标题
Identification of neoantigens for individualized therapeutic cancer vaccines
作者
关键词
-
出版物
NATURE REVIEWS DRUG DISCOVERY
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2022-02-01
DOI
10.1038/s41573-021-00387-y
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma
- (2021) Zhuting Hu et al. NATURE MEDICINE
- Advances in the development of personalized neoantigen-based therapeutic cancer vaccines
- (2021) Eryn Blass et al. Nature Reviews Clinical Oncology
- Neoantigen vaccine platforms in clinical development: understanding the future of personalized immunotherapy
- (2021) Suangson Supabphol et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses
- (2021) Jennifer A. Lo et al. Science Translational Medicine
- Low immunogenicity of common cancer hot spot mutations resulting in false immunogenic selection signals
- (2021) Arne Claeys et al. PLoS Genetics
- Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes
- (2021) Grégory Ehx et al. IMMUNITY
- Splicing patterns in SF3B1 mutated uveal melanoma generate shared immunogenic tumor-specific neo-epitopes
- (2021) Jeremy Bigot et al. Cancer Discovery
- Antigen Experienced T Cells from Peripheral Blood Recognize p53 Neoantigens
- (2020) Parisa Malekzadeh et al. CLINICAL CANCER RESEARCH
- Pan-cancer analysis of whole genomes
- (2020) NATURE
- Patterns of somatic structural variation in human cancer genomes
- (2020) Yilong Li et al. NATURE
- dbPepNeo: a manually curated database for human tumor neoantigen peptides
- (2020) Xiaoxiu Tan et al. Database-The Journal of Biological Databases and Curation
- Tumor neoantigenicity assessment with CSiN score incorporates clonality and immunogenicity to predict immunotherapy outcomes
- (2020) Tianshi Lu et al. Science Immunology
- The role of antigen-spreading in the efficacy of immunotherapies
- (2020) Peter Brossart CLINICAL CANCER RESEARCH
- Neoantigen responses, immune correlates, and favorable outcomes after ipilimumab treatment of patients with prostate cancer
- (2020) Sumit K. Subudhi et al. Science Translational Medicine
- MHC-I genotype and tumor mutational burden predict response to immunotherapy
- (2020) Aaron M. Goodman et al. Genome Medicine
- Visualizing Synaptic Transfer of Tumor Antigens among Dendritic Cells
- (2020) Megan K. Ruhland et al. CANCER CELL
- A genetic vaccine encoding shared cancer neoantigens to treat tumors with Microsatellite Instability.
- (2020) Guido Leoni et al. CANCER RESEARCH
- Intratumoral CD4+ T Cells Mediate Anti-tumor Cytotoxicity in Human Bladder Cancer
- (2020) David Y. Oh et al. CELL
- Breakthrough concepts in immune‐oncology: Cancer vaccines at the bedside
- (2020) Sohini Roy et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Escape from nonsense-mediated decay associates with anti-tumor immunogenicity
- (2020) Kevin Litchfield et al. Nature Communications
- Fc Gamma Receptors and Their Role in Antigen Uptake, Presentation, and T Cell Activation
- (2020) Fabian Junker et al. Frontiers in Immunology
- Commensal bacteria stimulate antitumor responses via T cell cross-reactivity
- (2020) Catherine A. Bessell et al. JCI Insight
- Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction
- (2020) Daniel K. Wells et al. CELL
- A Phase Ib Trial of Personalized Neoantigen Therapy Plus Anti-PD-1 in Patients with Advanced Melanoma, Non-small Cell Lung Cancer, or Bladder Cancer
- (2020) Patrick A. Ott et al. CELL
- Structural dissimilarity from self drives neoepitope escape from immune tolerance
- (2020) Jason R. Devlin et al. Nature Chemical Biology
- Shared Immunogenic Poly-Epitope Frameshift Mutations in Microsatellite Unstable Tumors
- (2020) Vladimir Roudko et al. CELL
- TCR Recognition of Peptide–MHC-I: Rule Makers and Breakers
- (2020) Christopher Szeto et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The Roles of Initiating Truncal Mutations in Human Cancers: The Order of Mutations and Tumor Cell Type Matters
- (2019) Arnold J. Levine et al. CANCER CELL
- Mutated nucleophosmin 1 as immunotherapy target in acute myeloid leukemia
- (2019) Dyantha I. van der Lee et al. JOURNAL OF CLINICAL INVESTIGATION
- Tumor mutational load predicts survival after immunotherapy across multiple cancer types
- (2019) Robert M. Samstein et al. NATURE GENETICS
- Turning the corner on therapeutic cancer vaccines
- (2019) Robert E. Hollingsworth et al. npj Vaccines
- A Synthetic DNA, Multi-Neoantigen Vaccine Drives Predominately MHC Class I CD8+ T-cell Responses, Impacting Tumor Challenge
- (2019) Elizabeth K. Duperret et al. Cancer Immunology Research
- Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal Cancer
- (2019) Winifred Lo et al. Cancer Immunology Research
- Memory T cells targeting oncogenic mutations detected in peripheral blood of epithelial cancer patients
- (2019) Gal Cafri et al. Nature Communications
- Neoantigen-directed immune escape in lung cancer evolution
- (2019) Rachel Rosenthal et al. NATURE
- Poly-specific neoantigen-targeted cancer vaccines delay patient derived tumor growth
- (2019) Luigi Aurisicchio et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Harnessing Tumor Mutations for Truly Individualized Cancer Vaccines
- (2019) Mathias Vormehr et al. Annual Review of Medicine
- Neoantigen identification strategies enable personalized immunotherapy in refractory solid tumors
- (2019) Fangjun Chen et al. JOURNAL OF CLINICAL INVESTIGATION
- Immunogenic neoantigens derived from gene fusions stimulate T cell responses
- (2019) Wei Yang et al. NATURE MEDICINE
- Induction of neoantigen-reactive T cells from healthy donors
- (2019) Muhammad Ali et al. Nature Protocols
- Deep learning: new computational modelling techniques for genomics
- (2019) Gökcen Eraslan et al. NATURE REVIEWS GENETICS
- Level of neo-epitope predecessor and mutation type determine T cell activation of MHC binding peptides
- (2019) Hanan Besser et al. Journal for ImmunoTherapy of Cancer
- MHCSeqNet: a deep neural network model for universal MHC binding prediction
- (2019) Poomarin Phloyphisut et al. BMC BIOINFORMATICS
- Pediatric patients with acute lymphoblastic leukemia generate abundant and functional neoantigen-specific CD8+ T cell responses
- (2019) Anthony E. Zamora et al. Science Translational Medicine
- Adenoviral vaccine targeting multiple neoantigens as strategy to eradicate large tumors combined with checkpoint blockade
- (2019) Anna Morena D’Alise et al. Nature Communications
- Immune Checkpoint Blockade Enhances Shared Neoantigen-Induced T Cell Immunity Directed against Mutated Calreticulin in Myeloproliferative Neoplasms
- (2019) Cansu Cimen Bozkus et al. Cancer Discovery
- Unique Neoantigens Arise from Somatic Mutations in Patients with Gastrointestinal Cancers
- (2019) Maria R. Parkhurst et al. Cancer Discovery
- Efficient Tumor Clearance and Diversified Immunity through Neoepitope Vaccines and Combinatorial Immunotherapy
- (2019) Karin L. Lee et al. Cancer Immunology Research
- Quantitative Prediction of the Landscape of T Cell Epitope Immunogenicity in Sequence Space
- (2019) Masato Ogishi et al. Frontiers in Immunology
- Determinants for Neoantigen Identification
- (2019) Andrea Garcia-Garijo et al. Frontiers in Immunology
- Defining HLA-II Ligand Processing and Binding Rules with Mass Spectrometry Enhances Cancer Epitope Prediction
- (2019) Jennifer G. Abelin et al. IMMUNITY
- Neoantigen quality, not quantity
- (2019) Nicholas McGranahan et al. Science Translational Medicine
- Machine-Learning Prediction of Tumor Antigen Immunogenicity in the Selection of Therapeutic Epitopes
- (2019) Christof C. Smith et al. Cancer Immunology Research
- T-Cell Receptor Cognate Target Prediction Based on Paired α and β Chain Sequence and Structural CDR Loop Similarities
- (2019) Esteban Lanzarotti et al. Frontiers in Immunology
- Structure Based Prediction of Neoantigen Immunogenicity
- (2019) Timothy P. Riley et al. Frontiers in Immunology
- MHC-II neoantigens shape tumour immunity and response to immunotherapy
- (2019) Elise Alspach et al. NATURE
- Predicting HLA class II antigen presentation through integrated deep learning
- (2019) Binbin Chen et al. NATURE BIOTECHNOLOGY
- Robust prediction of HLA class II epitopes by deep motif deconvolution of immunopeptidomes
- (2019) Julien Racle et al. NATURE BIOTECHNOLOGY
- Lack of detectable neoantigen depletion signals in the untreated cancer genome
- (2019) Jimmy Van den Eynden et al. NATURE GENETICS
- DeepHLApan: A Deep Learning Approach for Neoantigen Prediction Considering Both HLA-Peptide Binding and Immunogenicity
- (2019) Jingcheng Wu et al. Frontiers in Immunology
- Neoantigen Dissimilarity to the Self-Proteome Predicts Immunogenicity and Response to Immune Checkpoint Blockade
- (2019) Lee P. Richman et al. Cell Systems
- IDENTIFICATION OF MHC PEPTIDES USING MASS SPECTROMETRY FOR NEOANTIGEN DISCOVERY AND CANCER VACCINE DEVELOPMENT
- (2019) Rui Chen et al. MASS SPECTROMETRY REVIEWS
- A large peptidome dataset improves HLA class I epitope prediction across most of the human population
- (2019) Siranush Sarkizova et al. NATURE BIOTECHNOLOGY
- Dectin-1 Binding to Annexins on Apoptotic Cells Induces Peripheral Immune Tolerance via NADPH Oxidase-2
- (2019) Kevin Bode et al. Cell Reports
- Fusion genes: A promising tool combating against cancer
- (2018) Xiaofeng Dai et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Decentralised manufacturing of cell and gene therapy products: Learning from other healthcare sectors
- (2018) Richard P. Harrison et al. BIOTECHNOLOGY ADVANCES
- SvABA: genome-wide detection of structural variants and indels by local assembly
- (2018) Jeremiah A. Wala et al. GENOME RESEARCH
- Improved methods for predicting peptide binding affinity to MHC class II molecules
- (2018) Kamilla Kjaergaard Jensen et al. IMMUNOLOGY
- Tumor-infiltrating BRAFV600E-specific CD4+ T cells correlated with complete clinical response in melanoma
- (2018) Joshua R. Veatch et al. JOURNAL OF CLINICAL INVESTIGATION
- An Efficient Single-Cell RNA-Seq Approach to Identify Neoantigen-Specific T Cell Receptors
- (2018) Yong-Chen Lu et al. MOLECULAR THERAPY
- Strelka2: fast and accurate calling of germline and somatic variants
- (2018) Sangtae Kim et al. NATURE METHODS
- Personalized vaccines for cancer immunotherapy
- (2018) Ugur Sahin et al. SCIENCE
- Sensitive and frequent identification of high avidity neo-epitope specific CD8+ T cells in immunotherapy-naive ovarian cancer
- (2018) Sara Bobisse et al. Nature Communications
- Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution
- (2018) Mirjana Efremova et al. Nature Communications
- Systematic Analysis of Splice-Site-Creating Mutations in Cancer
- (2018) Reyka G. Jayasinghe et al. Cell Reports
- Driver Fusions and Their Implications in the Development and Treatment of Human Cancers
- (2018) Qingsong Gao et al. Cell Reports
- Tumor Immunity and Survival as a Function of Alternative Neopeptides in Human Cancer
- (2018) Andrew J. Rech et al. Cancer Immunology Research
- Computational Pipeline for the PGV-001 Neoantigen Vaccine Trial
- (2018) Alex Rubinsteyn et al. Frontiers in Immunology
- MHCflurry: Open-Source Class I MHC Binding Affinity Prediction
- (2018) Timothy J. O'Donnell et al. Cell Systems
- Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients
- (2018) André Kahles et al. CANCER CELL
- Evolutionary Pressure against MHC Class II Binding Cancer Mutations
- (2018) Rachel Marty et al. CELL
- Intron retention is a source of neoepitopes in cancer
- (2018) Alicia C Smart et al. NATURE BIOTECHNOLOGY
- Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors
- (2018) Diana Miao et al. NATURE GENETICS
- Predicting Antigen Presentation—What Could We Learn From a Million Peptides?
- (2018) David Gfeller et al. Frontiers in Immunology
- Multiregion Sequencing Reveals the Genetic Heterogeneity and Evolutionary History of Osteosarcoma and Matched Pulmonary Metastases
- (2018) Di Wang et al. CANCER RESEARCH
- Evolution of Metastases in Space and Time under Immune Selection
- (2018) Mihaela Angelova et al. CELL
- The Length Distribution and Multiple Specificity of Naturally Presented HLA-I Ligands
- (2018) David Gfeller et al. JOURNAL OF IMMUNOLOGY
- Actively personalized vaccination trial for newly diagnosed glioblastoma
- (2018) Norbert Hilf et al. NATURE
- Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial
- (2018) Derin B. Keskin et al. NATURE
- Deep learning using tumor HLA peptide mass spectrometry datasets improves neoantigen identification
- (2018) Brendan Bulik-Sullivan et al. NATURE BIOTECHNOLOGY
- A primer on deep learning in genomics
- (2018) James Zou et al. NATURE GENETICS
- A guide to deep learning in healthcare
- (2018) Andre Esteva et al. NATURE MEDICINE
- COSMIC: the Catalogue Of Somatic Mutations In Cancer
- (2018) John G Tate et al. NUCLEIC ACIDS RESEARCH
- Sources of erroneous sequences and artifact chimeric reads in next generation sequencing of genomic DNA from formalin-fixed paraffin-embedded samples
- (2018) Simon Haile et al. NUCLEIC ACIDS RESEARCH
- Deep multi-region whole-genome sequencing reveals heterogeneity and gene-by-environment interactions in treatment-naive, metastatic lung cancer
- (2018) Tracy L. Leong et al. ONCOGENE
- Noncoding regions are the main source of targetable tumor-specific antigens
- (2018) Céline M. Laumont et al. Science Translational Medicine
- Rejection of immunogenic tumor clones is limited by clonal fraction
- (2018) Ron S Gejman et al. eLife
- High-Throughput Stability Screening of Neoantigen/HLA Complexes Improves Immunogenicity Predictions
- (2018) Dylan T. Blaha et al. Cancer Immunology Research
- Active learning for computational chemogenomics
- (2017) Daniel Reker et al. Future Medicinal Chemistry
- Mass Spectrometry Profiling of HLA-Associated Peptidomes in Mono-allelic Cells Enables More Accurate Epitope Prediction
- (2017) Jennifer G. Abelin et al. IMMUNITY
- Novel and shared neoantigen derived from histone 3 variant H3.3K27M mutation for glioma T cell therapy
- (2017) Zinal S. Chheda et al. JOURNAL OF EXPERIMENTAL MEDICINE
- NetMHCpan-4.0: Improved Peptide–MHC Class I Interaction Predictions Integrating Eluted Ligand and Peptide Binding Affinity Data
- (2017) Vanessa Jurtz et al. JOURNAL OF IMMUNOLOGY
- Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis
- (2017) Samra Turajlic et al. LANCET ONCOLOGY
- The identification of challenges in tissue collection for biomarker studies: the Q-CROC-03 neoadjuvant breast cancer translational trial experience
- (2017) Adriana Aguilar-Mahecha et al. MODERN PATHOLOGY
- Integrative clinical genomics of metastatic cancer
- (2017) Dan R. Robinson et al. NATURE
- Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer
- (2017) Ugur Sahin et al. NATURE
- Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer
- (2017) Vinod P. Balachandran et al. NATURE
- A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy
- (2017) Marta Łuksza et al. NATURE
- Elements of cancer immunity and the cancer–immune set point
- (2017) Daniel S. Chen et al. NATURE
- An immunogenic personal neoantigen vaccine for patients with melanoma
- (2017) Patrick A. Ott et al. NATURE
- Tumour heterogeneity and resistance to cancer therapies
- (2017) Ibiayi Dagogo-Jack et al. Nature Reviews Clinical Oncology
- Tracking the Evolution of Non–Small-Cell Lung Cancer
- (2017) Mariam Jamal-Hanjani et al. NEW ENGLAND JOURNAL OF MEDICINE
- Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade
- (2017) Dung T. Le et al. SCIENCE
- Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy
- (2017) Diego Chowell et al. SCIENCE
- Resistance to checkpoint blockade therapy through inactivation of antigen presentation
- (2017) Moshe Sade-Feldman et al. Nature Communications
- Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade
- (2017) Pornpimol Charoentong et al. Cell Reports
- Deciphering HLA-I motifs across HLA peptidomes improves neo-antigen predictions and identifies allostery regulating HLA specificity
- (2017) Michal Bassani-Sternberg et al. PLoS Computational Biology
- An Analysis of Natural T Cell Responses to Predicted Tumor Neoepitopes
- (2017) Anne-Mette Bjerregaard et al. Frontiers in Immunology
- T cell therapy targeting a public neoantigen in microsatellite instable colon cancer reduces in vivo tumor growth
- (2017) Else M. Inderberg et al. OncoImmunology
- Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma
- (2016) Willy Hugo et al. CELL
- Targeting the Heterogeneity of Cancer with Individualized Neoepitope Vaccines
- (2016) O. Tu reci et al. CLINICAL CANCER RESEARCH
- Pan-Specific Prediction of Peptide–MHC Class I Complex Stability, a Correlate of T Cell Immunogenicity
- (2016) Michael Rasmussen et al. JOURNAL OF IMMUNOLOGY
- The JAK2V617F mutation is a target for specific T cells in the JAK2V617F-positive myeloproliferative neoplasms
- (2016) M O Holmström et al. LEUKEMIA
- Near-optimal probabilistic RNA-seq quantification
- (2016) Nicolas L Bray et al. NATURE BIOTECHNOLOGY
- Coming of age: ten years of next-generation sequencing technologies
- (2016) Sara Goodwin et al. NATURE REVIEWS GENETICS
- T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer
- (2016) Eric Tran et al. NEW ENGLAND JOURNAL OF MEDICINE
- Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade
- (2016) N. McGranahan et al. SCIENCE
- Targeting of cancer neoantigens with donor-derived T cell receptor repertoires
- (2016) E. Stronen et al. SCIENCE
- Evolution of Neoantigen Landscape during Immune Checkpoint Blockade in Non–Small Cell Lung Cancer
- (2016) Valsamo Anagnostou et al. Cancer Discovery
- Durable Complete Response from Metastatic Melanoma after Transfer of Autologous T Cells Recognizing 10 Mutated Tumor Antigens
- (2016) T. D. Prickett et al. Cancer Immunology Research
- Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity
- (2015) Michael S. Rooney et al. CELL
- T Cell Receptor Cross-Reactivity between Similar Foreign and Self Peptides Influences Naive Cell Population Size and Autoimmunity
- (2015) Ryan W. Nelson et al. IMMUNITY
- Modeling the Specific CD4+T Cell Response against a Tumor Neoantigen
- (2015) Héloïse Flament et al. JOURNAL OF IMMUNOLOGY
- Mass Spectrometry of Human Leukocyte Antigen Class I Peptidomes Reveals Strong Effects of Protein Abundance and Turnover on Antigen Presentation
- (2015) Michal Bassani-Sternberg et al. MOLECULAR & CELLULAR PROTEOMICS
- Mutant MHC class II epitopes drive therapeutic immune responses to cancer
- (2015) Sebastian Kreiter et al. NATURE
- Deep learning
- (2015) Yann LeCun et al. NATURE
- Gene essentiality and synthetic lethality in haploid human cells
- (2015) V. A. Blomen et al. SCIENCE
- Genomic correlates of response to CTLA-4 blockade in metastatic melanoma
- (2015) E. M. Van Allen et al. SCIENCE
- Neoantigens in cancer immunotherapy
- (2015) T. N. Schumacher et al. SCIENCE
- T cell exclusion, immune privilege, and the tumor microenvironment
- (2015) J. A. Joyce et al. SCIENCE
- Immunogenicity of somatic mutations in human gastrointestinal cancers
- (2015) E. Tran et al. SCIENCE
- A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells
- (2015) B. M. Carreno et al. SCIENCE
- Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
- (2015) N. A. Rizvi et al. SCIENCE
- Identification and characterization of essential genes in the human genome
- (2015) T. Wang et al. SCIENCE
- Clonal status of actionable driver events and the timing of mutational processes in cancer evolution
- (2015) Nicholas McGranahan et al. Science Translational Medicine
- Systematic pan-cancer analysis of tumour purity
- (2015) Dvir Aran et al. Nature Communications
- Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets
- (2015) P. K. Brastianos et al. Cancer Discovery
- Mutanome Engineered RNA Immunotherapy: Towards Patient-Centered Tumor Vaccination
- (2015) Mathias Vormehr et al. Journal of Immunology Research
- Modes of Antigen Presentation by Lymph Node Stromal Cells and Their Immunological Implications
- (2015) Sachiko Hirosue et al. Frontiers in Immunology
- The Timing of T Cell Priming and Cycling
- (2015) Reinhard Obst Frontiers in Immunology
- Deconstructing the Peptide-MHC Specificity of T Cell Recognition
- (2014) Michael E. Birnbaum et al. CELL
- NetTepi: an integrated method for the prediction of T cell epitopes
- (2014) Thomas Trolle et al. IMMUNOGENETICS
- Genomic and bioinformatic profiling of mutational neoepitopes reveals new rules to predict anticancer immunogenicity
- (2014) Fei Duan et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens
- (2014) Matthew M. Gubin et al. NATURE
- A vaccine targeting mutant IDH1 induces antitumour immunity
- (2014) Theresa Schumacher et al. NATURE
- Comprehensive characterization of complex structural variations in cancer by directly comparing genome sequence reads
- (2014) Valentí Moncunill et al. NATURE BIOTECHNOLOGY
- Integrating mapping-, assembly- and haplotype-based approaches for calling variants in clinical sequencing applications
- (2014) Andy Rimmer et al. NATURE GENETICS
- Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing
- (2014) Marco Gerlinger et al. NATURE GENETICS
- High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma
- (2014) Carsten Linnemann et al. NATURE MEDICINE
- PyClone: statistical inference of clonal population structure in cancer
- (2014) Andrew Roth et al. NATURE METHODS
- Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma
- (2014) Alexandra Snyder et al. NEW ENGLAND JOURNAL OF MEDICINE
- RADIA: RNA and DNA Integrated Analysis for Somatic Mutation Detection
- (2014) Amie J. Radenbaugh et al. PLoS One
- Cancer Immunotherapy Based on Mutation-Specific CD4+ T Cells in a Patient with Epithelial Cancer
- (2014) E. Tran et al. SCIENCE
- Anti-CTLA-4 therapy broadens the melanoma-reactive CD8+ T cell response
- (2014) P. Kvistborg et al. Science Translational Medicine
- HLA-Binding Properties of Tumor Neoepitopes in Humans
- (2014) E. F. Fritsch et al. Cancer Immunology Research
- Functional TCR Retrieval from Single Antigen-Specific Human T Cells Reveals Multiple Novel Epitopes
- (2014) P. Simon et al. Cancer Immunology Research
- Antigen mimicry between infectious agents and self or environmental antigens may lead to long-term regulation of inflammation
- (2014) Lain Pontes-de-Carvalho Frontiers in Immunology
- Oncology Meets Immunology: The Cancer-Immunity Cycle
- (2013) Daniel S. Chen et al. IMMUNITY
- NetMHCstab- predicting stability of peptide-MHC-I complexes; impacts for cytotoxic T lymphocyte epitope discovery
- (2013) Kasper W. Jørgensen et al. IMMUNOLOGY
- Tumor Exome Analysis Reveals Neoantigen-Specific T-Cell Reactivity in an Ipilimumab-Responsive Melanoma
- (2013) Nienke van Rooij et al. JOURNAL OF CLINICAL ONCOLOGY
- Mutated PPP1R3B Is Recognized by T Cells Used To Treat a Melanoma Patient Who Experienced a Durable Complete Tumor Regression
- (2013) Y.-C. Lu et al. JOURNAL OF IMMUNOLOGY
- Signatures of mutational processes in human cancer
- (2013) Ludmil B. Alexandrov et al. NATURE
- The regulatory landscape for actively personalized cancer immunotherapies
- (2013) Cedrik M Britten et al. NATURE BIOTECHNOLOGY
- Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples
- (2013) Kristian Cibulskis et al. NATURE BIOTECHNOLOGY
- High-throughput identification of antigen-specific TCRs by TCR gene capture
- (2013) Carsten Linnemann et al. NATURE MEDICINE
- Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells
- (2013) Paul F Robbins et al. NATURE MEDICINE
- Identification of a Titin-Derived HLA-A1-Presented Peptide as a Cross-Reactive Target for Engineered MAGE A3-Directed T Cells
- (2013) B. J. Cameron et al. Science Translational Medicine
- From Mouse to Human: Evolutionary Genomics Analysis of Human Orthologs of Essential Genes
- (2013) Benjamin Georgi et al. PLoS Genetics
- Immune response to mutant neo-antigens
- (2013) Rory J Geyer et al. OncoImmunology
- Strelka: accurate somatic small-variant calling from sequenced tumor–normal sample pairs
- (2012) Christopher T. Saunders et al. BIOINFORMATICS
- Exploiting the Mutanome for Tumor Vaccination
- (2012) J. C. Castle et al. CANCER RESEARCH
- Mutated BCR-ABL Generates Immunogenic T-cell Epitopes in CML Patients
- (2012) A. Cai et al. CLINICAL CANCER RESEARCH
- VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencing
- (2012) D. C. Koboldt et al. GENOME RESEARCH
- Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting
- (2012) Hirokazu Matsushita et al. NATURE
- Colocalization of Inflammatory Response with B7-H1 Expression in Human Melanocytic Lesions Supports an Adaptive Resistance Mechanism of Immune Escape
- (2012) J. M. Taube et al. Science Translational Medicine
- SomaticSniper: identification of somatic point mutations in whole genome sequencing data
- (2011) David E. Larson et al. BIOINFORMATICS
- A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides
- (2011) Linda Wooldridge et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A framework for variation discovery and genotyping using next-generation DNA sequencing data
- (2011) Mark A DePristo et al. NATURE GENETICS
- NetCTLpan: pan-specific MHC class I pathway epitope predictions
- (2010) Thomas Stranzl et al. IMMUNOGENETICS
- Naive tumor-specific CD4+T cells differentiated in vivo eradicate established melanoma
- (2010) Ying Xie et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Tumor-reactive CD4+T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts
- (2010) Sergio A. Quezada et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Mature dendritic cells use endocytic receptors to capture and present antigens
- (2010) C. D. Platt et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Accumulation of driver and passenger mutations during tumor progression
- (2010) I. Bozic et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Sequence Alignment/Map format and SAMtools
- (2009) H. Li et al. BIOINFORMATICS
- NetMHCpan, a method for MHC class I binding prediction beyond humans
- (2008) Ilka Hoof et al. IMMUNOGENETICS
- HLA antigen changes in malignant cells: epigenetic mechanisms and biologic significance
- (2008) M Campoli et al. ONCOGENE
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