Alarmins: awaiting a clinical response

Endogenous Damage-Associated Molecular Pattern Molecules at the Crossroads of Inflammation and Cancer

(2015) Geetha Srikrishna et al.   NEOPLASIA

Proinflammatory S100 Proteins Regulate the Accumulation of Myeloid-Derived Suppressor Cells

(2014) P. Sinha et al.   JOURNAL OF IMMUNOLOGY

HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection

(2011) Ulf Andersson et al.   Annual Review of Immunology

S100A8/A9 deficiency in nonhealing venous leg ulcers uncovered by multiplexed antibody microarray profiling

(2011) H. Trøstrup et al.   BRITISH JOURNAL OF DERMATOLOGY

Emergence of autoantibodies to HMGB1 is associated with survival in patients with septic shock

(2011) Stéphanie Barnay-Verdier et al.   INTENSIVE CARE MEDICINE

High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses

(2011) De Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Expression of Toll-like Receptors and Their Signaling Pathways in Rheumatoid Synovitis

(2011) YASUNOBU TAMAKI et al.   JOURNAL OF RHEUMATOLOGY

HMGB1 Attenuates Cardiac Remodelling in the Failing Heart via Enhanced Cardiac Regeneration and miR-206-Mediated Inhibition of TIMP-3

(2011) Federica Limana et al.   PLoS One

TNF-  promotes fracture repair by augmenting the recruitment and differentiation of muscle-derived stromal cells

(2011) G. E. Glass et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HMGB1 and RAGE in Inflammation and Cancer

(2010) Gary P. Sims et al.   Annual Review of Immunology

Protective targeting of high mobility group box chromosomal protein 1 in a spontaneous arthritis model

(2010) Therese Östberg et al.   ARTHRITIS AND RHEUMATISM

The alarmin functions of high-mobility group proteins

(2010) De Yang et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

High-mobility group box 1 and cancer

(2010) Daolin Tang et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Approaching Clinical Reality: Markers for Monitoring Systemic Inflammation and Sepsis

(2010) R. Claus et al.   CURRENT MOLECULAR MEDICINE

Methotrexate Withdrawal at 6 vs 12 Months in Juvenile Idiopathic Arthritis in RemissionA Randomized Clinical Trial

(2010) Dirk Foell   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Anti-TNF Therapy, from Rationale to Standard of Care: What Lessons Has It Taught Us?

(2010) M. Feldmann et al.   JOURNAL OF IMMUNOLOGY

Differential Proteomic Analysis Distinguishes Tissue Repair Biomarker Signatures in Wound Exudates Obtained from Normal Healing and Chronic Wounds

(2010) Sabine A. Eming et al.   JOURNAL OF PROTEOME RESEARCH

The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells

(2010) Karin Loser et al.   NATURE MEDICINE

Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures

(2010) Mattia Maroso et al.   NATURE MEDICINE

Expression and Role of Myeloid-related Protein-14 in Clinical and Experimental Sepsis

(2009) Marieke A. D. van Zoelen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Epitope-specific immunotherapy of rheumatoid arthritis: Clinical responsiveness occurs with immune deviation and relies on the expression of a cluster of molecules associated with T cell tolerance in a double-blind, placebo-controlled, pilot phase II trial

(2009) Eva C. Koffeman et al.   ARTHRITIS AND RHEUMATISM

TNFα promotes osteogenic differentiation of human mesenchymal stem cells by triggering the NF-κB signaling pathway

(2009) Katrin Hess et al.   BONE

TNF-alpha enhances engraftment of mesenchymal stem cells into infarcted myocardium

(2009) Yong Sook Kim   Frontiers in Bioscience-Landmark

Macrophages and fibroblasts during inflammation, tissue damage and organ injury

(2009) Trevor Glaros   Frontiers in Bioscience-Landmark

Human beta-defensin-3 promotes wound healing in infected diabetic wounds

(2009) Tobias Hirsch et al.   JOURNAL OF GENE MEDICINE

The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer

(2009) Jan M. Ehrchen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Serum high mobility group box-1 (HMGB1) is closely associated with the clinical and pathologic features of gastric cancer

(2009) Hye Chung et al.   Journal of Translational Medicine

RAGE (Receptor for Advanced Glycation Endproducts), RAGE Ligands, and their role in Cancer and Inflammation

