S-farnesylation is essential for antiviral activity of the long ZAP isoform against RNA viruses with diverse replication strategies

Association of Zinc Finger Antiviral Protein Binding to Viral Genomic RNA with Attenuation of Replication of Echovirus 7

(2021) Niluka Goonawardane et al.   mSphere

The polybasic cleavage site in the SARS-CoV-2 spike modulates viral sensitivity to Type I interferon and IFITM2

(2021) Helena Winstone et al.   JOURNAL OF VIROLOGY

The SARS-CoV-2 RNA interactome

(2021) Sungyul Lee et al.   MOLECULAR CELL

The dinucleotide composition of the Zika virus genome is shaped by conflicting evolutionary pressures in mammalian hosts and mosquito vectors

(2021) Jelke J. Fros et al.   PLOS BIOLOGY

Origin and evolution of the zinc finger antiviral protein

(2021) Daniel Gonçalves-Carneiro et al.   PLoS Pathogens

The emergence and ongoing convergent evolution of the SARS-CoV-2 N501Y lineages

(2021) Darren P. Martin et al.   CELL

A proximity-dependent biotinylation map of a human cell

(2021) Christopher D. Go et al.   NATURE

Endomembrane targeting of human OAS1 p46 augments antiviral activity

(2021) Frank W Soveg et al.   eLife

Targeted Restriction of Viral Gene Expression and Replication by the ZAP Antiviral System

(2021) Mattia Ficarelli et al.   Annual Review of Virology

CpG Frequency in the 5′ Third of the env Gene Determines Sensitivity of Primary HIV-1 Strains to the Zinc-Finger Antiviral Protein

(2020) Dorota Kmiec et al.   mBio

Molecular Mechanism of RNA Recognition by Zinc-Finger Antiviral Protein

(2020) Xiu Luo et al.   Cell Reports

CpG-creating mutations are costly in many human viruses

(2020) Victoria R. Caudill et al.   EVOLUTIONARY ECOLOGY

A molecular pore spans the double membrane of the coronavirus replication organelle

(2020) Georg Wolff et al.   SCIENCE

Intra-genome variability in the dinucleotide composition of SARS-CoV-2

(2020) Paul Digard et al.   Virus Evolution

SARS-CoV-2 Is Restricted by Zinc Finger Antiviral Protein despite Preadaptation to the Low-CpG Environment in Humans

(2020) Rayhane Nchioua et al.   mBio

Human cytomegalovirus evades ZAP detection by suppressing CpG dinucleotides in the major immediate early 1 gene

(2020) Yao-Tang Lin et al.   PLoS Pathogens

Zinc-finger antiviral protein (ZAP) is a restriction factor for replication of modified vaccinia virus Ankara (MVA) in human cells

(2020) Chen Peng et al.   PLoS Pathogens

Longitudinal observation and decline of neutralizing antibody responses in the three months following SARS-CoV-2 infection in humans

(2020) Jeffrey Seow et al.   Nature Microbiology

ZAP’s stress granule localization is correlated with its antiviral activity and induced by virus replication

(2019) Lok Man John Law et al.   PLoS Pathogens

The role of ZAP and OAS3/RNAseL pathways in the attenuation of an RNA virus with elevated frequencies of CpG and UpA dinucleotides

(2019) Valerie Odon et al.   NUCLEIC ACIDS RESEARCH

KHNYN is essential for the zinc finger antiviral protein (ZAP) to restrict HIV-1 containing clustered CpG dinucleotides

(2019) Mattia Ficarelli et al.   eLife

CpG dinucleotides inhibit HIV-1 replication through zinc finger antiviral protein (ZAP)-dependent and -independent mechanisms

(2019) Mattia Ficarelli et al.   JOURNAL OF VIROLOGY

RNA-binding protein isoforms ZAP-S and ZAP-L have distinct antiviral and immune resolution functions

(2019) Johannes Schwerk et al.   NATURE IMMUNOLOGY

Structure of the zinc-finger antiviral protein in complex with RNA reveals a mechanism for selective targeting of CG-rich viral sequences

(2019) Jennifer L. Meagher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HTLV-1 contains a high CG dinucleotide content and is susceptible to the host antiviral protein ZAP

(2019) Paola Miyazato et al.   Retrovirology

Within-patient mutation frequencies reveal fitness costs of CpG dinucleotides and drastic amino acid changes in HIV

(2018) Kristof Theys et al.   PLoS Genetics

TRIM25 Is Required for the Antiviral Activity of Zinc Finger Antiviral Protein

(2017) Xiaojiao Zheng et al.   JOURNAL OF VIROLOGY

CG dinucleotide suppression enables antiviral defence targeting non-self RNA

(2017) Matthew A. Takata et al.   NATURE

Increasing the CpG dinucleotide abundance in the HIV-1 genomic RNA inhibits viral replication

(2017) Irati Antzin-Anduetza et al.   Retrovirology

Inhibition of avian tumor virus replication by CCCH-type zinc finger antiviral protein

(2017) Mingjun Zhu et al.   Oncotarget

TRIM25 Enhances the Antiviral Action of Zinc-Finger Antiviral Protein (ZAP)

(2017) Melody M. H. Li et al.   PLoS Pathogens

CpG and UpA dinucleotides in both coding and non-coding regions of echovirus 7 inhibit replication initiation post-entry

(2017) Jelke Jan Fros et al.   eLife

Elevation of CpG frequencies in influenza A genome attenuates pathogenicity but enhances host response to infection

(2016) Eleanor Gaunt et al.   eLife

SnapShot: Antiviral Restriction Factors

(2015) Silvia F. Kluge et al.   CELL

Structural Basis for Lack of ADP-ribosyltransferase Activity in Poly(ADP-ribose) Polymerase-13/Zinc Finger Antiviral Protein

(2015) Tobias Karlberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Battle between influenza A virus and a newly identified antiviral activity of the PARP-containing ZAPL protein

(2015) Chien-Hung Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Zinc-Finger Antiviral Protein ZAP Inhibits LINE and Alu Retrotransposition

(2015) John B. Moldovan et al.   PLoS Genetics

The Broad-Spectrum Antiviral Protein ZAP Restricts Human Retrotransposition

(2015) John L. Goodier et al.   PLoS Genetics

The alternate triad motif of the poly(ADP-ribose) polymerase-like domain of the human zinc finger antiviral protein is essential for its antiviral activity

(2014) S. Glasker et al.   JOURNAL OF GENERAL VIROLOGY

The influence of CpG and UpA dinucleotide frequencies on RNA virus replication and characterization of the innate cellular pathways underlying virus attenuation and enhanced replication

(2014) Nicky J. Atkinson et al.   NUCLEIC ACIDS RESEARCH

Membranous Replication Factories Induced by Plus-Strand RNA Viruses

(2014) Inés Romero-Brey et al.   Viruses-Basel

Family-wide analysis of poly(ADP-ribose) polymerase activity

(2014) Sejal Vyas et al.   Nature Communications

PARP13 regulates cellular mRNA post-transcriptionally and functions as a pro-apoptotic factor by destabilizing TRAILR4 transcript

(2014) Tanya Todorova et al.   Nature Communications

RNA virus attenuation by codon pair deoptimisation is an artefact of increases in CpG/UpA dinucleotide frequencies

(2014) Fiona Tulloch et al.   eLife

Modelling mutational and selection pressures on dinucleotides in eukaryotic phyla –selection against CpG and UpA in cytoplasmically expressed RNA and in RNA viruses

(2013) Peter Simmonds et al.   BMC GENOMICS

Reciprocal Inhibition between Intracellular Antiviral Signaling and the RNAi Machinery in Mammalian Cells

(2013) Gil Ju Seo et al.   Cell Host & Microbe

Prenylome profiling reveals S-farnesylation is crucial for membrane targeting and antiviral activity of ZAP long-isoform

(2013) G. Charron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Hepatitis B Virus Replication by the Host Zinc Finger Antiviral Protein

(2013) Richeng Mao et al.   PLoS Pathogens

Translational repression precedes and is required for ZAP-mediated mRNA decay

(2012) Yiping Zhu et al.   EMBO JOURNAL

Structure of N-terminal domain of ZAP indicates how a zinc-finger protein recognizes complex RNA

(2012) Shoudeng Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Poly(ADP-Ribose) Regulates Stress Responses and MicroRNA Activity in the Cytoplasm

(2011) Anthony K.L. Leung et al.   MOLECULAR CELL

Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation

(2011) Y. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a Dominant Negative Inhibitor of Human Zinc Finger Antiviral Protein Reveals a Functional Endogenous Pool and Critical Homotypic Interactions

(2010) L. M. J. Law et al.   JOURNAL OF VIROLOGY

Functional Sindbis Virus Replicative Complexes Are Formed at the Plasma Membrane

(2010) E. I. Frolova et al.   JOURNAL OF VIROLOGY

ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses

(2010) Sumio Hayakawa et al.   NATURE IMMUNOLOGY

Positive Selection and Increased Antiviral Activity Associated with the PARP-Containing Isoform of Human Zinc-Finger Antiviral Protein

(2008) Julie A. Kerns et al.   PLoS Genetics

Patterns of Evolution and Host Gene Mimicry in Influenza and Other RNA Viruses

(2008) Benjamin D. Greenbaum et al.   PLoS Pathogens