The chaperone-binding activity of the mitochondrial surface receptor Tom70 protects the cytosol against mitoprotein-induced stress

The biogenesis of mitochondrial intermembrane space proteins

(2020) Ruairidh Edwards et al.   BIOLOGICAL CHEMISTRY

Biogenesis pathways of α-helical mitochondrial outer membrane proteins

(2020) Layla Drwesh et al.   BIOLOGICAL CHEMISTRY

Protein import by the mitochondrial disulfide relay in higher eukaryotes

(2020) Yannik Finger et al.   BIOLOGICAL CHEMISTRY

How the Mitoprotein-Induced Stress Response Safeguards the Cytosol: A Unified View

(2020) Felix Boos et al.   TRENDS IN CELL BIOLOGY

Systemic effects of mitochondrial stress

(2020) Raz Bar‐Ziv et al.   EMBO REPORTS

Reorganization of budding yeast cytoplasm upon energy depletion

(2020) Guendalina Marini et al.   MOLECULAR BIOLOGY OF THE CELL

The Mitochondrial Import Complex MIM Functions as Main Translocase for α-Helical Outer Membrane Proteins

(2020) Kim Nguyen Doan et al.   Cell Reports

Mitochondrial volume fraction and translation duration impact mitochondrial mRNA localization and protein synthesis

(2020) Tatsuhisa Tsuboi et al.   eLife

Biogenesis of Mitochondrial Metabolite Carriers

(2020) Patrick Horten et al.   Biomolecules

Mitochondrial protein-induced stress triggers a global adaptive transcriptional programme

(2019) Felix Boos et al.   NATURE CELL BIOLOGY

Mitochondrial carrier protein overloading and misfolding induce aggresomes and proteostatic adaptations in the cytosol

(2019) Yaxin Liu et al.   MOLECULAR BIOLOGY OF THE CELL

The tetratricopeptide-repeat motif is a versatile platform that enables diverse modes of molecular recognition

(2019) Albert Perez-Riba et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

TPR-containing proteins control protein organization and homeostasis for the endoplasmic reticulum

(2019) Jill B. Graham et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Mitochondrial protein translocation-associated degradation

(2019) Christoph U. Mårtensson et al.   NATURE

Nascent Polypeptide Domain Topology and Elongation Rate Direct the Cotranslational Hierarchy of Hsp70 and TRiC/CCT

(2019) Kevin C. Stein et al.   MOLECULAR CELL

The NADH Dehydrogenase Nde1 Executes Cell Death after Integrating Signals from Metabolism and Proteostasis on the Mitochondrial Surface

(2019) SreeDivya Saladi et al.   MOLECULAR CELL

Structure of the mitochondrial import gate reveals distinct preprotein paths

(2019) Yuhei Araiso et al.   NATURE

The ADP/ATP translocase drives mitophagy independent of nucleotide exchange

(2019) Atsushi Hoshino et al.   NATURE

UPRmt regulation and output: a stress response mediated by mitochondrial-nuclear communication

(2018) Andrew Melber et al.   CELL RESEARCH

Structural components involved in plastid protein import

(2018) Serena Schwenkert et al.   Essays in Biochemistry

Tom70 enhances mitochondrial preprotein import efficiency by binding to internal targeting sequences

(2018) Sandra Backes et al.   JOURNAL OF CELL BIOLOGY

Cytosolic Hsp70 and Hsp40 chaperones enable the biogenesis of mitochondrial β-barrel proteins

(2018) Tobias Jores et al.   JOURNAL OF CELL BIOLOGY

Genome-wide SWAp-Tag yeast libraries for proteome exploration

(2018) Uri Weill et al.   NATURE METHODS

MitoCPR—A surveillance pathway that protects mitochondria in response to protein import stress

(2018) Hilla Weidberg et al.   SCIENCE

Yeast aconitase mitochondrial import is modulated by interactions of its C and N terminal domains and Ssa1/2 (Hsp70)

(2018) Reut Ben-Menachem et al.   Scientific Reports

An ER surface retrieval pathway safeguards the import of mitochondrial membrane proteins in yeast

(2018) Katja G. Hansen et al.   SCIENCE

Mechanisms of Cotranslational Maturation of Newly Synthesized Proteins

(2018) Günter Kramer et al.   Annual Review of Biochemistry

Single-pot, solid-phase-enhanced sample preparation for proteomics experiments

(2018) Christopher S. Hughes et al.   Nature Protocols

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Recruitment of Cytosolic J-Proteins by TOM Receptors Promotes Mitochondrial Protein Biogenesis

(2018) Łukasz Opaliński et al.   Cell Reports

mPOS is a novel mitochondrial trigger of cell death - implications for neurodegeneration

(2017) Liam P. Coyne et al.   FEBS LETTERS

Two alternative binding mechanisms connect the protein translocation Sec71-Sec72 complex with heat shock proteins

(2017) Arati Tripathi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Landscape of submitochondrial protein distribution

(2017) F.-Nora Vögtle et al.   Nature Communications

Definition of a High-Confidence Mitochondrial Proteome at Quantitative Scale

(2017) Marcel Morgenstern et al.   Cell Reports

Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging

(2017) Johnathan Labbadia et al.   Cell Reports

The cytosolic cochaperone Sti1 is relevant for mitochondrial biogenesis and morphology

(2016) Hoda Hoseini et al.   FEBS Journal

Proteomic profiling of the mitochondrial ribosome identifies Atp25 as a composite mitochondrial precursor protein

(2016) Michael W. Woellhaf et al.   MOLECULAR BIOLOGY OF THE CELL

One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy

(2016) Ido Yofe et al.   NATURE METHODS

The MaxQuant computational platform for mass spectrometry-based shotgun proteomics

(2016) Stefka Tyanova et al.   Nature Protocols

A presequence-binding groove in Tom70 supports import of Mdl1 into mitochondria

(2015) Jonathan Melin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death

(2015) Xiaowen Wang et al.   NATURE

Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol

(2015) Lidia Wrobel et al.   NATURE

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins

(2015) Sarah E. Calvo et al.   NUCLEIC ACIDS RESEARCH

Molecular architecture of the active mitochondrial protein gate

(2015) T. Shiota et al.   SCIENCE

Ion Coalescence of Neutron Encoded TMT 10-Plex Reporter Ions

(2014) Thilo Werner et al.   ANALYTICAL CHEMISTRY

A discrete pathway for the transfer of intermembrane space proteins across the outer membrane of mitochondria

(2014) Agnieszka Gornicka et al.   MOLECULAR BIOLOGY OF THE CELL

Ultrasensitive proteome analysis using paramagnetic bead technology

(2014) C. S. Hughes et al.   Molecular Systems Biology

Targeting and plasticity of mitochondrial proteins revealed by proximity-specific ribosome profiling

(2014) C. C. Williams et al.   SCIENCE

Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling

(2014) C. H. Jan et al.   SCIENCE

Balony: a software package for analysis of data generated by synthetic genetic array experiments

(2013) Barry P Young et al.   BMC BIOINFORMATICS

Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System

(2013) Baohui Chen et al.   CELL

A novel single-cell screening platform reveals proteome plasticity during yeast stress responses

(2013) Michal Breker et al.   JOURNAL OF CELL BIOLOGY

The Role of Djp1 in Import of the Mitochondrial Protein Mim1 Demonstrates Specificity between a Cochaperone and Its Substrate Protein

(2013) D. Papic et al.   MOLECULAR AND CELLULAR BIOLOGY

SGAtools: one-stop analysis and visualization of array-based genetic interaction screens

(2013) Omar Wagih et al.   NUCLEIC ACIDS RESEARCH

High-Resolution Structural Analysis Shows How Tah1 Tethers Hsp90 to the R2TP Complex

(2013) Régis Back et al.   STRUCTURE

The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop

(2012) Andreas B Schmid et al.   EMBO JOURNAL

Structural and Functional Discussion of the Tetra-Trico-Peptide Repeat, a Protein Interaction Module

(2012) Natalie Zeytuni et al.   STRUCTURE

The protein chaperone Ssa1 affects mRNA localization to the mitochondria

(2011) Erez Eliyahu et al.   FEBS LETTERS

Structure of Minimal Tetratricopeptide Repeat Domain Protein Tah1 Reveals Mechanism of Its Interaction with Pih1 and Hsp90

(2011) Beatriz Jiménez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Structural Model of the Sgt2 Protein and Its Interactions with Chaperones and the Get4/Get5 Complex

(2011) Justin W. Chartron et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mitochondrial import protein Mim1 promotes biogenesis of multispanning outer membrane proteins

(2011) Thomas Becker et al.   JOURNAL OF CELL BIOLOGY

Multispan mitochondrial outer membrane protein Ugo1 follows a unique Mim1-dependent import pathway

(2011) Dražen Papić et al.   JOURNAL OF CELL BIOLOGY

Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

(2011) Jürgen Cox et al.   JOURNAL OF PROTEOME RESEARCH

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Recognition of Mitochondrial Targeting Sequences by the Import Receptors Tom20 and Tom22

(2010) Kieran A. Rimmer et al.   JOURNAL OF MOLECULAR BIOLOGY

HSP90 and Its R2TP/Prefoldin-like Cochaperone Are Involved in the Cytoplasmic Assembly of RNA Polymerase II

(2010) Séverine Boulon et al.   MOLECULAR CELL

Quantitative analysis of fitness and genetic interactions in yeast on a genome scale

(2010) Anastasia Baryshnikova et al.   NATURE METHODS

Substrate specificity of the TIM22 mitochondrial import pathway revealed with small molecule inhibitor of protein translocation

(2010) S. A. Hasson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global Analysis of the Mitochondrial N-Proteome Identifies a Processing Peptidase Critical for Protein Stability

(2009) F.-Nora Vögtle et al.   CELL

Importing Mitochondrial Proteins: Machineries and Mechanisms

(2009) Agnieszka Chacinska et al.   CELL

Molecular Chaperone Hsp70/Hsp90 Prepares the Mitochondrial Outer Membrane Translocon Receptor Tom71 for Preprotein Loading

(2009) Jingzhi Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roles of Tom70 in Import of Presequence-containing Mitochondrial Proteins

(2009) Hayashi Yamamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chaperone ligand-discrimination by the TPR-domain protein Tah1

(2008) Stefan H. Millson et al.   BIOCHEMICAL JOURNAL

Dominant membrane uncoupling by mutant adenine nucleotide translocase in mitochondrial diseases

(2008) X. Wang et al.   HUMAN MOLECULAR GENETICS

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY