Adaptive responses to neurodegenerative stress in glaucoma

A neuroglia-based interpretation of glaucomatous neuroretinal rim thinning in the optic nerve head

(2020) Eun Jung Lee et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Altered Energy Metabolism During Early Optic Nerve Crush Injury: Implications of Warburg-Like Aerobic Glycolysis in Facilitating Retinal Ganglion Cell Survival

(2020) Jingyi Zhu et al.   Neuroscience Bulletin

Of Mice and Monkeys: Neuroprotective Efficacy of the p38 Inhibitor BIRB 796 Depends on Model Duration in Experimental Glaucoma

(2020) Wendi S. Lambert et al.   Scientific Reports

TRPV1 Tunes Optic Nerve Axon Excitability in Glaucoma

(2020) Nolan R. McGrady et al.   Frontiers in Physiology

A method to quantify regional axonal transport blockade at the optic nerve head after short term intraocular pressure elevation in mice

(2020) Arina Korneva et al.   EXPERIMENTAL EYE RESEARCH

Aqp9 Gene Deletion Enhances Retinal Ganglion Cell (RGC) Death and Dysfunction Induced by Optic Nerve Crush: Evidence that Aquaporin 9 Acts as an Astrocyte-to-Neuron Lactate Shuttle in Concert with Monocarboxylate Transporters To Support RGC Function and Survival

(2020) Sotaro Mori et al.   MOLECULAR NEUROBIOLOGY

MCT2 overexpression rescues metabolic vulnerability and protects retinal ganglion cells in two models of glaucoma

(2020) Mohammad Harun-Or-Rashid et al.   NEUROBIOLOGY OF DISEASE

Relationship between Oxidative Stress Biomarkers and Visual Field Progression in Patients with Primary Angle Closure Glaucoma

(2020) Shengjie Li et al.   Oxidative Medicine and Cellular Longevity

Redistribution of metabolic resources through astrocyte networks mitigates neurodegenerative stress

(2020) Melissa L. Cooper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retinal energy metabolism in health and glaucoma

(2020) Robert J. Casson et al.   PROGRESS IN RETINAL AND EYE RESEARCH

The Neurovascular Unit in Glaucomatous Neurodegeneration

(2020) Lauren K. Wareham et al.   Frontiers in Cell and Developmental Biology

P2X7 Receptors Amplify CNS Damage in Neurodegenerative Diseases

(2020) Peter Illes   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CNS axonal degeneration and transport deficits at the optic nerve head precede structural and functional loss of retinal ganglion cells in a mouse model of glaucoma

(2020) Prabhavathi Maddineni et al.   Molecular Neurodegeneration

Inflammation in Glaucoma: From the back to the front of the eye, and beyond

(2020) Christophe Baudouin et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Disturbed glucose and pyruvate metabolism in glaucoma with neuroprotection by pyruvate or rapamycin

(2020) Jeffrey M. Harder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transmission of Mechanical Information by Purinergic Signaling

(2019) Nicholas Mikolajewicz et al.   BIOPHYSICAL JOURNAL

Voltage- and calcium-gated ion channels of neurons in the vertebrate retina

(2019) Matthew J. Van Hook et al.   PROGRESS IN RETINAL AND EYE RESEARCH

The Autism-Associated Gene Scn2a Contributes to Dendritic Excitability and Synaptic Function in the Prefrontal Cortex

(2019) Perry W.E. Spratt et al.   NEURON

Electrical synapses interconnecting axons revealed in the optic nerve head – a novel model of gap junctions’ involvement in optic nerve function

(2019) Adrian Smedowski et al.   ACTA OPHTHALMOLOGICA

Towards A Microbead Occlusion Model of Glaucoma for a Non-Human Primate

(2019) Wendi S. Lambert et al.   Scientific Reports

Elevated ocular pressure reduces voltage-gated sodium channel NaV1.2 protein expression in retinal ganglion cell axons

(2019) Michael L. Risner et al.   EXPERIMENTAL EYE RESEARCH

Insulin signalling promotes dendrite and synapse regeneration and restores circuit function after axonal injury

(2018) Jessica Agostinone et al.   BRAIN

The Role of Inflammation in Neurological Disorders

(2018) Diana Degan et al.   CURRENT PHARMACEUTICAL DESIGN

Structural and Functional Rescue of Chronic Metabolically Stressed Optic Nerves through Respiration

(2018) Mohammad Harun-Or-Rashid et al.   JOURNAL OF NEUROSCIENCE

Axogenic mechanism enhances retinal ganglion cell excitability during early progression in glaucoma

(2018) Michael L. Risner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycogen synthase protects neurons from cytotoxicity of mutant huntingtin by enhancing the autophagy flux

(2018) Anupama Rai et al.   Cell Death & Disease

Astrocyte remodeling without gliosis precedes optic nerve axonopathy

(2018) Melissa L. Cooper et al.   Acta Neuropathologica Communications

Involvement of Akt/CREB signaling pathways in the protective effect of EPA against interleukin-1β-induced cytotoxicity and BDNF down-regulation in cultured rat hippocampal neurons

(2018) YiLong Dong et al.   BMC NEUROSCIENCE

Suppression of Presymptomatic Oxidative Stress and Inflammation in Neurodegeneration by Grape-Derived Polyphenols

(2018) Francis Herman et al.   Frontiers in Pharmacology

Mechanically stimulated ATP release from mammalian cells: systematic review and meta-analysis

(2018) Nicholas Mikolajewicz et al.   JOURNAL OF CELL SCIENCE

The challenge of regenerative therapies for the optic nerve in glaucoma

(2017) David J. Calkins et al.   EXPERIMENTAL EYE RESEARCH

CoQ10 Deficiency May Indicate Mitochondrial Dysfunction in Cr(VI) Toxicity

(2017) Xiali Zhong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Optic nerve astrocyte reactivity protects function in experimental glaucoma and other nerve injuries

(2017) Daniel Sun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mitostasis in Neurons: Maintaining Mitochondria in an Extended Cellular Architecture

(2017) Thomas Misgeld et al.   NEURON

ROS regulation of axonal mitochondrial transport is mediated by Ca2+ and JNK in Drosophila

(2017) Pin-Chao Liao et al.   PLoS One

Vitamin B 3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice

(2017) Pete A. Williams et al.   SCIENCE

When do correlations increase with firing rates in recurrent networks?

(2017) Andrea K. Barreiro et al.   PLoS Computational Biology

Monitoring ATP dynamics in electrically active white matter tracts

(2017) Andrea Trevisiol et al.   eLife

Oral Delivery of a Synthetic Sterol Reduces Axonopathy and Inflammation in a Rodent Model of Glaucoma

(2017) Wendi S. Lambert et al.   Frontiers in Neuroscience

Metabolic Vulnerability in the Neurodegenerative Disease Glaucoma

(2017) Denise M. Inman et al.   Frontiers in Neuroscience

Glaucoma: Focus on mitochondria in relation to pathogenesis and neuroprotection

(2016) Neville N. Osborne et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Early astrocyte redistribution in the optic nerve precedes axonopathy in the DBA/2J mouse model of glaucoma

(2016) Melissa L. Cooper et al.   EXPERIMENTAL EYE RESEARCH

Glial coverage in the optic nerve expands in proportion to optic axon loss in chronic mouse glaucoma

(2016) Alejandra Bosco et al.   EXPERIMENTAL EYE RESEARCH

Persistence of intact retinal ganglion cell terminals after axonal transport loss in the DBA/2J mouse model of glaucoma

(2016) Matthew A. Smith et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Selective Vulnerability of Specific Retinal Ganglion Cell Types and Synapses after Transient Ocular Hypertension

