NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage

NOS knockout or inhibition but not disrupting PSD-95-NOS interaction protect against ischemic brain damage

(2016) Christoph Kleinschnitz et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement

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Pharmacology and Clinical Drug Candidates in Redox Medicine

(2015) V. Thao-Vi Dao et al.   ANTIOXIDANTS & REDOX SIGNALING

Antioxidants in Translational Medicine

(2015) Harald H.H.W. Schmidt et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactive Oxygen-Related Diseases: Therapeutic Targets and Emerging Clinical Indications

(2015) Ana I. Casas et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactive Oxygen Species Can Provide Atheroprotection via NOX4-Dependent Inhibition of Inflammation and Vascular RemodelingSignificance

(2015) Stephen P. Gray et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The NADPH oxidase Nox4 has anti-atherosclerotic functions

(2015) Christoph Schürmann et al.   EUROPEAN HEART JOURNAL

Detrimental role of pericyte Nox4 in the acute phase of brain ischemia

(2015) Ataru Nishimura et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A combined pre-clinical meta-analysis and randomized confirmatory trial approach to improve data validity for therapeutic target validation

(2015) Pamela WM. Kleikers et al.   Scientific Reports

Apoptosis meets autophagy-like cell death in the ischemic penumbra: Two sides of the same coin?

(2014) Abdelhaq Rami et al.   Autophagy

Nitric Oxide Synthase Inhibition with the Antipterin VAS203 Improves Outcome in Moderate and Severe Traumatic Brain Injury: A Placebo-Controlled Randomized Phase IIa Trial (NOSTRA)

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Broad Suppression of NADPH Oxidase Activity Exacerbates Ischemia/Reperfusion Injury Through Inadvertent Downregulation of Hypoxia-inducible Factor-1α and Upregulation of Peroxisome Proliferator–activated Receptor-α

(2013) Shouji Matsushima et al.   CIRCULATION RESEARCH

Role of NADPH oxidase isoforms NOX1, NOX2 and NOX4 in myocardial ischemia/reperfusion injury

(2013) Vincent Braunersreuther et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Neuroprotection After Stroke by Targeting NOX4 As a Source of Oxidative Stress

(2012) Kim A. Radermacher et al.   ANTIOXIDANTS & REDOX SIGNALING

Neuroprotection for Stroke: Current Status and Future Perspectives

(2012) Jens Minnerup et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Activation of TRPC6 channels is essential for lung ischaemia–reperfusion induced oedema in mice

(2012) Norbert Weissmann et al.   Nature Communications

NADPH Oxidase 4 Promotes Endothelial Angiogenesis Through Endothelial Nitric Oxide Synthase Activation

(2011) Siobhan M. Craige et al.   CIRCULATION

Regulation of myocardial growth and death by NADPH oxidase

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Therapeutic Targets for Neuroprotection in Acute Ischemic Stroke: Lost in Translation?

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Oxidative Stress in Ischemic Brain Damage: Mechanisms of Cell Death and Potential Molecular Targets for Neuroprotection

(2010) Hai Chen et al.   ANTIOXIDANTS & REDOX SIGNALING

Upregulation of Nox4 by Hypertrophic Stimuli Promotes Apoptosis and Mitochondrial Dysfunction in Cardiac Myocytes

(2010) Tetsuro Ago et al.   CIRCULATION RESEARCH

NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis

(2010) M. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart

(2010) J. Kuroda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NADPH Oxidase and Cardiac Failure

(2010) Junya Kuroda et al.   Journal of Cardiovascular Translational Research

Post-Stroke Inhibition of Induced NADPH Oxidase Type 4 Prevents Oxidative Stress and Neurodegeneration

(2010) Christoph Kleinschnitz et al.   PLOS BIOLOGY

The Hypoxia-Inducible Factor-2α Is Stabilized by Oxidative Stress Involving NOX4

(2009) Isabel Diebold et al.   ANTIOXIDANTS & REDOX SIGNALING

Good Laboratory Practice

(2008) Malcolm R. Macleod et al.   STROKE