Targeted Delivery of mRNA with One-Component Ionizable Amphiphilic Janus Dendrimers

Enhanced concanavalin A binding to preorganized mannose nanoarrays in glycodendrimersomes revealed multivalent interactions

(2021) Nina Yu. Kostina et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis

(2021) Christina Krienke et al.   SCIENCE

Nanomaterial Delivery Systems for mRNA Vaccines

(2021) Michael D. Buschmann et al.   Vaccines

One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA

(2021) Dapeng Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Scalable mRNA and siRNA Lipid Nanoparticle Production Using a Parallelized Microfluidic Device

(2021) Sarah J. Shepherd et al.   NANO LETTERS

mRNA vaccines for infectious diseases: principles, delivery and clinical translation

(2021) Namit Chaudhary et al.   NATURE REVIEWS DRUG DISCOVERY

An mRNA SARS-CoV-2 Vaccine Employing Charge-Altering Releasable Transporters with a TLR-9 Agonist Induces Neutralizing Antibodies and T Cell Memory

(2021) Ole A. W. Haabeth et al.   ACS Central Science

Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration

(2021) Manuel J. Carrasco et al.   Communications Biology

A Combinatorial Library of Lipid Nanoparticles for RNA Delivery to Leukocytes

(2020) Srinivas Ramishetti et al.   ADVANCED MATERIALS

An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors

(2020) Katharina Reinhard et al.   SCIENCE

Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing

(2020) Qiang Cheng et al.   Nature Nanotechnology

Nanovesicles displaying functional linear and branched oligomannose self-assembled from sequence-defined Janus glycodendrimers

(2020) Qi Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Research and Development on Therapeutic Agents and Vaccines for COVID-19 and Related Human Coronavirus Diseases

(2020) Cynthia Liu et al.   ACS Central Science

SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

(2020) Kizzmekia S. Corbett et al.   NATURE

Phase 1/2 study of COVID-19 RNA vaccine BNT162b1 in adults

(2020) Mark J. Mulligan et al.   NATURE

Monodisperse Macromolecules by Self-Interrupted Living Polymerization

(2020) Marian N. Holerca et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Branched-Tail Lipid Nanoparticles Potently Deliver mRNA In Vivo due to Enhanced Ionization at Endosomal pH

(2019) Khalid A. Hajj et al.   Small

Encoding biological recognition in a bicomponent cell-membrane mimic

(2019) Cesar Rodriguez-Emmenegger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligo(serine ester) Charge-Altering Releasable Transporters: Organocatalytic Ring-Opening Polymerization and their Use for in Vitro and in Vivo mRNA Delivery

(2019) Nancy L. Benner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Membrane-Mimetic Dendrimersomes Engulf Living Bacteria via Endocytosis

(2019) Nina Yu. Kostina et al.   NANO LETTERS

Encapsulation of hydrophobic components in dendrimersomes and decoration of their surface with proteins and nucleic acids

(2019) Paola Torre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid Nanoparticle Technology for Clinical Translation of siRNA Therapeutics

(2019) Jayesh A. Kulkarni et al.   ACCOUNTS OF CHEMICAL RESEARCH

On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA

(2018) Jayesh A. Kulkarni et al.   ACS Nano

Beyond Chemical Synthesis: Self-Organization?!

(2018) Jean-Marie Lehn   ISRAEL JOURNAL OF CHEMISTRY

A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates

(2018) Staci Sabnis et al.   MOLECULAR THERAPY

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

Screening Libraries of Amphiphilic Janus Dendrimers Based on Natural Phenolic Acids to Discover Monodisperse Unilamellar Dendrimersomes

(2018) Irene Buzzacchera et al.   BIOMACROMOLECULES

A Dual Targeting Dendrimer-Mediated siRNA Delivery System for Effective Gene Silencing in Cancer Therapy

(2018) Yiwen Dong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bioactive cell-like hybrids from dendrimersomes with a human cell membrane and its components

(2018) Srujana S. Yadavalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid Nanoparticle Systems for Enabling Gene Therapies