(2016) Y. Ou et al.   JOURNAL OF NEUROSCIENCE

Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma

(2016) Pete A. Williams et al.   Molecular Neurodegeneration

Astrocytes: Key Regulators of Neuroinflammation

(2016) Emanuela Colombo et al.   TRENDS IN IMMUNOLOGY

Involvement of P2X7 receptor in neuronal degeneration triggered by traumatic injury

(2016) Francisco M. Nadal-Nicolás et al.   Scientific Reports

Activation of transient receptor potential vanilloid-1 (TRPV1) influences how retinal ganglion cell neurons respond to pressure-related stress

(2015) Rebecca M Sappington et al.   Channels

Optic nerve head biomechanics in aging and disease

(2015) J. Crawford Downs   EXPERIMENTAL EYE RESEARCH

An energy theory of glaucoma

(2015) Ying Li et al.   GLIA

Mitochondrial Morphology Differences and Mitophagy Deficit in Murine Glaucomatous Optic Nerve

(2015) L. Coughlin et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Central Visual Pathways in Glaucoma

(2015) Samuel D. Crish et al.   JOURNAL OF NEURO-OPHTHALMOLOGY

Live Imaging of Calcium Dynamics during Axon Degeneration Reveals Two Functionally Distinct Phases of Calcium Influx

(2015) M. E. Vargas et al.   JOURNAL OF NEUROSCIENCE

Characteristic Patterns of Dendritic Remodeling in Early-Stage Glaucoma: Evidence from Genetically Identified Retinal Ganglion Cell Types

(2015) R. N. El-Danaf et al.   JOURNAL OF NEUROSCIENCE

Resistance to the most common optic neuropathy is associated with systemic mitochondrial efficiency

(2015) Gerassimos Lascaratos et al.   NEUROBIOLOGY OF DISEASE

Synapse Loss and Dendrite Remodeling in a Mouse Model of Glaucoma

(2015) Ryan H. Berry et al.   PLoS One

In vivo imaging of axonal transport of mitochondria in the diseased and aged mammalian CNS

(2015) Yuji Takihara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Why Do People (Still) Go Blind from Glaucoma?

(2015) Remo Susanna et al.   Translational Vision Science & Technology

Visual Field Improvement in the Collaborative Initial Glaucoma Treatment Study

(2014) David C. Musch et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Activity-Driven Local ATP Synthesis Is Required for Synaptic Function

(2014) Vidhya Rangaraju et al.   CELL

Mechanosensitive release of adenosine 5′-triphosphate through pannexin channels and mechanosensitive upregulation of pannexin channels in optic nerve head astrocytes: A mechanism for purinergic involvement in chronic strain

(2014) Jonathan M. Beckel et al.   GLIA

Activation of the TRPV1 cation channel contributes to stress-induced astrocyte migration

(2014) Karen W. Ho et al.   GLIA

The Pathophysiology and Treatment of Glaucoma

(2014) Robert N. Weinreb et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Short-Term Increases in Transient Receptor Potential Vanilloid-1 Mediate Stress-Induced Enhancement of Neuronal Excitation

(2014) C. Weitlauf et al.   JOURNAL OF NEUROSCIENCE

Absence of Transient Receptor Potential Vanilloid-1 Accelerates Stress-Induced Axonopathy in the Optic Projection

(2014) N. J. Ward et al.   JOURNAL OF NEUROSCIENCE

Patterns of functional vision loss in glaucoma determined with archetypal analysis

(2014) T. Elze et al.   Journal of the Royal Society Interface

Astrocyte glycogen as an emergency fuel under conditions of glucose deprivation or intense neural activity

(2014) Angus M. Brown et al.   METABOLIC BRAIN DISEASE

Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040

(2014) Yih-Chung Tham et al.   OPHTHALMOLOGY

Coenzyme Q10 ameliorates oxidative stress and prevents mitochondrial alteration in ischemic retinal injury

(2013) Dongwook Lee et al.   APOPTOSIS

Differential Progression of Structural and Functional Alterations in Distinct Retinal Ganglion Cell Types in a Mouse Model of Glaucoma

(2013) L. Della Santina et al.   JOURNAL OF NEUROSCIENCE

Neuroprotective effect of brain-derived neurotrophic factor mediated by autophagy through the PI3K/Akt/mTOR pathway

(2013) AI CHEN et al.   Molecular Medicine Reports

The intricate relationship between microtubules and their associated motor proteins during axon growth and maintenance

(2013) Andreas Prokop   Neural Development

Proximal inhibition of p38 MAPK stress signaling prevents distal axonopathy

(2013) Jason D. Dapper et al.   NEUROBIOLOGY OF DISEASE

α-Lipoic Acid Antioxidant Treatment Limits Glaucoma-Related Retinal Ganglion Cell Death and Dysfunction

(2013) Denise M. Inman et al.   PLoS One

Retinal ganglion cells: Energetics, compartmentation, axonal transport, cytoskeletons and vulnerability

(2013) Dao-Yi Yu et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Inhibition of oxidative stress by coenzyme Q10 increases mitochondrial mass and improves bioenergetic function in optic nerve head astrocytes

(2013) Y H Noh et al.   Cell Death & Disease

Glaucoma

(2013) A. King et al.   BMJ-British Medical Journal

Oxidative stress and mitochondrial dysfunction in glaucoma

(2012) Vicki Chrysostomou et al.   CURRENT OPINION IN PHARMACOLOGY

Intrinsic axonal degeneration pathways are critical for glaucomatous damage

(2012) Gareth R. Howell et al.   EXPERIMENTAL NEUROLOGY

Animal Models of Glaucoma

(2012) Rachida A. Bouhenni et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Axon degeneration: Molecular mechanisms of a self-destruction pathway

(2012) Jack T. Wang et al.   JOURNAL OF CELL BIOLOGY

Calpain inhibitor attenuated optic nerve damage in acute optic neuritis in rats

(2012) Arabinda Das et al.   JOURNAL OF NEUROCHEMISTRY

Unmyelinated Axons Show Selective Rostrocaudal Pathology in the Corpus Callosum After Traumatic Brain Injury

(2012) Thomas M. Reeves et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The Energetics of CNS White Matter

(2012) J. J. Harris et al.   JOURNAL OF NEUROSCIENCE

Why Do Axons Differ in Caliber?

(2012) J. A. Perge et al.   JOURNAL OF NEUROSCIENCE

Assembly of a new growth cone after axotomy: the precursor to axon regeneration

(2012) Frank Bradke et al.   NATURE REVIEWS NEUROSCIENCE

Failure of axonal transport induces a spatially coincident increase in astrocyte BDNF prior to synapse loss in a central target

(2012) S.D. Crish et al.   NEUROSCIENCE

Anterograde Degeneration along the Visual Pathway after Optic Nerve Injury

(2012) Yuyi You et al.   PLoS One

Critical pathogenic events underlying progression of neurodegeneration in glaucoma

(2012) David J. Calkins   PROGRESS IN RETINAL AND EYE RESEARCH

The optic nerve head is the site of axonal transport disruption, axonal cytoskeleton damage and putative axonal regeneration failure in a rat model of glaucoma

(2011) Glyn Chidlow et al.   ACTA NEUROPATHOLOGICA

Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

(2011) Mireille Bélanger et al.   Cell Metabolism

Myelination transition zone astrocytes are constitutively phagocytic and have synuclein dependent reactivity in glaucoma

(2011) J. V. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The molecular basis of retinal ganglion cell death in glaucoma

(2011) Mohammadali Almasieh et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Mitochondrial dysfunction in glaucoma and emerging bioenergetic therapies

