Shikonin induces apoptosis and prosurvival autophagy in human melanoma A375 cells via ROS-mediated ER stress and p38 pathways

Enhancement of cisplatin-induced colon cancer cells apoptosis by shikonin, a natural inducer of ROS in vitro and in vivo

(2016) Guodong He et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Emerging targeted therapies for melanoma

(2016) Douglas B. Johnson et al.   EXPERT OPINION ON EMERGING DRUGS

Shikonin causes apoptosis by up-regulating p73 and down-regulating ICBP90 in human cancer cells

(2015) Soon Young Jang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Diacerein retards cell growth of chondrosarcoma cells at the G2/M cell cycle checkpoint via cyclin B1/CDK1 and CDK2 downregulation

(2015) Birgit Lohberger et al.   BMC CANCER

Notch3 overexpression causes arrest of cell cycle progression by inducing Cdh1 expression in human breast cancer cells

(2015) Chun-Fa Chen et al.   CELL CYCLE

Shikonin inhibits the cell viability, adhesion, invasion and migration of the human gastric cancer cell line MGC-803 via the Toll-like receptor 2/nuclear factor-kappa B pathway

(2015) Ji Ping Liu et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis

(2015) Anna Fernández et al.   JOURNAL OF PINEAL RESEARCH

Apoptosis, autophagy, necroptosis, and cancer metastasis

(2015) Zhenyi Su et al.   Molecular Cancer

Shikonin Suppresses Skin Carcinogenesis via Inhibiting Cell Proliferation

(2015) Wenjuan Li et al.   PLoS One

Skin Cancer

(2015) Miguel A. Linares et al.   PRIMARY CARE

Natural products induce a G protein-mediated calcium pathway activating p53 in cancer cells

(2015) Paul R. van Ginkel et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Auranofin induces apoptosis by ROS-mediated ER stress and mitochondrial dysfunction and displayed synergistic lethality with piperlongumine in gastric cancer

(2015) Peng Zou et al.   Oncotarget

Shikonin suppresses tumor growth and synergizes with gemcitabine in a pancreatic cancer xenograft model: Involvement of NF-κB signaling pathway

(2014) Yongwei Wang et al.   BIOCHEMICAL PHARMACOLOGY

Cadmium Induces PC12 Cells Apoptosis via an Extracellular Signal-Regulated Kinase and c-Jun N-Terminal Kinase-Mediated Mitochondrial Apoptotic Pathway

(2014) Chenyang Jiang et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Plant natural products: from traditional compounds to new emerging drugs in cancer therapy

(2014) L. Ouyang et al.   CELL PROLIFERATION

Shikonin time-dependently induced necrosis or apoptosis in gastric cancer cells via generation of reactive oxygen species

(2014) Mu-Jang Lee et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Extracellular signal-regulated kinase, receptor interacting protein, and reactive oxygen species regulate shikonin-induced autophagy in human hepatocellular carcinoma

(2014) Ke Gong et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cytotoxic Autophagy in Cancer Therapy

(2014) Khushboo Sharma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Shikonin induces cell cycle arrest in human gastric cancer (AGS) by early growth response 1 (Egr1)-mediated p21 gene expression

(2014) Sun-Joong Kim et al.   JOURNAL OF ETHNOPHARMACOLOGY

Melanoma

(2014) Brian Owens   NATURE

Shikonin promotes autophagy in BXPC-3 human pancreatic cancer cells through the PI3K/Akt signaling pathway

(2014) SHUQING SHI et al.   Oncology Letters

Apoptosis and Molecular Targeting Therapy in Cancer

(2014) Mohamed Hassan et al.   Biomed Research International

Free Radicals in Cross Talk Between Autophagy and Apoptosis

(2013) Vitaliy O. Kaminskyy et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactive oxygen species-mediated activation of the Akt/ASK1/p38 signaling cascade and p21Cip1 downregulation are required for shikonin-induced apoptosis

(2013) Jiwon Ahn et al.   APOPTOSIS

Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis

(2013) Matthew Brentnall et al.   BMC CELL BIOLOGY

New drug targets in metastatic melanoma

(2013) Blanca Homet et al.   JOURNAL OF PATHOLOGY

The role of iron and reactive oxygen species in cell death

(2013) Scott J Dixon et al.   Nature Chemical Biology

Targeting cell cycle regulation in cancer therapy

(2013) Santiago Diaz-Moralli et al.   PHARMACOLOGY & THERAPEUTICS

The crosstalk between autophagy and apoptosis: where does this lead?

(2012) Claire Gordy et al.   Protein & Cell

Shikonin extracted from medicinal Chinese herbs exerts anti-inflammatory effect via proteasome inhibition

(2011) Li Lu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Silibinin activated ROS–p38–NF-κB positive feedback and induced autophagic death in human fibrosarcoma HT1080 cells

(2011) Wen-Jun Duan et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Shikonin Induces Apoptosis through Reactive Oxygen Species/Extracellular Signal-Regulated Kinase Pathway in Osteosarcoma Cells

(2010) I-Chang Chang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN