Heterogeneity of autoimmune diseases: pathophysiologic insights from genetics and implications for new therapies
出版年份 2015 全文链接
标题
Heterogeneity of autoimmune diseases: pathophysiologic insights from genetics and implications for new therapies
作者
关键词
-
出版物
NATURE MEDICINE
Volume 21, Issue 7, Pages 730-738
出版商
Springer Nature
发表日期
2015-06-29
DOI
10.1038/nm.3897
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Integrative analysis of 111 reference human epigenomes
- (2015) Anshul Kundaje et al. NATURE
- Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers
- (2015) Suna Onengut-Gumuscu et al. NATURE GENETICS
- Efficacy and Safety of Alirocumab in Reducing Lipids and Cardiovascular Events
- (2015) Jennifer G. Robinson et al. NEW ENGLAND JOURNAL OF MEDICINE
- Efficacy and Safety of Evolocumab in Reducing Lipids and Cardiovascular Events
- (2015) Marc S. Sabatine et al. NEW ENGLAND JOURNAL OF MEDICINE
- A New Initiative on Precision Medicine
- (2015) Francis S. Collins et al. NEW ENGLAND JOURNAL OF MEDICINE
- Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis
- (2015) John Bowes et al. Nature Communications
- Comparative Genomic Profiling of Synovium Versus Skin Lesions in Psoriatic Arthritis
- (2015) Jennifer Belasco et al. Arthritis & Rheumatology
- Ustekinumab for the treatment of patients with active ankylosing spondylitis: results of a 28-week, prospective, open-label, proof-of-concept study (TOPAS)
- (2014) Denis Poddubnyy et al. ANNALS OF THE RHEUMATIC DISEASES
- Not all monoclonals are created equal – Lessons from failed drug trials in Crohn's disease
- (2014) Arthur Kaser BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY
- Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment
- (2014) Yonit Lavin et al. CELL
- Recent developments in the treatment of patients with systemic lupus erythematosus: focusing on biologic therapies
- (2014) Zozik Fattah et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Anatomical localization of commensal bacteria in immune cell homeostasis and disease
- (2014) Thomas C. Fung et al. IMMUNOLOGICAL REVIEWS
- Guidelines for investigating causality of sequence variants in human disease
- (2014) D. G. MacArthur et al. NATURE
- Genetic and epigenetic fine mapping of causal autoimmune disease variants
- (2014) Kyle Kai-How Farh et al. NATURE
- PTPN22: the archetypal non-HLA autoimmunity gene
- (2014) Stephanie M. Stanford et al. Nature Reviews Rheumatology
- Brodalumab, an Anti-IL17RA Monoclonal Antibody, in Psoriatic Arthritis
- (2014) Philip J. Mease et al. NEW ENGLAND JOURNAL OF MEDICINE
- A 52-Week Placebo-Controlled Trial of Evolocumab in Hyperlipidemia
- (2014) Dirk J. Blom et al. NEW ENGLAND JOURNAL OF MEDICINE
- Secukinumab in Plaque Psoriasis — Results of Two Phase 3 Trials
- (2014) Richard G. Langley et al. NEW ENGLAND JOURNAL OF MEDICINE
- Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4
- (2014) H. S. Kuehn et al. SCIENCE
- Innate Immune Activity Conditions the Effect of Regulatory Variants upon Monocyte Gene Expression
- (2014) B. P. Fairfax et al. SCIENCE
- Statin-Related Cognitive Impairment in the Real World
- (2014) Jonathan McDonagh JAMA Internal Medicine
- Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriatic arthritis: a 24-week, randomised, double-blind, placebo-controlled, phase II proof-of-concept trial
- (2013) Iain B McInnes et al. ANNALS OF THE RHEUMATIC DISEASES
- The Human Skin–Associated Autoantigen α-NAC Activates Monocytes and Dendritic Cells via TLR-2 and Primes an IL-12-Dependent Th1 Response
- (2013) Susanne Hradetzky et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Efficacy and safety of ustekinumab in patients with active psoriatic arthritis: 1 year results of the phase 3, multicentre, double-blind, placebo-controlled PSUMMIT 1 trial
- (2013) Iain B McInnes et al. LANCET
- Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled trial
- (2013) Dominique Baeten et al. LANCET
- Genetics of rheumatoid arthritis contributes to biology and drug discovery
- (2013) Yukinori Okada et al. NATURE
- How Cytokine Networks Fuel Inflammation: Toward a cytokine-based disease taxonomy
- (2013) Georg Schett et al. NATURE MEDICINE
- Genetic insights into common pathways and complex relationships among immune-mediated diseases
- (2013) Miles Parkes et al. NATURE REVIEWS GENETICS
- Genome-Wide Association Study and Gene Expression Analysis Identifies CD84 as a Predictor of Response to Etanercept Therapy in Rheumatoid Arthritis
- (2013) Jing Cui et al. PLoS Genetics
- Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis
- (2013) Jose U Scher et al. eLife
- Ustekinumab in the treatment of psoriatic arthritis: latest findings and clinical potential
- (2013) Alice Gottlieb et al. Therapeutic Advances in Musculoskeletal Disease
- Serious Infection and Mortality in Patients With Crohn's Disease: More Than 5 Years of Follow-Up in the TREAT™ Registry
- (2012) Gary R Lichtenstein et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Abatacept for Crohn's Disease and Ulcerative Colitis
- (2012) William J. Sandborn et al. GASTROENTEROLOGY
- Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial
- (2012) Wolfgang Hueber et al. GUT
- Seven newly identified loci for autoimmune thyroid disease
- (2012) Jason D. Cooper et al. HUMAN MOLECULAR GENETICS
- Characterization of TLR4-mediated auto-antibody production in a mouse model of histidyl-tRNA synthetase-induced myositis
- (2012) Lisa Harlow et al. Innate Immunity
- Rituximab Treatment for Spondyloarthritis. A Nationwide Series: Data from the AIR Registry of the French Society of Rheumatology
- (2012) D. WENDLING et al. JOURNAL OF RHEUMATOLOGY
- TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis
- (2012) Adam P. Gregory et al. NATURE
- Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β
- (2012) Christina E. Zielinski et al. NATURE
- Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
- (2012) Luke Jostins et al. NATURE
- High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis
- (2012) Steve Eyre et al. NATURE GENETICS
- Hiding under the skin: A welcome surprise in psoriasis
- (2012) James G Krueger NATURE MEDICINE
- Effect of a Monoclonal Antibody to PCSK9 on LDL Cholesterol
- (2012) Evan A. Stein et al. NEW ENGLAND JOURNAL OF MEDICINE
- Ustekinumab Induction and Maintenance Therapy in Refractory Crohn's Disease
- (2012) William J. Sandborn et al. NEW ENGLAND JOURNAL OF MEDICINE
- Systematic Review and Meta-Analysis of the Efficacy and Safety of Existing TNF Blocking Agents in Treatment of Rheumatoid Arthritis
- (2012) Kalle J. Aaltonen et al. PLoS One
- Innate Lymphoid Cells Promote Anatomical Containment of Lymphoid-Resident Commensal Bacteria
- (2012) G. F. Sonnenberg et al. SCIENCE
- Interactions Between the Microbiota and the Immune System
- (2012) L. V. Hooper et al. SCIENCE
- Integrating Autoimmune Risk Loci with Gene-Expression Data Identifies Specific Pathogenic Immune Cell Subsets
- (2011) Xinli Hu et al. AMERICAN JOURNAL OF HUMAN GENETICS
- The value of early intervention in RA—a window of opportunity
- (2011) Ferdinand Breedveld CLINICAL RHEUMATOLOGY
- Randomised placebo-controlled trial of rituximab (anti-CD20) in active ulcerative colitis
- (2011) K. Leiper et al. GUT
- Twin studies in autoimmune disease: Genetics, gender and environment
- (2011) Dimitrios P. Bogdanos et al. JOURNAL OF AUTOIMMUNITY
- Human nutrition, the gut microbiome and the immune system
- (2011) Andrew L. Kau et al. NATURE
- The autoimmune disease–associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness
- (2011) Jinyi Zhang et al. NATURE GENETICS
- Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease
- (2011) Gosia Trynka et al. NATURE GENETICS
- Genomics and the Multifactorial Nature of Human Autoimmune Disease
- (2011) Judy H. Cho et al. NEW ENGLAND JOURNAL OF MEDICINE
- The IL23R R381Q Gene Variant Protects against Immune-Mediated Diseases by Impairing IL-23-Induced Th17 Effector Response in Humans
- (2011) Paola Di Meglio et al. PLoS One
- Functional Studies on the IBD Susceptibility Gene IL23R Implicate Reduced Receptor Function in the Protective Genetic Variant R381Q
- (2011) Svetlana Pidasheva et al. PLoS One
- Inflammatory disease protective R381Q IL23 receptor polymorphism results in decreased primary CD4+ and CD8+ human T-cell functional responses
- (2011) R. Sarin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Reengineering Translational Science: The Time Is Right
- (2011) F. S. Collins Science Translational Medicine
- Different response to rituximab in tumor necrosis factor blocker-naive patients with active ankylosing spondylitis and in patients in whom tumor necrosis factor blockers have failed: A twenty-four-week clinical trial
- (2010) I.-H. Song et al. ARTHRITIS AND RHEUMATISM
- Th17 and Regulatory T Cells in Mediating and Restraining Inflammation
- (2010) Dan R. Littman et al. CELL
- Increased limb involvement in murine collagen-induced arthritis following treatment with anti-interferon-gamma
- (2010) R. O. WILLIAMS et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells
- (2010) Philip P. Ahern et al. IMMUNITY
- Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci
- (2010) John D Reveille et al. NATURE GENETICS
- Adaptation – not by sweeps alone
- (2010) Jonathan K. Pritchard et al. NATURE REVIEWS GENETICS
- Comparison of Ustekinumab and Etanercept for Moderate-to-Severe Psoriasis
- (2010) Christopher E.M. Griffiths et al. NEW ENGLAND JOURNAL OF MEDICINE
- Trait-Associated SNPs Are More Likely to Be eQTLs: Annotation to Enhance Discovery from GWAS
- (2010) Dan L. Nicolae et al. PLoS Genetics
- Plasticity of CD4+ T Cell Lineage Differentiation
- (2009) Liang Zhou et al. IMMUNITY
- PTPN22 Deficiency Cooperates with the CD45 E613R Allele to Break Tolerance on a Non-Autoimmune Background
- (2009) J. Zikherman et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: The PTPN22 Allelic Variant Associated with Autoimmunity Impairs B Cell Signaling
- (2009) A. F. Arechiga et al. JOURNAL OF IMMUNOLOGY
- Rheumatoid arthritis
- (2009) Lars Klareskog et al. LANCET
- Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways
- (2009) Rajan P Nair et al. NATURE GENETICS
- A protective function for interleukin 17A in T cell–mediated intestinal inflammation
- (2009) William O'Connor Jr et al. NATURE IMMUNOLOGY
- Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor
- (2009) Erik-Oliver Glocker et al. NEW ENGLAND JOURNAL OF MEDICINE
- Psoriasis
- (2009) Frank O. Nestle et al. NEW ENGLAND JOURNAL OF MEDICINE
- TGF-β: A Master of All T Cell Trades
- (2008) Ming O. Li et al. CELL
- Innate immunity and intestinal microbiota in the development of Type 1 diabetes
- (2008) Li Wen et al. NATURE
- B-Cell Depletion with Rituximab in Relapsing–Remitting Multiple Sclerosis
- (2008) Stephen L. Hauser et al. NEW ENGLAND JOURNAL OF MEDICINE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started