(2009) Louis J Sparvero et al.   Journal of Translational Medicine

Alarmins and antimicrobial immunity

(2009) D. Yang et al.   MEDICAL MYCOLOGY

Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis

(2009) Peter C. Taylor et al.   Nature Reviews Rheumatology

IMMUNOLOGY: Dangers In and Out

(2009) M. E. Bianchi et al.   SCIENCE

HMGB1 IS MARKEDLY ELEVATED WITHIN 6 HOURS OF MECHANICAL TRAUMA IN HUMANS

(2009) Erik D. Peltz et al.   SHOCK

HMGB1 Mediates Endogenous TLR2 Activation and Brain Tumor Regression

(2009) James F Curtin et al.   PLOS MEDICINE

Calprotectin (a major S100 leucocyte protein) predicts 10-year radiographic progression in patients with rheumatoid arthritis

(2008) H B. Hammer et al.   ANNALS OF THE RHEUMATIC DISEASES

Stimulation of chondrocyte-mediated cartilage destruction by S100A8 in experimental murine arthritis

(2008) P. L. E. M. van Lent et al.   ARTHRITIS AND RHEUMATISM

S100B's double life: Intracellular regulator and extracellular signal

(2008) Rosario Donato et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Tumors Sound the Alarmin(s)

(2008) S. B. Coffelt et al.   CANCER RESEARCH

RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis

(2008) Olga Turovskaya et al.   CARCINOGENESIS

High-mobility group box 1 restores cardiac function after myocardial infarction in transgenic mice

(2008) T. Kitahara et al.   CARDIOVASCULAR RESEARCH

Role of high-mobility group box 1 protein in post-infarction healing process and left ventricular remodelling

(2008) T. Kohno et al.   CARDIOVASCULAR RESEARCH

High-Mobility Group Box-1 in Ischemia-Reperfusion Injury of the Heart

(2008) Martin Andrassy et al.   CIRCULATION

Effects of HMGB1 on Ischemia-Reperfusion Injury in the Rat Heart

(2008) Susumu Oozawa et al.   CIRCULATION JOURNAL

HMGB1: a two-headed signal regulating tumor progression and immunity

(2008) Lara Campana et al.   CURRENT OPINION IN IMMUNOLOGY

Gene profiling in human blood leucocytes during recovery from septic shock

(2008) Didier Payen et al.   INTENSIVE CARE MEDICINE

RDP58 inhibits T cell-mediated bladder inflammation in an autoimmune cystitis model

(2008) Wujiang Liu et al.   JOURNAL OF AUTOIMMUNITY

Induction of inflammatory and immune responses by HMGB1–nucleosome complexes: implications for the pathogenesis of SLE

(2008) Vilma Urbonaviciute et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein

(2008) Pingyan Cheng et al.   JOURNAL OF EXPERIMENTAL MEDICINE

High-Mobility Group Box 1 Protein in Human and Murine Skin: Involvement in Wound Healing

(2008) Stefania Straino et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The HMGB1 Receptor RAGE Mediates Ischemic Brain Damage

(2008) S. Muhammad et al.   JOURNAL OF NEUROSCIENCE

The S100A8–serum amyloid A3–TLR4 paracrine cascade establishes a pre-metastatic phase

(2008) Sachie Hiratsuka et al.   NATURE CELL BIOLOGY

Systemic TNF blockade does not modulate synovial expression of the pro-inflammatory mediator HMGB1 in rheumatoid arthritis patients – a prospective clinical study

(2008) Erik Sundberg et al.   ARTHRITIS RESEARCH & THERAPY

Induction of arthritis by high mobility group box chromosomal protein 1 is independent of tumour necrosis factor signalling

(2008) Rille Pullerits et al.   ARTHRITIS RESEARCH & THERAPY

Myeloid-related proteins S100A8/S100A9 regulate joint inflammation and cartilage destruction during antigen-induced arthritis

(2007) P L E M van Lent et al.   ANNALS OF THE RHEUMATIC DISEASES

A review of the S100 proteins in cancer

(2007) I. Salama et al.   EJSO

The host defence peptide LL-37/hCAP-18 is a growth factor for lung cancer cells

(2007) Judith von Haussen et al.   LUNG CANCER

Functional analysis of the host defense peptide Human Beta Defensin-1: New insight into its potential role in cancer

(2007) Rebecca S. Bullard et al.   MOLECULAR IMMUNOLOGY