Network pharmacology: curing causal mechanisms instead of treating symptoms

On the limits of active module identification

(2021) Olga Lazareva et al.   BRIEFINGS IN BIOINFORMATICS

A Therapy for Most with Cystic Fibrosis

(2020) Christine E. Bear   CELL

Update on targeted cancer therapies, single or in combination, and their fine tuning for precision medicine

(2020) Sara S Bashraheel et al.   BIOMEDICINE & PHARMACOTHERAPY

Toward a More Precise Future for Oncology

(2020) Yonina R. Murciano-Goroff et al.   CANCER CELL

Capivasertib, an AKT Kinase Inhibitor, as Monotherapy or in Combination With Fulvestrant in Patients With AKT1E17K-Mutant, ER-Positive Metastatic Breast Cancer

(2020) Lillian M Smyth et al.   CLINICAL CANCER RESEARCH

Glioblastoma in Adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) Consensus Review on Current Management and Future Directions

(2020) Patrick Y Wen et al.   NEURO-ONCOLOGY

Olinciguat, an Oral sGC Stimulator, Exhibits Diverse Pharmacology Across Preclinical Models of Cardiovascular, Metabolic, Renal, and Inflammatory Disease

(2020) Daniel P. Zimmer et al.   Frontiers in Pharmacology

Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing

(2020) Sepideh Sadegh et al.   Nature Communications

Optical Mapping of cAMP Signaling at the Nanometer Scale

(2020) Andreas Bock et al.   CELL

Nox1/4 inhibition exacerbates age dependent perivascular inflammation and fibrosis in a model of spontaneous hypertension

(2020) R. Nosalski et al.   PHARMACOLOGICAL RESEARCH

On the Clinical Pharmacology of Reactive Oxygen Species

(2020) Ana I. Casas et al.   PHARMACOLOGICAL REVIEWS

AKAP Signaling Islands: Venues for Precision Pharmacology

(2020) Mitchell H. Omar et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Larotrectinib: First Global Approval

(2019) Lesley J. Scott   DRUGS

Network-based prediction of drug combinations

(2019) Feixiong Cheng et al.   Nature Communications

From single drug targets to synergistic network pharmacology in ischemic stroke

(2019) Ana I. Casas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GUILDify v2.0: A Tool to Identify Molecular Networks Underlying Human Diseases, Their Comorbidities and Their Druggable Targets

(2019) Joaquim Aguirre-Plans et al.   JOURNAL OF MOLECULAR BIOLOGY

Calcium-dependent blood-brain barrier breakdown by NOX5 limits postreperfusion benefit in stroke

(2019) Ana I. Casas et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular profiling of cancer patients enables personalized combination therapy: the I-PREDICT study

(2019) Jason K. Sicklick et al.   NATURE MEDICINE

Soluble Guanylate Cyclase Agonists Induce Bronchodilation in Human Small Airways

(2019) Cynthia J. Koziol-White et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Advances in gene therapy for cystic fibrosis lung disease

(2019) Ziying Yan et al.   HUMAN MOLECULAR GENETICS

A New Pathway to Airway Relaxation - Targeting the “Other” Cyclase in Asthma

(2019) Maggie Lam et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Assessment of network module identification across complex diseases

(2019) Sarvenaz Choobdar et al.   NATURE METHODS

Elexacaftor/Ivacaftor/Tezacaftor: First Approval

(2019) Sheridan M. Hoy   DRUGS

Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration

(2019) Andrew P. Voigt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-nuclei RNA-seq on human retinal tissue provides improved transcriptome profiling

(2019) Qingnan Liang et al.   Nature Communications

Oncogenic Signaling Pathways in The Cancer Genome Atlas

(2018) Francisco Sanchez-Vega et al.   CELL

HER kinase inhibition in patients with HER2- and HER3-mutant cancers

(2018) David M. Hyman et al.   NATURE

IID 2018 update: context-specific physical protein–protein interactions in human, model organisms and domesticated species

(2018) Max Kotlyar et al.   NUCLEIC ACIDS RESEARCH

Statistical and Machine Learning Approaches to Predict Gene Regulatory Networks From Transcriptome Datasets

(2018) Keiichi Mochida et al.   Frontiers in Plant Science

New clinical trial designs in the era of precision medicine: An overview of definitions, strengths, weaknesses, and current use in oncology

(2018) Perrine Janiaud et al.   CANCER TREATMENT REVIEWS

WikiPathways: a multifaceted pathway database bridging metabolomics to other omics research

(2017) Denise N Slenter et al.   NUCLEIC ACIDS RESEARCH

NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage

(2017) Ana I. Casas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Large-scale detection of drug off-targets: hypotheses for drug repurposing and understanding side-effects

(2017) Matthieu Chartier et al.   BMC Pharmacology & Toxicology

Simple and complex retinal dystrophies are associated with profoundly different disease networks

(2017) Christina Kiel et al.   Scientific Reports

Clinical relevance of cyclic GMP modulators: A translational success story of network pharmacology

(2016) JM Oettrich et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

NOS knockout or inhibition but not disrupting PSD-95-NOS interaction protect against ischemic brain damage

(2016) Christoph Kleinschnitz et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Precision Oncology Medicine: The Clinical Relevance of Patient-Specific Biomarkers Used to Optimize Cancer Treatment

(2016) Keith T. Schmidt et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Erratum: Universal resilience patterns in complex networks

(2016) Jianxi Gao et al.   NATURE

Can you teach old drugs new tricks?

(2016) Nicola Nosengo   NATURE

Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

(2016) David Ellinghaus et al.   NATURE GENETICS

Network pharmacology of cancer: From understanding of complex interactomes to the design of multi-target specific therapeutics from nature

(2016) Paramasivan Poornima et al.   PHARMACOLOGICAL RESEARCH

Controllability analysis of the directed human protein interaction network identifies disease genes and drug targets

(2016) Arunachalam Vinayagam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systems Pharmacology and Rational Polypharmacy: Nitric Oxide−Cyclic GMP Signaling Pathway as an Illustrative Example and Derivation of the General Case

(2016) Farshid S. Garmaroudi et al.   PLoS Computational Biology

Pharmacology and Clinical Drug Candidates in Redox Medicine

(2015) V. Thao-Vi Dao et al.   ANTIOXIDANTS & REDOX SIGNALING

Clinical Relevance of Biomarkers of Oxidative Stress

(2015) Jeroen Frijhoff et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactive Oxygen Species Can Provide Atheroprotection via NOX4-Dependent Inhibition of Inflammation and Vascular RemodelingSignificance

(2015) Stephen P. Gray et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Personalized medicine: Time for one-person trials

(2015) Nicholas J. Schork   NATURE

Heterogeneity of autoimmune diseases: pathophysiologic insights from genetics and implications for new therapies

(2015) Judy H Cho et al.   NATURE MEDICINE

Uncovering disease-disease relationships through the incomplete interactome

(2015) J. Menche et al.   SCIENCE

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

A combined pre-clinical meta-analysis and randomized confirmatory trial approach to improve data validity for therapeutic target validation

(2015) Pamela WM. Kleikers et al.   Scientific Reports

CUSP9* treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline augmenting continuous low dose temozolomide

(2015) Richard E. Kast et al.   Oncotarget

Genetic Targeting or Pharmacologic Inhibition of NADPH Oxidase Nox4 Provides Renoprotection in Long-Term Diabetic Nephropathy

(2014) J. C. Jha et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations

(2014) Pawel Buczkowicz et al.   NATURE GENETICS

Potentiator ivacaftor abrogates pharmacological correction of  F508 CFTR in cystic fibrosis

(2014) D. M. Cholon et al.   Science Translational Medicine

NADPH Oxidase, NOX1, Mediates Vascular Injury in Ischemic Retinopathy

(2013) Jennifer L. Wilkinson-Berka et al.   ANTIOXIDANTS & REDOX SIGNALING

NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus–Accelerated Atherosclerosis

(2013) Stephen P. Gray et al.   CIRCULATION

Animal Models in Obesity and Hypertension

(2013) Gabriella Segal-Lieberman et al.   CURRENT HYPERTENSION REPORTS

A Novel Paradigm for Heart Failure With Preserved Ejection Fraction

(2013) Walter J. Paulus et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Early Diagnosis of Complex Diseases by Molecular Biomarkers, Network Biomarkers, and Dynamical Network Biomarkers

(2013) Rui Liu et al.   MEDICINAL RESEARCH REVIEWS

Dysfunctional nitric oxide signalling increases risk of myocardial infarction

(2013) Jeanette Erdmann et al.   NATURE

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

Exploring the human diseasome: the human disease network

(2012) K.-I. Goh et al.   Briefings in Functional Genomics

Personalized Cardiovascular Medicine and Drug Development

(2012) Joseph Loscalzo   CIRCULATION

NADPH oxidases as a source of oxidative stress and molecular target in ischemia/reperfusion injury

(2012) Pamela W. M. Kleikers et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Diagnostic, prognostic, and predictive biomarkers in pancreatic cancer

(2012) Jordan M. Winter et al.   JOURNAL OF SURGICAL ONCOLOGY

Ivacaftor

(2012) Pamela B. Davis et al.   NATURE REVIEWS DRUG DISCOVERY

Diagnosing the decline in pharmaceutical R&D efficiency

(2012) Jack W. Scannell et al.   NATURE REVIEWS DRUG DISCOVERY

Animal models for the study of arterial hypertension

(2011) Waleska C Dornas et al.   JOURNAL OF BIOSCIENCES

Believe it or not: how much can we rely on published data on potential drug targets?

(2011) Florian Prinz et al.   NATURE REVIEWS DRUG DISCOVERY

Preexistence and Clonal Selection of MET Amplification in EGFR Mutant NSCLC

(2010) Alexa B. Turke et al.   CANCER CELL

Patrick Vallance

(2010)   NATURE REVIEWS DRUG DISCOVERY

Post-Stroke Inhibition of Induced NADPH Oxidase Type 4 Prevents Oxidative Stress and Neurodegeneration

(2010) Christoph Kleinschnitz et al.   PLOS BIOLOGY

Rationalizing the chemical space of protein–protein interaction inhibitors

(2009) Olivier Sperandio et al.   DRUG DISCOVERY TODAY

Are animal models predictive for humans?

(2009) Niall Shanks et al.   Philosophy Ethics and Humanities in Medicine

Prognostic versus predictive value of biomarkers in oncology

(2008) C.N.A.M. Oldenhuis et al.   EUROPEAN JOURNAL OF CANCER

Network pharmacology: the next paradigm in drug discovery

(2008) Andrew L Hopkins   Nature Chemical Biology