A combined pre-clinical meta-analysis and randomized confirmatory trial approach to improve data validity for therapeutic target validation

SYRCLE’s risk of bias tool for animal studies

(2014) Carlijn R Hooijmans et al.   BMC Medical Research Methodology

Systematic Reviews and Meta-Analysis of Preclinical Studies: Why Perform Them and How to Appraise Them Critically

(2014) Emily S Sena et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Preclinical Phase III Trials in Translational Stroke Research

(2014) Johannes Boltze et al.   STROKE

Allometric Dose Retranslation Unveiled Substantial Immunological Side Effects of Granulocyte Colony–Stimulating Factor After Stroke

(2014) Daniel-Christoph Wagner et al.   STROKE

Transient Receptor Potential Melastatin Subfamily Member 2 Cation Channel Regulates Detrimental Immune Cell Invasion in Ischemic Stroke

(2014) Mathias Gelderblom et al.   STROKE

Are We Ready to Translate T-Cell Transmigration in Stroke?

(2014) Wolf-Rüdiger Schäbitz et al.   STROKE

Open Science and Reporting Animal Studies: Who's Accountable?

(2014) Jonathan A. Eisen et al.   PLOS BIOLOGY

NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus–Accelerated Atherosclerosis

(2013) Stephen P. Gray et al.   CIRCULATION

Pharmacological inhibition of NOX reduces atherosclerotic lesions, vascular ROS and immune–inflammatory responses in diabetic Apoe −/− mice

(2013) E. Di Marco et al.   DIABETOLOGIA

NOX2 deficiency ameliorates cerebral injury through reduction of complexin II-mediated glutamate excitotoxicity in experimental stroke

(2013) Ziying Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Meta-analysis of data from animal studies: A practical guide

(2013) H.M. Vesterinen et al.   JOURNAL OF NEUROSCIENCE METHODS

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel Approaches to Neuroprotection Trials in Acute Ischemic Stroke

(2013) Michael Tymianski   STROKE

Granulocyte Colony–Stimulating Factor in Patients With Acute Ischemic Stroke

(2013) E. Bernd Ringelstein et al.   STROKE

Evaluation of Excess Significance Bias in Animal Studies of Neurological Diseases

(2013) Konstantinos K. Tsilidis et al.   PLOS BIOLOGY

Progress in Using Systematic Reviews of Animal Studies to Improve Translational Research

(2013) C. R. Hooijmans et al.   PLOS MEDICINE

Neuroprotection After Stroke by Targeting NOX4 As a Source of Oxidative Stress

(2012) Kim A. Radermacher et al.   ANTIOXIDANTS & REDOX SIGNALING

Brain infarct volume after permanent focal ischemia is not dependent on Nox2 expression

(2012) Hyun Ah Kim et al.   BRAIN RESEARCH

NOX4 Is a Janus-Faced Reactive Oxygen Species Generating NADPH Oxidase

(2012) Harald H.H.W. Schmidt et al.   CIRCULATION RESEARCH

Nox4 Is a Protective Reactive Oxygen Species Generating Vascular NADPH Oxidase

(2012) Katrin Schröder et al.   CIRCULATION RESEARCH

International, Multicenter Randomized Preclinical Trials in Translational Stroke Research: It's Time to Act

(2012) Ulrich Dirnagl et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Activation of TRPC6 channels is essential for lung ischaemia–reperfusion induced oedema in mice

(2012) Norbert Weissmann et al.   Nature Communications

Significance of marrow-derived nicotinamide adenine dinucleotide phosphate oxidase in experimental ischemic stroke

(2011) Xian N. Tang et al.   ANNALS OF NEUROLOGY

Stroke in Patients With Type 2 Diabetes Mellitus, Chronic Kidney Disease, and Anemia Treated With Darbepoetin Alfa

(2011) Hicham Skali et al.   CIRCULATION

Intravenous Recombinant Tissue Plasminogen Activator Administered after 3 H following Onset of Ischaemic Stroke: A Metaanalysis

(2011) Samuel J. Maiser et al.   International Journal of Stroke

A search filter for increasing the retrieval of animal studies in Embase

(2011) Rob B M de Vries et al.   LABORATORY ANIMALS

Reliability of 'new drug target' claims called into question

(2011) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets

(2011) Grant R. Drummond et al.   NATURE REVIEWS DRUG DISCOVERY

Phase II failures: 2008–2010

(2011) John Arrowsmith   NATURE REVIEWS DRUG DISCOVERY

Believe it or not: how much can we rely on published data on potential drug targets?

(2011) Florian Prinz et al.   NATURE REVIEWS DRUG DISCOVERY

NADPH oxidase is involved in post-ischemic brain inflammation

(2011) Hai Chen et al.   NEUROBIOLOGY OF DISEASE

Nox2 Oxidase Activity Accounts for the Oxidative Stress and Vasomotor Dysfunction in Mouse Cerebral Arteries following Ischemic Stroke

(2011) T. Michael De Silva et al.   PLoS One

Oxidative Stress in Ischemic Brain Damage: Mechanisms of Cell Death and Potential Molecular Targets for Neuroprotection

(2010) Hai Chen et al.   ANTIOXIDANTS & REDOX SIGNALING

Comparative pharmacology of chemically distinct NADPH oxidase inhibitors

(2010) S Wind et al.   BRITISH JOURNAL OF PHARMACOLOGY

Preclinical Drug Evaluation for Combination Therapy in Acute Stroke Using Systematic Review, Meta-Analysis, and Subsequent Experimental Testing

(2010) Victoria E O'Collins et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mechanisms Contributing to Cerebral Infarct Size after Stroke: Gender, Reperfusion, T Lymphocytes, and Nox2-Derived Superoxide

(2010) Vanessa H Brait et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Enhancing search efficiency by means of a search filter for finding all studies on animal experimentation in PubMed

(2010) Carlijn R Hooijmans et al.   LABORATORY ANIMALS

NADPH oxidase Nox1 contributes to ischemic injury in experimental stroke in mice

(2010) Timo Kahles et al.   NEUROBIOLOGY OF DISEASE

Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy

(2010) Emily S. Sena et al.   PLOS BIOLOGY

Can Animal Models of Disease Reliably Inform Human Studies?

(2010) H. Bart van der Worp et al.   PLOS MEDICINE

Importance of NOX1 for angiotensin II-induced cerebrovascular superoxide production and cortical infarct volume following ischemic stroke

(2009) Katherine A. Jackman et al.   BRAIN RESEARCH

Inhibition of NADPH Oxidase is Neuroprotective after Ischemia—Reperfusion

(2009) Hai Chen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A Trial of Darbepoetin Alfa in Type 2 Diabetes and Chronic Kidney Disease

(2009) Marc A. Pfeffer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Survey of the Quality of Experimental Design, Statistical Analysis and Reporting of Research Using Animals

(2009) Carol Kilkenny et al.   PLoS One

Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations

(2009) Marc Fisher et al.   STROKE

Normobaric hyperoxia inhibits NADPH oxidase-mediated matrix metalloproteinase-9 induction in cerebral microvessels in experimental stroke

(2008) Wenlan Liu et al.   JOURNAL OF NEUROCHEMISTRY

Meta-Analysis of the Efficacy of Granulocyte-Colony Stimulating Factor in Animal Models of Focal Cerebral Ischemia

(2008) Jens Minnerup et al.   STROKE

Evidence for the Efficacy of NXY-059 in Experimental Focal Cerebral Ischaemia Is Confounded by Study Quality

(2008) Malcolm R. Macleod et al.   STROKE

Empirical Evidence of Bias in the Design of Experimental Stroke Studies

(2008) Nicolas A. Crossley et al.   STROKE

Methodological Quality of Animal Studies of Neuroprotective Agents Currently in Phase II/III Acute Ischemic Stroke Trials

(2008) Maria Philip et al.   STROKE