The oncomicropeptide APPLE promotes hematopoietic malignancy by enhancing translation initiation

Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease

(2021) Mehdi Eshraghi et al.   Nature Communications

The lncRNA LAMP5-AS1 drives leukemia cell stemness by directly modulating DOT1L methyltransferase activity in MLL leukemia

(2020) Wen-Tao Wang et al.   Journal of Hematology & Oncology

Activation of the lysosome-associated membrane protein LAMP5 by DOT1L serves as a bodyguard for MLL fusion oncoproteins to evade degradation in leukemia

(2019) Wen-Tao Wang et al.   CLINICAL CANCER RESEARCH

CircMYBL2, a circRNA from MYBL2, Regulates FLT3 Translation by Recruiting PTBP1 to Promote FLT3-ITD AML Progression

(2019) Yu-Meng Sun et al.   BLOOD

Micropeptide CIP 2A‐ BP encoded by LINC 00665 inhibits triple‐negative breast cancer progression

(2019) Binbin Guo et al.   EMBO JOURNAL

The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia

(2019) Dimitrios Papaioannou et al.   Nature Communications

LncRNA-encoded polypeptide ASRPS inhibits triple-negative breast cancer angiogenesis

(2019) Yirong Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The small peptide world in long noncoding RNAs

(2018) Seo-Won Choi et al.   BRIEFINGS IN BIOINFORMATICS

Micropeptides Encoded in Transcripts Previously Identified as Long Noncoding RNAs: A New Chapter in Transcriptomics and Proteomics

(2018) Fouzia Yeasmin et al.   Frontiers in Genetics

Functional genomic landscape of acute myeloid leukaemia

(2018) Jeffrey W. Tyner et al.   NATURE

Micropeptide

(2018) Maria E. Sousa et al.   PLoS Genetics

A Peptide Encoded by a Putative lncRNA HOXB-AS3 Suppresses Colon Cancer Growth

(2017) Jin-Zhou Huang et al.   MOLECULAR CELL

Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control

(2017) Isaia Barbieri et al.   NATURE

Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells

(2017) Ly P Vu et al.   NATURE GENETICS

CPC2: a fast and accurate coding potential calculator based on sequence intrinsic features

(2017) Yu-Jian Kang et al.   NUCLEIC ACIDS RESEARCH

Mining for Micropeptides

(2017) Catherine A. Makarewich et al.   TRENDS IN CELL BIOLOGY

Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia

(2016) David B. Sykes et al.   CELL

Dynamics of Translation of Single mRNA Molecules In Vivo

(2016) Xiaowei Yan et al.   CELL

Ribosome Footprint Profiling of Translation throughout the Genome

(2016) Nicholas T. Ingolia   CELL

Molecular Pathways: The eIF4F Translation Initiation Complex—New Opportunities for Cancer Treatment

(2016) Hélène Malka-Mahieu et al.   CLINICAL CANCER RESEARCH

Nuclear Noncoding RNAs and Genome Stability

(2016) Jasbeer S. Khanduja et al.   MOLECULAR CELL

The m 6 A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells

(2016) Shuibin Lin et al.   MOLECULAR CELL

mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide

(2016) Akinobu Matsumoto et al.   NATURE

A human microprotein that interacts with the mRNA decapping complex

(2016) Nadia G D'Lima et al.   Nature Chemical Biology

Homoharringtonine (omacetaxine mepesuccinate) as an adjunct for FLT3-ITD acute myeloid leukemia

(2016) S. S. Y. Lam et al.   Science Translational Medicine

Translation Initiation Factors: Reprogramming Protein Synthesis in Cancer

(2016) Jennifer Chu et al.   TRENDS IN CELL BIOLOGY

Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance

(2015) D. Grimwade et al.   BLOOD

Targeting the eIF4F Translation Initiation Complex: A Critical Nexus for Cancer Development

(2015) J. Pelletier et al.   CANCER RESEARCH

A Micropeptide Encoded by a Putative Long Noncoding RNA Regulates Muscle Performance