(2010) Shanjean Lee et al.   EXPERIMENTAL EYE RESEARCH

A biomechanical paradigm for axonal insult within the optic nerve head in aging and glaucoma

(2010) Claude F. Burgoyne   EXPERIMENTAL EYE RESEARCH

Metabolic Vulnerability Disposes Retinal Ganglion Cell Axons to Dysfunction in a Model of Glaucomatous Degeneration

(2010) S. Baltan et al.   JOURNAL OF NEUROSCIENCE

Demyelination Increases Axonal Stationary Mitochondrial Size and the Speed of Axonal Mitochondrial Transport

(2010) S. Kiryu-Seo et al.   JOURNAL OF NEUROSCIENCE

Reactive astrocytes give neurons less support: implications for Alzheimer's disease

(2010) Megan L. Steele et al.   NEUROBIOLOGY OF AGING

Neurodegeneration in glaucoma: progression and calcium-dependent intracellular mechanisms

(2010) S.D. Crish et al.   NEUROSCIENCE

Mechanisms of acute axonal degeneration in the optic nerve in vivo

(2010) J. Knoferle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distal axonopathy with structural persistence in glaucomatous neurodegeneration

(2010) S. D. Crish et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial optic neuropathies – Disease mechanisms and therapeutic strategies

(2010) Patrick Yu-Wai-Man et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Mechanisms of axonal injury: internodal nanocomplexes and calcium deregulation

(2010) David P. Stirling et al.   TRENDS IN MOLECULAR MEDICINE

Mitochondrial trafficking and morphology in neuronal injury

(2009) Gordon L. Rintoul et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Biomechanics of the optic nerve head

(2009) Ian A. Sigal et al.   EXPERIMENTAL EYE RESEARCH

Altered Brain Mitochondrial Metabolism in Healthy Aging as Assessed by in vivo Magnetic Resonance Spectroscopy

(2009) Fawzi Boumezbeur et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The morphology and spatial arrangement of astrocytes in the optic nerve head of the mouse

(2009) Daniel Sun et al.   JOURNAL OF COMPARATIVE NEUROLOGY

How the Optic Nerve Allocates Space, Energy Capacity, and Information

(2009) J. A. Perge et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial cytochrome c oxidase expression in the central nervous system is elevated at sites of pressure gradient elevation but not absolute pressure increase

(2009) Chandrakumar Balaratnasingam et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Distinct contributions of Nav1.6 and Nav1.2 in action potential initiation and backpropagation

(2009) Wenqin Hu et al.   NATURE NEUROSCIENCE

Role of Axonal Transport in Neurodegenerative Diseases

(2008) Kurt J. De Vos et al.   Annual Review of Neuroscience

Neuroprotection in Glaucoma Using Calpain-1 Inhibitors: Regional Differences in Calpain-1 Activity in the Trabecular Meshwork, Optic Nerve and Implications for Therapeutics

(2008) Bharathi Govindarajan et al.   CNS & Neurological Disorders-Drug Targets

TheWldSgene delays axonal but not somatic degeneration in a rat glaucoma model

(2008) Bogdan Beirowski et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Energy limitation as a selective pressure on the evolution of sensory systems

(2008) J. E. Niven et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Enhanced Sensitivity of Striatal Neurons to Axonal Transport Defects Induced by Mutant Huntingtin

(2008) L.-S. Her et al.   JOURNAL OF NEUROSCIENCE

Retinal Ganglion Cells Downregulate Gene Expression and Lose Their Axons within the Optic Nerve Head in a Mouse Glaucoma Model

(2008) I. Soto et al.   JOURNAL OF NEUROSCIENCE

Insulin Receptor Signaling Regulates Synapse Number, Dendritic Plasticity, and Circuit Function In Vivo

(2008) Shu-Ling Chiu et al.   NEURON

Risk Factors for Glaucoma Onset and Progression

(2008) Anne L. Coleman et al.   SURVEY OF OPHTHALMOLOGY