Phosphodiesterase 1b (PDE1B) Regulates Spatial and Contextual Memory in Hippocampus

Targeting the dopamine D1 receptor or its downstream signalling by inhibiting phosphodiesterase-1 improves cognitive performance

(2018) Anton Pekcec et al.   BRITISH JOURNAL OF PHARMACOLOGY

Integrating new findings and examining clinical applications of pattern separation

(2018) Stephanie L. Leal et al.   NATURE NEUROSCIENCE

PDE4D regulates Spine Plasticity and Memory in the Retrosplenial Cortex

(2018) Karsten Baumgärtel et al.   Scientific Reports

Phosphodiesterase-1b deletion confers depression-like behavioral resistance separate from stress-related effects in mice

(2017) J. R. Hufgard et al.   GENES BRAIN AND BEHAVIOR

Discovery of Selective Phosphodiesterase 1 Inhibitors with Memory Enhancing Properties

(2017) Brian Dyck et al.   JOURNAL OF MEDICINAL CHEMISTRY

The PDE4 inhibitor roflumilast improves memory in rodents at non-emetic doses

(2016) Tim Vanmierlo et al.   BEHAVIOURAL BRAIN RESEARCH

Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases

(2016) Peng Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory

(2016) R. Havekes et al.   JOURNAL OF NEUROSCIENCE

Locus coeruleus and dopaminergic consolidation of everyday memory

(2016) Tomonori Takeuchi et al.   NATURE

Dopamine release from the locus coeruleus to the dorsal hippocampus promotes spatial learning and memory

(2016) Kimberly A. Kempadoo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preclinical profile of ITI-214, an inhibitor of phosphodiesterase 1, for enhancement of memory performance in rats

(2016) Gretchen L. Snyder et al.   PSYCHOPHARMACOLOGY

Advances in targeting cyclic nucleotide phosphodiesterases

(2014) Donald H. Maurice et al.   NATURE REVIEWS DRUG DISCOVERY

The PDE4 Inhibitor HT-0712 Improves Hippocampus-Dependent Memory in Aged Mice

(2014) Marco Peters et al.   NEUROPSYCHOPHARMACOLOGY

Effects of the D1 Dopamine Receptor Agonist Dihydrexidine (DAR-0100A) on Working Memory in Schizotypal Personality Disorder

(2014) Daniel R Rosell et al.   NEUROPSYCHOPHARMACOLOGY

Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders

(2012) Mazen A Kheirbek et al.   NATURE NEUROSCIENCE

Predicting the emetic liability of novel chemical entities: a comparative study

(2011) Nathalie Percie du Sert et al.   BRITISH JOURNAL OF PHARMACOLOGY

Phosphodiesterase-4D Knock-Out and RNA Interference-Mediated Knock-Down Enhance Memory and Increase Hippocampal Neurogenesis via Increased cAMP Signaling

(2011) Y.-F. Li et al.   JOURNAL OF NEUROSCIENCE

Phosphodiesterase 4 inhibition enhances the dopamine D1 receptor/PKA/DARPP-32 signaling cascade in frontal cortex

(2011) Mahomi Kuroiwa et al.   PSYCHOPHARMACOLOGY

Neuronal Calcium Homeostasis and Dysregulation

(2010) Marc Gleichmann et al.   ANTIOXIDANTS & REDOX SIGNALING

Phosphodiesterase Inhibitors as Potential Cognition Enhancing Agents

(2010) Christopher Schmidt   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Dopamine and Memory: Modulation of the Persistence of Memory for Novel Hippocampal NMDA Receptor-Dependent Paired Associates

(2010) I. Bethus et al.   JOURNAL OF NEUROSCIENCE

Advanced Research on Dopamine Signaling to Develop Drugs for the Treatment of Mental Disorders: Biochemical and Behavioral Profiles of Phosphodiesterase Inhibition in Dopaminergic Neurotransmission

(2010) Akinori Nishi et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Vinpocetine inhibits NF- B-dependent inflammation via an IKK-dependent but PDE-independent mechanism

(2010) K.-I. Jeon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunohistochemical Localization of Phosphodiesterase 2A in Multiple Mammalian Species

(2009) Diane T. Stephenson et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Sleep deprivation impairs cAMP signalling in the hippocampus

(2009) Christopher G. Vecsey et al.   NATURE

Dopamine Controls Persistence of Long-Term Memory Storage

(2009) J. I. Rossato et al.   SCIENCE

Enhanced long-term potentiation and impaired learning in phosphodiesterase 4D-knockout (PDE4D−/−) mice

(2008) Kris Rutten et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Computational models of schizophrenia and dopamine modulation in the prefrontal cortex

(2008) Edmund T. Rolls et al.   NATURE REVIEWS NEUROSCIENCE