The Highwire Ubiquitin Ligase Promotes Axonal Degeneration by Tuning Levels of Nmnat Protein

Axon Degeneration and Regeneration: Insights from Drosophila Models of Nerve Injury

(2012) Yanshan Fang et al.   Annual Review of Cell and Developmental Biology

A Novel Drosophila Model of Nerve Injury Reveals an Essential Role of Nmnat in Maintaining Axonal Integrity

(2012) Yanshan Fang et al.   CURRENT BIOLOGY

WldS Prevents Axon Degeneration through Increased Mitochondrial Flux and Enhanced Mitochondrial Ca2+ Buffering

(2012) Michelle A. Avery et al.   CURRENT BIOLOGY

Axon degeneration: Molecular mechanisms of a self-destruction pathway

(2012) Jack T. Wang et al.   JOURNAL OF CELL BIOLOGY

A Conditioning Lesion Protects Axons from Degeneration via the Wallenda/DLK MAP Kinase Signaling Cascade

(2012) X. Xiong et al.   JOURNAL OF NEUROSCIENCE

Dual Leucine Zipper Kinase Is Required for Retrograde Injury Signaling and Axonal Regeneration

(2012) Jung Eun Shin et al.   NEURON

dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway

(2012) J. M. Osterloh et al.   SCIENCE

CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy

(2011) M. Cecilia Ljungberg et al.   HUMAN MOLECULAR GENETICS

NMNAT suppresses Tau-induced neurodegeneration by promoting clearance of hyperphosphorylated Tau oligomers in a Drosophila model of tauopathy

(2011) Yousuf O. Ali et al.   HUMAN MOLECULAR GENETICS

Nmnat exerts neuroprotective effects in dendrites and axons

(2011) Yuhui Wen et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation

(2011) Shuji Wakatsuki et al.   NATURE CELL BIOLOGY

Drosophila homeodomain-interacting protein kinase inhibits the Skp1-Cul1-F-box E3 ligase complex to dually promote Wingless and Hedgehog signaling

(2011) S. Swarup et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wallerian Degeneration, WldS, and Nmnat

(2010) Michael P. Coleman et al.   Annual Review of Neuroscience

PHRs: bridging axon guidance, outgrowth and synapse development

(2010) Michelle D Po et al.   CURRENT OPINION IN NEUROBIOLOGY

Wallerian degeneration of zebrafish trigeminal axons in the skin is required for regeneration and developmental pruning

(2010) S. M. Martin et al.   DEVELOPMENT

Expression, Localization, and Biochemical Characterization of Nicotinamide Mononucleotide Adenylyltransferase 2

(2010) Paul R. Mayer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury

(2010) Xin Xiong et al.   JOURNAL OF CELL BIOLOGY

Overexpression of Wldsor Nmnat2 in mauthner cells by single-cell electroporation delays axon degeneration in live zebrafish

(2010) Yan Feng et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Endogenous Nmnat2 Is an Essential Survival Factor for Maintenance of Healthy Axons

(2010) Jonathan Gilley et al.   PLOS BIOLOGY

Impaired regenerative response of primary sensory neurons in ZPK/DLK gene-trap mice

(2009) Aki Itoh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The DLK-1 Kinase Promotes mRNA Stability and Local Translation in C. elegans Synapses and Axon Regeneration

(2009) Dong Yan et al.   CELL

Molecular mechanisms that enhance synapse stability despite persistent disruption of the spectrin/ankyrin/microtubule cytoskeleton

(2009) Catherine M. Massaro et al.   JOURNAL OF CELL BIOLOGY

WldSrequires Nmnat1 enzymatic activity and N16–VCP interactions to suppress Wallerian degeneration

(2009) Michelle A. Avery et al.   JOURNAL OF CELL BIOLOGY

Nicotinamide Mononucleotide Adenylyltransferase Expression in Mitochondrial Matrix Delays Wallerian Degeneration

(2009) N. Yahata et al.   JOURNAL OF NEUROSCIENCE

PHR Regulates Growth Cone Pausing at Intermediate Targets through Microtubule Disassembly

(2009) M. Hendricks et al.   JOURNAL OF NEUROSCIENCE

Fbxo45 Forms a Novel Ubiquitin Ligase Complex and Is Required for Neuronal Development

(2009) T. Saiga et al.   MOLECULAR AND CELLULAR BIOLOGY

Principles of ubiquitin and SUMO modifications in DNA repair

(2009) Steven Bergink et al.   NATURE

A dual leucine kinase–dependent axon self-destruction program promotes Wallerian degeneration

(2009) Bradley R Miller et al.   NATURE NEUROSCIENCE

Axon Regeneration Requires a Conserved MAP Kinase Pathway

(2009) M. Hammarlund et al.   SCIENCE

Pam (Protein associated with Myc) functions as an E3 Ubiquitin ligase and regulates TSC/mTOR signaling

(2008) Sangyeul Han et al.   CELLULAR SIGNALLING

Cellular and molecular determinants targeting theCaenorhabditis elegansPHR protein RPM-1 to perisynaptic regions

(2008) Benjamin Abrams et al.   DEVELOPMENTAL DYNAMICS

NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration

(2008) R. Grace Zhai et al.   NATURE