Activation of the NLRP3 Inflammasome Is Associated with Valosin-Containing Protein Myopathy

Multiple inflammasome complexes are activated in autistic spectrum disorders

(2016) Marina Saresella et al.   BRAIN BEHAVIOR AND IMMUNITY

Metaflammasome components in the human brain: a role in dementia with Alzheimer's pathology?

(2016) Mariko Taga et al.   BRAIN PATHOLOGY

Inflammasome Involvement in Alzheimer’s Disease

(2016) Ingar Olsen et al.   JOURNAL OF ALZHEIMERS DISEASE

Activation of phagocytic activity in astrocytes by reduced expression of the inflammasome component ASC and its implication in a mouse model of Alzheimer disease

(2016) Julien Couturier et al.   Journal of Neuroinflammation

The Inflammasomes and Autoinflammatory Syndromes

(2015) Lori Broderick et al.   Annual Review of Pathology-Mechanisms of Disease

A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation

(2015) Jonathan L. Schmid-Burgk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice

(2015) David P. Sester et al.   JOURNAL OF IMMUNOLOGY

The pathogenic role of the inflammasome in neurodegenerative diseases

(2015) Leslie C. Freeman et al.   JOURNAL OF NEUROCHEMISTRY

Daily heat stress treatment rescues denervation-activated mitochondrial clearance and atrophy in skeletal muscle

(2015) Yuki Tamura et al.   JOURNAL OF PHYSIOLOGY-LONDON

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Physical Training Regulates Mitochondrial Parameters and Neuroinflammatory Mechanisms in an Experimental Model of Parkinson’s Disease

(2015) Talita Tuon et al.   Oxidative Medicine and Cellular Longevity

Mechanisms of inflammasome activation: recent advances and novel insights

(2015) Sivapriya K. Vanaja et al.   TRENDS IN CELL BIOLOGY

The Nlrp3 inflammasome admits defeat

(2015) Christina J. Groß et al.   TRENDS IN IMMUNOLOGY

NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases

(2015) Amna Abderrazak et al.   Redox Biology

Myogenic Precursors from iPS Cells for Skeletal Muscle Cell Replacement Therapy

(2015) Isart Roca et al.   Journal of Clinical Medicine

Rapamycin and Chloroquine: The In Vitro and In Vivo Effects of Autophagy-Modifying Drugs Show Promising Results in Valosin Containing Protein Multisystem Proteinopathy

(2015) Angèle Nalbandian et al.   PLoS One

Mechanistic Effects of IVIg in Neuroinflammatory Diseases: Conclusions Based on Clinicopathologic Correlations

(2014) Marinos C. Dalakas   JOURNAL OF CLINICAL IMMUNOLOGY

A Novel Flow Cytometric Method To Assess Inflammasome Formation

(2014) David P. Sester et al.   JOURNAL OF IMMUNOLOGY

Inflammasomes in neuroinflammation and changes in brain function: a focused review

(2014) Gaurav Singhal et al.   Frontiers in Neuroscience

Adaptive changes in autophagy after UPS impairment in Parkinson's disease

(2013) Yu-fei Shen et al.   ACTA PHARMACOLOGICA SINICA

Cytokine Profiling in Patients with VCP-Associated Disease

(2013) Eric Dec et al.   CTS-Clinical and Translational Science

Lipid-enriched diet rescues lethality and slows down progression in a murine model of VCP-associated disease

(2013) Katrina J. Llewellyn et al.   HUMAN MOLECULAR GENETICS

Regulation of Akt-mTOR, ubiquitin-proteasome and autophagy-lysosome pathways in response to formoterol administration in rat skeletal muscle

(2013) Olivier Roger Joassard et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

NLRP3 polymorphisms are associated with late-onset Alzheimer's disease in Han Chinese