(2017) Pieter R. Cullis et al.   MOLECULAR THERAPY

Dendrimers as Nanocarriers for Nucleic Acid and Drug Delivery in Cancer Therapy

(2017) Livia Palmerston Mendes et al.   MOLECULES

Charge-altering releasable transporters (CARTs) for the delivery and release of mRNA in living animals

(2017) Colin J. McKinlay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Janus dendrimersomes coassembled from fluorinated, hydrogenated, and hybrid Janus dendrimers as models for cell fusion and fission

(2017) Qi Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tools for translation: non-viral materials for therapeutic mRNA delivery

(2017) Khalid A. Hajj et al.   Nature Reviews Materials

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

(2016) Lena M. Kranz et al.   NATURE

Onion-like glycodendrimersomes from sequence-defined Janus glycodendrimers and influence of architecture on reactivity to a lectin

(2016) Qi Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioactive cell-like hybrids coassembled from (glyco)dendrimersomes with bacterial membranes

(2016) Qi Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, andToxoplasma gondiichallenges with a single dose

(2016) Jasdave S. Chahal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

(2015) Norbert Pardi et al.   JOURNAL OF CONTROLLED RELEASE

Glycodendrimersomes from Sequence-Defined Janus Glycodendrimers Reveal High Activity and Sensor Capacity for the Agglutination by Natural Variants of Human Lectins

(2015) Shaodong Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dendrimer-Inspired Nanomaterials for the in Vivo Delivery of siRNA to Lung Vasculature

(2015) Omar F. Khan et al.   NANO LETTERS

A supramolecular helix that disregards chirality

(2015) Cécile Roche et al.   Nature Chemistry

Ionizable Amphiphilic Dendrimer-Based Nanomaterials with Alkyl-Chain-Substituted Amines for Tunable siRNA Delivery to the Liver Endothelium In Vivo

(2014) Omar F. Khan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mimicking Biological Membranes with Programmable Glycan Ligands Self-Assembled from Amphiphilic Janus Glycodendrimers

(2014) Shaodong Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Emerging concepts in dendrimer-based nanomedicine: from design principles to clinical applications

(2014) R. M. Kannan et al.   JOURNAL OF INTERNAL MEDICINE

Homochiral Columns Constructed by Chiral Self-Sorting During Supramolecular Helical Organization of Hat-Shaped Molecules

(2014) Cécile Roche et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Self-assembly of amphiphilic Janus dendrimers into uniform onion-like dendrimersomes with predictable size and number of bilayers

(2014) S. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity

(2014) Kathryn A. Whitehead et al.   Nature Communications

Polymer Nanocarrier System for Endosome Escape and Timed Release of siRNA with Complete Gene Silencing and Cell Death in Cancer Cells

(2013) Wenyi Gu et al.   BIOMACROMOLECULES

Modular Synthesis of Amphiphilic Janus Glycodendrimers and Their Self-Assembly into Glycodendrimersomes and Other Complex Architectures with Bioactivity to Biomedically Relevant Lectins

(2013) Virgil Percec et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

(2012) Muthusamy Jayaraman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rational design of smart supramolecular assemblies for gene delivery: chemical challenges in the creation of artificial viruses

(2011) Kanjiro Miyata et al.   CHEMICAL SOCIETY REVIEWS

Predicting the Size and Properties of Dendrimersomes from the Lamellar Structure of Their Amphiphilic Janus Dendrimers

(2011) Mihai Peterca et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Self-Assembly of Janus Dendrimers into Uniform Dendrimersomes and Other Complex Architectures

(2010) V. Percec et al.   SCIENCE

Dendron-Mediated Self-Assembly, Disassembly, and Self-Organization of Complex Systems

(2009) Brad M. Rosen et al.   CHEMICAL REVIEWS

Viral vectors: from virology to transgene expression

(2008) D Bouard et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nonviral Vectors for Gene Delivery

(2008) Meredith A. Mintzer et al.   CHEMICAL REVIEWS