(2015) Douglas M. Anderson et al.   CELL

Differential Requirements for eIF4E Dose in Normal Development and Cancer

(2015) Morgan L. Truitt et al.   CELL

Musashi2 sustains the mixed-lineage leukemia–driven stem cell regulatory program

(2015) Sun-Mi Park et al.   JOURNAL OF CLINICAL INVESTIGATION

MMEJ-assisted gene knock-in using TALENs and CRISPR-Cas9 with the PITCh systems

(2015) Tetsushi Sakuma et al.   Nature Protocols

Targeting the translation machinery in cancer

(2015) Mamatha Bhat et al.   NATURE REVIEWS DRUG DISCOVERY

Ribosome profiling reveals the what, when, where and how of protein synthesis

(2015) Gloria A. Brar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Acute Myeloid Leukemia

(2015) Hartmut Döhner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality

(2014) Michelle R. Arkin et al.   CHEMISTRY & BIOLOGY

A Human Short Open Reading Frame (sORF)-encoded Polypeptide That Stimulates DNA End Joining

(2014) Sarah A. Slavoff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of nuclear RNA interference in human cells by subcellular fractionation and Argonaute loading

(2014) Keith T Gagnon et al.   Nature Protocols

Ribosome profiling: new views of translation, from single codons to genome scale

(2014) Nicholas T. Ingolia   NATURE REVIEWS GENETICS

Long non-coding RNAs as a source of new peptides

(2014) Jorge Ruiz-Orera et al.   eLife

The evolving molecular genetic landscape in acute myeloid leukaemia

(2013) Mathijs A. Sanders et al.   CURRENT OPINION IN HEMATOLOGY

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Genetic Screens in Human Cells Using the CRISPR-Cas9 System

(2013) Tim Wang et al.   SCIENCE

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

A new framework for understanding IRES-mediated translation

(2012) Anton A. Komar et al.   GENE

Interdomain Allostery Promotes Assembly of the Poly(A) mRNA Complex with PABP and eIF4G

(2012) Nozhat Safaee et al.   MOLECULAR CELL

Peptidomic discovery of short open reading frame–encoded peptides in human cells

(2012) Sarah A Slavoff et al.   Nature Chemical Biology

The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments

(2012) Nicholas T Ingolia et al.   Nature Protocols

Selective Depletion of rRNA Enables Whole Transcriptome Profiling of Archival Fixed Tissue

(2012) John D. Morlan et al.   PLoS One

Translational Control in Cancer Etiology

(2012) D. Ruggero   Cold Spring Harbor Perspectives in Biology

Targeting translation in acute myeloid leukemia: A new paradigm for therapy?

(2011) Jerome Tamburini et al.   CELL CYCLE

Inhibition of eIF4E with ribavirin cooperates with common chemotherapies in primary acute myeloid leukemia specimens

(2011) B C Kraljacic et al.   LEUKEMIA

Mutations in maltose-binding protein that alter affinity and solubility properties

(2010) Iris H. Walker et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Targeting the translational machinery as a novel treatment strategy for hematologic malignancies

(2010) P. R. Hagner et al.   BLOOD

The mechanism of eukaryotic translation initiation and principles of its regulation

(2010) Richard J. Jackson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin

(2009) S. Assouline et al.   BLOOD

SUnSET, a nonradioactive method to monitor protein synthesis

(2009) Enrico K Schmidt et al.   NATURE METHODS

Advances in molecular genetics and treatment of core-binding factor acute myeloid leukemia

(2008) Krzysztof Mrózek et al.   CURRENT OPINION IN ONCOLOGY

Requirement of RNA Binding of Mammalian Eukaryotic Translation Initiation Factor 4GI (eIF4GI) for Efficient Interaction of eIF4E with the mRNA Cap

(2008) A. Yanagiya et al.   MOLECULAR AND CELLULAR BIOLOGY