Old Stars and New Players in the Brain Tumor Microenvironment

The irradiated brain microenvironment supports glioma stemness and survival via astrocyte-derived Transglutaminase 2

(2021) Tracy J Berg et al.   CANCER RESEARCH

Microglia in Cancer Therapy–Related Cognitive Impairment

(2021) Erin M. Gibson et al.   TRENDS IN NEUROSCIENCES

The immune-inflammatory response of oligodendrocytes in a murine model of preterm white matter injury: the role of TLR3 activation

(2021) Marta Boccazzi et al.   Cell Death & Disease

High-throughput phenotypic screen and transcriptional analysis identify new compounds and targets for macrophage reprogramming

(2021) Guangan Hu et al.   Nature Communications

Single-cell RNA sequencing reveals functional heterogeneity of glioma-associated brain macrophages

(2021) Natalia Ochocka et al.   Nature Communications

Multiple sclerosis risk gene Mertk is required for microglial activation and subsequent remyelination

(2021) Kimberle Shen et al.   Cell Reports

Insulin signaling mediates neurodegeneration in glioma

(2021) Patricia Jarabo et al.   Life Science Alliance

Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization

(2021) Ana Rita Pombo Antunes et al.   NATURE NEUROSCIENCE

The white matter is a pro-differentiative niche for glioblastoma

(2021) Lucy J. Brooks et al.   Nature Communications

Prognostic factors of patients with Gliomas – an analysis on 335 patients with Glioblastoma and other forms of Gliomas

(2020) Jianfeng Liang et al.   BMC CANCER

Astrocytic trans-Differentiation Completes a Multicellular Paracrine Feedback Loop Required for Medulloblastoma Tumor Growth

(2020) Maojin Yao et al.   CELL

PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis

(2020) Kwanha Yu et al.   NATURE

Cxcr4 distinguishes HSC-derived monocytes from microglia and reveals monocyte immune responses to experimental stroke

(2020) Yves Werner et al.   NATURE NEUROSCIENCE

Astrocyte senescence promotes glutamate toxicity in cortical neurons

(2020) Chandani Limbad et al.   PLoS One

Gliomas Interact with Non-glioma Brain Cells via Extracellular Vesicles

(2020) Xiaofei Gao et al.   Cell Reports

Microglia Heterogeneity in the Single-Cell Era

(2020) Takahiro Masuda et al.   Cell Reports

Extracellular Vesicle-Mediated Communication between the Glioblastoma and Its Microenvironment

(2020) Esperanza R. Matarredona et al.   Cells

Single-Cell Mapping of Human Brain Cancer Reveals Tumor-Specific Instruction of Tissue-Invading Leukocytes

(2020) Ekaterina Friebel et al.   CELL

Interrogation of the Microenvironmental Landscape in Brain Tumors Reveals Disease-Specific Alterations of Immune Cells

(2020) Florian Klemm et al.   CELL

Glioblastoma hijacks microglial gene expression to support tumor growth

(2020) Sybren L. N. Maas et al.   Journal of Neuroinflammation

Control of brain tumor growth by reactivating myeloid cells with niacin

(2020) Susobhan Sarkar et al.   Science Translational Medicine

Glioma-Induced Alterations in Neuronal Activity and Neurovascular Coupling during Disease Progression

(2020) Mary Katherine Montgomery et al.   Cell Reports

Time course of neurological deficits after surgery for primary brain tumours

(2020) Maria Zetterling et al.   ACTA NEUROCHIRURGICA

Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity

(2020) Phi T. Nguyen et al.   CELL

Senolytic CAR T cells reverse senescence-associated pathologies

(2020) Corina Amor et al.   NATURE

Remodelling the matrix

(2020) Darran Yates   NATURE REVIEWS NEUROSCIENCE

Synaptic input to brain tumors: clinical implications

(2020) Varun Venkataramani et al.   NEURO-ONCOLOGY

Differential roles of pyramidal and fast-spiking, GABAergic neurons in the control of glioma cell proliferation

