OF MEDICINAL CHEMISTRY
- Sphingosine-1-Phosphate and Its Receptors: A Mutual Link between Blood Coagulation and Inflammation
- (2015) Shailaja Mahajan-Thakur et al. MEDIATORS OF INFLAMMATION
- An FDA oncology analysis of antibody-drug conjugates
- (2015) Haleh Saber et al. REGULATORY TOXICOLOGY AND PHARMACOLOGY
- Molecular Property Design: Does Everyone Get It?
- (2015) Paul D. Leeson et al. ACS Medicinal Chemistry Letters
- The Prevalence of Age-Related Eye Diseases and Cataract Surgery among Older Adults in the City of Lodz, Poland
- (2015) Michal Szymon Nowak et al. Journal of Ophthalmology
- New oral anticoagulants: their advantages and disadvantages compared with vitamin K antagonists in the prevention and treatment of patients with thromboembolic events
- (2015) Agon Mekaj et al. Therapeutics and Clinical Risk Management
- Antibody-Drug Conjugates: An Emerging Concept in Cancer Therapy
- (2014) Ravi V. J. Chari et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Macrophage activation syndrome and cytokine-directed therapies
- (2014) Grant S. Schulert et al. BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
- Paroxysmal nocturnal hemoglobinuria
- (2014) R. A. Brodsky BLOOD
- Relapsing and progressive forms of multiple sclerosis
- (2014) Ranjan Dutta et al. CURRENT OPINION IN NEUROLOGY
- Associations of Childhood Eczema Severity
- (2014) Jonathan I. Silverberg et al. Dermatitis
- An analysis of FDA-approved drugs for infectious disease: antibacterial agents
- (2014) Michael S. Kinch et al. DRUG DISCOVERY TODAY
- Trends in pharmaceutical targeting of clinical indications: 1930–2013
- (2014) Michael S. Kinch et al. DRUG DISCOVERY TODAY
- Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals
- (2014) Edon Vitaku et al. JOURNAL OF MEDICINAL CHEMISTRY
- Clinical development success rates for investigational drugs
- (2014) Michael Hay et al. NATURE BIOTECHNOLOGY
- Calcitonin Gene-Related Peptide: Physiology and Pathophysiology
- (2014) F. A. Russell et al. PHYSIOLOGICAL REVIEWS
- Interleukin 6 and Rheumatoid Arthritis
- (2014) Yuji Yoshida et al. Biomed Research International
- Emerging Pharmacologic Therapies for Constipation-predominant Irritable Bowel Syndrome and Chronic Constipation
- (2014) Shanti Eswaran et al. Journal of Neurogastroenterology and Motility
- Understanding the Molecular Properties and Metabolism of Top Prescribed Drugs
- (2013) Haizhen Zhong et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Unveiling Benznidazole's mechanism of action through overexpression of DNA repair proteins inTrypanosoma cruzi
- (2013) Matheus Andrade Rajão et al. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
- Antibiotics present and future
- (2013) S. Altman FEBS LETTERS
- Using Deuterium in Drug Discovery: Leaving the Label in the Drug
- (2013) Thomas G. Gant JOURNAL OF MEDICINAL CHEMISTRY
- Computation of the binding affinities of catechol-O-methyltransferase inhibitors: Multisubstate relative free energy calculations
- (2012) P. Nuno Palma et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- Finding the sweet spot: the role of nature and nurture in medicinal chemistry
- (2012) Michael M. Hann et al. NATURE REVIEWS DRUG DISCOVERY
- Lixisenatide for type 2 diabetes mellitus
- (2011) Mikkel Christensen et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- What has polar surface area ever done for drug discovery?
- (2011) David E Clark Future Medicinal Chemistry
- Interleukin-23: as a drug target for autoimmune inflammatory diseases
- (2011) Chunlei Tang et al. IMMUNOLOGY
- Applying Medicinal Chemistry Transformations and Multiparameter Optimization to Guide the Search for High-Quality Leads and Candidates
- (2011) Matthew Segall et al. Journal of Chemical Information and Modeling
- Lambert–Eaton myasthenic syndrome: from clinical characteristics to therapeutic strategies
- (2011) Maarten J Titulaer et al. LANCET NEUROLOGY
- Diabetes in Cushing syndrome: basic and clinical aspects
- (2011) Gherardo Mazziotti et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Burden of Mortality Associated With Autoimmune Diseases Among Females in the United Kingdom
- (2010) Sara L. Thomas et al. AMERICAN JOURNAL OF PUBLIC HEALTH
- Antibody–drug conjugates: targeted drug delivery for cancer
- (2010) Stephen C Alley et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Metabolism of Fostamatinib, the Oral Methylene Phosphate Prodrug of the Spleen Tyrosine Kinase Inhibitor R406 in Humans: Contribution of Hepatic and Gut Bacterial Processes to the Overall Biotransformation
- (2010) D. J. Sweeny et al. DRUG METABOLISM AND DISPOSITION
- Discovery of CP-690,550: A Potent and Selective Janus Kinase (JAK) Inhibitor for the Treatment of Autoimmune Diseases and Organ Transplant Rejection
- (2010) Mark E. Flanagan et al. JOURNAL OF MEDICINAL CHEMISTRY
- Prodrugs: Some Thoughts and Current Issues
- (2010) Valentino J. Stella JOURNAL OF PHARMACEUTICAL SCIENCES
- Challenges and prospects for pharmacotherapy in functional gastrointestinal disorders
- (2010) Gareth J. Sanger et al. Therapeutic Advances in Gastroenterology
- Impact of OATP transporters on pharmacokinetics
- (2009) A Kalliokoski et al. BRITISH JOURNAL OF PHARMACOLOGY
- Ocrelizumab: a step forward in the evolution of B-cell therapy
- (2009) Fariha Kausar et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Use of the Biopharmaceutical Classification System in Early Drug Development
- (2008) M. Sherry Ku AAPS Journal
- The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
- (2008) Ralph J. DeBerardinis et al. Cell Metabolism
- Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfied with laxatives
- (2008) J Tack et al. GUT
- Proprotein convertase subtilisin/kexin type 9 (PCSK9): Hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration
- (2008) Ahmed Zaid et al. HEPATOLOGY
- Interleukin-23: Immunological roles and clinical implications
- (2008) Zi Yan Tan et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Network pharmacology: the next paradigm in drug discovery
- (2008) Andrew L Hopkins Nature Chemical Biology
- PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release
- (2008) R. Singh et al. SCIENCE
- Pharmacokinetics in Drug Discovery
- (2007) Ana Ruiz-Garcia et al. JOURNAL OF PHARMACEUTICAL SCIENCES
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started