期刊
FEBS LETTERS
卷 588, 期 5, 页码 678-684出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2013.12.037
关键词
Yeast; Tim50; Tom20; Presequence recognition; NMR
资金
- MEXT
- CREST from JST
- Grants-in-Aid for Scientific Research [22227003, 24121713] Funding Source: KAKEN
The mitochondrial targeting signal in the presequence of mitochondrial precursor proteins is recognized by Tom20 and subsequently by Tim50 in mitochondria. Yeast Tim50 contains two presequence binding sites in the conserved core domain and in the fungi-specific C-terminal presequence binding domain (PBD). We report the NMR analyses on interactions of a shorter variant of PBD (sPBD), a shorter variant of PBD, with presequences. The presequence is recognized by sPBD in a similar manner to Tom20. sPBD can also bind to the core domain of Tim50 through the presequence binding region, which could promote transfer of the presequence from sPBD to the core domain in Tim50. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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