(2020) Elena Tantillo et al.   NEUROBIOLOGY OF DISEASE

Dynamic changes in glioma macrophage populations after radiotherapy reveal CSF-1R inhibition as a strategy to overcome resistance

(2020) Leila Akkari et al.   Science Translational Medicine

Voluntary Physical Exercise Reduces Motor Dysfunction and Hampers Tumor Cell Proliferation in a Mouse Model of Glioma

(2020) Elena Tantillo et al.   International Journal of Environmental Research and Public Health

Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain

(2020) Joshua D. Crapser et al.   EBioMedicine

Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression

(2020) Astrid De Boeck et al.   Nature Communications

A MAC2-positive progenitor-like microglial population is resistant to CSF1R inhibition in adult mouse brain

(2020) Lihong Zhan et al.   eLife

Protective Functions of Reactive Astrocytes Following Central Nervous System Insult

(2020) Mathias Linnerbauer et al.   Frontiers in Immunology

A map of tumor–host interactions in glioma at single-cell resolution

(2020) Francesca Pia Caruso et al.   GigaScience

Organotypic Models to Study Human Glioblastoma: Studying the Beast in Its Ecosystem

(2020) David Pamies et al.   iScience

Microglia are effector cells of CD47-SIRPα antiphagocytic axis disruption against glioblastoma

(2019) Gregor Hutter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytes Maintain Glutamate Homeostasis in the CNS by Controlling the Balance between Glutamate Uptake and Release

(2019) Shaimaa Mahmoud et al.   Cells

Dexamethasone in Glioblastoma Multiforme Therapy: Mechanisms and Controversies

(2019) Marta Cenciarini et al.   Frontiers in Molecular Neuroscience

Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis

(2019) Alexandra M. Nicaise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Environmental enrichment, new neurons and the neurobiology of individuality

(2019) Gerd Kempermann   NATURE REVIEWS NEUROSCIENCE

Cell-of-origin susceptibility to glioblastoma formation declines with neural lineage restriction

(2019) Sheila Alcantara Llaguno et al.   NATURE NEUROSCIENCE

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution

(2019) Takahiro Masuda et al.   NATURE

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

(2019) Peisu Zhang et al.   NATURE NEUROSCIENCE

Aberrant oligodendroglial–vascular interactions disrupt the blood–brain barrier, triggering CNS inflammation

(2019) Jianqin Niu et al.   NATURE NEUROSCIENCE

Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39

(2019) Maisa C. Takenaka et al.   NATURE NEUROSCIENCE

Pathological and Molecular Features of Glioblastoma and Its Peritumoral Tissue

(2019) Alessio D’Alessio et al.   Cancers

The Emerging Nature of Astrocyte Diversity

(2019) Baljit S. Khakh et al.   Annual Review of Neuroscience

Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma

(2019) Peiwen Chen et al.   CANCER CELL

An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma

(2019) Cyril Neftel et al.   CELL

Re-education of macrophages as a therapeutic strategy in cancer

(2019) Joanna Kowal et al.   Immunotherapy

Genetic manipulation of autonomic nerve fiber innervation and activity and its effect on breast cancer progression

(2019) Atsunori Kamiya et al.   NATURE NEUROSCIENCE

Chemokines: Key Molecules that Orchestrate Communication among Neurons, Microglia and Astrocytes to Preserve Brain Function

(2019) Flavia Trettel et al.   NEUROSCIENCE

Tumour-associated macrophages exhibit anti-tumoural properties in Sonic Hedgehog medulloblastoma

(2019) Victor Maximov et al.   Nature Communications

Tumor-associated reactive astrocytes aid the evolution of immunosuppressive environment in glioblastoma

(2019) Dieter Henrik Heiland et al.   Nature Communications

Brain tumours repurpose endogenous neuron to microglia signalling mechanisms to promote their own proliferation

(2019) Kelda Chia et al.   eLife

The Potential of Astrocytes as Immune Modulators in Brain Tumors

(2019) Neibla Priego et al.   Frontiers in Immunology

Astrocytes enhance glioblastoma growth

(2019) Alessandro Mega et al.   GLIA

NG2 glia are required for maintaining microglia homeostatic state

(2019) Yingjun Liu et al.   GLIA

Electrical and synaptic integration of glioma into neural circuits

(2019) Humsa S. Venkatesh et al.   NATURE

Glutamatergic synaptic input to glioma cells drives brain tumour progression

(2019) Varun Venkataramani et al.   NATURE

Synaptic proximity enables NMDAR signalling to promote brain metastasis

(2019) Qiqun Zeng et al.   NATURE

PD-L1/PD-1 Axis in Glioblastoma Multiforme

(2019) Jakub Litak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mapping microglia states in the human brain through the integration of high-dimensional techniques

(2019) Roman Sankowski et al.   NATURE NEUROSCIENCE

Emerging intersections between neuroscience and glioma biology

(2019) Erik Jung et al.   NATURE NEUROSCIENCE

Microglia/Brain Macrophages as Central Drivers of Brain Tumor Pathobiology

(2019) David H. Gutmann et al.   NEURON

Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination

(2019) Leslie Kirby et al.   Nature Communications

LXRβ controls glioblastoma cell growth, lipid balance, and immune modulation independently of ABCA1

(2019) Deven Patel et al.   Scientific Reports

Immune cells within the tumor microenvironment: Biological functions and roles in cancer immunotherapy

(2019) Xu Lei et al.   CANCER LETTERS

Potassium and glutamate transport is impaired in scar-forming tumor-associated astrocytes

(2019) Susan C. Campbell et al.   NEUROCHEMISTRY INTERNATIONAL

Glioblastoma cells vampirize WNT from neurons and trigger a JNK/MMP signaling loop that enhances glioblastoma progression and neurodegeneration

(2019) Marta Portela et al.   PLOS BIOLOGY

Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation

(2018) Luca Peruzzotti-Jametti et al.   Cell Stem Cell

Canonical TGF-β Signaling Negatively Regulates Neuronal Morphogenesis through TGIF/Smad Complex-Mediated CRMP2 Suppression

(2018) Hideyuki Nakashima et al.   JOURNAL OF NEUROSCIENCE

STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis

(2018) Neibla Priego et al.   NATURE MEDICINE

Epigenetic regulation of brain region-specific microglia clearance activity

(2018) Pinar Ayata et al.   NATURE NEUROSCIENCE

Neural electrical activity and neural network growth

(2018) F.M. Gafarov   NEURAL NETWORKS

A Combination of Ontogeny and CNS Environment Establishes Microglial Identity

(2018) F. Chris Bennett et al.   NEURON

Normal aging induces A1-like astrocyte reactivity

(2018) Laura E. Clarke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two-Step Senescence-Focused Cancer Therapies

(2018) Cynthia J. Sieben et al.   TRENDS IN CELL BIOLOGY

Tumor initiating cells induce Cxcr4-mediated infiltration of pro-tumoral macrophages into the brain

(2018) Kelda Chia et al.   eLife

Oligodendrocyte Progenitor Cells and Macrophages/Microglia Produce Glioma Stem Cell Niches at the Tumor Border

(2018) Takuichiro Hide et al.   EBioMedicine

Single‐cell transcriptomics reveals distinct inflammation‐induced microglia signatures

(2018) Carole Sousa et al.   EMBO REPORTS

Astrocytes, the rising stars of the glioblastoma microenvironment

(2018) Mayra Brandao et al.   GLIA

Human glioblastoma arises from subventricular zone cells with low-level driver mutations

(2018) Joo Ho Lee et al.   NATURE

Microglia/Astrocytes–Glioblastoma Crosstalk: Crucial Molecular Mechanisms and Microenvironmental Factors

(2018) Diana Matias et al.   Frontiers in Cellular Neuroscience

Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment

(2018) Erin M. Gibson et al.   CELL

Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes

(2018) Timothy R. Hammond et al.   IMMUNITY

Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis

(2018) Ana Mendanha Falcão et al.   NATURE MEDICINE

Invasion of white matter tracts by glioma stem cells is regulated by a NOTCH1–SOX2 positive-feedback loop

(2018) Jun Wang et al.   NATURE NEUROSCIENCE

Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy

(2018) Bhanu P. Tewari et al.   Nature Communications

Mitochondrial enzyme GLUD2 plays a critical role in glioblastoma progression

(2018) Sara Franceschi et al.   EBioMedicine

Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium

(2018) Giorgio Seano et al.   Nature Biomedical Engineering

Mutant IDH1 regulates the tumor-associated immune system in gliomas

(2017) Nduka M. Amankulor et al.   GENES & DEVELOPMENT

Tumor-related neurocognitive dysfunction in patients with diffuse glioma: a systematic review of neurocognitive functioning prior to anti-tumor treatment

(2017) Emma van Kessel et al.   JOURNAL OF NEURO-ONCOLOGY

Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma

(2017) Humsa S. Venkatesh et al.   NATURE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity

(2017) Sydney R. Gordon et al.   NATURE

Identification of diverse astrocyte populations and their malignant analogs

(2017) Chia-Ching John Lin et al.   NATURE NEUROSCIENCE

A new fate mapping system reveals context-dependent random or clonal expansion of microglia

(2017) Tuan Leng Tay et al.   NATURE NEUROSCIENCE

High-dimensional, single-cell characterization of the brain's immune compartment

(2017) Ben Korin et al.   NATURE NEUROSCIENCE

Tumour-associated macrophages as treatment targets in oncology

(2017) Alberto Mantovani et al.   Nature Reviews Clinical Oncology

Tumor microtubes convey resistance to surgical lesions and chemotherapy in gliomas

(2017) Sophie Weil et al.   NEURO-ONCOLOGY

Orexin activation counteracts decreases in nonexercise activity thermogenesis (NEAT) caused by high-fat diet

(2017) P.E. Bunney et al.   PHYSIOLOGY & BEHAVIOR

Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq

(2017) Andrew S. Venteicher et al.   SCIENCE

Endothelial Activation and Blood–Brain Barrier Disruption in Neurotoxicity after Adoptive Immunotherapy with CD19 CAR-T Cells

(2017) Juliane Gust et al.   Cancer Discovery

The potential roles of aquaporin 4 in malignant gliomas

(2017) Yu-Long Lan et al.   Oncotarget

Single-Cell RNA-Seq Analysis of Infiltrating Neoplastic Cells at the Migrating Front of Human Glioblastoma

(2017) Spyros Darmanis et al.   Cell Reports

Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

(2017) Katharine Askew et al.   Cell Reports

Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution

(2017) Hansruedi Mathys et al.   Cell Reports

Environmental stimuli shape microglial plasticity in glioma

(2017) Stefano Garofalo et al.   eLife

Reactive Astrocytes in Brain Metastasis

(2017) David Wasilewski et al.   Frontiers in Oncology

Neurotoxicity from immune-checkpoint inhibition in the treatment of melanoma: a single centre experience and review of the literature

(2016) L. Spain et al.   ANNALS OF ONCOLOGY

Nerve growth factor improves visual loss in childhood optic gliomas: a randomized, double-blind, phase II clinical trial

(2016) Benedetto Falsini et al.   BRAIN

Intrinsic Astrocyte Heterogeneity Influences Tumor Growth in Glioma Mouse Models

(2016) David M. Irvin et al.   BRAIN PATHOLOGY

Tissue-Resident Macrophage Ontogeny and Homeostasis

(2016) Florent Ginhoux et al.   IMMUNITY

Native Oligodendrocytes in Astrocytomas Might Inhibit Tumor Proliferation by WIF1 Expression

(2016) Martin Asslaber et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

PI3Kγ is a molecular switch that controls immune suppression

(2016) Megan M. Kaneda et al.   NATURE

Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer

(2016) Qing Chen et al.   NATURE

Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype

(2016) Xianli Shen et al.   NATURE IMMUNOLOGY

Sall1 is a transcriptional regulator defining microglia identity and function

(2016) Anne Buttgereit et al.   NATURE IMMUNOLOGY

Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues

(2016) Saeid Zanganeh et al.   Nature Nanotechnology

The role of microglia and macrophages in glioma maintenance and progression

(2016) Dolores Hambardzumyan et al.   NATURE NEUROSCIENCE

Seizures and gliomas — towards a single therapeutic approach

(2016) Gilles Huberfeld et al.   Nature Reviews Neurology

Endogenous GABAA receptor activity suppresses glioma growth

(2016) A Blanchart et al.   ONCOGENE

Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival

(2016) Jonas Kloepper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New tools for studying microglia in the mouse and human CNS

(2016) Mariko L. Bennett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas

(2016) D. F. Quail et al.   SCIENCE

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis

(2016) Megan K. Ruhland et al.   Nature Communications

Human astrocytes secrete IL-6 to promote glioma migration and invasion through upregulation of cytomembrane MMP14

(2016) Weiliang Chen et al.   Oncotarget

Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis

(2016) Anna-Maria Georgoudaki et al.   Cell Reports

Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies

(2016) Robert L. Bowman et al.   Cell Reports

Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion

(2015) Humsa S. Venkatesh et al.   CELL

Axo-glial communication through neurexin-neuroligin signaling regulates myelination and oligodendrocyte differentiation

(2015) Dustin T. Proctor et al.   GLIA

Aging-like changes in the transcriptome of irradiated microglia

(2015) Matthew D. Li et al.   GLIA

Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System

(2015) Julia Bruttger et al.   IMMUNITY

Microglia and astrocytes attenuate the replication of the oncolytic vaccinia virus LIVP 1.1.1 in murine GL261 gliomas by acting as vaccinia virus traps

(2015) Christina Kober et al.   Journal of Translational Medicine

Brain tumour cells interconnect to a functional and resistant network

(2015) Matthias Osswald et al.   NATURE

Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth

(2015) Wenchao Zhou et al.   NATURE CELL BIOLOGY

Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study

(2015) Nicholas Butowski et al.   NEURO-ONCOLOGY

Epilepsy in glioma patients: mechanisms, management, and impact of anticonvulsant therapy: Table 1.

(2015) Terri S. Armstrong et al.   NEURO-ONCOLOGY

Enriched environment reduces glioma growth through immune and non-immune mechanisms in mice

(2015) Stefano Garofalo et al.   Nature Communications

Microglia Versus Myeloid Cell Nomenclature during Brain Inflammation

(2015) Melanie Greter et al.   Frontiers in Immunology

Glioma

(2015) Michael Weller et al.   Nature Reviews Disease Primers

Reactive Astrocytes Protect Melanoma Cells from Chemotherapy by Sequestering Intracellular Calcium through Gap Junction Communication Channels

(2015) Qingtang Lin et al.   NEOPLASIA

Serpins Promote Cancer Cell Survival and Vascular Co-Option in Brain Metastasis

(2014) Manuel Valiente et al.   CELL

Osteopontin-CD44 Signaling in the Glioma Perivascular Niche Enhances Cancer Stem Cell Phenotypes and Promotes Aggressive Tumor Growth

(2014) Alexander Pietras et al.   Cell Stem Cell

Peritumoral epilepsy: Relating form and function for surgical success

(2014) Christopher J.A. Cowie et al.   EPILEPSY & BEHAVIOR

GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy

(2014) Susan L. Campbell et al.   GLIA

Paracrine regulation of glioma cells invasion by astrocytes is mediated by glial-derived neurotrophic factor

(2014) Ayelet Shabtay-Orbach et al.   INTERNATIONAL JOURNAL OF CANCER

Glioma-associated microglial MMP9 expression is upregulated by TLR2 signaling and sensitive to minocycline

(2014) Feng Hu et al.   INTERNATIONAL JOURNAL OF CANCER

Neuronal Hyperactivity Recruits Microglial Processes via Neuronal NMDA Receptors and Microglial P2Y12 Receptors after Status Epilepticus

(2014) U. B. Eyo et al.   JOURNAL OF NEUROSCIENCE

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Identification of distinct ChAT+ neurons and activity-dependent control of postnatal SVZ neurogenesis

(2014) Patricia Paez-Gonzalez et al.   NATURE NEUROSCIENCE

A neurocentric perspective on glioma invasion

(2014) Vishnu Anand Cuddapah et al.   NATURE REVIEWS NEUROSCIENCE

Transformation of quiescent adult oligodendrocyte precursor cells into malignant glioma through a multistep reactivation process

(2014) Rui Pedro Galvao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal Activity Promotes Oligodendrogenesis and Adaptive Myelination in the Mammalian Brain

(2014) E. M. Gibson et al.   SCIENCE

Cortical GABAergic excitation contributes to epileptic activities around human glioma

(2014) J. Pallud et al.   Science Translational Medicine

A role for intracellular zinc in glioma alteration of neuronal chloride equilibrium

(2014) S Di Angelantonio et al.   Cell Death & Disease

Disruption of astrocyte–vascular coupling and the blood–brain barrier by invading glioma cells

(2014) Stacey Watkins et al.   Nature Communications

Enhancing Chemotherapy Efficacy in Pten -Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor Immunity

(2014) Alberto Toso et al.   Cell Reports

Pazopanib Inhibits the Activation of PDGFRβ-Expressing Astrocytes in the Brain Metastatic Microenvironment of Breast Cancer Cells

(2013) Brunilde Gril et al.   AMERICAN JOURNAL OF PATHOLOGY

Oligodendrocyte Progenitor Cells Promote Neovascularization in Glioma by Disrupting the Blood-Brain Barrier

(2013) Y. Huang et al.   CANCER RESEARCH

Glutamate transporters in the biology of malignant gliomas

(2013) Stephanie M. Robert et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

GABA suppresses neurogenesis in the adult hippocampus through GABAB receptors

(2013) C. Giachino et al.   DEVELOPMENT

Tumor-associated edema in brain cancer patients: pathogenesis and management

(2013) Patrick Roth et al.   Expert Review of Anticancer Therapy

PD-L1 Expression by Neurons Nearby Tumors Indicates Better Prognosis in Glioblastoma Patients

(2013) Y. Liu et al.   JOURNAL OF NEUROSCIENCE

Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

(2013) Won-Suk Chung et al.   NATURE

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells

(2013) Susobhan Sarkar et al.   NATURE NEUROSCIENCE

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

Glutamate and tumor-associated epilepsy: Glial cell dysfunction in the peritumoral environment

(2013) Susan C. Buckingham et al.   NEUROCHEMISTRY INTERNATIONAL

Mature BDNF promotes the growth of glioma cells in vitro

(2013) JING XIONG et al.   ONCOLOGY REPORTS

Multifarious functions of PDGFs and PDGFRs in tumor growth and metastasis

(2013) Yihai Cao   TRENDS IN MOLECULAR MEDICINE

Enriched environment and physical activity reverse astrogliodegeneration in the hippocampus of AD transgenic mice

(2013) J J Rodríguez et al.   Cell Death & Disease

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Effect of cancer therapy on neural stem cells

(2012) Erin Gibson et al.   CURRENT OPINION IN ONCOLOGY

Crosstalk between oligodendrocytes and cerebral endothelium contributes to vascular remodeling after white matter injury

(2012) Loc-Duyen D. Pham et al.   GLIA

miR-155 is up-regulated in primary and secondary glioblastoma and promotes tumour growth by inhibiting GABA receptors

(2012) Santo Marsigliante   INTERNATIONAL JOURNAL OF ONCOLOGY

Unknown

(2012) Salvatore Coniglio et al.   MOLECULAR MEDICINE

Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision

(2012) Juan Song et al.   NATURE

Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1

(2012) Kristin Stock et al.   NATURE MEDICINE

Astrocyte-Specific Expression Patterns Associated with the PDGF-Induced Glioma Microenvironment

(2012) Amanda M. Katz et al.   PLoS One

GABA-A Channel Subunit Expression in Human Glioma Correlates with Tumor Histology and Clinical Outcome

(2012) Anja Smits et al.   PLoS One

Astrocyte Senescence as a Component of Alzheimer’s Disease

(2012) Rekha Bhat et al.   PLoS One

The pathogenesis of tumor-related epilepsy and its implications for clinical treatment

(2012) Gan You et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Asymmetry-Defective Oligodendrocyte Progenitors Are Glioma Precursors

(2011) Sista Sugiarto et al.   CANCER CELL

Mosaic Analysis with Double Markers Reveals Tumor Cell of Origin in Glioma

(2011) Chong Liu et al.   CELL

Anomalous levels of Cl− transporters cause a decrease of GABAergic inhibition in human peritumoral epileptic cortex

(2011) Luca Conti et al.   EPILEPSIA

Compromised Health-Related Quality of Life in Patients With Low-Grade Glioma

(2011) Neil K. Aaronson et al.   JOURNAL OF CLINICAL ONCOLOGY

Glutamate release by primary brain tumors induces epileptic activity

(2011) Susan C Buckingham et al.   NATURE MEDICINE

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Glutamate and the biology of gliomas

(2010) John de Groot et al.   GLIA

Training of Working Memory Impacts Structural Connectivity

(2010) H. Takeuchi et al.   JOURNAL OF NEUROSCIENCE

Glioma cancer stem cells induce immunosuppressive macrophages/microglia

(2010) Adam Wu et al.   NEURO-ONCOLOGY

Intercellular calcium signaling between astrocytes and oligodendrocytes via gap junctions in culture

(2010) B. Parys et al.   NEUROSCIENCE

Prolonged activation of NMDA receptors promotes dephosphorylation and alters postendocytic sorting of GABAB receptors

(2010) M. Terunuma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Tumor-associated epilepsy and glioma: Are there common genetic pathways?

(2009) Shala Ghaderi Berntsson et al.   ACTA ONCOLOGICA

Astrocytes in the damaged brain: Molecular and cellular insights into their reactive response and healing potential

(2009) Annalisa Buffo et al.   BIOCHEMICAL PHARMACOLOGY

Neuron-glia synapses in the brain

(2009) Dwight E. Bergles et al.   BRAIN RESEARCH REVIEWS

Malignant Astrocytomas Originate from Neural Stem/Progenitor Cells in a Somatic Tumor Suppressor Mouse Model

(2009) Sheila Alcantara Llaguno et al.   CANCER CELL

Nurturing brain plasticity: impact of environmental enrichment

(2009) L Baroncelli et al.   CELL DEATH AND DIFFERENTIATION

In vivo assessment of high-grade glioma biochemistry using microdialysis: a study of energy-related molecules, growth factors and cytokines

(2009) Hani J. Marcus et al.   JOURNAL OF NEURO-ONCOLOGY

Training induces changes in white-matter architecture

(2009) Jan Scholz et al.   NATURE NEUROSCIENCE

GABA’s Control of Stem and Cancer Cell Proliferation in Adult Neural and Peripheral Niches

(2009) Stephanie Z. Young et al.   PHYSIOLOGY

Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion

(2009) D. S. Markovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor-Targeted Interferon-α Delivery by Tie2-Expressing Monocytes Inhibits Tumor Growth and Metastasis

(2008) Michele De Palma et al.   CANCER CELL

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Glutamate-induced glioma cell proliferation is prevented by functional expression of the glutamate transporter GLT-1

(2008) Nicolas Vanhoutte et al.   FEBS LETTERS

A role for glutamate in growth and invasion of primary brain tumors

(2008) Harald Sontheimer   JOURNAL OF NEUROCHEMISTRY

Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas

(2008) Y Komohara et al.   JOURNAL OF PATHOLOGY

Small interfering RNA–mediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema

(2008) Nicolai E Savaskan et al.   NATURE MEDICINE

Remyelination in the CNS: from biology to therapy

(2008) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE

A Biological Function for the Neuronal Activity-Dependent Component of Bdnf Transcription in the Development of Cortical Inhibition

(2008) Elizabeth J. Hong et al.   NEURON