Coordinated Translocation of Presequence-Containing Precursor Proteins Across Two Mitochondrial Membranes: Knowns and Unknowns of How TOM and TIM23 Complexes Cooperate With Each Other

The chaperone-binding activity of the mitochondrial surface receptor Tom70 protects the cytosol against mitoprotein-induced stress

(2021) Sandra Backes et al.   Cell Reports

Mapping protein interactions in the active TOM-TIM23 supercomplex

(2021) Ridhima Gomkale et al.   Nature Communications

How to get to the other side of the mitochondrial inner membrane – the protein import motor

(2020) Dejana Mokranjac   BIOLOGICAL CHEMISTRY

From cytosol to mitochondria: the beginning of a protein journey

(2020) Maria Clara Avendaño-Monsalve et al.   BIOLOGICAL CHEMISTRY

In Vivo Dissection of the Intrinsically Disordered Receptor Domain of Tim23

(2020) Umut Günsel et al.   JOURNAL OF MOLECULAR BIOLOGY

Cytosolic Events in the Biogenesis of Mitochondrial Proteins

(2020) Yury S. Bykov et al.   TRENDS IN BIOCHEMICAL SCIENCES

Atomic structure of human TOM core complex

(2020) Wenhe Wang et al.   Cell Discovery

Mitochondrial proteins: from biogenesis to functional networks

(2019) Nikolaus Pfanner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A mutagenesis analysis of Tim50, the major receptor of the TIM23 complex, identifies regions that affect its interaction with Tim23

(2019) Dana Dayan et al.   Scientific Reports

Transport of Proteins into Mitochondria

(2019) Katja G. Hansen et al.   PROTEIN JOURNAL

Versatility of Preprotein Transfer from the Cytosol to Mitochondria

(2019) Thomas Becker et al.   TRENDS IN CELL BIOLOGY

Structure of the mitochondrial import gate reveals distinct preprotein paths

(2019) Yuhei Araiso et al.   NATURE

Cryo-EM structure of the mitochondrial protein-import channel TOM complex at near-atomic resolution

(2019) Kyle Tucker et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hsp70 at the membrane: driving protein translocation

(2018) Elizabeth A. Craig   BMC BIOLOGY

Cardiolipin mediates membrane and channel interactions of the mitochondrial TIM23 protein import complex receptor Tim50

(2017) Ketan Malhotra et al.   Science Advances

Cooperation of TOM and TIM23 Complexes during Translocation of Proteins into Mitochondria

(2015) Karin Waegemann et al.   JOURNAL OF MOLECULAR BIOLOGY

A Perspective on Transport of Proteins into Mitochondria: A Myriad of Open Questions

(2015) Walter Neupert   JOURNAL OF MOLECULAR BIOLOGY

Unlocking the presequence import pathway

(2015) Christian Schulz et al.   TRENDS IN CELL BIOLOGY

NMR analyses on the interactions of the yeast Tim50 C-terminal region with the presequence and Tim50 core domain

(2014) Bytul Rahman et al.   FEBS LETTERS

Molecular Basis of the Dynamic Structure of the TIM23 Complex in the Mitochondrial Intermembrane Space

(2014) Rakhi Bajaj et al.   STRUCTURE

Signal recognition initiates reorganization of the presequence translocase during protein import

(2013) Oleksandr Lytovchenko et al.   EMBO JOURNAL

Direct Interaction of Mitochondrial Targeting Presequences with Purified Components of the TIM23 Protein Complex

(2011) Milit Marom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tim50’s presequence receptor domain is essential for signal driven transport across the TIM23 complex

(2011) Christian Schulz et al.   JOURNAL OF CELL BIOLOGY

Structural Basis for the Function of Tim50 in the Mitochondrial Presequence Translocase

(2011) Xinguo Qian et al.   JOURNAL OF MOLECULAR BIOLOGY

In vivo protein-interaction mapping of a mitochondrial translocator protein Tom22 at work

(2011) T. Shiota et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The intermembrane space domain of Tim23 is intrinsically disordered with a distinct binding region for presequences

(2010) Laura de la Cruz et al.   PROTEIN SCIENCE

Global Analysis of the Mitochondrial N-Proteome Identifies a Processing Peptidase Critical for Protein Stability

(2009) F.-Nora Vögtle et al.   CELL

Tim23–Tim50 pair coordinates functions of translocators and motor proteins in mitochondrial protein import

(2009) Yasushi Tamura et al.   JOURNAL OF CELL BIOLOGY

Role of Tim50 in the Transfer of Precursor Proteins from the Outer to the Inner Membrane of Mitochondria

(2009) Dejana Mokranjac et al.   MOLECULAR BIOLOGY OF THE CELL

Active remodelling of the TIM23 complex during translocation of preproteins into mitochondria

(2008) Du\[sbreve]an Popov-Čeleketić et al.   EMBO JOURNAL

Interaction of Tim23 with Tim50 Is Essential for Protein Translocation by the Mitochondrial TIM23 Complex

(2008) Lada Gevorkyan-Airapetov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quaternary Structure of the Mitochondrial TIM23 Complex Reveals Dynamic Association between Tim23p and Other Subunits

(2007) Nathan N. Alder et al.   MOLECULAR BIOLOGY OF THE CELL