Article
Biochemistry & Molecular Biology
Rachel C. Knopp, Kristen K. Baumann, Miranda L. Wilson, William A. Banks, Michelle A. Erickson
Summary: The study found that amyloid beta pathology associated with Alzheimer's disease exacerbates the neuroinflammatory response to systemic inflammatory insult. Selective regulation of cytokines by amyloid beta was identified, and it suggests that amyloid beta pathology could contribute to worse outcomes following systemic inflammatory insult.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Anna Sulatskaya, Anastasiia O. Kosolapova, Alexander G. Bobylev, Mikhail Belousov, Kirill S. Antonets, Maksim Sulatsky, Irina M. Kuznetsova, Konstantin K. Turoverov, Olesya Stepanenko, Anton A. Nizhnikov
Summary: Both amyloids and beta-barrel proteins have beta-sheet-rich structures, with the latter being able to form functional amyloids in vivo. These beta-barrel amyloid proteins can interact with each other and form toxic oligomers, potentially contributing to the development of amyloidoses. Rapidly growing discoveries suggest that the number and diversity of functions of amyloid-forming beta-barrel proteins are significantly greater than currently understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Ze Chen, Thea Laurentius, Yvonne Fait, Aline Mueller, Eva Mueckter, Leo Cornelius Bollheimer, Mahtab Nourbakhsh
Summary: Sarcopenia, characterized by muscle loss, can be diagnosed by measuring appendicular skeletal muscle index (ASMI). A study on older adults found positive correlations between ASMI and nutritional status (p = 0.001) and serum creatine kinase (CK) (p = 0.019), but negative correlations with serum CXCL12a (p = 0.023) and interleukin (IL)-7 (p = 0.024). The study identified advanced age, malnutrition, low CK levels, and high CXCL12a levels as risk factors for sarcopenia. Combining low CK and high CXCL12a levels can be used as serum markers for sarcopenia. The linear correlation between ASMI and CXCL12a levels may aid future studies on sarcopenia.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Alexander G. Bobylev, Elmira Yakupova, Liya G. Bobyleva, Nikolay Molochkov, Alexander A. Timchenko, Maria A. Timchenko, Hiroshi Kihara, Alexey D. Nikulin, Azat G. Gabdulkhakov, Tatiana N. Melnik, Nikita Penkov, Michail Y. Lobanov, Alexey S. Kazakov, Miklos Kellermayer, Zsolt Martonfalvi, Oxana Galzitskaya, Ivan M. Vikhlyantsev
Summary: The giant protein titin, found in striated and smooth muscles, undergoes nonspecific amyloid aggregation in vitro. The high-molecular-weight isoform of chicken smooth-muscle titin forms amorphous amyloid aggregates with a quaternary cross-beta structure. These aggregates do not affect the secondary structure of the protein and can partially disaggregate at higher ionic strengths. This study suggests that specific domains/segments of titin are involved in the amyloid aggregation process. Understanding amyloidogenesis could be expanded by studying titin as an object of interest.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Hiba Hasan, Sudhanshu Bhushan, Monika Fijak, Andreas Meinhardt
Summary: Infection and inflammation are relevant factors that can lead to male reproductive disorders, causing damage to the testis and affecting spermatogenesis and steroidogenesis. Increased levels of oxidative stress and pro-inflammatory cytokines negatively impact germ cells. The activation of inflammatory pathways is a common feature in male testicular disorders beyond established infectious/inflammatory cues.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alexander G. Bobylev, Roman S. Fadeev, Liya G. Bobyleva, Margarita I. Kobyakova, Yuri M. Shlyapnikov, Daniil V. Popov, Ivan M. Vikhlyantsev
Summary: The study found that amyloid aggregates of smooth-muscle titin can impair cell adhesion and lead to cell death. The surface roughness may be a key factor contributing to the highly antiadhesive properties. The negative impact of amyloid aggregates on cell adhesion is likely intrinsic to other amyloid proteins with similar structure and properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Eunbi Cho, Kumju Youn, Huiyoung Kwon, Jieun Jeon, Wan-Seob Cho, Se Jin Park, Seung Hwan Son, Dae Sik Jang, Chan Young Shin, Minho Moon, Mira Jun, Nam-Jung Kim, Dong Hyun Kim
Summary: This study investigated the effects of eugenitol in an AD mouse model and found that it inhibits the formation of A beta plaques and reduces neuronal cell death. In silico docking simulation showed that eugenitol may interact with A beta monomers and fibrils.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Immunology
Priscilla Vilela dos Santos, Debora Nonato Miranda de Toledo, Debora Maria Soares de Souza, Tatiana Prata Menezes, Luiza Oliveira Perucci, Zolder Marinho Silva, Daniela Caldas Teixeira, Ed Wilson Rodrigues Vieira, Valter Ferreira de Andrade-Neto, Nathalia Sernizon Guimaraes, Andre Talvani
Summary: This study evaluated the available information on inflammatory and regulatory plasma mediators in pregnant women diagnosed with toxoplasmosis. Eight studies were included in the analysis, and the results showed that infected pregnant women had higher levels of IL-5, IL-6, IL-8, IL-17, CCL5, and IL-10 in their plasma. These findings suggest that the immune status of pregnant women determines the course of T. gondii infection, and the balance between inflammatory and regulatory cytokines mitigates the adverse effects on the placenta and fetus.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Vilim Molnar, Vid Matisic, Ivan Kodvanj, Roko Bjelica, Zeljko Jelec, Damir Hudetz, Eduard Rod, Fabijan Cukelj, Trpimir Vrdoljak, Dinko Vidovic, Mario Staresinic, Srecko Sabalic, Borut Dobricic, Tadija Petrovic, Darko Anticevic, Igor Boric, Rok Kosir, Ursula Prosenc Zmrzljak, Dragan Primorac
Summary: Osteoarthritis is a common cause of disability worldwide, affecting all joint tissues equally. The pathogenesis involves low-grade inflammation leading to an imbalance between anabolic and catabolic processes. The complex network of cytokines regulating these processes plays a central role in the development and progression of osteoarthritis, with concentrations of proinflammatory and anti-inflammatory cytokines varying based on disease stage and activity levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Rheumatology
Akihiro Kimura, Takeshi Takagi, Thiprampai Thamamongood, Satoshi Sakamoto, Takumi Ito, Iwao Seki, Masahiro Okamoto, Hiroyuki Aono, Satoshi Serada, Tetsuji Naka, Hiroaki Imataka, Kensuke Miyake, Takuya Ueda, Miki Miyanokoshi, Keisuke Wakasugi, Noriko Iwamoto, Norio Ohmagari, Takahiro Iguchi, Takeshi Nitta, Hiroshi Takayanagi, Hiroyuki Yamashita, Hiroshi Kaneko, Haruka Tsuchiya, Keishi Fujio, Hiroshi Handa, Harumi Suzuki
Summary: This study demonstrates that extracellular aaRSs play a significant role in the pathogenesis of rheumatoid arthritis (RA). These aaRSs induce pro-inflammatory cytokines and PAD4 release, leading to the development of inflammatory responses and citrullination. Inhibition of aaRSs can alleviate arthritic symptoms in a mouse RA model, suggesting their potential as antirheumatic drugs.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Antonio J. Figueira, Guilherme G. Moreira, Joana Saavedra, Isabel Cardoso, Claudio M. Gomes
Summary: The hallmark of Alzheimer's disease (AD) includes the aggregation of amyloid-beta (A beta), tau, and neuroinflammation. In this study, the researchers found that S100B protein, which is upregulated in AD, can inhibit the aggregation of A beta 42, and this activity is dependent on Ca2+ binding. They also discovered that S100B exists in tetrameric form, and tetrameric S100B is more effective in inhibiting A beta 42 aggregation. These findings highlight the importance of S100B protein in regulating AD proteotoxicity.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
David M. M. Cauvi, Dennis Hawisher, Julia Derunes, Antonio De Maio
Summary: Phospholipids play important roles in cellular membranes, vesicles, and lipid nanoparticles. The presence of phospholipids can alter the transcriptome and proteome of cells, as well as modulate signaling pathways, leading to changes in cellular functions.
Article
Chemistry, Physical
Miaomiao Liu, Wenjuan Wang, Xiuping Hao, Xiaoyan Dong
Summary: Alzheimer's disease and type 2 diabetes mellitus show extensive correlation through cross-aggregation between related pathogenic peptides. This study investigates the cross-amyloid aggregation process of amyloid beta protein (A beta) and human islet amyloid polypeptide (hIAPP). The presence of seeds significantly changes the aggregation pathway, forming heterogeneous aggregates with increased cytotoxicity. Both solution and solid surface results demonstrate that seeds can induce rapid aggregation and promote the aggregation of heterogeneous monomers.
ACTA PHYSICO-CHIMICA SINICA
(2022)
Article
Veterinary Sciences
Garrett J. Mullenix, Elizabeth S. Greene, Nima K. Emami, Guillermo Tellez-Isaias, Walter G. Bottje, Gisela F. Erf, Michael T. Kidd, Sami Dridi
Summary: The study demonstrates that the inclusion of Spirulina can reduce systemic inflammation and bacterial translocation induced by a low protein diet, making it a promising alternative protein source in poultry diets.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Review
Immunology
Tong Yue, Yu Shi, Sihui Luo, Jianping Weng, Yali Wu, Xueying Zheng
Summary: Diabetic retinopathy is a common complication of diabetes mellitus that is largely driven by inflammation. Understanding and elucidating the inflammation-related mechanisms is crucial for prevention and management of diabetic retinopathy.
FRONTIERS IN IMMUNOLOGY
(2022)