Shikonin, a naphthalene ingredient: Therapeutic actions, pharmacokinetics, toxicology, clinical trials and pharmaceutical researches
出版年份 2021 全文链接
标题
Shikonin, a naphthalene ingredient: Therapeutic actions, pharmacokinetics, toxicology, clinical trials and pharmaceutical researches
作者
关键词
-
出版物
PHYTOMEDICINE
Volume 94, Issue -, Pages 153805
出版商
Elsevier BV
发表日期
2021-10-26
DOI
10.1016/j.phymed.2021.153805
参考文献
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- Shikonin Attenuates Hepatic Steatosis by Enhancing Beta Oxidation and Energy Expenditure via AMPK Activation
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- Isobutyrylshikonin has a potentially stronger cytotoxic effect in oral cancer cells than its analogue shikonin in vitro
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- Higher levels of dynamin-related protein 1 are associated with reduced radiation sensitivity of glioblastoma cells
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- Shikonin blocks human lung adenocarcinoma cell migration and invasion in the inflammatory microenvironment via the IL‑6/STAT3 signaling pathway
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- Apple latent spherical virus (ALSV)-induced gene silencing in a medicinal plant, Lithospermum erythrorhizon
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- Shikonin Inhibits Cancer Through P21 Upregulation and Apoptosis Induction
- (2020) Fangfang Wang et al. Frontiers in Pharmacology
- Regulation of glycolysis and the Warburg effect in wound healing
- (2020) Roohi Vinaik et al. JCI Insight
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- (2020) Xianbo Huang et al. Aging-US
- Antitumor Effect of Shikonin, a PKM2 Inhibitor, in Cholangiocarcinoma Cell Lines
- (2020) UNCHALEE THONSRI et al. ANTICANCER RESEARCH
- Shikonin relieves osteoporosis of ovariectomized mice by inhibiting RANKL-induced NF-κB and NFAT pathways
- (2020) Yong Chen et al. EXPERIMENTAL CELL RESEARCH
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- (2020) Chunfang Liu et al. JOURNAL OF ETHNOPHARMACOLOGY
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- (2020) Mehrdad Nasrollahzadeh Sabet et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- Integrated proteomics and metabolomics reveals the comprehensive characterization of antitumor mechanism underlying Shikonin on colon cancer patient-derived xenograft model
- (2020) Yang Chen et al. Scientific Reports
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- Shikonin induces tumor apoptosis in glioma cells via endoplasmic reticulum stress, and Bax/Bak mediated mitochondrial outer membrane permeability
- (2020) Xiaoqin Ma et al. JOURNAL OF ETHNOPHARMACOLOGY
- Shikonin differentially regulates glucose metabolism via PKM2 and HIF1α to overcome apoptosis in a refractory HCC cell line
- (2020) Wei Yang et al. LIFE SCIENCES
- Dissection for Floral Micromorphology and Plastid Genome of Valuable Medicinal Borages Arnebia and Lithospermum (Boraginaceae)
- (2020) Inkyu Park et al. Frontiers in Plant Science
- Preparation of a shikonin-based pH-sensitive color indicator for monitoring the freshness of fish and pork
- (2020) Parya Ezati et al. FOOD CHEMISTRY
- Antibiofilm activity of shikonin against Listeria monocytogenes and inhibition of key virulence factors
- (2020) Jiahui Li et al. FOOD CONTROL
- Structure and properties of oxycellulose fabric crosslinked with soy protein
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- Fabrication of cellulose nanofiber-based functional color indicator film incorporated with shikonin extracted from Lithospermum erythrorhizon root
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- Shikonin inhibits cancer cell cycling by targeting Cdc25s
- (2019) Shoude Zhang et al. BMC CANCER
- Combination of shikonin with paclitaxel overcomes multidrug resistance in human ovarian carcinoma cells in a P-gp-independent manner through enhanced ROS generation
- (2019) Zhu Wang et al. Chinese Medicine
- Shikonin induces apoptosis and prosurvival autophagy in human melanoma A375 cells via ROS-mediated ER stress and p38 pathways
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- Simultaneous polychromatic flow cytometric detection of multiple forms of regulated cell death
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- Shikonin attenuates acetaminophen-induced acute liver injury via inhibition of oxidative stress and inflammation
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- Shikonin derivatives for cancer prevention and therapy
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- Synthesis, biological function and evaluation of Shikonin in cancer therapy
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- Reprogramming Tumor Immune Microenvironment (TIME) and Metabolism via Biomimetic Targeting Codelivery of Shikonin/JQ1
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- Shikonin-induced necroptosis in nasopharyngeal carcinoma cells via ROS overproduction and upregulation of RIPK1/RIPK3/MLKL expression
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- Shikonin Prolongs Allograft Survival via Induction of CD4+FoxP3+ Regulatory T Cells
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- Shikonin inhibits triple-negative breast cancer-cell metastasis by reversing the epithelial-to-mesenchymal transition via glycogen synthase kinase 3β-regulated suppression of β-catenin signaling
- (2019) Yan Chen et al. BIOCHEMICAL PHARMACOLOGY
- MLKL contributes to shikonin-induced glioma cell necroptosis via promotion of chromatinolysis
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- Application of “macromolecular crowding” in vitro to investigate the naphthoquinones shikonin, naphthazarin and related analogues for the treatment of dermal scars
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- Ultrasound-Assisted Ionic Liquid Solid–Liquid Extraction Coupled with Aqueous Two-Phase Extraction of Naphthoquinone Pigments in Arnebia euchroma (Royle) Johnst.
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- Microwave-assisted ionic liquid microextraction combined with high performance liquid chromatography for the determination of naphthoquinones from Arnebia euchroma (Royle) Johnst
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- AS1411 Aptamer/Hyaluronic Acid-Bifunctionalized Microemulsion Co-loading Shikonin and Docetaxel for Enhanced Antiglioma Therapy
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- Biological Effects of Shikonin in Human Gingival Fibroblasts via ERK 1/2 Signaling Pathway
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- Pharmacological properties and derivatives of shikonin—A review in recent years
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- Evaluation of the inhibition risk of shikonin on human and rat UDP-glucuronosyltransferases (UGT) through the cocktail approach
- (2019) Yi Cheng et al. TOXICOLOGY LETTERS
- Shikonin attenuates hyperhomocysteinemia-induced CD4+ T cell inflammatory activation and atherosclerosis in ApoE−/− mice by metabolic suppression
- (2019) Si-lin Lü et al. ACTA PHARMACOLOGICA SINICA
- Shikonin-induced Apoptosis of Colon Cancer Cells Is Reduced by Peroxiredoxin V Expression
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- Shikonin suppresses progression and epithelial–mesenchymal transition in hepatocellular carcinoma (HCC) cells by modulating miR‐106b/SMAD7/TGF‐β signaling pathway
- (2019) Xiaojing Li et al. CELL BIOLOGY INTERNATIONAL
- ER-mediated anti-tumor effects of shikonin on breast cancer
- (2019) Yang Yang et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Shikonin improve sepsis‐induced lung injury via regulation of miRNA‐140‐5p/TLR4—a vitro and vivo study
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- Comparative genome/transcriptome analysis probes Boraginales' phylogenetic position, WGDs in Boraginales, and key enzyme genes in the alkannin/shikonin core pathway
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- Shikonin attenuates sympathetic remodeling in chronic heart failure mice via regulating miR-124
- (2019) Wen-Lin Liu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Cutting off the fuel supply to calcium pumps in pancreatic cancer cells: role of pyruvate kinase-M2 (PKM2)
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- Spectrum-effect relationship for anti-tumor activity of shikonins and shikonofurans in medicinal Zicao by UHPLC-MS/MS and chemometric approaches
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- Synergistic Cytotoxicity Of Shikonin-Silver Nanoparticles As An Opportunity For Lung Cancer
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- Molecular identification and phytochemical screening of endophytic fungi isolated from Lithospermum officinale L. roots: A new source of shikonin
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- Inhibitory function of Shikonin on MRGPRX2-mediated pseudo-allergic reactions induced by the secretagogue
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- Targeting Cell Necroptosis and Apoptosis Induced by Shikonin via Receptor Interacting Protein Kinases in Estrogen Receptor Positive Breast Cancer Cell Line, MCF-7
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- Shikonin protects H9C2 cardiomyocytes against hypoxia/reoxygenation injury through activation of PI3K/Akt signaling pathway
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- The protective effect of shikonin on renal tubular epithelial cell injury induced by high glucose
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- Shikonin Exerts Cytotoxic Effects in Human Colon Cancers by Inducing Apoptotic Cell Death via the Endoplasmic Reticulum and Mitochondria-Mediated Pathways
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- Shikonin suppresses proliferation and induces apoptosis in endometrioid endometrial cancer cells via modulating miR-106b /PTEN/AKT/mTOR signaling pathway
- (2018) Caimei Huang et al. BIOSCIENCE REPORTS
- Shikonin inhibits myeloid differentiation protein 2 to prevent LPS-induced acute lung injury
- (2018) Yali Zhang et al. BRITISH JOURNAL OF PHARMACOLOGY
- RIP1 and RIP3 contribute to shikonin-induced glycolysis suppression in glioma cells via increase of intracellular hydrogen peroxide
- (2018) Bin Lu et al. CANCER LETTERS
- The Critical Role of PTEN/PI3K/AKT Signaling Pathway in Shikonin-Induced Apoptosis and Proliferation Inhibition of Chronic Myeloid Leukemia
- (2018) Yu Chen et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Design and characterization of α -lipoic acyl shikonin ester twin drugs as tubulin and PDK1 dual inhibitors
- (2018) Hong-Yan Lin et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Gromwell (Lithospermum erythrorhizon ) root extract protects against glycation and related inflammatory and oxidative stress while offering UV absorption capability
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- Lactoferrin functionalized PEG-PLGA nanoparticles of shikonin for brain targeting therapy of glioma
- (2018) Hanmei Li et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Determination of blood concentrations of main active compounds in Zi-Cao-Cheng-Qi decoction and their total plasma protein binding rates based on hollow fiber liquid phase microextraction coupled with high performance liquid chromatography
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- Shikonin upregulates the expression of drug-metabolizing enzymes and drug transporters in primary rat hepatocytes
- (2018) Chin-Shiu Huang et al. JOURNAL OF ETHNOPHARMACOLOGY
- Alleviation of hepatic fibrosis and autophagy via inhibition of transforming growth factor-β 1/Smads pathway through shikonin
- (2018) Tong Liu et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Synthesis and Bioevaluation of Shikonin Derivatives
- (2018) Sufen Cao et al. Letters in Drug Design & Discovery
- Shikonin enhances sensitization of gefitinib against wild-type EGFR non-small cell lung cancer via inhibition PKM2/stat3/cyclinD1 signal pathway
- (2018) Jian-cai Tang et al. LIFE SCIENCES
- Advance in Anti-tumor Mechanisms of Shikonin, Alkannin and their Derivatives
- (2018) Xu Zhang et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- Anticancer Efficacy of Targeted Shikonin Liposomes Modified with RGD in Breast Cancer Cells
- (2018) Xianchun Wen et al. MOLECULES
- Evidence for Shikonin acting as an active inhibitor of human carboxylesterases 2: Implications for herb-drug combination
- (2018) Jia-Nan Li et al. PHYTOTHERAPY RESEARCH
- Shikonin Prevents Early Phase Inflammation Associated with Azoxymethane/Dextran Sulfate Sodium-Induced Colon Cancer and Induces Apoptosis in Human Colon Cancer Cells
- (2018) Isabel Andújar et al. PLANTA MEDICA
- De Novo Transcriptome Assembly and Characterization of Lithospermum officinale to Discover Putative Genes Involved in Specialized Metabolites Biosynthesis
- (2018) Amit Rai et al. PLANTA MEDICA
- Sarcoma-Targeting Peptide-Decorated Polypeptide Nanogel Intracellularly Delivers Shikonin for Upregulated Osteosarcoma Necroptosis and Diminished Pulmonary Metastasis
- (2018) Suoyuan Li et al. Theranostics
- Efficacy of Shikonin against Esophageal Cancer Cells and its possible mechanisms in vitro and in vivo
- (2018) Jian-Cai Tang et al. Journal of Cancer
- Shikonin Inhibites Migration and Invasion of Thyroid Cancer Cells by Downregulating DNMT1
- (2018) Yue Zhang et al. MEDICAL SCIENCE MONITOR
- Shikonin-mediated up-regulation of miR-34a and miR-202 inhibits retinoblastoma proliferation
- (2018) Yan Su et al. Toxicology Research
- Development of a Porcine Full-Thickness Burn Hypertrophic Scar Model and Investigation of the Effects of Shikonin on Hypertrophic Scar Remediation
- (2018) Xingwang Deng et al. Frontiers in Pharmacology
- Senescence Inducer Shikonin ROS-Dependently Suppressed Lung Cancer Progression
- (2018) Hongming Zheng et al. Frontiers in Pharmacology
- Shikonin exerts anti-inflammatory effects in LPS-induced mastitis by inhibiting NF-κB signaling pathway
- (2018) Chao Yang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Downregulation of PKM2 decreases FASN expression in bladder cancer cells through AKT/mTOR/SREBP-1c axis
- (2018) Ting Tao et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Assessment of the skin sensitizing potential of chemicals, contained in foods and/or cosmetic ingredients, using a modified local lymph node assay with an elicitation phase (LLNA:DAE) method
- (2018) Kunihiko Yamashita et al. JOURNAL OF TOXICOLOGICAL SCIENCES
- Advanced Drug Delivery Nanosystems for Shikonin: A Calorimetric and Electron Paramagnetic Resonance Study
- (2018) Konstantinos N. Kontogiannopoulos et al. LANGMUIR
- Comparative proteomic analysis of Lithospermum erythrorhizon reveals regulation of a variety of metabolic enzymes leading to comprehensive understanding of the shikonin biosynthetic pathway
- (2018) Kojiro Takanashi et al. PLANT AND CELL PHYSIOLOGY
- Shikonin Inhibits Tumor Growth in Mice by Suppressing Pyruvate Kinase M2-mediated Aerobic Glycolysis
- (2018) Xiaoyue Zhao et al. Scientific Reports
- Shikonin exerts antitumor activity by causing mitochondrial dysfunction in hepatocellular carcinoma through PKM2-AMPK-PGC1α signaling pathway
- (2018) Bing Liu et al. Biochemistry and Cell Biology
- Anti-tumor activity of Shikonin against afatinib resistant non-small cell lung cancer via negative regulation of PI3K/Akt signaling pathway
- (2018) Baiying Li et al. BIOSCIENCE REPORTS
- Shikonin sensitizes A549 cells to TRAIL-induced apoptosis through the JNK, STAT3 and AKT pathways
- (2018) Zhi Lan Guo et al. BMC CELL BIOLOGY
- DMAKO-20 as a New Multitarget Anticancer Prodrug Activated by the Tumor Specific CYP1B1 Enzyme
- (2018) Jiahua Cui et al. MOLECULAR PHARMACEUTICS
- Shikonin Attenuates Acetaminophen-Induced Hepatotoxicity by Upregulation of Nrf2 through Akt/GSK3β Signaling
- (2018) Huachao Li et al. MOLECULES
- Harnessing Integrated Omics Approaches For Plant Specialized Metabolism Research: New Insights Into Shikonin Biosynthesis
- (2018) Darren C J Wong PLANT AND CELL PHYSIOLOGY
- Shikonin alleviates allergic airway remodeling by inhibiting the ERK-NF-κB signaling pathway
- (2017) Tian-Yue Wang et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Successful in vivo hyperthermal therapy toward breast cancer by Chinese medicine shikonin-loaded thermosensitive micelle
- (2017) Yonghua Su et al. International Journal of Nanomedicine
- Shikonin Inhibited Migration and Invasion of Human Lung Cancer Cells via Suppression of c-Met-Mediated Epithelial-to-Mesenchymal Transition
- (2017) Yei-San Hsieh et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Shikonin changes the lipopolysaccharide-induced expression of inflammation-related genes in macrophages
- (2017) Lucia Satiko Yoshida et al. Journal of Natural Medicines
- Development of a novel hollow-fiber liquid-phase microextraction based on oil-in-salt and its comparison with conventional one
- (2017) Miao-miao Li et al. JOURNAL OF SEPARATION SCIENCE
- Shikonin alleviates the biotoxicity produced by pneumococcal pneumolysin
- (2017) Xiaoran Zhao et al. LIFE SCIENCES
- Pyruvate kinase M2 is a poor prognostic marker of and a therapeutic target in ovarian cancer
- (2017) Tai-Kuang Chao et al. PLoS One
- Assessment of the inhibition risk of shikonin on cytochrome P450 via cocktail inhibition assay
- (2017) Shuowen Tang et al. TOXICOLOGY LETTERS
- Effect of Zicao ointment on second-degree burns in rats
- (2017) Hong-bin Luo et al. TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
- Shikonin enhances Adriamycin antitumor effects by inhibiting efflux pumps in A549 cells
- (2017) Xuchun Liu et al. Oncology Letters
- Shikonin induces ROS-based mitochondria-mediated apoptosis in colon cancer
- (2017) Wenquan Liang et al. Oncotarget
- Shikonin protects against D-Galactosamine and lipopolysaccharide-induced acute hepatic injury by inhibiting TLR4 signaling pathway
- (2017) Meng-Xiang Lin et al. Oncotarget
- The protective effects of Shikonin on lipopolysaccharide/d-galactosamine-induced acute liver injury via inhibiting MAPK and NF-κB and activating Nrf2/HO-1 signaling pathways
- (2017) Ye Tian et al. RSC Advances
- Anti-inflammatory properties of shikonin contribute to improved early-stage diabetic retinopathy
- (2017) Po-Lin Liao et al. Scientific Reports
- Phytochemicals Approach for Developing Cancer Immunotherapeutics
- (2017) Shu-Yi Yin et al. Frontiers in Pharmacology
- The protective effects of shikonin on hepatic ischemia/reperfusion injury are mediated by the activation of the PI3K/Akt pathway
- (2017) Tong Liu et al. Scientific Reports
- Transcriptome analysis explores genes related to shikonin biosynthesis in Lithospermeae plants and provides insights into Boraginales’ evolutionary history
- (2017) Feng-Yao Wu et al. Scientific Reports
- Antinociceptive properties of shikonin: in vitro and in vivo studies
- (2016) Bhawana Gupta et al. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
- Inhibition of neutrophil superoxide generation by shikonin is associated with suppression of cellular Ca2+ fluxes
- (2016) Kimiko Kazumura et al. JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
- Homocysteine Activates B Cells via Regulating PKM2-Dependent Metabolic Reprogramming
- (2016) Jiacheng Deng et al. JOURNAL OF IMMUNOLOGY
- Shikonin inhibits TNF-α production through suppressing PKC-NF-κB-dependent decrease of IL-10 in rheumatoid arthritis-like cell model
- (2016) Wen-Xiao Sun et al. Journal of Natural Medicines
- Shikonin inhibits inflammation and chondrocyte apoptosis by regulation of the PI3K/Akt signaling pathway in a rat model of osteoarthritis
- (2016) Daijie Fu et al. Experimental and Therapeutic Medicine
- Endogenous nitric oxide accumulation is involved in the antifungal activity of Shikonin against Candida albicans
- (2016) Zebin Liao et al. Emerging Microbes & Infections
- Shikonin Inhibits Intestinal Calcium-Activated Chloride Channels and Prevents Rotaviral Diarrhea
- (2016) Yu Jiang et al. Frontiers in Pharmacology
- N-end rule pathway inhibition assists colon tumor regression via necroptosis
- (2016) Pritha Agarwalla et al. Molecular Therapy-Oncolytics
- Shikonin inhibits adipogenic differentiation via regulation of mir-34a-FKBP1B
- (2015) Young Jin Jang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The Inhibitory Effect of Shikonin on the Agonist-Induced Regulation of Vascular Contractility
- (2015) Hyun Dong Je et al. Biomolecules & Therapeutics
- Shikonin inhibits TNF-α-induced growth and invasion of rat aortic vascular smooth muscle cells
- (2015) Xuemin Zhang et al. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
- Functional and mechanistic investigation of Shikonin in scarring
- (2015) Yan Xie et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Fabrication of nanostructured PEDOT clusters using β-cyclodextrin as substrate and applied for simultaneous determination of hyperoside and shikonin
- (2015) Liping Wu et al. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
- Shikonin inhibits inflammatory responses in rabbit chondrocytes and shows chondroprotection in osteoarthritic rabbit knee
- (2015) Feng Li et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Shikonin reduces TGF-β1-induced collagen production and contraction in hypertrophic scar-derived human skin fibroblasts
- (2015) CHEN FAN et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Determination of Shikonin and Rosmarinic Acid inEchium vulgareL. andEchium russicumJ.F. Gmel. by Capillary Electrophoresis
- (2015) Sławomir Dresler et al. JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
- Wound-healing activity of an oligomer of alkannin/shikonin, isolated from root bark ofOnosma echioides
- (2015) Gawand Nikita et al. NATURAL PRODUCT RESEARCH
- Shikonin protects against obesity through the modulation of adipogenesis, lipogenesis, and β-oxidation in vivo
- (2015) So Young Gwon et al. Journal of Functional Foods
- Extraction of Shikonin with Surfactant-Assisted Ultrasonic from Arnebia euchroma
- (2014) ASIAN JOURNAL OF CHEMISTRY
- Self-reporter shikonin-Act-loaded solid lipid nanoparticle: Formulation, physicochemical characterization and geno/cytotoxicity evaluation
- (2014) Morteza Eskandani et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Extracellular signal-regulated kinase, receptor interacting protein, and reactive oxygen species regulate shikonin-induced autophagy in human hepatocellular carcinoma
- (2014) Ke Gong et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Sterically stabilized liposomes as a potent carrier for shikonin
- (2014) K. N. Kontogiannopoulos et al. JOURNAL OF LIPOSOME RESEARCH
- In Vitro Induction of Erythrocyte Phosphatidylserine Translocation by the Natural Naphthoquinone Shikonin
- (2014) Adrian Lupescu et al. Toxins
- Shikonin, a natural product from the root of Lithospermum erythrorhizon, is a cytotoxic DNA-binding agent
- (2013) Changmin Chen et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Optimization of Shikonin Homogenate Extraction from Arnebia euchroma Using Response Surface Methodology
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- Preparation, cellular uptake and angiogenic suppression of shikonin-containing liposomesin vitroandin vivo
- (2012) Hongmei Xia et al. BIOSCIENCE REPORTS
- Shikonin and its derivatives: a patent review
- (2012) Rubing Wang et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Addition of β-Lactoglobulin Produces Water-Soluble Shikonin
- (2012) Alen Albreht et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Anti-adenovirus Activities of Shikonin, a Component of Chinese Herbal Medicine in Vitro
- (2011) Hong Gao et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Shikonin-loaded liposomes as a new drug delivery system: Physicochemical characterization and in vitro cytotoxicity
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- Quantitative determination of shikonin derivatives with UV-Vis spectrophotometric methods in the roots of Onosma nigricaule
- (2011) Ufuk Ozgen et al. REVIEWS IN ANALYTICAL CHEMISTRY
- Simultaneous Quantitative Analysis of Shikonin and Deoxyshikonin in Rat Plasma by Rapid LC–ESI–MS–MS
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- A new facile synthesis of shikalkin
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