Seipin deficiency alters brown adipose tissue thermogenesis and insulin sensitivity in a non-cell autonomous mode

Berardinelli-Seip Congenital Lipodystrophy 2/Seipin Is Not Required for Brown Adipogenesis but Regulates Brown Adipose Tissue Development and Function

(2016) Hongyi Zhou et al.   MOLECULAR AND CELLULAR BIOLOGY

Expression of seipin in adipose tissue rescues lipodystrophy, hepatic steatosis and insulin resistance in seipin null mice

(2015) Mingming Gao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Seipin is necessary for normal brain development and spermatogenesis in addition to adipogenesis

(2015) Chihiro Ebihara et al.   HUMAN MOLECULAR GENETICS

Seipin performs dissectible functions in promoting lipid droplet biogenesis and regulating droplet morphology

(2015) Bethany R. Cartwright et al.   MOLECULAR BIOLOGY OF THE CELL

Seipin oligomers can interact directly with AGPAT2 and lipin 1, physically scaffolding critical regulators of adipogenesis

(2015) Md. Mesbah Uddin Talukder et al.   Molecular Metabolism

Seipin Promotes Adipose Tissue Fat Storage through the ER Ca2+-ATPase SERCA

(2014) Junfeng Bi et al.   Cell Metabolism

Adipose-Specific Knockout of Seipin/Bscl2 Results in Progressive Lipodystrophy

(2014) L. Liu et al.   DIABETES

Molecular Mechanisms Underlying Fasting Modulated Liver Insulin Sensitivity and Metabolism in Male LipodystrophicBscl2/Seipin-Deficient Mice

(2014) Weiqin Chen et al.   ENDOCRINOLOGY

The different shades of fat

(2014) Vivian Peirce et al.   NATURE

Function of seipin: New insights from Bscl2/seipin knockout mouse models

(2013) Lucile Dollet et al.   BIOCHIMIE

Thiazolidinediones partially reverse the metabolic disturbances observed in Bscl2/seipin-deficient mice

(2013) X. Prieur et al.   DIABETOLOGIA

Altered Lipid Metabolism in Residual White Adipose Tissues of Bscl2 Deficient Mice

(2013) Weiqin Chen et al.   PLoS One

Pharmacological strategies for targeting BAT thermogenesis

(2013) Andrew Whittle et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Assessment of brown adipose tissue function

(2013) Sam Virtue et al.   Frontiers in Physiology

Berardinelli-Seip Congenital Lipodystrophy 2/Seipin Is a Cell-Autonomous Regulator of Lipolysis Essential for Adipocyte Differentiation

(2012) W. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Seipin ablation in mice results in severe generalized lipodystrophy

(2011) X. Cui et al.   HUMAN MOLECULAR GENETICS

Lipodystrophies: Genetic and Acquired Body Fat Disorders

(2011) Abhimanyu Garg   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Tissue-Autonomous Function of Drosophila Seipin in Preventing Ectopic Lipid Droplet Formation

(2011) Yuan Tian et al.   PLoS Genetics

A Role for Phosphatidic Acid in the Formation of “Supersized” Lipid Droplets

(2011) Weihua Fei et al.   PLoS Genetics

Enhanced Metabolic Flexibility Associated with Elevated Adiponectin Levels

(2010) Ingrid Wernstedt Asterholm et al.   AMERICAN JOURNAL OF PATHOLOGY

Seipin deficiency alters fatty acid Δ9 desaturation and lipid droplet formation in Berardinelli-Seip congenital lipodystrophy

(2009) Emilie Boutet et al.   BIOCHIMIE

The Human Lipodystrophy Gene Product Berardinelli-Seip Congenital Lipodystrophy 2/Seipin Plays a Key Role in Adipocyte Differentiation

(2009) Weiqin Chen et al.   ENDOCRINOLOGY

The Human Lipodystrophy Gene BSCL2/Seipin May Be Essential for Normal Adipocyte Differentiation

(2008) V. A. Payne et al.   DIABETES

Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast

(2008) Weihua Fei et al.   JOURNAL OF CELL BIOLOGY