Brain endothelial TAK1 and NEMO safeguard the neurovascular unit

A Review of String Vessels or Collapsed, Empty Basement Membrane Tubes

(2017) William R. Brown   JOURNAL OF ALZHEIMERS DISEASE

Non-muscle Mlck is required for  -catenin- and FoxO1-dependent downregulation of Cldn5 in IL-1 -mediated barrier dysfunction in brain endothelial cells

(2014) R. S. Beard et al.   JOURNAL OF CELL SCIENCE

Behavioural alterations relevant to developmental brain disorders in mice with neonatally induced ventral hippocampal lesions

(2013) Arne Naert et al.   BRAIN RESEARCH BULLETIN

Endothelial TRPV4 channels mediate dilation of cerebral arteries: impairment and recovery in cerebrovascular pathologies related to Alzheimer's disease

(2013) Luqing Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition

(2013) Y Dondelinger et al.   CELL DEATH AND DIFFERENTIATION

Glial influence on the blood brain barrier

(2013) Jorge Ivan Alvarez et al.   GLIA

The Role of the Cerebral Capillaries in Acute Ischemic Stroke: The Extended Penumbra Model

(2013) Leif Østergaard et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Blood–Brain Barrier Dysfunction as a Cause and Consequence of Alzheimer's Disease

(2013) Michelle A Erickson et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice

(2013) Annika Keller et al.   NATURE GENETICS

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation

(2013) Tobias Goldmann et al.   NATURE NEUROSCIENCE

Molecular control of the NEMO family of ubiquitin-binding proteins

(2013) Kristopher Clark et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Early cortical thickness changes predict β-amyloid deposition in a mouse model of Alzheimer's disease

(2013) Marilyn Grand'Maison et al.   NEUROBIOLOGY OF DISEASE

A20 in inflammation and autoimmunity

(2013) Leen Catrysse et al.   TRENDS IN IMMUNOLOGY

TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration

(2012) S. Morioka et al.   BLOOD

Conditional Targeting of Tumor Necrosis Factor Receptor–Associated Factor 6 Reveals Opposing Functions of Toll-Like Receptor Signaling in Endothelial and Myeloid Cells in a Mouse Model of Atherosclerosis

(2012) Apostolos Polykratis et al.   CIRCULATION

Neurological findings in incontinentia pigmenti; a review

(2012) Marije E.C. Meuwissen et al.   European Journal of Medical Genetics

Age-Dependent Rescue by Simvastatin of Alzheimer's Disease Cerebrovascular and Memory Deficits

(2012) X.-K. Tong et al.   JOURNAL OF NEUROSCIENCE

Interleukin receptor activates a MYD88–ARNO–ARF6 cascade to disrupt vascular stability

(2012) Weiquan Zhu et al.   NATURE

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

(2012) Robert D. Bell et al.   NATURE

Cortical atrophy and hypoperfusion in a transgenic mouse model of Alzheimer's disease

(2012) François Hébert et al.   NEUROBIOLOGY OF AGING

NEMO Inhibits Programmed Necrosis in an NFκB-Independent Manner by Restraining RIP1

(2012) Marie Anne O’Donnell et al.   PLoS One

Elementary Ca2+ Signals Through Endothelial TRPV4 Channels Regulate Vascular Function

(2012) S. K. Sonkusare et al.   SCIENCE

Targeting of TAK1 in inflammatory disorders and cancer

(2012) Hiroaki Sakurai   TRENDS IN PHARMACOLOGICAL SCIENCES

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

TNF- /Fas-RIP-1-induced cell death signaling separates murine hematopoietic stem cells/progenitors into 2 distinct populations

(2011) Y. Xiao et al.   BLOOD

NF-κB Activity in Perinatal Brain During Infectious and Hypoxic-Ischemic Insults Revealed by a Reporter Mouse

(2011) Anders Kielland et al.   BRAIN PATHOLOGY

TAK1 in brain endothelial cells mediates fever and lethargy

(2011) Dirk A. Ridder et al.   JOURNAL OF EXPERIMENTAL MEDICINE

C5a/CD88 signaling alters blood-brain barrier integrity in lupus through nuclear factor-κB

(2011) Alexander Jacob et al.   JOURNAL OF NEUROCHEMISTRY

Adenosine Receptor Signaling Modulates Permeability of the Blood-Brain Barrier

(2011) A. J. Carman et al.   JOURNAL OF NEUROSCIENCE

Occludin: One Protein, Many Forms

(2011) P. M. Cummins   MOLECULAR AND CELLULAR BIOLOGY

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

(2011) Berislav V. Zlokovic   NATURE REVIEWS NEUROSCIENCE

TNFAIP3 Maintains Intestinal Barrier Function and Supports Epithelial Cell Tight Junctions

(2011) Lauren E. Kolodziej et al.   PLoS One

Early infantile manifestations of incontinentia pigmenti mimicking acute encephalopathy

(2010) Shinpei Abe et al.   BRAIN & DEVELOPMENT

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

(2010) N Vanlangenakker et al.   CELL DEATH AND DIFFERENTIATION

Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission

(2010) Ann Van der Jeugd et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Unbiased average age-appropriate atlases for pediatric studies

(2010) Vladimir Fonov et al.   NEUROIMAGE

Plasmodium falciparum-infected erythrocytes induce NF- B regulated inflammatory pathways in human cerebral endothelium

(2009) A. K. Tripathi et al.   BLOOD

GFP-p65 knock-in mice as a tool to study NF-κB dynamics in vivo

(2009) Rossana De Lorenzi et al.   GENESIS

Lymphocytic Choriomeningitis Virus-Induced Mortality in Mice Is Triggered by Edema and Brain Herniation

(2009) C. M. Matullo et al.   JOURNAL OF VIROLOGY

Molecular signatures of disease brain endothelia provide new sites for CNS-directed enzyme therapy

(2009) Yong Hong Chen et al.   NATURE MEDICINE

Endothelial basement membrane laminin α5 selectively inhibits T lymphocyte extravasation into the brain

(2009) Chuan Wu et al.   NATURE MEDICINE

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

Simvastatin improves cerebrovascular function and counters soluble amyloid-beta, inflammation and oxidative stress in aged APP mice

(2009) Xin-Kang Tong et al.   NEUROBIOLOGY OF DISEASE

Immune Proteins in Brain Development and Synaptic Plasticity

(2009) Lisa M. Boulanger   NEURON

Endothelial Cell-Specific NF-κB Inhibition Protects Mice from Atherosclerosis

(2008) Ralph Gareus et al.   Cell Metabolism

Divergent roles of endothelial NF-κB in multiple organ injury and bacterial clearance in mouse models of sepsis

(2008) Xiaobing Ye et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Longitudinal neuroanatomical changes determined by deformation-based morphometry in a mouse model of Alzheimer's disease

(2008) Jonathan C. Lau et al.   NEUROIMAGE

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON

Extensive cerebral infarction in the newborn due to incontinentia pigmenti

(2007) Femke Maingay-de Groof et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY