BMS-470539 Attenuates Oxidative Stress and Neuronal Apoptosis via MC1R/cAMP/PKA/Nurr1 Signaling Pathway in a Neonatal Hypoxic-Ischemic Rat Model

Activation of MC1R with BMS-470539 attenuates neuroinflammation via cAMP/PKA/Nurr1 pathway after neonatal hypoxic-ischemic brain injury in rats

(2021) Shufeng Yu et al.   Journal of Neuroinflammation

Activation of Nurr1 with Amodiaquine Protected Neuron and Alleviated Neuroinflammation after Subarachnoid Hemorrhage in Rats

(2021) Huaijun Chen et al.   Oxidative Medicine and Cellular Longevity

Age‐related calcium dysregulation linked with tau pathology and impaired cognition in non‐human primates

(2021) Dibyadeep Datta et al.   Alzheimers & Dementia

Progress in nasal drug delivery systems

(2021) Flavia Laffleur et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Novel anti-inflammatory and chondroprotective effects of the human melanocortin MC1 receptor agonist BMS-470539 dihydrochloride and human melanocortin MC3 receptor agonist PG-990 on lipopolysaccharide activated chondrocytes

(2020) Vedia C. Can et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Extracellular Vesicles Derived from Neural Progenitor Cells––a Preclinical Evaluation for Stroke Treatment in Mice

(2020) X. Zheng et al.   Translational Stroke Research

TRPM7 Mediates Neuronal Cell Death Upstream of Calcium/Calmodulin-Dependent Protein Kinase II and Calcineurin Mechanism in Neonatal Hypoxic-Ischemic Brain Injury

(2020) Ekaterina Turlova et al.   Translational Stroke Research

Knockdown of Arginyl-tRNA Synthetase Attenuates Ischemia-Induced Cerebral Cortex Injury in Rats After Middle Cerebral Artery Occlusion

(2020) Yang Liu et al.   Translational Stroke Research

Combination treatments with therapeutic hypothermia for hypoxic‐ischemic neuroprotection

(2020) Kelly Q Zhou et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

IRF5 Signaling in Phagocytes Is Detrimental to Neonatal Hypoxic Ischemic Encephalopathy

(2020) Abdullah Al Mamun et al.   Translational Stroke Research

Rh-CSF1 Attenuates Oxidative Stress and Neuronal Apoptosis via the CSF1R/PLCG2/PKA/UCP2 Signaling Pathway in a Rat Model of Neonatal HIE

(2020) Xiao Hu et al.   Oxidative Medicine and Cellular Longevity

TREM-1 Exacerbates Neuroinflammatory Injury via NLRP3 Inflammasome-Mediated Pyroptosis in Experimental Subarachnoid Hemorrhage

(2020) Pengfei Xu et al.   Translational Stroke Research

Royal Jelly Alleviates Cognitive Deficits and β-Amyloid Accumulation in APP/PS1 Mouse Model Via Activation of the cAMP/PKA/CREB/BDNF Pathway and Inhibition of Neuronal Apoptosis

(2019) Mengmeng You et al.   Frontiers in Aging Neuroscience

Chemerin reverses neurological impairments and ameliorates neuronal apoptosis through ChemR23/CAMKK2/AMPK pathway in neonatal hypoxic–ischemic encephalopathy

(2019) Yixin Zhang et al.   Cell Death & Disease

Molecular Insights into NR4A2(Nurr1): an Emerging Target for Neuroprotective Therapy Against Neuroinflammation and Neuronal Cell Death

(2019) Md. Jakaria et al.   MOLECULAR NEUROBIOLOGY

The Role of Mitochondrial and Endoplasmic Reticulum Reactive Oxygen Species Production in Models of Perinatal Brain Injury

(2019) Gagandeep Singh-Mallah et al.   ANTIOXIDANTS & REDOX SIGNALING

Human nonvisual opsin 3 regulates pigmentation of epidermal melanocytes through functional interaction with melanocortin 1 receptor

(2019) Rana N. Ozdeslik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism and Treatment Related to Oxidative Stress in Neonatal Hypoxic-Ischemic Encephalopathy

(2019) Xingping Qin et al.   Frontiers in Molecular Neuroscience

Ghrelin attenuates oxidative stress and neuronal apoptosis via GHSR-1α/AMPK/Sirt1/PGC-1α/UCP2 pathway in a rat model of neonatal HIE

(2019) Juan Huang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Activation of Melanocortin 1 Receptor Attenuates Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage viathe Suppression of Neuroinflammation through AMPK/TBK1/NF-κB Pathway in Rats

(2019) Weilin Xu et al.   Neurotherapeutics

Adenoviral TMBIM6 vector attenuates ER-stress-induced apoptosis in a neonatal hypoxic-ischemic rat model

(2019) Desislava Doycheva et al.   Disease Models & Mechanisms

Activation of TGR5 with INT-777 attenuates oxidative stress and neuronal apoptosis via cAMP/PKCε/ALDH2 pathway after subarachnoid hemorrhage in rats

(2019) Gang Zuo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inhibition of cAMP/PKA Pathway Protects Optic Nerve Head Astrocytes against Oxidative Stress by Akt/Bax Phosphorylation-Mediated Mfn1/2 Oligomerization

(2019) Won-Kyu Ju et al.   Oxidative Medicine and Cellular Longevity

Cicadidae Periostracum, the Cast-Off Skin of Cicada, Protects Dopaminergic Neurons in a Model of Parkinson’s Disease

(2019) Hye-Sun Lim et al.   Oxidative Medicine and Cellular Longevity

Neuroprotective effect of olfactory ensheathing cells co-transfected with Nurr1 and Ngn2 in both in vitro and in vivo models of Parkinson's disease

(2018) Qingqing Liu et al.   LIFE SCIENCES

Zinc Promotes Osteoblast Differentiation in Human Mesenchymal Stem Cells Via Activation of the cAMP-PKA-CREB Signaling Pathway

(2018) Kwang Hwan Park et al.   STEM CELLS AND DEVELOPMENT

Role of PPAR-β/δ/miR-17/TXNIP pathway in neuronal apoptosis after neonatal hypoxic-ischemic injury in rats

(2018) Marcin Gamdzyk et al.   NEUROPHARMACOLOGY

Evaluation of intranasal delivery route of drug administration for brain targeting

(2018) Franciska Erdő et al.   BRAIN RESEARCH BULLETIN

Activation of 5-HT1A receptors promotes retinal ganglion cell function by inhibiting the cAMP-PKA pathway to modulate presynaptic GABA release in chronic glaucoma

(2018) Xujiao Zhou et al.   JOURNAL OF NEUROSCIENCE

The α-melanocyte stimulating hormone/peroxisome proliferator activated receptor-γ pathway down-regulates proliferation in melanoma cell lines

(2017) Enrica Flori et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Palmitoylation-dependent activation of MC1R prevents melanomagenesis

(2017) Shuyang Chen et al.   NATURE

The cAMP-PKA Signaling Pathway Regulates Pathogenicity, Hyphal Growth, Appressorial Formation, Conidiation, and Stress Tolerance in Colletotrichum higginsianum

(2017) Wenjun Zhu et al.   Frontiers in Microbiology

Orphan nuclear receptor Nurr1 as a potential novel marker for progression in human pancreatic ductal adenocarcinoma

(2016) Li Ji et al.   Experimental and Therapeutic Medicine

Significance of the Melanocortin 1 and Endothelin B Receptors in Melanocyte Homeostasis and Prevention of Sun-Induced Genotoxicity

(2016) Viki B. Swope et al.   Frontiers in Genetics

Neuroprotective Strategies after Neonatal Hypoxic Ischemic Encephalopathy

(2015) Brandon Dixon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hypoxic-Ischemic Encephalopathy

(2015) Martha Douglas-Escobar et al.   JAMA Pediatrics

Parathyroid hormone activates the orphan nuclear receptor Nurr1 to induce FGF23 transcription

(2014) Tomer Meir et al.   KIDNEY INTERNATIONAL

PKA-Mediated Phosphorylation of ATR Promotes Recruitment of XPA to UV-Induced DNA Damage

(2014) Stuart G. Jarrett et al.   MOLECULAR CELL

RNA-guided gene activation by CRISPR-Cas9–based transcription factors

(2013) Pablo Perez-Pinera et al.   NATURE METHODS

NURR1 in Parkinson disease—from pathogenesis to therapeutic potential

(2013) Mickael Decressac et al.   Nature Reviews Neurology

Single Administration of Tripeptide α-MSH(11–13) Attenuates Brain Damage by Reduced Inflammation and Apoptosis after Experimental Traumatic Brain Injury in Mice

(2013) Eva-Verena Schaible et al.   PLoS One

Alpha-Melanocyte–Stimulating Hormone Suppresses Oxidative Stress through a p53-Mediated Signaling Pathway in Human Melanocytes

(2012) Ana Luisa Kadekaro et al.   MOLECULAR CANCER RESEARCH

PGE2 targets squamous cell carcinoma cell with the activated epidermal growth factor receptor family for survival against 5-fluorouracil through NR4A2 induction

(2011) Hideo Shigeishi et al.   CANCER LETTERS

Targeting the melanocortin receptor system for anti-stroke therapy

(2010) Paul M. Holloway et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Cytoplasmic mislocalization of the orphan nuclear receptor Nurr1 is a prognostic factor in bladder cancer

(2009) Teruo Inamoto et al.   CANCER

A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death

(2009) Kaoru Saijo et al.   CELL

NGFI-B Nuclear Orphan Receptor Nurr1 Interacts with p53 and Suppresses Its Transcriptional Activity

(2009) T. Zhang et al.   MOLECULAR CANCER RESEARCH