Seipin localizes at endoplasmic-reticulum-mitochondria contact sites to control mitochondrial calcium import and metabolism in adipocytes

Seipin traps triacylglycerols to facilitate their nanoscale clustering in the endoplasmic reticulum membrane

(2021) Xavier Prasanna et al.   PLOS BIOLOGY

Seipin Deficiency Accelerates Heart Failure Due to Calcium Handling Abnormalities and Endoplasmic Reticulum Stress in Mice

(2021) Xiaoyue Wu et al.   Frontiers in Cardiovascular Medicine

IsoCor: isotope correction for high-resolution MS labeling experiments

(2019) Pierre Millard et al.   BIOINFORMATICS

Seipin Facilitates Triglyceride Flow to Lipid Droplet and Counteracts Droplet Ripening via Endoplasmic Reticulum Contact

(2019) Veijo T. Salo et al.   DEVELOPMENTAL CELL

Sphingosine kinase 1 overexpression induces MFN2 fragmentation and alters mitochondrial matrix Ca2+ handling in HeLa cells

(2019) I. Pulli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

ilastik: interactive machine learning for (bio)image analysis

(2019) Stuart Berg et al.   NATURE METHODS

Heterozygous deletion of Seipin in islet beta cells of male mice has an impact on insulin synthesis and secretion through reduced PPARγ expression

(2019) Jianwei Xiong et al.   DIABETOLOGIA

Oxysterol-binding protein related-proteins (ORPs) 5 and 8 regulate calcium signaling at specific cell compartments

(2018) Ilari Pulli et al.   CELL CALCIUM

Adipose specific disruption of seipin causes early-onset generalised lipodystrophy and altered fuel utilisation without severe metabolic disease

(2018) George D. Mcilroy et al.   Molecular Metabolism

Seipin regulates lipid homeostasis by ensuring calcium‐dependent mitochondrial metabolism

(2018) Long Ding et al.   EMBO JOURNAL

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Pet10p is a yeast perilipin that stabilizes lipid droplets and promotes their assembly

(2017) Qiang Gao et al.   JOURNAL OF CELL BIOLOGY

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondria-Associated Membranes Response to Nutrient Availability and Role in Metabolic Diseases

(2017) Pierre Theurey et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Seipin regulates ER–lipid droplet contacts and cargo delivery

(2016) Veijo T Salo et al.   EMBO JOURNAL

Mitochondria-associated endoplasmic reticulum membranes allow adaptation of mitochondrial metabolism to glucose availability in the liver

(2016) Pierre Theurey et al.   Journal of Molecular Cell Biology

SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase

(2016) Martin Pagac et al.   Cell Reports

Microscopy Image Browser: A Platform for Segmentation and Analysis of Multidimensional Datasets

(2016) Ilya Belevich et al.   PLOS BIOLOGY

Seipin is required for converting nascent to mature lipid droplets

(2016) Huajin Wang et al.   eLife

Study of Endoplasmic Reticulum and Mitochondria Interactions by In Situ Proximity Ligation Assay in Fixed Cells

(2016) Emily Tubbs et al.   Jove-Journal of Visualized Experiments

Seipin deficiency alters brown adipose tissue thermogenesis and insulin sensitivity in a non-cell autonomous mode

(2016) L. Dollet et al.   Scientific Reports

Integrative Analyses of Human Reprogramming Reveal Dynamic Nature of Induced Pluripotency

(2015) Davide Cacchiarelli et al.   CELL

Berardinelli-Seip congenital lipodystrophy 2 regulates adipocyte lipolysis, browning, and energy balance in adult animals

(2015) Hongyi Zhou et al.   JOURNAL OF LIPID RESEARCH

Mitochondrial calcium and the regulation of metabolism in the heart

(2015) George S.B. Williams et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Seipin oligomers can interact directly with AGPAT2 and lipin 1, physically scaffolding critical regulators of adipogenesis

(2015) Md. Mesbah Uddin Talukder et al.   Molecular Metabolism

Seipin Promotes Adipose Tissue Fat Storage through the ER Ca2+-ATPase SERCA

(2014) Junfeng Bi et al.   Cell Metabolism

Adipose-Specific Knockout of Seipin/Bscl2 Results in Progressive Lipodystrophy

(2014) L. Liu et al.   DIABETES

Mitochondrial response to nutrient availability and its role in metabolic disease

(2014) A. W. Gao et al.   EMBO Molecular Medicine

Chronic enrichment of hepatic endoplasmic reticulum–mitochondria contact leads to mitochondrial dysfunction in obesity

(2014) Ana Paula Arruda et al.   NATURE MEDICINE

Imaging intraorganellar Ca2+ at subcellular resolution using CEPIA

(2014) Junji Suzuki et al.   Nature Communications

Thiazolidinediones partially reverse the metabolic disturbances observed in Bscl2/seipin-deficient mice

(2013) X. Prieur et al.   DIABETOLOGIA

The CRAPome: a contaminant repository for affinity purification–mass spectrometry data

(2013) Dattatreya Mellacheruvu et al.   NATURE METHODS

Subcellular calcium measurements in mammalian cells using jellyfish photoprotein aequorin-based probes

(2013) Massimo Bonora et al.   Nature Protocols

Alleviation of seipinopathy-related ER stress by triglyceride storage

(2012) M. Holtta-Vuori et al.   HUMAN MOLECULAR GENETICS

Berardinelli-Seip Congenital Lipodystrophy 2/Seipin Is a Cell-Autonomous Regulator of Lipolysis Essential for Adipocyte Differentiation

(2012) W. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Mitochondrial dysfunction in white adipose tissue

(2012) Christine M. Kusminski et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The human lipodystrophy protein seipin is an ER membrane adaptor for the adipogenic PA phosphatase lipin 1

(2012) M.F. Michelle Sim et al.   Molecular Metabolism

Highly-efficient, fluorescent, locus directed cre and FlpO deleter mice on a pure C57BL/6N genetic background

(2011) Marie-Christine Birling et al.   GENESIS

Seipin ablation in mice results in severe generalized lipodystrophy

(2011) X. Cui et al.   HUMAN MOLECULAR GENETICS

Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity

(2011) Suneng Fu et al.   NATURE

ER Tubules Mark Sites of Mitochondrial Division

(2011) J. R. Friedman et al.   SCIENCE

A Role for Phosphatidic Acid in the Formation of “Supersized” Lipid Droplets

(2011) Weihua Fei et al.   PLoS Genetics

Tamoxifen-inducible Cre-mediated recombination in adipocytes

(2010) Antonia Sassmann et al.   GENESIS

Regulation of mitochondrial dehydrogenases by calcium ions

(2009) Richard M. Denton   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Seipin deficiency alters fatty acid Δ9 desaturation and lipid droplet formation in Berardinelli-Seip congenital lipodystrophy

(2009) Emilie Boutet et al.   BIOCHIMIE

Universal sample preparation method for proteome analysis

(2009) Jacek R Wiśniewski et al.   NATURE METHODS

Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells

(2009) Mariusz R Wieckowski et al.   Nature Protocols

Live Cell Multicolor Imaging of Lipid Droplets with a New Dye, LD540

(2009) Johanna Spandl et al.   TRAFFIC

MAM: more than just a housekeeper

(2009) Teruo Hayashi et al.   TRENDS IN CELL BIOLOGY

The Human Lipodystrophy Gene BSCL2/Seipin May Be Essential for Normal Adipocyte Differentiation

(2008) V. A. Payne et al.   DIABETES

Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast

(2008) Weihua Fei et al.   JOURNAL OF CELL BIOLOGY