NMNAT2 is downregulated in glaucomatous RGCs, and RGC-specific gene therapy rescues neurodegeneration and visual function

Adaptive responses to neurodegenerative stress in glaucoma

(2021) David J. Calkins   PROGRESS IN RETINAL AND EYE RESEARCH

Chronic mild and acute severe glaucomatous neurodegeneration derived from silicone oil-induced ocular hypertension

(2021) Fang Fang et al.   Scientific Reports

SARM1 signaling mechanisms in the injured nervous system

(2021) Shilpa Sambashivan et al.   CURRENT OPINION IN NEUROBIOLOGY

Neuroprotection by WldS depends on retinal ganglion cell type and age in glaucoma

(2021) Michael L. Risner et al.   Molecular Neurodegeneration

Neuronal NMNAT2 Overexpression Does Not Achieve Significant Neuroprotection in Experimental Autoimmune Encephalomyelitis/Optic Neuritis

(2021) Pingting Liu et al.   Frontiers in Cellular Neuroscience

Toward a new definition of glaucomatous optic neuropathy for clinical research

(2020) Jayant Iyer et al.   CURRENT OPINION IN OPHTHALMOLOGY

Acetate supplementation restores chromatin accessibility and promotes tumor cell differentiation under hypoxia

(2020) Yang Li et al.   Cell Death & Disease

Mouse γ-Synuclein Promoter-Mediated Gene Expression and Editing in Mammalian Retinal Ganglion Cells

(2020) Qizhao Wang et al.   JOURNAL OF NEUROSCIENCE

Programmed axon degeneration: from mouse to mechanism to medicine

(2020) Michael P. Coleman et al.   NATURE REVIEWS NEUROSCIENCE

Longitudinal Morphological and Functional Assessment of RGC Neurodegeneration After Optic Nerve Crush in Mouse

(2020) Liang Li et al.   Frontiers in Cellular Neuroscience

The SARM1 axon degeneration pathway: control of the NAD+ metabolome regulates axon survival in health and disease

(2020) Matthew D Figley et al.   CURRENT OPINION IN NEUROBIOLOGY

SARM1 acts downstream of neuroinflammatory and necroptotic signaling to induce axon degeneration

(2020) Kwang Woo Ko et al.   JOURNAL OF CELL BIOLOGY

AKT-dependent and -independent pathways mediate PTEN deletion-induced CNS axon regeneration

(2019) Haoliang Huang et al.   Cell Death & Disease

Severe biallelic loss-of-function mutations in nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) in two fetuses with fetal akinesia deformation sequence

(2019) Marshall Lukacs et al.   EXPERIMENTAL NEUROLOGY

Homozygous NMNAT2 mutation in sisters with polyneuropathy and erythromelalgia

(2019) Peter Huppke et al.   EXPERIMENTAL NEUROLOGY

Silicone oil-induced ocular hypertension and glaucomatous neurodegeneration in mouse

(2019) Jie Zhang et al.   eLife

NAD+ in Brain Aging and Neurodegenerative Disorders

(2019) Sofie Lautrup et al.   Cell Metabolism

Systematic reviews and randomised controlled trials on open angle glaucoma

(2019) Richard Wormald et al.   EYE

Role of SARM1 and DR6 in retinal ganglion cell axonal and somal degeneration following axonal injury

(2018) Kimberly A. Fernandes et al.   EXPERIMENTAL EYE RESEARCH

NMNAT1 E257K variant, associated with Leber Congenital Amaurosis (LCA9), causes a mild retinal degeneration phenotype

(2018) Aiden Eblimit et al.   EXPERIMENTAL EYE RESEARCH

NAD + and sirtuins in retinal degenerative diseases: A look at future therapies

(2018) Jonathan B. Lin et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Biomechanical aspects of axonal damage in glaucoma: A brief review

(2017) Cheri Stowell et al.   EXPERIMENTAL EYE RESEARCH

Glaucoma

(2017) Jost B Jonas et al.   LANCET

The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD + Cleavage Activity that Promotes Pathological Axonal Degeneration

(2017) Kow Essuman et al.   NEURON

Vitamin B 3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice

(2017) Pete A. Williams et al.   SCIENCE

Neuroprotection by eIF2α-CHOP inhibition and XBP-1 activation in EAE/optic neuritiss

(2017) Haoliang Huang et al.   Cell Death & Disease

Nicotinamide and WLDS Act Together to Prevent Neurodegeneration in Glaucoma

(2017) Pete A. Williams et al.   Frontiers in Neuroscience

Rescue of Glaucomatous Neurodegeneration by Differentially Modulating Neuronal Endoplasmic Reticulum Stress Molecules

(2016) L. Yang et al.   JOURNAL OF NEUROSCIENCE

An Atypical SCF-like Ubiquitin Ligase Complex Promotes Wallerian Degeneration through Regulation of Axonal Nmnat2

(2016) Yuya Yamagishi et al.   Cell Reports

NAMPT-Mediated NAD + Biosynthesis Is Essential for Vision In Mice

(2016) Jonathan B. Lin et al.   Cell Reports

NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies

(2016) Yousuf O. Ali et al.   PLOS BIOLOGY

mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system

(2016) Linqing Miao et al.   eLife

Primary open-angle glaucoma

(2016) Robert N. Weinreb et al.   Nature Reviews Disease Primers

Electrophysiological assessment of retinal ganglion cell function

(2015) Vittorio Porciatti   EXPERIMENTAL EYE RESEARCH

Latanoprost for open-angle glaucoma (UKGTS): a randomised, multicentre, placebo-controlled trial

(2015) David F Garway-Heath et al.   LANCET

Axonal transport declines with age in two distinct phases separated by a period of relative stability

(2015) Stefan Milde et al.   NEUROBIOLOGY OF AGING

Local axonal protection by WldS as revealed by conditional regulation of protein stability

(2015) Jack T. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SARM1 activation triggers axon degeneration locally via NAD+ destruction

(2015) J. Gerdts et al.   SCIENCE

NAD+ in aging, metabolism, and neurodegeneration

(2015) E. Verdin   SCIENCE

Absence of SARM1 Rescues Development and Survival of NMNAT2-Deficient Axons

(2015) Jonathan Gilley et al.   Cell Reports

Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040

(2014) Yih-Chung Tham et al.   OPHTHALMOLOGY

The mTORC1 effectors S6K1 and 4E-BP play different roles in CNS axon regeneration

(2014) Liu Yang et al.   Nature Communications

Sarm1-Mediated Axon Degeneration Requires Both SAM and TIR Interactions

(2013) J. Gerdts et al.   JOURNAL OF NEUROSCIENCE

Rescue of Peripheral and CNS Axon Defects in Mice Lacking NMNAT2

(2013) J. Gilley et al.   JOURNAL OF NEUROSCIENCE

Une nouvelle forme d’amaurose congénitale de Leber 

(2013) Josseline Kaplan et al.   M S-MEDECINE SCIENCES

Deletions within its subcellular targeting domain enhance the axon protective capacity of Nmnat2 in vivo

(2013) Stefan Milde et al.   Scientific Reports

The Phr1 Ubiquitin Ligase Promotes Injury-Induced Axon Self-Destruction

(2013) Elisabetta Babetto et al.   Cell Reports

Subcellular Localization Determines the Stability and Axon Protective Capacity of Axon Survival Factor Nmnat2

(2013) Stefan Milde et al.   PLOS BIOLOGY

Under Pressure: Cellular and Molecular Responses During Glaucoma, a Common Neurodegeneration with Axonopathy

(2012) Robert W. Nickells et al.   Annual Review of Neuroscience

Intrinsic axonal degeneration pathways are critical for glaucomatous damage

(2012) Gareth R. Howell et al.   EXPERIMENTAL NEUROLOGY

Mutations in NMNAT1 cause Leber congenital amaurosis with early-onset severe macular and optic atrophy

(2012) Isabelle Perrault et al.   NATURE GENETICS

NMNAT1 mutations cause Leber congenital amaurosis

(2012) Marni J Falk et al.   NATURE GENETICS

Exome sequencing identifies NMNAT1 mutations as a cause of Leber congenital amaurosis

(2012) Pei-Wen Chiang et al.   NATURE GENETICS

Mutations in NMNAT1 cause Leber congenital amaurosis and identify a new disease pathway for retinal degeneration

(2012) Robert K Koenekoop et al.   NATURE GENETICS

dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway

(2012) J. M. Osterloh et al.   SCIENCE

The Highwire Ubiquitin Ligase Promotes Axonal Degeneration by Tuning Levels of Nmnat Protein

(2012) Xin Xiong et al.   PLOS BIOLOGY

A biomechanical paradigm for axonal insult within the optic nerve head in aging and glaucoma

(2010) Claude F. Burgoyne   EXPERIMENTAL EYE RESEARCH

Overexpression of Wldsor Nmnat2 in mauthner cells by single-cell electroporation delays axon degeneration in live zebrafish

(2010) Yan Feng et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Endogenous Nmnat2 Is an Essential Survival Factor for Maintenance of Healthy Axons

(2010) Jonathan Gilley et al.   PLOS BIOLOGY

Transgenic Mice Expressing the Nmnat1 Protein Manifest Robust Delay in Axonal Degeneration In Vivo

(2009) Y. Sasaki et al.   JOURNAL OF NEUROSCIENCE

Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity

(2009) Tingting Yan et al.   NEUROCHEMISTRY INTERNATIONAL

Cell-type-specific isolation of ribosome-associated mRNA from complex tissues

(2009) E. Sanz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TheWldSgene delays axonal but not somatic degeneration in a rat glaucoma model

(2008) Bogdan Beirowski et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function

(2008) J. D. Cahoy et al.   JOURNAL OF NEUROSCIENCE