Melatonin Suppresses Ferroptosis Induced by High Glucose via Activation of the Nrf2/HO-1 Signaling Pathway in Type 2 Diabetic Osteoporosis

Ferroptosis-driven nanotherapeutics for cancer treatment

(2020) Xinzhu Shan et al.   JOURNAL OF CONTROLLED RELEASE

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

NIPA2 regulates osteoblast function by modulating mitophagy in type 2 diabetes osteoporosis

(2020) Wei Zhao et al.   Scientific Reports

Nrf2 and Ferroptosis: A New Research Direction for Neurodegenerative Diseases

(2020) Xiaohua Song et al.   Frontiers in Neuroscience

Melatonin: Another avenue for treating osteoporosis?

(2019) Tian Li et al.   JOURNAL OF PINEAL RESEARCH

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

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Role of Nrf2 in Fracture Healing: Clinical Aspects of Oxidative Stress

(2019) Yusuke Kubo et al.   CALCIFIED TISSUE INTERNATIONAL

Melatonin prevents bone destruction in mice with retinoic acid–induced osteoporosis

(2019) Xudong Wang et al.   MOLECULAR MEDICINE

Melatonin Prevents Mice Cortical Astrocytes From Hemin-Induced Toxicity Through Activating PKCα/Nrf2/HO-1 Signaling in vitro

(2019) Xiao Chen et al.   Frontiers in Neuroscience

ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation

(2019) Eunhee Park et al.   Cell Death & Disease

Curculigoside Protects against Excess-Iron-Induced Bone Loss by Attenuating Akt-FoxO1-Dependent Oxidative Damage to Mice and Osteoblastic MC3T3-E1 Cells

(2019) Quanlong Zhang et al.   Oxidative Medicine and Cellular Longevity

Melatonin Suppresses Estrogen Deficiency-Induced Osteoporosis and Promotes Osteoblastogenesis by Inactivating the NLRP3 Inflammasome

(2018) Lijun Xu et al.   CALCIFIED TISSUE INTERNATIONAL

Neuroprotective Effects of Melatonin on Experimental Allergic Encephalomyelitis Mice Via Anti-Oxidative Stress Activity

(2018) Ting Long et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Biological effects of melatonin on osteoblast/osteoclast cocultures, bone, and quality of life: Implications of a role for MT2 melatonin receptors, MEK1/2, and MEK5 in melatonin-mediated osteoblastogenesis

(2018) Sifat Maria et al.   JOURNAL OF PINEAL RESEARCH

Melatonin and its metabolites vs oxidative stress: From individual actions to collective protection

(2018) Annia Galano et al.   JOURNAL OF PINEAL RESEARCH

Animal models of obesity and diabetes mellitus

(2018) Maximilian Kleinert et al.   Nature Reviews Endocrinology

Inhibition of Nrf2 alters cell stress induced by chronic iron exposure in human proximal tubular epithelial cells

(2018) S.E.G. van Raaij et al.   TOXICOLOGY LETTERS

Melatonin modulates autophagy and inflammation protecting human placental trophoblast from hypoxia/reoxygenation

(2018) Lucas Sagrillo-Fagundes et al.   JOURNAL OF PINEAL RESEARCH

The protective effect of melatonin on brain ischemia and reperfusion in rats and humans: In vivo assessment and a randomized controlled trial

(2018) Zhewei Zhao et al.   JOURNAL OF PINEAL RESEARCH

Melatonin attenuates acute kidney ischemia/reperfusion injury in diabetic rats by activation of the SIRT1/Nrf2/HO-1 signaling pathway

(2018) Si Shi et al.   BIOSCIENCE REPORTS

Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer

(2018) Daiha Shin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Icariin protects against iron overload-induced bone loss via suppressing oxidative stress

(2018) Xingzhi Jing et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Melatonin therapy reduces the risk of osteoporosis and normalizes bone formation in multiple sclerosis

(2017) Majid Ghareghani et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Regulation of DMT1 on autophagy and apoptosis in osteoblast

(2017) Fei Liu et al.   International Journal of Medical Sciences

Olanzapine-induced early cardiovascular effects are mediated by the biological clock and prevented by melatonin

(2017) Francisco Romo-Nava et al.   JOURNAL OF PINEAL RESEARCH

Rapid modulation of the silent information regulator 1 by melatonin after hypoxia-ischemia in the neonatal rat brain

(2017) Silvia Carloni et al.   JOURNAL OF PINEAL RESEARCH

Melatonin promotes circadian rhythm-induced proliferation through Clock/histone deacetylase 3/c-Myc interaction in mouse adipose tissue

(2017) Zhenjiang Liu et al.   JOURNAL OF PINEAL RESEARCH

Evaluation of cell death pathways initiated by antitumor drugs melatonin and valproic acid in bladder cancer cells

(2017) Siwei Liu et al.   FEBS Open Bio

Autophagy protects osteoblasts from advanced glycation end products-induced apoptosis through intracellular reactive oxygen species

(2016) Lei Yang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Mechanisms of diabetes mellitus-induced bone fragility

(2016) Nicola Napoli et al.   Nature Reviews Endocrinology

Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells

(2016) S Ma et al.   Cell Death & Disease

Melatonin suppresses autophagy in type 2 diabetic osteoporosis

(2016) Wei-Lin Zhang et al.   Oncotarget

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

Regulation of DMT1 on Bone Microstructure in Type 2 Diabetes

(2015) Wei-Lin Zhang et al.   International Journal of Medical Sciences

Fracture risk in patients with newly diagnosed type 2 diabetes: a retrospective database analysis in primary care

(2015) Wolfgang Rathmann et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Bone mineral density evaluation of patients with type 2 diabetes mellitus

(2015) Camli Adil et al.   Journal of Physical Therapy Science

Fracture risk in diabetic elderly men: the MrOS study

(2014) Nicola Napoli et al.   DIABETOLOGIA

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Melatonin Antagonizes Mn-Induced Oxidative Injury Through the Activation of Keap1–Nrf2–ARE Signaling Pathway in the Striatum of Mice

(2014) Yu Deng et al.   NEUROTOXICITY RESEARCH

Modeling type 2 diabetes in rats using high fat diet and streptozotocin

(2014) Søs Skovsø   Journal of Diabetes Investigation

Iron Overload Inhibits Osteoblast Biological Activity Through Oxidative Stress

(2013) Yin-Feng He et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

ZnT7 can protect MC3T3-E1 cells from oxidative stress-induced apoptosis via PI3K/Akt and MAPK/ERK signaling pathways

(2013) Dan Liang et al.   CELLULAR SIGNALLING

The role of melatonin in the cells of the innate immunity: a review

(2013) Juan R. Calvo et al.   JOURNAL OF PINEAL RESEARCH

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Role of Advanced Glycation End Products (AGEs) in Osteoporosis in Diabetes

(2011) Sho-ichi Yamagishi   CURRENT DRUG TARGETS

Melatonin osteoporosis prevention study (MOPS): a randomized, double-blind, placebo-controlled study examining the effects of melatonin on bone health and quality of life in perimenopausal women

(2011) Mary P. Kotlarczyk et al.   JOURNAL OF PINEAL RESEARCH

Bone loss caused by iron overload in a murine model: importance of oxidative stress

(2010) J. Tsay et al.   BLOOD

Diabetes and Bone

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The Characterization of High-Fat Diet and Multiple Low-Dose Streptozotocin Induced Type 2 Diabetes Rat Model

(2009) Ming Zhang et al.   Experimental Diabetes Research

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY