Ferroptosis: A New Regulatory Mechanism in Osteoporosis

Mitochondrial Iron Overload-Mediated Inhibition of Nrf2-HO-1/GPX4 Assisted ALI-Induced Nephrotoxicity

(2021) Hui-Fang Deng et al.   Frontiers in Pharmacology

Mitochondrial Ferritin Deficiency Promotes Osteoblastic Ferroptosis Via Mitophagy in Type 2 Diabetic Osteoporosis

(2021) XinDong Wang et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Exosomes derived from vascular endothelial cells antagonize glucocorticoid‐induced osteoporosis by inhibiting ferritinophagy with resultant limited ferroptosis of osteoblasts

(2021) Run‐Ze Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Relevance of the Pyroptosis-Related Inflammasome Pathway in the Pathogenesis of Diabetic Kidney Disease

(2021) Pan Liu et al.   Frontiers in Immunology

Understanding the role of cysteine in ferroptosis: progress & paradoxes

(2021) Carson D. Poltorack et al.   FEBS Journal

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

(2021) Chao Mao et al.   NATURE

Ferroptosis as a mechanism to mediate p53 function in tumor radiosensitivity

(2021) Guang Lei et al.   ONCOGENE

Osteoporosis medication after fracture in older adults: an administrative data analysis

(2021) Y. Yamamoto et al.   OSTEOPOROSIS INTERNATIONAL

Genetic Events Inhibiting Apoptosis in Diffuse Large B Cell Lymphoma

(2021) Etienne Leveille et al.   Cancers

Hypoxia inhibits RANKL-induced ferritinophagy and protects osteoclasts from ferroptosis

(2021) Shuo Ni et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Influence of Strontium on Bone Tissue Metabolism and Its Application in Osteoporosis Treatment

(2021) Barbara Kołodziejska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma

(2020) Yongfei Yang et al.   Nature Communications

Iron metabolism and type 2 diabetes mellitus: A meta‐analysis and systematic review

(2020) Jingfang Liu et al.   Journal of Diabetes Investigation

Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis

(2020) Xuexian Fang et al.   CIRCULATION RESEARCH

Pathophysiology and Management of Type 2 Diabetes Mellitus Bone Fragility

(2020) C. Eller-Vainicher et al.   Journal of Diabetes Research

Ferroptosis and Its Potential Role in Human Diseases

(2020) Chu Han et al.   Frontiers in Pharmacology

Ferroptotic Cell Death: New Regulatory Mechanisms for Metabolic Diseases

(2020) Yifei Le et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Programmed cell death pathways in hearing loss: A review of apoptosis, autophagy and programmed necrosis

(2020) Junhao Wu et al.   CELL PROLIFERATION

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy

(2020) Pranavi Koppula et al.   Protein & Cell

Iron Metabolism in Ferroptosis

(2020) Xin Chen et al.   Frontiers in Cell and Developmental Biology

Mitochondrial dysfunction promotes aquaporin expression that controls hydrogen peroxide permeability and ferroptosis

(2020) Yuko Takashi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis

(2020) Yajie Li et al.   HUMAN REPRODUCTION

Do TUNEL and Other Apoptosis Assays Detect Cell Death in Preclinical Studies?

(2020) Razmik Mirzayans et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin Suppresses Ferroptosis Induced by High Glucose via Activation of the Nrf2/HO-1 Signaling Pathway in Type 2 Diabetic Osteoporosis

(2020) Hongdong Ma et al.   Oxidative Medicine and Cellular Longevity

Chemically Induced Models of Parkinson’s Disease: History and Perspectives for the Involvement of Ferroptosis

(2020) Shuheng Wen et al.   Frontiers in Cellular Neuroscience

GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis

(2019) Giovanni C. Forcina et al.   PROTEOMICS

Osteoporosis

(2019) Juliet E Compston et al.   LANCET

ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway

(2019) Bo Chu et al.   NATURE CELL BIOLOGY

Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance

(2019) Jonathan K. M. Lim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sulfasalazine‑induced ferroptosis in breast cancer cells is reduced by the inhibitory effect of estrogen receptor on the transferrin receptor

(2019) Haochen Yu et al.   ONCOLOGY REPORTS

Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases

(2019) Toshitaka Nakamura et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The Effect of Abnormal Iron Metabolism on Osteoporosis

(2019) Jingmin Che et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

The multifaceted role of iron in renal health and disease

(2019) Rachel P. L. van Swelm et al.   Nature Reviews Nephrology

Inactivation of the glutathione peroxidase GPx4 by the ferroptosis‐inducing molecule RSL3 requires the adaptor protein 14‐3‐3ε

(2019) Ana‐Marija Vučković et al.   FEBS LETTERS

Programmed Cell-Death by Ferroptosis: Antioxidants as Mitigators

(2019) Kajarabille et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular vesicles from endothelial progenitor cells prevent steroid-induced osteoporosis by suppressing the ferroptotic pathway in mouse osteoblasts based on bioinformatics evidence

(2019) Jinsen Lu et al.   Scientific Reports

Low-Concentration PTX And RSL3 Inhibits Tumor Cell Growth Synergistically By Inducing Ferroptosis In Mutant p53 Hypopharyngeal Squamous Carcinoma

(2019) Jing Ye et al.   Cancer Management and Research

Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming

(2018) Agnes L.C. Ong et al.   AGEING RESEARCH REVIEWS

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Unsolved mysteries: How does lipid peroxidation cause ferroptosis?

(2018) Huizhong Feng et al.   PLOS BIOLOGY

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

(2018) Ron Shah et al.   ACS Central Science

Ferroptosis and necroinflammation, a yet poorly explored link

(2018) Bettina Proneth et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial Iron in Human Health and Disease

(2018) Diane M. Ward et al.   Annual Review of Physiology

Role of Mitochondria in Ferroptosis

(2018) Minghui Gao et al.   MOLECULAR CELL

RSL3 Drives Ferroptosis Through GPX4 Inactivation and ROS Production in Colorectal Cancer

(2018) Xinbing Sui et al.   Frontiers in Pharmacology

Characterization of ferroptosis in murine models of hemochromatosis

(2017) Hao Wang et al.   HEPATOLOGY

Global aetiology and epidemiology of type 2 diabetes mellitus and its complications

(2017) Yan Zheng et al.   Nature Reviews Endocrinology

Postmenopausal Iron Overload Exacerbated Bone Loss by Promoting the Degradation of Type I Collagen

(2017) Qian Cheng et al.   Biomed Research International

FANCD2 protects against bone marrow injury from ferroptosis

(2016) Xinxin Song et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of baicalein as a ferroptosis inhibitor by natural product library screening

(2016) Yangchun Xie et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

An essential role for functional lysosomes in ferroptosis of cancer cells

(2016) S. Torii et al.   BIOCHEMICAL JOURNAL

Iron overload inhibits osteogenic commitment and differentiation of mesenchymal stem cells via the induction of ferritin

(2016) Enikő Balogh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Ferroptosis, a new form of cell death, and its relationships with tumourous diseases

(2016) Haitao Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Mechanisms of diabetes mellitus-induced bone fragility

(2016) Nicola Napoli et al.   Nature Reviews Endocrinology

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondria and Iron: current questions

(2016) Bibbin T. Paul et al.   Expert Review of Hematology

Recent discoveries in the cycling, growing and aging of the p53 field

(2016) James A. McCubrey et al.   Aging-US

Dynamic roles of p53-mediated metabolic activities in ROS-induced stress responses

(2015) Le Jiang et al.   CELL CYCLE

Ironing out Ferroportin

(2015) Hal Drakesmith et al.   Cell Metabolism

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Modulation of radiochemoimmunotherapy-induced B16 melanoma cell death by the pan-caspase inhibitor zVAD-fmk induces anti-tumor immunity in a HMGB1-, nucleotide- and T-cell-dependent manner

(2015) N Werthmöller et al.   Cell Death & Disease

Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells

(2015) Rinaldo Florencio-Silva et al.   Biomed Research International

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

The bone marrow hematopoietic microenvironment is impaired in iron-overloaded mice

(2014) Hiroshi Okabe et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Nox family NADPH oxidases: Molecular mechanisms of activation

(2014) Ralf P. Brandes et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

(2014) Antonio Ayala et al.   Oxidative Medicine and Cellular Longevity

Iron and Diabetes Risk

(2013) Judith A. Simcox et al.   Cell Metabolism

In Vivo Assessment of Bone Quality in Postmenopausal Women With Type 2 Diabetes

(2013) Joshua N Farr et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Comparative evaluation of serum levels of main minerals and postmenopausal osteoporosis

(2013) Emre Okyay et al.   MATURITAS

Osteoporosis in the European Union: medical management, epidemiology and economic burden

(2013) E. Hernlund et al.   Archives of Osteoporosis

The Cystine/Glutamate Antiporter System xc− in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities

(2012) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Ferric ion could facilitate osteoclast differentiation and bone resorption through the production of reactive oxygen species

(2012) Peng Jia et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Lipoxygenase and Leukotriene Pathways: Biochemistry, Biology, and Roles in Disease

(2011) Jesper Z. Haeggström et al.   CHEMICAL REVIEWS

Coordination of PGC-1β and iron uptake in mitochondrial biogenesis and osteoclast activation

(2009) Kiyo-aki Ishii et al.   NATURE MEDICINE

The role of iron in type 2 diabetes in humans

(2008) Swapnil N. Rajpathak et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Diabetes and fragility fractures — A burgeoning epidemic?

(2008) Sol Epstein et al.   BONE

Role of iron metabolism and oxidative damage in postmenopausal bone loss

(2008) Patrizia D'Amelio et al.   BONE

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY

Synaptotagmin VII Regulates Bone Remodeling by Modulating Osteoclast and Osteoblast Secretion

(2008) Haibo Zhao et al.   DEVELOPMENTAL CELL

Glutathione: Overview of its protective roles, measurement, and biosynthesis

(2008) Henry Jay Forman et al.   MOLECULAR ASPECTS OF MEDICINE