Shikonin differentially regulates glucose metabolism via PKM2 and HIF1α to overcome apoptosis in a refractory HCC cell line

PGC1α suppresses metastasis of HCC by inhibiting Warburg effect via PPARγ‐dependent WNT/β‐catenin/PDK1 axis

(2020) Qiaozhu Zuo et al.   HEPATOLOGY

Succinylation-dependent mitochondrial translocation of PKM2 promotes cell survival in response to nutritional stress

(2019) Hailong Qi et al.   Cell Death & Disease

Hypoxia/pseudohypoxia‐mediated activation of hypoxia‐inducible factor‐1α in cancer

(2019) Yoshihiro Hayashi et al.   CANCER SCIENCE

PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma

(2019) Jiao Feng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Shikonin inhibits triple-negative breast cancer-cell metastasis by reversing the epithelial-to-mesenchymal transition via glycogen synthase kinase 3β-regulated suppression of β-catenin signaling

(2019) Yan Chen et al.   BIOCHEMICAL PHARMACOLOGY

MLKL contributes to shikonin-induced glioma cell necroptosis via promotion of chromatinolysis

(2019) Ye Ding et al.   CANCER LETTERS

Direct impact of cisplatin on mitochondria induces ROS production that dictates cell fate of ovarian cancer cells

(2019) Markus Kleih et al.   Cell Death & Disease

Circadian clock gene NPAS2 promotes reprogramming of glucose metabolism in hepatocellular carcinoma cells

(2019) Peng Yuan et al.   CANCER LETTERS

The Role of Sirtuins in Antioxidant and Redox Signaling

(2018) Chandra K. Singh et al.   ANTIOXIDANTS & REDOX SIGNALING

Metabolic reprogramming enables hepatocarcinoma cells to efficiently adapt and survive to a nutrient-restricted microenvironment

(2018) Shamir Cassim et al.   CELL CYCLE

How the Warburg effect supports aggressiveness and drug resistance of cancer cells?

(2018) Philippe Icard et al.   DRUG RESISTANCE UPDATES

Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin

(2018) Dannielle DeWaal et al.   Nature Communications

Aberrant Metabolism in Hepatocellular Carcinoma Provides Diagnostic and Therapeutic Opportunities

(2018) Serena De Matteis et al.   Oxidative Medicine and Cellular Longevity

Reactive oxygen species (ROS) are a key determinant of cancer's metabolic phenotype

(2017) Stefan Rodic et al.   INTERNATIONAL JOURNAL OF CANCER

Chrysin inhibited tumor glycolysis and induced apoptosis in hepatocellular carcinoma by targeting hexokinase-2

(2017) Dong Xu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma

(2017) Qiuran Xu et al.   Molecular Cancer

Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2

(2016) Ji Liang et al.   CELL RESEARCH

PARP Inhibition Suppresses Growth of EGFR-Mutant Cancers by Targeting Nuclear PKM2

(2016) Nan Li et al.   Cell Reports

Shikonin induces mitochondria-mediated apoptosis and enhances chemotherapeutic sensitivity of gastric cancer through reactive oxygen species

(2016) Wenquan Liang et al.   Scientific Reports

PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation

(2015) Valeria Iansante et al.   Nature Communications

Aberrant IDH3α expression promotes malignant tumor growth by inducing HIF-1-mediated metabolic reprogramming and angiogenesis

(2014) L Zeng et al.   ONCOGENE

The pentose phosphate pathway and cancer

(2014) Krushna C. Patra et al.   TRENDS IN BIOCHEMICAL SCIENCES

JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1 -mediated glucose metabolism

(2013) H.-J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIF1α Modulates Cell Fate Reprogramming Through Early Glycolytic Shift and Upregulation of PDK1-3 and PKM2

(2013) Alessandro Prigione et al.   STEM CELLS

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

(2011) Lydia W.S. Finley et al.   CANCER CELL

Intracellular ATP Levels Are a Pivotal Determinant of Chemoresistance in Colon Cancer Cells

(2011) Y. Zhou et al.   CANCER RESEARCH

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2

(2011) J Chen et al.   ONCOGENE

Nuclear Control of Respiratory Chain Expression by Nuclear Respiratory Factors and PGC-1-Related Coactivator

(2010) Richard C. Scarpulla   Annals of the New York Academy of Sciences

SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress

(2010) Hyun-Seok Kim et al.   CANCER CELL

GLUT1 Expression Is Increased in Hepatocellular Carcinoma and Promotes Tumorigenesis

(2009) Thomas Amann et al.   AMERICAN JOURNAL OF PATHOLOGY

A chemical genomics screen highlights the essential role of mitochondria in HIF-1 regulation

(2008) X. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA