The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells

Lack of Evidence of ACE2 Expression and Replicative Infection by SARSCoV-2 in Human Endothelial Cells

(2021) Ian R. McCracken et al.   CIRCULATION

Neuroinvasion of SARS-CoV-2 in human and mouse brain

(2021) Eric Song et al.   JOURNAL OF EXPERIMENTAL MEDICINE

No evidence for basigin/CD147 as a direct SARS-CoV-2 spike binding receptor

(2021) Jarrod Shilts et al.   Scientific Reports

Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system

(2021) Man Lung Yeung et al.   CELL

Susceptibility-weighted imaging reveals cerebral microvascular injury in severe COVID-19

(2021) John Conklin et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Post-acute COVID-19 syndrome

(2021) Ani Nalbandian et al.   NATURE MEDICINE

RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis

(2021) Matija Zelic et al.   Cell Reports

Processing of the SARS-CoV pp1a/ab nsp7-10 region

(2020) Boris Krichel et al.   BIOCHEMICAL JOURNAL

Evidence of SARS-CoV-2 Infection in Returning Travelers from Wuhan, China

(2020) Sebastian Hoehl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibitors Targeting RIPK1/RIPK3: Old and New Drugs

(2020) Sofie Martens et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Feline Infectious Peritonitis Virus Nsp5 Inhibits Type I Interferon Production by Cleaving NEMO at Multiple Sites

(2020) Si Chen et al.   Viruses-Basel

Neuropathology of COVID-19: a spectrum of vascular and acute disseminated encephalomyelitis (ADEM)-like pathology

(2020) R. Ross Reichard et al.   ACTA NEUROPATHOLOGICA

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Cerebral angiogenesis ameliorates pathological disorders in Nemo-deficient mice with small-vessel disease

(2020) Yun Jiang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Central Nervous System Involvement by Severe Acute Respiratory Syndrome Coronavirus ‐2 (SARS‐CoV‐2)

(2020) Alberto Paniz‐Mondolfi et al.   JOURNAL OF MEDICAL VIROLOGY

Endothelial cell infection and endotheliitis in COVID-19

(2020) Zsuzsanna Varga et al.   LANCET

Proteomics of SARS-CoV-2-infected host cells reveals therapy targets

(2020) Denisa Bojkova et al.   NATURE

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

(2020) Maximilian Ackermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neurologic Features in Severe SARS-CoV-2 Infection

(2020) Julie Helms et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multiorgan and Renal Tropism of SARS-CoV-2

(2020) Victor G. Puelles et al.   NEW ENGLAND JOURNAL OF MEDICINE

COVID-19 –associated Diffuse Leukoencephalopathy and Microhemorrhages

(2020) Alireza Radmanesh et al.   RADIOLOGY

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

(2020) Linlin Zhang et al.   SCIENCE

Microvascular injury and hypoxic damage: emerging neuropathological signatures in COVID-19

(2020) Zane Jaunmuktane et al.   ACTA NEUROPATHOLOGICA

COVID-19–Associated PRES–like Encephalopathy with Perivascular Gadolinium Enhancement

(2020) G. Conte et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

COVID ‐19: A Global Threat to the Nervous System

(2020) Igor J. Koralnik et al.   ANNALS OF NEUROLOGY

The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings

(2020) Ross W Paterson et al.   BRAIN

SARS‐CoV‐2 endothelial infection causes COVID‐19 chilblains: histopathological, immunohistochemical and ultrastructural study of seven paediatric cases

(2020) I. Colmenero et al.   BRITISH JOURNAL OF DERMATOLOGY

Interpericyte tunnelling nanotubes regulate neurovascular coupling

(2020) Luis Alarcon-Martinez et al.   NATURE

Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target

(2020) Lauren Mifflin et al.   NATURE REVIEWS DRUG DISCOVERY

Neurochemical evidence of astrocytic and neuronal injury commonly found in COVID-19

(2020) Nelly Kanberg et al.   NEUROLOGY

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

Effects of COVID-19 on the Nervous System

(2020) Costantino Iadecola et al.   CELL

Inactivation of Adeno-Associated Viral Vectors by Oxidant-Based Disinfectants

(2020) Joelle Korte et al.   HUMAN GENE THERAPY

Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans

(2020) Prabhu S. Arunachalam et al.   SCIENCE

Neuropilin-1 is a host factor for SARS-CoV-2 infection

(2020) James L. Daly et al.   SCIENCE

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

(2020) Ludovico Cantuti-Castelvetri et al.   SCIENCE

Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19

(2020) Jenny Meinhardt et al.   NATURE NEUROSCIENCE

Flow-Mediated Susceptibility and Molecular Response of Cerebral Endothelia to SARS-CoV-2 Infection

(2020) Naoki Kaneko et al.   STROKE

Brain endothelial specific gene therapy improves experimental Sandhoff disease

(2019) Godwin Dogbevia et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Blood-brain barrier dysfunction in aging induces hyperactivation of TGFβ signaling and chronic yet reversible neural dysfunction

(2019) Vladimir V. Senatorov et al.   Science Translational Medicine

Microglial control of astrocytes in response to microbial metabolites

(2018) Veit Rothhammer et al.   NATURE

RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer

(2018) Wei Wang et al.   CANCER CELL

The interplay of IKK, NF-κB and RIPK1 signaling in the regulation of cell death, tissue homeostasis and inflammation

(2017) Vangelis Kondylis et al.   IMMUNOLOGICAL REVIEWS

Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain

(2017) Blue B Lake et al.   NATURE BIOTECHNOLOGY

Porcine deltacoronavirus nsp5 inhibits interferon-β production through the cleavage of NEMO

(2017) Xinyu Zhu et al.   VIROLOGY

A Review of String Vessels or Collapsed, Empty Basement Membrane Tubes

(2017) William R. Brown   JOURNAL OF ALZHEIMERS DISEASE

A brain microvasculature endothelial cell‐specific viral vector with the potential to treat neurovascular and neurological diseases

(2016) Jakob Körbelin et al.   EMBO Molecular Medicine

Expansion microscopy with conventional antibodies and fluorescent proteins

(2016) Tyler J Chozinski et al.   NATURE METHODS

Trafficking of Endogenous Immunoglobulins by Endothelial Cells at the Blood-Brain Barrier

(2016) Roberto Villaseñor et al.   Scientific Reports

Brain endothelial TAK1 and NEMO safeguard the neurovascular unit

(2015) Dirk A. Ridder et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Porcine Epidemic Diarrhea Virus 3C-Like Protease Regulates Its Interferon Antagonism by Cleaving NEMO

(2015) Dang Wang et al.   JOURNAL OF VIROLOGY

Combinatorial labeling of single cells for gene expression cytometry

(2015) H. C. Fan et al.   SCIENCE

Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids

(2014) Jiaxi Wu et al.   Annual Review of Immunology

Elapid Snake Venom Analyses Show the Specificity of the Peptide Composition at the Level of Genera Naja and Notechis

(2014) Aisha Munawar et al.   Toxins

Neurological findings in incontinentia pigmenti; a review

(2012) Marije E.C. Meuwissen et al.   European Journal of Medical Genetics

OMERO: flexible, model-driven data management for experimental biology

(2012) Chris Allan et al.   NATURE METHODS

TAK1 in brain endothelial cells mediates fever and lethargy

(2011) Dirk A. Ridder et al.   JOURNAL OF EXPERIMENTAL MEDICINE

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

(2011) Patrick-Simon Welz et al.   NATURE

Nuclear initiated NF-κB signaling: NEMO and ATM take center stage

(2010) Shigeki Miyamoto   CELL RESEARCH

Systematic Comparison of Constitutive Promoters and the Doxycycline-Inducible Promoter

(2010) Jane Yuxia Qin et al.   PLoS One

Endothelial Cell-Specific NF-κB Inhibition Protects Mice from Atherosclerosis

(2008) Ralph Gareus et al.   Cell Metabolism

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY