Seipin Deficiency Accelerates Heart Failure Due to Calcium Handling Abnormalities and Endoplasmic Reticulum Stress in Mice

Left ventricular response in the transition from hypertrophy to failure recapitulates distinct roles of Akt, β-arrestin-2, and CaMKII in mice with aortic regurgitation

(2020) Jian Wu et al.   Annals of Translational Medicine

ER Stress-Induced Secretion of Proteins and Their Extracellular Functions in the Heart

(2020) Bianca A. Meyer et al.   Cells

Variations in Energy Metabolism Precede Alterations in Cardiac Structure and Function in Hypertrophic Preconditioning

(2020) Jian Wu et al.   Frontiers in Cardiovascular Medicine

The worldwide mutational landscape of Berardinelli-Seip congenital lipodystrophy

(2019) Aquiles Sales Craveiro Sarmento et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

SEIPIN overexpression in the liver may alleviate hepatic steatosis by influencing the intracellular calcium level

(2019) Qiang Li et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Seipin deletion in mice enhances phosphorylation and aggregation of tau protein through reduced neuronal PPARγ and insulin resistance

(2019) Huanxian Chang et al.   NEUROBIOLOGY OF DISEASE

Renal injury in Seipin-deficient lipodystrophic mice and its reversal by adipose tissue transplantation or leptin administration alone: adipose tissue–kidney crosstalk

(2018) Xue-Jing Liu et al.   FASEB JOURNAL

Correcting Calcium Dysregulation in Chronic Heart Failure Using SERCA2a Gene Therapy

(2018) T. Samuel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cartilage intermediate layer protein-1 alleviates pressure overload-induced cardiac fibrosis via interfering TGF-β1 signaling

(2018) Cheng-Lin Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Adipose tissue transplantation ameliorates lipodystrophy-associated metabolic disorders in seipin-deficient mice

(2018) Huan Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

IL-18 cleavage triggers cardiac inflammation and fibrosis upon β-adrenergic insult

(2017) Han Xiao et al.   EUROPEAN HEART JOURNAL

Echinacoside's nigrostriatal dopaminergic protection against 6-OHDA-Induced endoplasmic reticulum stress through reducing the accumulation of Seipin

(2017) Yajie Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

FGF21 Improves the Adipocyte Dysfunction Related to Seipin Deficiency

(2016) Lucile Dollet et al.   DIABETES

Seipin regulates ER–lipid droplet contacts and cargo delivery

(2016) Veijo T Salo et al.   EMBO JOURNAL

Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy

(2015) Guanghong Jia et al.   Nature Reviews Endocrinology

Congenital generalized lipodystrophies—new insights into metabolic dysfunction

(2015) Nivedita Patni et al.   Nature Reviews Endocrinology

Towards a mechanistic understanding of lipodystrophy and seipin functions

(2014) Kenneth Wee et al.   BIOSCIENCE REPORTS

Seipin Promotes Adipose Tissue Fat Storage through the ER Ca2+-ATPase SERCA

(2014) Junfeng Bi et al.   Cell Metabolism

Molecular Mechanisms Underlying Fasting Modulated Liver Insulin Sensitivity and Metabolism in Male LipodystrophicBscl2/Seipin-Deficient Mice

(2014) Weiqin Chen et al.   ENDOCRINOLOGY

Cardiac Steatosis and Left Ventricular Hypertrophy in Patients With Generalized Lipodystrophy as Determined by Magnetic Resonance Spectroscopy and Imaging

(2013) Michael D. Nelson et al.   AMERICAN JOURNAL OF CARDIOLOGY

Function of seipin: New insights from Bscl2/seipin knockout mouse models

(2013) Lucile Dollet et al.   BIOCHIMIE

Calnexin Silencing in Mouse Neonatal Cardiomyocytes Induces Ca2+Cycling Defects, ER Stress, and Apoptosis

(2013) Nicolas Bousette et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Early infantile cardiomyopathy and liver disease: A multisystemic disorder caused by congenital lipodystrophy

(2013) François-Guillaume Debray et al.   MOLECULAR GENETICS AND METABOLISM

CaMKII inhibition in heart failure, beneficial, harmful, or both

(2012) Jun Cheng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cardiac-Specific Deletion of Acetyl CoA Carboxylase 2 Prevents Metabolic Remodeling During Pressure-Overload Hypertrophy

(2012) Stephen C. Kolwicz et al.   CIRCULATION RESEARCH

Seipin ablation in mice results in severe generalized lipodystrophy

(2011) X. Cui et al.   HUMAN MOLECULAR GENETICS

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(2011) Wei Xin et al.   MOLECULAR MEDICINE

Relations of Circulating Resistin and Adiponectin and Cardiac Structure and Function: The Framingham Offspring Study

(2011) David D. McManus et al.   Obesity

Tissue-Autonomous Function of Drosophila Seipin in Preventing Ectopic Lipid Droplet Formation

(2011) Yuan Tian et al.   PLoS Genetics

Cardiomyopathy in Congenital and Acquired Generalized Lipodystrophy

(2010) Beatrice C. Lupsa et al.   MEDICINE

The Human Lipodystrophy Gene BSCL2/Seipin May Be Essential for Normal Adipocyte Differentiation

(2008) V. A. Payne et al.   DIABETES