TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation

TAK1 regulates resident macrophages by protecting lysosomal integrity

(2017) Yosuke Sakamachi et al.   Cell Death & Disease

TAK1 inhibitor 5Z-7-oxozeaenol sensitizes cervical cancer to doxorubicin-induced apoptosis

(2017) Shan Guan et al.   Oncotarget

Noncanonical cell death program independent of caspase activation cascade and necroptotic modules is elicited by loss of TGFβ-activated kinase 1

(2017) September R. Mihaly et al.   Scientific Reports

Heterozygous Mutations in MAP3K7 , Encoding TGF-β-Activated Kinase 1, Cause Cardiospondylocarpofacial Syndrome

(2016) Carine Le Goff et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mutations in MAP3K7 that Alter the Activity of the TAK1 Signaling Complex Cause Frontometaphyseal Dysplasia

(2016) Emma M. Wade et al.   AMERICAN JOURNAL OF HUMAN GENETICS

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

(2016) Zhenyu Zhong et al.   CELL

The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation

(2016) Deepika Sharma et al.   JOURNAL OF CELL BIOLOGY

Autoinflammatory Skin Disorders: The Inflammasome in Focus

(2016) Prajwal Gurung et al.   TRENDS IN MOLECULAR MEDICINE

TAK1 regulates caspase 8 activation and necroptotic signaling via multiple cell death checkpoints

(2016) Xiaoyun Guo et al.   Cell Death & Disease

TAK1 selective inhibition: state of the art and future opportunities

(2015) Iain Kilty et al.   Future Medicinal Chemistry

A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation

(2015) Jonathan L. Schmid-Burgk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling

(2015) Yves Dondelinger et al.   MOLECULAR CELL

Mitochondria: diversity in the regulation of the NLRP3 inflammasome

(2015) Prajwal Gurung et al.   TRENDS IN MOLECULAR MEDICINE

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

(2015) Kate E. Lawlor et al.   Nature Communications

Targeting of TGF-β-activated protein kinase 1 inhibits chemokine (C-C motif) receptor 7 expression, tumor growth and metastasis in breast cancer

(2015) Hui-Ling Huang et al.   Oncotarget

TAK1 control of cell death

(2014) S R Mihaly et al.   CELL DEATH AND DIFFERENTIATION

The Lysosome Rupture-activated TAK1-JNK Pathway Regulates NLRP3 Inflammasome Activation

(2014) Masahiro Okada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation

(2014) Sho Morioka et al.   JOURNAL OF CELL BIOLOGY

Enterocyte-Derived TAK1 Signaling Prevents Epithelium Apoptosis and the Development of Ileitis and Colitis

(2014) R. Kajino-Sakamoto et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice

(2014) S. B. Berger et al.   JOURNAL OF IMMUNOLOGY

FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes

(2014) P. Gurung et al.   JOURNAL OF IMMUNOLOGY

An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome

(2014) Scott W Canna et al.   NATURE GENETICS

RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway

(2014) Xiaqiong Wang et al.   NATURE IMMUNOLOGY

Osteopetrosis in TAK1-deficient mice owing to defective NF-κB and NOTCH signaling

(2014) Gaurav Swarnkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition

(2013) Y Dondelinger et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

(2013) Shankar S. Iyer et al.   IMMUNITY

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

Cell type-specific function of TAK1 in innate immune signaling

(2013) Adebusola A. Ajibade et al.   TRENDS IN IMMUNOLOGY

TAK1 Inhibition Promotes Apoptosis in KRAS-Dependent Colon Cancers

(2012) Anurag Singh et al.   CELL

Cell Volume Regulation Modulates NLRP3 Inflammasome Activation

(2012) Vincent Compan et al.   IMMUNITY

TAK1 Negatively Regulates NF-κB and p38 MAP Kinase Activation in Gr-1+CD11b+ Neutrophils

(2012) Adebusola Alagbala Ajibade et al.   IMMUNITY

Caspase-8 Blocks Kinase RIPK3-Mediated Activation of the NLRP3 Inflammasome

(2012) Tae-Bong Kang et al.   IMMUNITY

Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation

(2012) Christine Juliana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toll or Interleukin-1 Receptor (TIR) Domain-containing Adaptor Inducing Interferon-β (TRIF)-mediated Caspase-11 Protease Production Integrates Toll-like Receptor 4 (TLR4) Protein- and Nlrp3 Inflammasome-mediated Host Defense against Enteropathogens

(2012) Prajwal Gurung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TAK1 Is Essential for Osteoclast Differentiation and Is an Important Modulator of Cell Death by Apoptosis and Necroptosis

(2012) Betty Lamothe et al.   MOLECULAR AND CELLULAR BIOLOGY

Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity

(2012) Bénédicte F. Py et al.   MOLECULAR CELL

Deletion of TAK1 in the Myeloid Lineage Results in the Spontaneous Development of Myelomonocytic Leukemia in Mice

(2012) Betty Lamothe et al.   PLoS One

Targeting of TAK1 in inflammatory disorders and cancer

(2012) Hiroaki Sakurai   TRENDS IN PHARMACOLOGICAL SCIENCES

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Role of the Nlrp3 Inflammasome in Microbial Infection

(2011) Paras K. Anand et al.   Frontiers in Microbiology

TAK1 Suppresses a NEMO-Dependent but NF-κB-Independent Pathway to Liver Cancer

(2010) Kira Bettermann et al.   CANCER CELL

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

(2010) N Vanlangenakker et al.   CELL DEATH AND DIFFERENTIATION

TGF- -Activated Kinase 1 Signaling Maintains Intestinal Integrity by Preventing Accumulation of Reactive Oxygen Species in the Intestinal Epithelium

(2010) R. Kajino-Sakamoto et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis

(2009) S. Inokuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

TAK1 is required for the survival of hematopoietic cells and hepatocytes in mice

(2008) Minghui Tang et al.   JOURNAL OF EXPERIMENTAL MEDICINE