Extracellular Vesicles Derived from Neural Progenitor Cells––a Preclinical Evaluation for Stroke Treatment in Mice

B cells migrate into remote brain areas and support neurogenesis and functional recovery after focal stroke in mice

(2020) Sterling B. Ortega et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ablation of the microRNA-17-92 cluster in neural stem cells diminishes adult hippocampal neurogenesis and cognitive function

(2019) Wan Long Pan et al.   FASEB JOURNAL

MicroRNA-124 regulates the expression of p62/p38 and promotes autophagy in the inflammatory pathogenesis of Parkinson's disease

(2019) Longping Yao et al.   FASEB JOURNAL

Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis

(2019) Laura M. Doyle et al.   Cells

Enhancement of therapeutic potential of mesenchymal stem cell-derived extracellular vesicles

(2019) Kyong-Su Park et al.   Stem Cell Research & Therapy

Levels of tight junction protein CLDND1 are regulated by microRNA-124 in the cerebellum of stroke-prone spontaneously hypertensive rats

(2018) Hiroshi Matsuoka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Extracellular Vesicles Derived from Wharton’s Jelly Mesenchymal Stem Cells Prevent and Resolve Programmed Cell Death Mediated by Perinatal Hypoxia-Ischemia in Neuronal Cells

(2018) Marianne S. Joerger-Messerli et al.   CELL TRANSPLANTATION

The Transport Mechanism of Extracellular Vesicles at the Blood-Brain Barrier

(2018) Junichi Matsumoto et al.   CURRENT PHARMACEUTICAL DESIGN

The 70-kDa heat shock protein (Hsp70) as a therapeutic target for stroke

(2018) Jong Youl Kim et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Extracellular vesicles have variable dose-dependent effects on cultured draining cells in the eye

(2018) Saray Tabak et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Exosomes Secreted by Adipose-Derived Stem Cells Contribute to Angiogenesis of Brain Microvascular Endothelial Cells Following Oxygen–Glucose Deprivation In Vitro Through MicroRNA-181b/TRPM7 Axis

(2018) Yujia Yang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Multipotent mesenchymal stromal cell–derived exosomes improve functional recovery after experimental intracerebral hemorrhage in the rat

(2018) Yuxia Han et al.   JOURNAL OF NEUROSURGERY

MicroRNA-124-loaded nanoparticles increase survival and neuronal differentiation of neural stem cells in vitro but do not contribute to stroke outcome in vivo

(2018) Cláudia Saraiva et al.   PLoS One

Human Neural Stem Cell Extracellular Vesicles Improve Recovery in a Porcine Model of Ischemic Stroke

(2018) Robin L. Webb et al.   STROKE

Distinct function of miR-17-92 cluster in the dorsal and ventral adult hippocampal neurogenesis

(2018) Junghee Jin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Multicellular Crosstalk Between Exosomes and the Neurovascular Unit After Cerebral Ischemia. Therapeutic Implications

(2018) Ana-Maria Zagrean et al.   Frontiers in Neuroscience

Peptide modified mesenchymal stem cells as targeting delivery system transfected with miR-133b for the treatment of cerebral ischemia

(2017) Bing Huang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

MicroRNA: Relevance to stroke diagnosis, prognosis, and therapy

(2017) Hamed Mirzaei et al.   JOURNAL OF CELLULAR PHYSIOLOGY

MicroRNA-17–92 Cluster in Exosomes Enhance Neuroplasticity and Functional Recovery After Stroke in Rats

(2017) Hongqi Xin et al.   STROKE

Human Neural Stem Cell Extracellular Vesicles Improve Tissue and Functional Recovery in the Murine Thromboembolic Stroke Model

(2017) Robin L. Webb et al.   Translational Stroke Research

Exosome Mediated Delivery of miR-124 Promotes Neurogenesis after Ischemia

(2017) Jialei Yang et al.   Molecular Therapy-Nucleic Acids

MiRNA-124 induces neuroprotection and functional improvement after focal cerebral ischemia

(2016) Somayyeh Hamzei Taj et al.   BIOMATERIALS

Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake

(2016) Erik R. Abels et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The role of the miR-17-92 cluster in neurogenesis and angiogenesis in the central nervous system of adults

(2016) Ping Yang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Mesenchymal Stromal Cell-Derived Extracellular Vesicles Protect the Fetal Brain After Hypoxia-Ischemia

(2016) Daan R.M.G. Ophelders et al.   Stem Cells Translational Medicine

MicroRNAs: New Biomarkers for Diagnosis, Prognosis, Therapy Prediction and Therapeutic Tools for Breast Cancer

(2015) Gloria Bertoli et al.   Theranostics

Extracellular Vesicles Improve Post-Stroke Neuroregeneration and Prevent Postischemic Immunosuppression

(2015) Thorsten R. Doeppner et al.   Stem Cells Translational Medicine

Conditioned medium of human adipose-derived mesenchymal stem cells mediates protection in neurons following glutamate excitotoxicity by regulating energy metabolism and GAP-43 expression

(2014) Peng Hao et al.   METABOLIC BRAIN DISEASE

Effects of acute versus post-acute systemic delivery of neural progenitor cells on neurological recovery and brain remodeling after focal cerebral ischemia in mice

(2014) T R Doeppner et al.   Cell Death & Disease

Neural Precursor Cell Transplantation Enhances Functional Recovery and Reduces Astrogliosis in Bilateral Compressive/Contusive Cervical Spinal Cord Injury

(2014) Jared T. Wilcox et al.   Stem Cells Translational Medicine

The Life and Fate of Mesenchymal Stem Cells

(2014) Elke Eggenhofer et al.   Frontiers in Immunology

Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Promote Functional Recovery and Neurovascular Plasticity After Stroke in Rats

(2013) Hongqi Xin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mesenchymal Stem Cells from Human Umbilical Cord Express Preferentially Secreted Factors Related to Neuroprotection, Neurogenesis, and Angiogenesis

(2013) Jui-Yu Hsieh et al.   PLoS One

Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication

(2013) Carsten Frühbeis et al.   PLOS BIOLOGY

Mesenchymal Stromal Cells Rescue Cortical Neurons from Apoptotic Cell Death in an In Vitro Model of Cerebral Ischemia

(2012) Franziska Scheibe et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Pathophysiologic Cascades in Ischemic Stroke

(2012) Changhong Xing et al.   International Journal of Stroke

Assessing Post-Stroke Behavior in Mouse Models of Focal Ischemia

(2012) Mustafa Balkaya et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Microvesicles derived from endothelial progenitor cells protect the kidney from ischemia–reperfusion injury by microRNA-dependent reprogramming of resident renal cells

(2012) Vincenzo Cantaluppi et al.   KIDNEY INTERNATIONAL

Transduction of Neural Precursor Cells with TAT-Heat Shock Protein 70 Chaperone: Therapeutic Potential Against Ischemic Stroke after Intrastriatal and Systemic Transplantation

(2012) Thorsten R. Doeppner et al.   STEM CELLS

Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Alleviate Liver Fibrosis

(2012) Tingfen Li et al.   STEM CELLS AND DEVELOPMENT

Characterisation of exosomes derived from human cells by nanoparticle tracking analysis and scanning electron microscopy

(2011) Viktoriya Sokolova et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury

(2011) S. Gatti et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

ExoCarta 2012: database of exosomal proteins, RNA and lipids

(2011) S. Mathivanan et al.   NUCLEIC ACIDS RESEARCH

Human Mesenchymal Stromal Cells and their Derivative, SB623 Cells, Rescue Neural Cells via Trophic Support following in Vitro Ischemia

(2010) Ciara C. Tate et al.   CELL TRANSPLANTATION

Human embryonic neural stem cell transplantation increases subventricular zone cell proliferation and promotes peri-infarct angiogenesis after focal cerebral ischemia

(2010) Pengbo Zhang et al.   NEUROPATHOLOGY

Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury

(2010) Ruenn Chai Lai et al.   Stem Cell Research

Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms

(2009) Marco Bacigaluppi et al.   BRAIN

Intravenous hMSCs Improve Myocardial Infarction in Mice because Cells Embolized in Lung Are Activated to Secrete the Anti-inflammatory Protein TSG-6

(2009) Ryang Hwa Lee et al.   Cell Stem Cell

Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium

(2008) Leo Timmers et al.   Stem Cell Research