(2013) Meng-Shan Tan et al.   JOURNAL OF NEUROIMMUNOLOGY

The NLRP3 Inflammasome in Alzheimer’s Disease

(2013) Meng-Shan Tan et al.   MOLECULAR NEUROBIOLOGY

Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function

(2013) Anna Sokolovska et al.   NATURE IMMUNOLOGY

Exercise Training Reverses Skeletal Muscle Atrophy in an Experimental Model of VCP Disease

(2013) Angèle Nalbandian et al.   PLoS One

Measuring the Strength of Mice

(2013) Robert M.J. Deacon   Jove-Journal of Visualized Experiments

Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-43

(2012) Azusa Uchida et al.   BRAIN

Nitric oxide stress in sporadic inclusion body myositis muscle fibres: inhibition of inducible nitric oxide synthase prevents interleukin-1β-induced accumulation of β-amyloid and cell death

(2012) Jens Schmidt et al.   BRAIN

TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria

(2012) Vijay A.K. Rathinam et al.   CELL

A progressive translational mouse model of human valosin-containing protein disease: TheVCPR155H/+mouse

(2012) Angèle Nalbandian et al.   MUSCLE & NERVE

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

The Homozygote VCPR155H/R155H Mouse Model Exhibits Accelerated Human VCP-Associated Disease Pathology

(2012) Angèle Nalbandian et al.   PLoS One

Heightened inflammasome activation is linked to age-related cognitive impairment in Fischer 344 rats

(2011) Lana J Mawhinney et al.   BMC NEUROSCIENCE

Generation of skeletal muscle cells from embryonic and induced pluripotent stem cells as anin vitromodel and for therapy of muscular dystrophies

(2011) Sabrina Salani et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

(2011) Yue Zhao et al.   NATURE

On the development of markers for pathological TDP-43 in amyotrophic lateral sclerosis with and without dementia

(2011) F. Geser et al.   PROGRESS IN NEUROBIOLOGY

NLRP3 inflammasomes link inflammation and metabolic disease

(2011) Dominic De Nardo et al.   TRENDS IN IMMUNOLOGY

Inflammasome Up-Regulation and Activation in Dysferlin-Deficient Skeletal Muscle

(2010) Rashmi Rawat et al.   AMERICAN JOURNAL OF PATHOLOGY

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Inflammasomes: current understanding and open questions

(2010) Franz Bauernfeind et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The NLRP3 inflammasome, a target for therapy in diverse disease states

(2010) Graham P. Cook et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Pore Formation Triggered by Legionella spp. Is an Nlrc4 Inflammasome-Dependent Host Cell Response That Precedes Pyroptosis

(2010) T. N. Silveira et al.   INFECTION AND IMMUNITY

VCP Associated Inclusion Body Myopathy and Paget Disease of Bone Knock-In Mouse Model Exhibits Tissue Pathology Typical of Human Disease

(2010) Mallikarjun Badadani et al.   PLoS One

TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration

(2010) Hans Wils et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome

(2010) E. A. Miao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

(2010) K. Schroder et al.   SCIENCE

A genital tract peptide epitope vaccine targeting TLR-2 efficiently induces local and systemic CD8+ T cells and protects against herpes simplex virus type 2 challenge

(2009) X Zhang et al.   Mucosal Immunology

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

The NLRP3 inflammasome: A sensor of immune danger signals

(2009) Suzanne L. Cassel et al.   SEMINARS IN IMMUNOLOGY

Caspase-7 Activation by the Nlrc4/Ipaf Inflammasome Restricts Legionella pneumophila Infection

(2009) Anwari Akhter et al.   PLoS Pathogens

Clinical studies in familial VCP myopathy associated with Paget disease of bone and frontotemporal dementia

(2008) Virginia. E. Kimonis et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

VCP disease associated with myopathy, Paget disease of bone and frontotemporal dementia: Review of a unique disorder

(2008) Virginia E. Kimonis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Interrelation of inflammation and APP in sIBM: IL-1β induces accumulation of β-amyloid in skeletal muscle

(2008) Jens Schmidt et al.   BRAIN

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY