Alpha synuclein, the culprit in Parkinson disease, is required for normal immune function

A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice

(2020) Timothy R Sampson et al.   eLife

Constipation, deficit in colon contractions and alpha-synuclein inclusions within the colon precede motor abnormalities and neurodegeneration in the central nervous system in a mouse model of alpha-synucleinopathy

(2019) Lucia Rota et al.   Translational Neurodegeneration

Lipopolysaccharide from Gut Microbiota Modulates α-Synuclein Aggregation and Alters Its Biological Function

(2019) Dipita Bhattacharyya et al.   ACS Chemical Neuroscience

Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease

(2019) Sangjune Kim et al.   NEURON

Gastrointestinal Immunity and Alpha-Synuclein

(2019) Denise Barbut et al.   Journal of Parkinsons Disease

Inflammatory Bowel Diseases and Parkinson’s Disease

(2019) Tomasz Brudek   Journal of Parkinsons Disease

Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders

(2018) Sigrid Breit et al.   Frontiers in Psychiatry

New Perspectives on Roles of Alpha-Synuclein in Parkinson’s Disease

(2018) Guoxin Zhang et al.   Frontiers in Aging Neuroscience

HMGN1 and R848 Synergistically Activate Dendritic Cells Using Multiple Signaling Pathways

(2018) Md Masud Alam et al.   Frontiers in Immunology

Alarmins and immunity

(2017) De Yang et al.   IMMUNOLOGICAL REVIEWS

A Role for Neuronal Alpha-Synuclein in Gastrointestinal Immunity

(2017) Ethan Stolzenberg et al.   Journal of Innate Immunity

Holocranohistochemistry enables the visualization of α-synuclein expression in the murine olfactory system and discovery of its systemic anti-microbial effects

(2017) Julianna J. Tomlinson et al.   JOURNAL OF NEURAL TRANSMISSION

T cells from patients with Parkinson’s disease recognize α-synuclein peptides

(2017) David Sulzer et al.   NATURE

Lewy Bodies and the Mechanisms of Neuronal Cell Death in Parkinson's Disease and Dementia with Lewy Bodies

(2016) John H. T. Power et al.   BRAIN PATHOLOGY

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

A critical role for alpha-synuclein in development and function of T lymphocytes

(2016) Afshin Shameli et al.   IMMUNOBIOLOGY

TNFR2 expression by CD4 effector T cells is required to induce full-fledged experimental colitis

(2016) Xin Chen et al.   Scientific Reports

Exposure to bacterial endotoxin generates a distinct strain of α-synuclein fibril

(2016) Changyoun Kim et al.   Scientific Reports

Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans

(2016) Shu G. Chen et al.   Scientific Reports

Exogenous α-synuclein induces toll-like receptor 4 dependent inflammatory responses in astrocytes

(2015) Emmy H. Rannikko et al.   BMC NEUROSCIENCE

Is membrane homeostasis the missing link between inflammation and neurodegenerative diseases?

(2015) Natalia Sánchez de Groot et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

GM-CSF Mouse Bone Marrow Cultures Comprise a Heterogeneous Population of CD11c+MHCII+ Macrophages and Dendritic Cells

(2015) Julie Helft et al.   IMMUNITY

Alpha-Synuclein Expression Restricts RNA Viral Infections in the Brain

(2015) Erica L. Beatman et al.   JOURNAL OF VIROLOGY

Tissue-Specific Signals Control Reversible Program of Localization and Functional Polarization of Macrophages

(2014) Yasutaka Okabe et al.   CELL

 -Synuclein in cutaneous autonomic nerves

(2013) N. Wang et al.   NEUROLOGY

Cerebral causes and consequences of parkinsonian resting tremor: a tale of two circuits?

(2012) R. C. Helmich et al.   BRAIN

α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, andEscherichia coliExists Predominantly as Disordered Monomer

(2012) Bruno Fauvet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alarmins: awaiting a clinical response

(2012) James K. Chan et al.   JOURNAL OF CLINICAL INVESTIGATION

Peptidoglycan-induced T helper 2 immune response in mice involves interleukin-10 secretion from Langerhans cells

(2012) Katsuhiko Matsui et al.   MICROBIOLOGY AND IMMUNOLOGY

High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses

(2011) De Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mechanism of Membrane Interaction and Disruption by α-Synuclein

(2011) Nicholas P. Reynolds et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

A soluble  -synuclein construct forms a dynamic tetramer

(2011) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

   -Synuclein triple knockout mice reveal age-dependent neuronal dysfunction

(2010) B. Greten-Harrison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2–MyD88 signal pathway in dendritic cells and enhances Th2 immune responses

(2008) De Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Red Blood Cells Are the Major Source of Alpha-Synuclein in Blood

(2008) Robin Barbour et al.   Neurodegenerative Diseases