Memory suppressor genes: Modulating acquisition, consolidation, and forgetting

Dopamine-based mechanism for transient forgetting

(2021) John Martin Sabandal et al.   NATURE

The Kinase Specificity of Protein Kinase Inhibitor Peptide

(2021) Yao Chen et al.   Frontiers in Pharmacology

Presynaptic inhibition of dopamine neurons controls optimistic bias

(2021) Nobuhiro Yamagata et al.   eLife

A Feedforward Circuit Regulates Action Selection of Pre-mating Courtship Behavior in Female Drosophila

(2020) Hiroshi Ishimoto et al.   CURRENT BIOLOGY

Rolipram treatment during consolidation ameliorates long-term object location memory in aged male mice

(2020) Mathieu E. Wimmer et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Ras acts as a molecular switch between two forms of consolidated memory in Drosophila

(2020) Nathaniel C. Noyes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptomics of Gabra4 knockout mice reveals common NMDAR pathways underlying autism, memory, and epilepsy

(2020) Cuixia Fan et al.   Molecular Autism

An Antisense Oligonucleotide Leads to Suppressed Transcription of Hdac2 and Long-Term Memory Enhancement

(2020) Shane G. Poplawski et al.   Molecular Therapy-Nucleic Acids

miR-92a Suppresses Mushroom Body-Dependent Memory Consolidation in Drosophila

(2020) Tugba Guven-Ozkan et al.   eNeuro

Pharmacological inhibition of phosphodiesterase 7 enhances consolidation processes of spatial memory

(2020) Susan McQuown et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Inhibition of PDE2 and PDE4 synergistically improves memory consolidation processes

(2020) Dean Paes et al.   NEUROPHARMACOLOGY

Phosphodiesterase 1b (PDE1B) Regulates Spatial and Contextual Memory in Hippocampus

(2019) Susan McQuown et al.   Frontiers in Molecular Neuroscience

Serotonin receptor HTR6-mediated mTORC1 signaling regulates dietary restriction–induced memory enhancement

(2019) Ling-Ling Teng et al.   PLOS BIOLOGY

Social Memory and Social Patterns Alterations in the Absence of STriatal-Enriched Protein Tyrosine Phosphatase

(2019) Gloria Blázquez et al.   Frontiers in Behavioral Neuroscience

Synaptic retinoic acid receptor signaling mediates mTOR-dependent metaplasticity that controls hippocampal learning

(2019) Yu-Tien Hsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dopamine Neurotransmission in the Ventral Tegmental Area Promotes Active Forgetting of Cocaine-Associated Memory

(2019) Fernando Castillo Díaz et al.   MOLECULAR NEUROBIOLOGY

Neuroplastin 65 modulates anxiety‐ and depression‐like behavior likely through adult hippocampal neurogenesis and central 5‐ HT activity

(2019) Huanhuan Li et al.   FEBS Journal

Disrupting the hippocampal Piwi pathway enhances contextual fear memory in mice

(2019) Laura J. Leighton et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

eIF2α phosphorylation and the regulation of translation

(2019) Erik Boye et al.   CURRENT GENETICS

Genetic dissection of active forgetting in labile and consolidated memories in Drosophila

(2019) Yang Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AIM2 deletion promotes neuroplasticity and spatial memory of mice

(2019) Jian Chen et al.   BRAIN RESEARCH BULLETIN

Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling

(2019) Zhi-Xiang Xu et al.   Nature Communications

Wilm’s tumor 1 promotes memory flexibility

(2019) Chiara Mariottini et al.   Nature Communications

Interplay between α2-chimaerin and Rac1 activity determines dynamic maintenance of long-term memory

(2019) Li Lv et al.   Nature Communications

Nitric oxide acts as a cotransmitter in a subset of dopaminergic neurons to diversify memory dynamics

(2019) Yoshinori Aso et al.   eLife

JIP1-Mediated JNK Activation Negatively Regulates Synaptic Plasticity and Spatial Memory

(2018) Caroline Morel et al.   JOURNAL OF NEUROSCIENCE

NPY Induces Stress Resilience via Downregulation ofIhin Principal Neurons of Rat Basolateral Amygdala

(2018) Heika Silveira Villarroel et al.   JOURNAL OF NEUROSCIENCE

The Drosophila Receptor Tyrosine Kinase Alk constrains long-term memory formation

(2018) Jean Y. Gouzi et al.   JOURNAL OF NEUROSCIENCE

Dunce Phosphodiesterase Acts as a Checkpoint for Drosophila Long-Term Memory in a Pair of Serotonergic Neurons

(2018) Lisa Scheunemann et al.   NEURON

Neuropsychological investigation of “the amazing memory man”.

(2018) Jason Brandt et al.   NEUROPSYCHOLOGY

ROCK inhibition in models of neurodegeneration and its potential for clinical translation

(2018) Jan Christoph Koch et al.   PHARMACOLOGY & THERAPEUTICS

Memory instability as a gateway to generalization

(2018) Edwin M. Robertson   PLOS BIOLOGY

Stromalin Constrains Memory Acquisition by Developmentally Limiting Synaptic Vesicle Pool Size

(2018) Anna Phan et al.   NEURON

Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting

(2018) Ankit Awasthi et al.   SCIENCE

Social Isolation Induces Rac1-Dependent Forgetting of Social Memory

(2018) Yunlong Liu et al.   Cell Reports

Forebrain-Specific Transgene Rescue of 11β-HSD1 Associates with Impaired Spatial Memory and Reduced Hippocampal Brain-Derived Neurotrophic Factor mRNA Levels in Aged 11β-HSD1 Deficient Mice

(2017) S. Caughey et al.   JOURNAL OF NEUROENDOCRINOLOGY

Local Inhibition of PERK Enhances Memory and Reverses Age-Related Deterioration of Cognitive and Neuronal Properties

(2017) Vijendra Sharma et al.   JOURNAL OF NEUROSCIENCE

The Persistence and Transience of Memory

(2017) Blake A. Richards et al.   NEURON

The neural basis of reversal learning: An updated perspective

(2017) A. Izquierdo et al.   NEUROSCIENCE

MicroRNA-mediated disruption of dendritogenesis during a critical period of development influences cognitive capacity later in life

(2017) Quan Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

piRNA Biogenesis in Drosophila melanogaster

(2017) Xiawei Huang et al.   TRENDS IN GENETICS

Autism-like behaviours and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice

(2017) Naoko Morimura et al.   Nature Communications

Dopamine Receptor DAMB Signals via Gq to Mediate Forgetting in Drosophila

(2017) Sophie Himmelreich et al.   Cell Reports

Galectin-3 Negatively Regulates Hippocampus-Dependent Memory Formation through Inhibition of Integrin Signaling and Galectin-3 Phosphorylation

(2017) Yan-Chu Chen et al.   Frontiers in Molecular Neuroscience

Learning performances and vulnerability to amyloid toxicity in the butyrylcholinesterase knockout mouse

(2016) Tangui Maurice et al.   BEHAVIOURAL BRAIN RESEARCH

Hippocampal Activation of Rac1 Regulates the Forgetting of Object Recognition Memory

(2016) Yunlong Liu et al.   CURRENT BIOLOGY

Blocking Synaptic Removal of GluA2-Containing AMPA Receptors Prevents the Natural Forgetting of Long-Term Memories

(2016) P. V. Migues et al.   JOURNAL OF NEUROSCIENCE

Neuroplastin 65 mediates cognitive functions via excitatory/inhibitory synapse imbalance and ERK signal pathway

(2016) Siyiti Amuti et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Drosophila SLC22A Transporter Is a Memory Suppressor Gene that Influences Cholinergic Neurotransmission to the Mushroom Bodies

(2016) Yunchao Gai et al.   NEURON

Scribble Scaffolds a Signalosome for Active Forgetting

(2016) Isaac Cervantes-Sandoval et al.   NEURON

Distinct cognitive effects and underlying transcriptome changes upon inhibition of individual miRNAs in hippocampal neurons

(2016) Josephine Malmevik et al.   Scientific Reports

Cdc42-Dependent Forgetting Regulates Repetition Effect in Prolonging Memory Retention

(2016) Xuchen Zhang et al.   Cell Reports

MiR-980 Is a Memory Suppressor MicroRNA that Regulates the Autism-Susceptibility Gene A2bp1

(2016) Tugba Guven-Ozkan et al.   Cell Reports

CCR5 is a suppressor for cortical plasticity and hippocampal learning and memory

(2016) Miou Zhou et al.   eLife

Dopaminergic neurons write and update memories with cell-type-specific rules

(2016) Yoshinori Aso et al.   eLife

α5GABAAreceptor deficiency causes autism-like behaviors

(2016) Agnieszka A. Zurek et al.   Annals of Clinical and Translational Neurology

Blocking miRNA Biogenesis in Adult Forebrain Neurons Enhances Seizure Susceptibility, Fear Memory, and Food Intake by Increasing Neuronal Responsiveness

(2015) Anna Fiorenza et al.   CEREBRAL CORTEX

Identification of Genes That Promote or Inhibit Olfactory Memory Formation in Drosophila

(2015) Erica Walkinshaw et al.   GENETICS

microRNAs That Promote or Inhibit Memory Formation in Drosophila melanogaster

(2015) Germain U. Busto et al.   GENETICS

Expression of Quinone Reductase-2 in the Cortex Is a Muscarinic Acetylcholine Receptor-Dependent Memory Consolidation Constraint

(2015) Akiva N. Rappaport et al.   JOURNAL OF NEUROSCIENCE

Tonic Inhibitory Control of Dentate Gyrus Granule Cells by α5-Containing GABA A Receptors Reduces Memory Interference

(2015) Elif Engin et al.   JOURNAL OF NEUROSCIENCE

Protein Phosphatase-1 Inhibitor-2 Is a Novel Memory Suppressor

(2015) H. Yang et al.   JOURNAL OF NEUROSCIENCE

Inhibition of Rac1 Activity in the Hippocampus Impairs the Forgetting of Contextual Fear Memory

(2015) Lizhu Jiang et al.   MOLECULAR NEUROBIOLOGY

Mechanisms for spatiotemporal regulation of Rho-GTPase signaling at synapses

(2015) Joseph G. Duman et al.   NEUROSCIENCE LETTERS

Perceived social isolation, evolutionary fitness and health outcomes: a lifespan approach

(2015) L. C. Hawkley et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Enhanced memory consolidation in mice lacking the circadian modulators Sharp1 and -2 caused by elevated Igf2 signaling in the cortex

(2015) Ali Shahmoradi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice

(2015) Monica D. Bjørge et al.   Cell Reports

Downregulation of the Host Gene jigr1 by miR-92 Is Essential for Neuroblast Self-Renewal in Drosophila

(2015) Yeliz Yuva-Aydemir et al.   PLoS Genetics

Identification of Genes That Promote or Inhibit Olfactory Memory Formation in Drosophila

(2015) Erica Walkinshaw et al.   GENETICS

microRNAs That Promote or Inhibit Memory Formation in Drosophila melanogaster

(2015) Germain U. Busto et al.   GENETICS

Post-training activation of Rac1 in the basolateral amygdala is required for the formation of both short-term and long-term auditory fear memory

(2015) Qinqin Gao et al.   Frontiers in Molecular Neuroscience

Forgetting Is Regulated via Musashi-Mediated Translational Control of the Arp2/3 Complex

(2014) Nils Hadziselimovic et al.   CELL

Histone H2A.Z subunit exchange controls consolidation of recent and remote memory

(2014) Iva B. Zovkic et al.   NATURE

Sparse, decorrelated odor coding in the mushroom body enhances learned odor discrimination

(2014) Andrew C Lin et al.   NATURE NEUROSCIENCE

Neurons Are Recruited to a Memory Trace Based on Relative Neuronal Excitability Immediately before Training

(2014) Adelaide P. Yiu et al.   NEURON

Mice deficient in phosphodiesterase-4A display anxiogenic-like behavior

(2014) Rolf T. Hansen et al.   PSYCHOPHARMACOLOGY

Loss of Cdc42 leads to defects in synaptic plasticity and remote memory recall

(2014) Il Hwan Kim et al.   eLife

MicroRNA-182 Regulates Amygdala-Dependent Memory Formation

(2013) E. M. Griggs et al.   JOURNAL OF NEUROSCIENCE

Loss of Histone Deacetylase 2 Improves Working Memory and Accelerates Extinction Learning

(2013) M. J. Morris et al.   JOURNAL OF NEUROSCIENCE

Depletion of Perineuronal Nets Enhances Recognition Memory and Long-Term Depression in the Perirhinal Cortex

(2013) C. Romberg et al.   JOURNAL OF NEUROSCIENCE

Control of Synaptic Plasticity and Memory via Suppression of Poly(A)-Binding Protein

(2013) Arkady Khoutorsky et al.   NEURON

NMDA receptors and memory encoding

(2013) Richard G.M. Morris   NEUROPHARMACOLOGY

GluA2-dependent AMPA receptor endocytosis and the decay of early and late long-term potentiation: possible mechanisms for forgetting of short- and long-term memories

(2013) O. Hardt et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Forgetting in C. elegans Is Accelerated by Neuronal Communication via the TIR-1/JNK-1 Pathway

(2013) Akitoshi Inoue et al.   Cell Reports

Enhanced learning and memory in GAT1 heterozygous mice

(2012) Jun Shi et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Inactivation of Pde8b enhances memory, motor performance, and protects against age-induced motor coordination decay

(2012) L.-C. L. Tsai et al.   GENES BRAIN AND BEHAVIOR

Receptor protein tyrosine phosphatase sigma regulates synapse structure, function and plasticity

(2012) Katherine E. Horn et al.   JOURNAL OF NEUROCHEMISTRY

Consolidated and Labile Odor Memory Are Separately Encoded within the Drosophila Brain

(2012) L. Scheunemann et al.   JOURNAL OF NEUROSCIENCE

Enhanced cAMP Response Element-Binding Protein Activity Increases Neuronal Excitability, Hippocampal Long-Term Potentiation, and Classical Eyeblink Conditioning in Alert Behaving Mice

(2012) A. Gruart et al.   JOURNAL OF NEUROSCIENCE

MEF2 negatively regulates learning-induced structural plasticity and memory formation

(2012) Christina J Cole et al.   NATURE NEUROSCIENCE

Slow oscillations in two pairs of dopaminergic neurons gate long-term memory formation in Drosophila

(2012) Pierre-Yves Plaçais et al.   NATURE NEUROSCIENCE

New insights into the regulation and cellular functions of the ARP2/3 complex

(2012) Jeremy D. Rotty et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dopamine Is Required for Learning and Forgetting in Drosophila

(2012) Jacob A. Berry et al.   NEURON

Olfactory Maps in the Brain

(2011) Venkatesh N. Murthy   Annual Review of Neuroscience

Suppression of PKR Promotes Network Excitability and Enhanced Cognition by Interferon-γ-Mediated Disinhibition

(2011) Ping Jun Zhu et al.   CELL

Striatal-enriched protein tyrosine phosphatase (STEP) knockout mice have enhanced hippocampal memory

(2011) Deepa V. Venkitaramani et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Cdc42: An important regulator of neuronal morphology

(2011) Chen Chen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Phosphodiesterase-4D Knock-Out and RNA Interference-Mediated Knock-Down Enhance Memory and Increase Hippocampal Neurogenesis via Increased cAMP Signaling

(2011) Y.-F. Li et al.   JOURNAL OF NEUROSCIENCE

Attenuating GABAA Receptor Signaling in Dopamine Neurons Selectively Enhances Reward Learning and Alters Risk Preference in Mice

(2011) J. G. Parker et al.   JOURNAL OF NEUROSCIENCE

Alterations of Endocannabinoid Signaling, Synaptic Plasticity, Learning, and Memory in Monoacylglycerol Lipase Knock-out Mice

(2011) B. Pan et al.   JOURNAL OF NEUROSCIENCE

Insulin receptor substrate 2 is a negative regulator of memory formation

(2011) E. E. Irvine et al.   LEARNING & MEMORY

Inhibition of mTOR by rapamycin in the amygdala or hippocampus impairs formation and reconsolidation of inhibitory avoidance memory

(2011) Paulo F.C. Jobim et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Ras?ERK Signaling in Behavior: Old Questions and New Perspectives

(2011) Stefania Fasano et al.   Frontiers in Behavioral Neuroscience

Prefrontal dopamine and the dynamic control of human long-term memory

(2011) M Wimber et al.   Translational Psychiatry

Forgetting Is Regulated through Rac Activity in Drosophila

(2010) Yichun Shuai et al.   CELL

ERK in Learning and Memory: A Review of Recent Research

(2010) Sheng Peng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Loss of Quinone Reductase 2 Function Selectively Facilitates Learning Behaviors

(2010) C.-E. Benoit et al.   JOURNAL OF NEUROSCIENCE

Acute Inhibition of PKA Activity at Old Ages Ameliorates Age-Related Memory Impairment in Drosophila

(2010) D. Yamazaki et al.   JOURNAL OF NEUROSCIENCE

MicroRNA Loss Enhances Learning and Memory in Mice

(2010) W. Konopka et al.   JOURNAL OF NEUROSCIENCE

Regulation of Synaptic Rac1 Activity, Long-Term Potentiation Maintenance, and Learning and Memory by BCR and ABR Rac GTPase-Activating Proteins

(2010) D. Oh et al.   JOURNAL OF NEUROSCIENCE

PKMζ maintains memories by regulating GluR2-dependent AMPA receptor trafficking

(2010) Paola Virginia Migues et al.   NATURE NEUROSCIENCE

PKA Dynamics in a Drosophila Learning Center: Coincidence Detection by Rutabaga Adenylyl Cyclase and Spatial Regulation by Dunce Phosphodiesterase

(2010) Nicolas Gervasi et al.   NEURON

RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory

(2010) S. E. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DREAM (Downstream Regulatory Element Antagonist Modulator) contributes to synaptic depression and contextual fear memory

(2010) Long-Jun Wu et al.   Molecular Brain

Peripheral delivery of a ROCK inhibitor improves learning and working memory.

(2009) Matthew J. Huentelman et al.   BEHAVIORAL NEUROSCIENCE

Writing Memories with Light-Addressable Reinforcement Circuitry

(2009) Adam Claridge-Chang et al.   CELL

An inducible change in Fox-1/A2BP1 splicing modulates the alternative splicing of downstream neuronal target exons

(2009) J.-A. Lee et al.   GENES & DEVELOPMENT

Disruption of the Ether-a-go-go K+ Channel Gene BEC1/KCNH3 Enhances Cognitive Function

(2009) A. Miyake et al.   JOURNAL OF NEUROSCIENCE

The GABAA Receptor RDL Suppresses the Conditioned Stimulus Pathway for Olfactory Learning

(2009) X. Liu et al.   JOURNAL OF NEUROSCIENCE

Enhanced long-term and impaired short-term spatial memory in GluA1 AMPA receptor subunit knockout mice: Evidence for a dual-process memory model

(2009) D. J. Sanderson et al.   LEARNING & MEMORY

The role of calsenilin/DREAM/KChIP3 in contextual fear conditioning

(2009) J. C. Alexander et al.   LEARNING & MEMORY

A central role for the small GTPase Rac1 in hippocampal plasticity and spatial learning and memory

(2009) Ursula Haditsch et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

HDAC2 negatively regulates memory formation and synaptic plasticity

(2009) Ji-Song Guan et al.   NATURE

CREB regulates excitability and the allocation of memory to subsets of neurons in the amygdala

(2009) Yu Zhou et al.   NATURE NEUROSCIENCE

Trace and contextual fear conditioning is enhanced in mice lacking the α4 subunit of the GABAA receptor

(2009) M.D. Moore et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Dynamics of Learning-Related cAMP Signaling and Stimulus Integration in the Drosophila Olfactory Pathway

(2009) Seth M. Tomchik et al.   NEURON

The savant syndrome: an extraordinary condition. A synopsis: past, present, future

(2009) D. A. Treffert   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Selective Erasure of a Fear Memory

(2009) J.-H. Han et al.   SCIENCE

mTOR signaling: At the crossroads of plasticity, memory and disease

(2009) Charles A. Hoeffer et al.   TRENDS IN NEUROSCIENCES

A New Component in Synaptic Plasticity: Upregulation of Kinesin in the Neurons of the Gill-Withdrawal Reflex

(2008) Sathyanarayanan V. Puthanveettil et al.   CELL

Lack of DREAM Protein Enhances Learning and Memory and Slows Brain Aging

(2008) Ángela Fontán-Lozano et al.   CURRENT BIOLOGY

The cohesin complex and its roles in chromosome biology

(2008) J.-M. Peters et al.   GENES & DEVELOPMENT

Ablation of Ca2+Channel β3 Subunit Leads to EnhancedN-Methyl-d-aspartate Receptor-dependent Long Term Potentiation and Improved Long Term Memory

(2008) Daejong Jeon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inducible cAMP Early Repressor Acts as a Negative Regulator for Kindling Epileptogenesis and Long-Term Fear Memory

(2008) N. Kojima et al.   JOURNAL OF NEUROSCIENCE

Transgenic inhibition of neuronal calcineurin activity in the forebrain facilitates fear conditioning, but inhibits the extinction of contextual fear memories

(2008) Robbert Havekes et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Removal of FKBP12 Enhances mTOR-Raptor Interactions, LTP, Memory, and Perseverative/Repetitive Behavior

(2008) Charles A. Hoeffer et al.   NEURON

Protein kinase A inhibits a consolidated form of memory in Drosophila

(2008) J. Horiuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of protein synthesis in memory consolidation: Progress amid decades of debate

(2007) Pepe J. Hernandez et al.   NEUROBIOLOGY OF LEARNING AND MEMORY