标题
mRNA vaccines for infectious diseases: principles, delivery and clinical translation
作者
关键词
-
出版物
NATURE REVIEWS DRUG DISCOVERY
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2021-08-25
DOI
10.1038/s41573-021-00283-5
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis
- (2021) Christina Krienke et al. SCIENCE
- Proof-of-concept of a low-dose unmodified mRNA-based rabies vaccine formulated with lipid nanoparticles in human volunteers: A phase 1 trial
- (2021) Cassandra Aldrich et al. VACCINE
- Development of mRNA Vaccines: Scientific and Regulatory Issues
- (2021) Ivana Knezevic et al. Vaccines
- Nanomaterial Delivery Systems for mRNA Vaccines
- (2021) Michael D. Buschmann et al. Vaccines
- Self-assembled mRNA vaccines
- (2021) Jeonghwan Kim et al. ADVANCED DRUG DELIVERY REVIEWS
- Reports of Anaphylaxis After Receipt of mRNA COVID-19 Vaccines in the US—December 14, 2020-January 18, 2021
- (2021) Tom T. Shimabukuro et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants
- (2021) Zijun Wang et al. NATURE
- BNT162b vaccines protect rhesus macaques from SARS-CoV-2
- (2021) Annette B. Vogel et al. NATURE
- Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR–Cas gene editing
- (2021) Shuai Liu et al. NATURE MATERIALS
- BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting
- (2021) Noa Dagan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Serum Neutralizing Activity Elicited by mRNA-1273 Vaccine — Preliminary Report
- (2021) Kai Wu et al. NEW ENGLAND JOURNAL OF MEDICINE
- Neutralizing Activity of BNT162b2-Elicited Serum
- (2021) Yang Liu et al. NEW ENGLAND JOURNAL OF MEDICINE
- mRNA Vaccines against Flaviviruses
- (2021) Clayton J. Wollner et al. Vaccines
- Immunogenicity of COVID-19 mRNA Vaccines in Pregnant and Lactating Women
- (2021) Ai-ris Y. Collier et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- mRNA therapeutics in cancer immunotherapy
- (2021) Jan D. Beck et al. Molecular Cancer
- A single dose of self-transcribing and replicating RNA-based SARS-CoV-2 vaccine produces protective adaptive immunity in mice
- (2021) Ruklanthi de Alwis et al. MOLECULAR THERAPY
- Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses
- (2021) Kevin O. Saunders et al. NATURE
- Nanotechnology approaches for global infectious diseases
- (2021) Ameya R. Kirtane et al. Nature Nanotechnology
- Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons
- (2021) Tom T. Shimabukuro et al. NEW ENGLAND JOURNAL OF MEDICINE
- Two Randomized Trials of Neutralizing Antibodies to Prevent HIV-1 Acquisition
- (2021) Lawrence Corey et al. NEW ENGLAND JOURNAL OF MEDICINE
- Antibody Persistence through 6 Months after the Second Dose of mRNA-1273 Vaccine for Covid-19
- (2021) Nicole Doria-Rose et al. NEW ENGLAND JOURNAL OF MEDICINE
- Interim Estimates of Vaccine Effectiveness of BNT162b2 and mRNA-1273 COVID-19 Vaccines in Preventing SARS-CoV-2 Infection Among Health Care Personnel, First Responders, and Other Essential and Frontline Workers — Eight U.S. Locations, December 2020–March 2021
- (2021) Mark G. Thompson et al. MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
- How will emerging SARS-CoV-2 variants impact herd immunity?
- (2021) Giuseppe Lippi et al. Annals of Translational Medicine
- Microfluidic formulation of nanoparticles for biomedical applications
- (2021) Sarah J. Shepherd et al. BIOMATERIALS
- SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses
- (2021) Jackson S. Turner et al. NATURE
- BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans
- (2021) Ugur Sahin et al. NATURE
- SARS-CoV-2 variants, spike mutations and immune escape
- (2021) William T. Harvey et al. NATURE REVIEWS MICROBIOLOGY
- The challenge and prospect of mRNA therapeutics landscape
- (2020) Yuhua Weng et al. BIOTECHNOLOGY ADVANCES
- Effectiveness, immunogenicity, and safety of influenza vaccines with MF59 adjuvant in healthy people of different age groups
- (2020) Jing Yang et al. MEDICINE
- A new coronavirus associated with human respiratory disease in China
- (2020) Fan Wu et al. NATURE
- Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis
- (2020) Xucheng Hou et al. Nature Nanotechnology
- Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
- (2020) Daniel Wrapp et al. SCIENCE
- Nucleoside-modified mRNA vaccination partially overcomes maternal antibody inhibition of de novo immune responses in mice
- (2020) Elinor Willis et al. Science Translational Medicine
- Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA
- (2020) Siddharth Patel et al. Nature Communications
- Nanomedicines to Deliver mRNA: State of the Art and Future Perspectives
- (2020) Itziar Gómez-Aguado et al. Nanomaterials
- Optimization of an mRNA vaccine assisted with cyclodextrin-polyethyleneimine conjugates
- (2020) Lu Tan et al. Drug Delivery and Translational Research
- Opportunities and Challenges in the Delivery of mRNA-Based Vaccines
- (2020) Abishek Wadhwa et al. Pharmaceutics
- Modified mRNA/lipid nanoparticle-based vaccines expressing respiratory syncytial virus F protein variants are immunogenic and protective in rodent models of RSV infection
- (2020) Amy S. Espeseth et al. npj Vaccines
- Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein
- (2020) Alexandra C. Walls et al. CELL
- A Multi-Targeting, Nucleoside-Modified mRNA Influenza Virus Vaccine Provides Broad Protection in Mice
- (2020) Alec W. Freyn et al. MOLECULAR THERAPY
- Anti-PfGARP activates programmed cell death of parasites and reduces severe malaria
- (2020) Dipak K. Raj et al. NATURE
- Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing
- (2020) Qiang Cheng et al. Nature Nanotechnology
- Cell entry mechanisms of SARS-CoV-2
- (2020) Jian Shang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Contributions of maternal and fetal antiviral immunity in congenital disease
- (2020) Laura J. Yockey et al. SCIENCE
- Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver
- (2020) Lei Miao et al. Nature Communications
- COVID-19 vaccines: breaking record times to first-in-human trials
- (2020) Young Chan Kim et al. npj Vaccines
- mRNA Vaccines Encoding the HA Protein of Influenza A H1N1 Virus Delivered by Cationic Lipid Nanoparticles Induce Protective Immune Responses in Mice
- (2020) Xinyu Zhuang et al. Vaccines
- Surface-Functionalized PEGylated Nanoparticles Deliver Messenger RNA to Pulmonary Immune Cells
- (2020) Xiyu Ke et al. ACS Applied Materials & Interfaces
- Controlling timing and location in vaccines
- (2020) Darrell J. Irvine et al. ADVANCED DRUG DELIVERY REVIEWS
- Anti-PEG antibodies: Properties, formation, testing and role in adverse immune reactions to PEGylated nano-biopharmaceuticals
- (2020) Gergely Tibor Kozma et al. ADVANCED DRUG DELIVERY REVIEWS
- A Thermostable mRNA Vaccine against COVID-19
- (2020) Na-Na Zhang et al. CELL
- Recent advances in mRNA vaccine technology
- (2020) Norbert Pardi et al. CURRENT OPINION IN IMMUNOLOGY
- A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice
- (2020) Dorottya Laczkó et al. IMMUNITY
- A Potent Branched-Tail Lipid Nanoparticle Enables Multiplexed mRNA Delivery and Gene Editing In Vivo
- (2020) Khalid A. Hajj et al. NANO LETTERS
- SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness
- (2020) Kizzmekia S. Corbett et al. NATURE
- Phase 1/2 study of COVID-19 RNA vaccine BNT162b1 in adults
- (2020) Mark J. Mulligan et al. NATURE
- Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates
- (2020) Kizzmekia S. Corbett et al. NEW ENGLAND JOURNAL OF MEDICINE
- An mRNA Vaccine against SARS-CoV-2 — Preliminary Report
- (2020) Lisa A. Jackson et al. NEW ENGLAND JOURNAL OF MEDICINE
- Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice
- (2020) Paul F. McKay et al. Nature Communications
- Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing
- (2020) Tuo Wei et al. Nature Communications
- Current Challenges in Vaccinology
- (2020) Richard B. Kennedy et al. Frontiers in Immunology
- Modified mRNA-LNP vaccines confer protection against experimental DENV-2 infection in mice
- (2020) Mengling Zhang et al. Molecular Therapy-Methods & Clinical Development
- Leveraging mRNA Sequences and Nanoparticles to Deliver SARS‐CoV‐2 Antigens In Vivo
- (2020) Chunxi Zeng et al. ADVANCED MATERIALS
- Self-amplifying RNA vaccines for infectious diseases
- (2020) Kristie Bloom et al. GENE THERAPY
- Human germinal centres engage memory and naive B cells after influenza vaccination
- (2020) Jackson S. Turner et al. NATURE
- COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses
- (2020) Ugur Sahin et al. NATURE
- A global survey of potential acceptance of a COVID-19 vaccine
- (2020) Jeffrey V. Lazarus et al. NATURE MEDICINE
- Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates
- (2020) Edward E. Walsh et al. NEW ENGLAND JOURNAL OF MEDICINE
- Visualization of the HIV-1 Env glycan shield across scales
- (2020) Zachary T. Berndsen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Prospects for a safe COVID-19 vaccine
- (2020) Barton F. Haynes et al. Science Translational Medicine
- Analysis of SARS-CoV-2 vertical transmission during pregnancy
- (2020) Claudio Fenizia et al. Nature Communications
- Intramuscular Delivery of Replicon RNA Encoding ZIKV-117 Human Monoclonal Antibody Protects against Zika Virus Infection
- (2020) Jesse H. Erasmus et al. Molecular Therapy-Methods & Clinical Development
- A Systematic Study of Unsaturation in Lipid Nanoparticles Leads to Improved mRNA Transfection In Vivo
- (2020) Sang Lee et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- COVID-19 mortality risk for older men and women
- (2020) N. David Yanez et al. BMC PUBLIC HEALTH
- SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation
- (2020) Katlyn Lederer et al. IMMUNITY
- COVID-19: neonatal–perinatal perspectives
- (2020) Alejandra Barrero-Castillero et al. Journal of Perinatology
- Eliciting B cell immunity against infectious diseases using nanovaccines
- (2020) Ankur Singh Nature Nanotechnology
- Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine
- (2020) Lindsey R. Baden et al. NEW ENGLAND JOURNAL OF MEDICINE
- Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
- (2020) Fernando P. Polack et al. NEW ENGLAND JOURNAL OF MEDICINE
- Suspicions grow that nanoparticles in Pfizer’s COVID-19 vaccine trigger rare allergic reactions
- (2020) Jop Vrieze SCIENCE
- Temperature concerns could slow the rollout of new coronavirus vaccines
- (2020) Jocelyn Kaiser SCIENCE
- The case for an HIV cure and how to get there
- (2020) Mark Dybul et al. Lancet HIV
- Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium
- (2019) Asha Kumari Patel et al. ADVANCED MATERIALS
- Branched-Tail Lipid Nanoparticles Potently Deliver mRNA In Vivo due to Enhanced Ionization at Endosomal pH
- (2019) Khalid A. Hajj et al. Small
- Phase Ib evaluation of a self-adjuvanted protamine formulated mRNA-based active cancer immunotherapy, BI1361849 (CV9202), combined with local radiation treatment in patients with stage IV non-small cell lung cancer
- (2019) Alexandros Papachristofilou et al. Journal for ImmunoTherapy of Cancer
- Characterization of HIV-1 nucleoside-modified mRNA vaccines in rabbits and rhesus macaques
- (2019) Norbert Pardi et al. Molecular Therapy-Nucleic Acids
- Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery
- (2019) Piotr S. Kowalski et al. MOLECULAR THERAPY
- Nanoparticles Containing Oxidized Cholesterol Deliver mRNA to the Liver Microenvironment at Clinically Relevant Doses
- (2019) Kalina Paunovska et al. ADVANCED MATERIALS
- Peptide-mediated delivery of therapeutic mRNA in ovarian cancer
- (2019) Dirk van den Brand et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- mRNA vaccines against H10N8 and H7N9 influenza viruses of pandemic potential are immunogenic and well tolerated in healthy adults in phase 1 randomized clinical trials
- (2019) Robert A. Feldman et al. VACCINE
- Inside out: optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA
- (2019) Anna K. Blakney et al. GENE THERAPY
- Human 5′ UTR design and variant effect prediction from a massively parallel translation assay
- (2019) Paul J. Sample et al. NATURE BIOTECHNOLOGY
- A proof of concept for structure-based vaccine design targeting RSV in humans
- (2019) Michelle C. Crank et al. SCIENCE
- Mannosylation of LNP Results in Improved Potency for Self-Amplifying RNA (SAM) Vaccines
- (2019) Roshan Goswami et al. ACS Infectious Diseases
- A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection
- (2019) Nurgun Kose et al. Science Immunology
- Constrained Nanoparticles Deliver siRNA and sgRNA to T Cells In Vivo without Targeting Ligands
- (2019) Melissa P. Lokugamage et al. ADVANCED MATERIALS
- Recent advances in polymeric materials for the delivery of RNA therapeutics
- (2019) David Ulkoski et al. Expert Opinion on Drug Delivery
- Protective Efficacy of Nucleic Acid Vaccines Against Transmission of Zika Virus During Pregnancy in Mice
- (2019) Brett W Jagger et al. JOURNAL OF INFECTIOUS DISEASES
- Three decades of messenger RNA vaccine development
- (2019) Rein Verbeke et al. Nano Today
- Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation
- (2019) Lei Miao et al. NATURE BIOTECHNOLOGY
- Immunosenescence and human vaccine immune responses
- (2019) Stephen N. Crooke et al. Immunity & Ageing
- Enhancement of Motor Function Recovery after Spinal Cord Injury in Mice by Delivery of Brain-Derived Neurotrophic Factor mRNA
- (2019) Samuel T. Crowley et al. Molecular Therapy-Nucleic Acids
- Tailoring mRNA Vaccine to Balance Innate/Adaptive Immune Response
- (2019) Sergio Linares-Fernández et al. TRENDS IN MOLECULAR MEDICINE
- Fine-Tuning of Hydrophobicity in Amphiphilic Polyaspartamide Derivatives for Rapid and Transient Expression of Messenger RNA Directed Toward Genome Engineering in Brain
- (2019) Hyun Jin Kim et al. ACS Central Science
- On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA
- (2018) Jayesh A. Kulkarni et al. ACS Nano
- Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses
- (2018) Norbert Pardi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Rapid Establishment of a Cold Chain Capacity of –60°C or Colder for the STRIVE Ebola Vaccine Trial During the Ebola Outbreak in Sierra Leone
- (2018) Morrison O Jusu et al. JOURNAL OF INFECTIOUS DISEASES
- Estimates of global seasonal influenza-associated respiratory mortality: a modelling study
- (2018) A Danielle Iuliano et al. LANCET
- Development of vaccines against Zika virus
- (2018) Gregory A Poland et al. LANCET INFECTIOUS DISEASES
- The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates
- (2018) Natalie I Mazur et al. LANCET INFECTIOUS DISEASES
- Self-Amplifying RNA Vaccines Give Equivalent Protection against Influenza to mRNA Vaccines but at Much Lower Doses
- (2018) Annette B. Vogel et al. MOLECULAR THERAPY
- A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates
- (2018) Staci Sabnis et al. MOLECULAR THERAPY
- Lipid Nanoparticle Formulations for Enhanced Co-delivery of siRNA and mRNA
- (2018) Rebecca L. Ball et al. NANO LETTERS
- A modular platform for targeted RNAi therapeutics
- (2018) Ranit Kedmi et al. Nature Nanotechnology
- mRNA vaccines — a new era in vaccinology
- (2018) Norbert Pardi et al. NATURE REVIEWS DRUG DISCOVERY
- Neutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection
- (2018) Alvaro Baeza Garcia et al. Nature Communications
- Correlation of the cytotoxic effects of cationic lipids with their headgroups
- (2018) Shaohui Cui et al. Toxicology Research
- Uridine Depletion and Chemical Modification Increase Cas9 mRNA Activity and Reduce Immunogenicity without HPLC Purification
- (2018) Sriram Vaidyanathan et al. Molecular Therapy-Nucleic Acids
- Pregnancy and infection: using disease pathogenesis to inform vaccine strategy
- (2018) Meghan S. Vermillion et al. npj Vaccines
- Optimization of a Degradable Polymer–Lipid Nanoparticle for Potent Systemic Delivery of mRNA to the Lung Endothelium and Immune Cells
- (2018) James C. Kaczmarek et al. NANO LETTERS
- Biomedical applications of mRNA nanomedicine
- (2018) Qingqing Xiong et al. Nano Research
- mRNA vaccination with charge-altering releasable transporters elicits human T cell responses and cures established tumors in mice
- (2018) Ole A. W. Haabeth et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies
- (2018) Norbert Pardi et al. Nature Communications
- The great escape: how cationic polyplexes overcome the endosomal barrier
- (2018) Tanja Bus et al. Journal of Materials Chemistry B
- Improving mRNA-Based Therapeutic Gene Delivery by Expression-Augmenting 3′ UTRs Identified by Cellular Library Screening
- (2018) Alexandra G. Orlandini von Niessen et al. MOLECULAR THERAPY
- Structural and molecular mechanisms for the control of eukaryotic 5′–3′ mRNA decay
- (2018) Jeffrey S. Mugridge et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Cell specific delivery of modified mRNA expressing therapeutic proteins to leukocytes
- (2018) Nuphar Veiga et al. Nature Communications
- Efficient Induction of T Cells against Conserved HIV-1 Regions by Mosaic Vaccines Delivered as Self-Amplifying mRNA
- (2018) Nathifa Moyo et al. Molecular Therapy-Methods & Clinical Development
- Modified mRNA-Based Vaccines Elicit Robust Immune Responses and Protect Guinea Pigs From Ebola Virus Disease
- (2017) Michelle Meyer et al. JOURNAL OF INFECTIOUS DISEASES
- Safety and immunogenicity of a mRNA rabies vaccine in healthy adults: an open-label, non-randomised, prospective, first-in-human phase 1 clinical trial
- (2017) Martin Alberer et al. LANCET
- Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study
- (2017) Ting Shi et al. LANCET
- Lipid Nanoparticle Systems for Enabling Gene Therapies
- (2017) Pieter R. Cullis et al. MOLECULAR THERAPY
- Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses
- (2017) Kapil Bahl et al. MOLECULAR THERAPY
- Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination
- (2017) Norbert Pardi et al. NATURE
- Elimination of large tumors in mice by mRNA-encoded bispecific antibodies
- (2017) Christiane R Stadler et al. NATURE MEDICINE
- Functional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them
- (2017) Kathrin Leppek et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Charge-altering releasable transporters (CARTs) for the delivery and release of mRNA in living animals
- (2017) Colin J. McKinlay et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains
- (2017) Seth J. Zost et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Systemic delivery of factor IX messenger RNA for protein replacement therapy
- (2017) Suvasini Ramaswamy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Immunogenicity and protective efficacy induced by self-amplifying mRNA vaccines encoding bacterial antigens
- (2017) Giulietta Maruggi et al. VACCINE
- Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge
- (2017) Norbert Pardi et al. Nature Communications
- Surface De-PEGylation Controls Nanoparticle-Mediated siRNA Delivery In Vitro and In Vivo
- (2017) Xi Zhu et al. Theranostics
- Arginine-Rich Peptide-Based mRNA Nanocomplexes Efficiently Instigate Cytotoxic T Cell Immunity Dependent on the Amphipathic Organization of the Peptide
- (2017) Vimal K. Udhayakumar et al. Advanced Healthcare Materials
- A thermostable messenger RNA based vaccine against rabies
- (2017) Lothar Stitz et al. PLoS Neglected Tropical Diseases
- Tools for translation: non-viral materials for therapeutic mRNA delivery
- (2017) Khalid A. Hajj et al. Nature Reviews Materials
- Unmodified mRNA in LNPs constitutes a competitive technology for prophylactic vaccines
- (2017) Johannes Lutz et al. npj Vaccines
- A universal influenza virus vaccine candidate confers protection against pandemic H1N1 infection in preclinical ferret studies
- (2017) Raffael Nachbagauer et al. npj Vaccines
- The role of helper lipids in lipid nanoparticles (LNPs) designed for oligonucleotide delivery
- (2016) Xinwei Cheng et al. ADVANCED DRUG DELIVERY REVIEWS
- Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Delivery
- (2016) Owen S. Fenton et al. ADVANCED MATERIALS
- Polymer-Lipid Nanoparticles for Systemic Delivery of mRNA to the Lungs
- (2016) James C. Kaczmarek et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- The role of cholesterol in membrane fusion
- (2016) Sung-Tae Yang et al. CHEMISTRY AND PHYSICS OF LIPIDS
- Emerging Role of Zika Virus in Adverse Fetal and Neonatal Outcomes
- (2016) Alice Panchaud et al. CLINICAL MICROBIOLOGY REVIEWS
- Risk of anaphylaxis after vaccination in children and adults
- (2016) Michael M. McNeil et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Enhanced intranasal delivery of mRNA vaccine by overcoming the nasal epithelial barrier via intra- and paracellular pathways
- (2016) Man Li et al. JOURNAL OF CONTROLLED RELEASE
- Messenger RNA-based therapeutics for brain diseases: An animal study for augmenting clearance of beta-amyloid by intracerebral administration of neprilysin mRNA loaded in polyplex nanomicelles
- (2016) Chin-Yu Lin et al. JOURNAL OF CONTROLLED RELEASE
- Materials for non-viral intracellular delivery of messenger RNA therapeutics
- (2016) Kevin J. Kauffman et al. JOURNAL OF CONTROLLED RELEASE
- Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy
- (2016) Matthias A. Oberli et al. NANO LETTERS
- Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy
- (2016) Lena M. Kranz et al. NATURE
- Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus
- (2016) Wanwisa Dejnirattisai et al. NATURE IMMUNOLOGY
- Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe
- (2016) Selidji T. Agnandji et al. NEW ENGLAND JOURNAL OF MEDICINE
- Self-Amplifying mRNA Vaccines Expressing Multiple Conserved Influenza Antigens Confer Protection against Homologous and Heterosubtypic Viral Challenge
- (2016) Diletta Magini et al. PLoS One
- Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination
- (2016) Hok Hei Tam et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, andToxoplasma gondiichallenges with a single dose
- (2016) Jasdave S. Chahal et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model
- (2016) Kejin Zhou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Understanding Ebola: the 2014 epidemic
- (2016) Jolie Kaner et al. Globalization and Health
- Messenger RNA delivery of a cartilage-anabolic transcription factor as a disease-modifying strategy for osteoarthritis treatment
- (2016) Hailati Aini et al. Scientific Reports
- Expression of CD39 on Activated T Cells Impairs their Survival in Older Individuals
- (2016) Fengqin Fang et al. Cell Reports
- Broadly Neutralizing Activity of Zika Virus-Immune Sera Identifies a Single Viral Serotype
- (2016) Kimberly A. Dowd et al. Cell Reports
- An mRNA Vaccine Encoding Rabies Virus Glycoprotein Induces Protection against Lethal Infection in Mice and Correlates of Protection in Adult and Newborn Pigs
- (2016) Margit Schnee et al. PLoS Neglected Tropical Diseases
- Perinatal Cytomegalovirus and Varicella Zoster Virus Infections
- (2015) Kristy M. Bialas et al. CLINICS IN PERINATOLOGY
- Induction of HIV-1 gag specific immune responses by cationic micelles mediated delivery of gag mRNA
- (2015) Mengnan Zhao et al. DRUG DELIVERY
- Treatment of neurological disorders by introducing mRNA in vivo using polyplex nanomicelles
- (2015) Miyuki Baba et al. JOURNAL OF CONTROLLED RELEASE
- Induction of Broad-Based Immunity and Protective Efficacy by Self-amplifying mRNA Vaccines Encoding Influenza Virus Hemagglutinin
- (2015) Michela Brazzoli et al. JOURNAL OF VIROLOGY
- Murine Antibody Responses to Cleaved Soluble HIV-1 Envelope Trimers Are Highly Restricted in Specificity
- (2015) Joyce K. Hu et al. JOURNAL OF VIROLOGY
- Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals
- (2015) Andreas Thess et al. MOLECULAR THERAPY
- An Orthogonal Array Optimization of Lipid-like Nanoparticles for mRNA Delivery in Vivo
- (2015) Bin Li et al. NANO LETTERS
- Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs
- (2015) Kevin J. Kauffman et al. NANO LETTERS
- Alternative 3′ UTRs act as scaffolds to regulate membrane protein localization
- (2015) Binyamin D. Berkovits et al. NATURE
- The modern era of HIV-1 vaccine development
- (2015) J. R. Mascola SCIENCE
- A highly stable prefusion RSV F vaccine derived from structural analysis of the fusion mechanism
- (2015) Anders Krarup et al. Nature Communications
- Messenger RNA-based therapeutics for the treatment of apoptosis-associated diseases
- (2015) Akitsugu Matsui et al. Scientific Reports
- Extremely High Mutation Rate of HIV-1 In Vivo
- (2015) José M. Cuevas et al. PLOS BIOLOGY
- Estimating the Global Burden of Endemic Canine Rabies
- (2015) Katie Hampson et al. PLoS Neglected Tropical Diseases
- Self-adjuvanted mRNA vaccination in advanced prostate cancer patients: a first-in-man phase I/IIa study
- (2015) Hubert Kübler et al. Journal for ImmunoTherapy of Cancer
- Development and characterization of self-assembling nanoparticles using a bio-inspired amphipathic peptide for gene delivery
- (2014) Helen O. McCarthy et al. JOURNAL OF CONTROLLED RELEASE
- The Adjuvants Aluminum Hydroxide and MF59 Induce Monocyte and Granulocyte Chemoattractants and Enhance Monocyte Differentiation toward Dendritic Cells
- (2014) A. Seubert et al. JOURNAL OF IMMUNOLOGY
- Potent Immune Responses in Rhesus Macaques Induced by Nonviral Delivery of a Self-amplifying RNA Vaccine Expressing HIV Type 1 Envelope With a Cationic Nanoemulsion
- (2014) W. M. Bogers et al. JOURNAL OF INFECTIOUS DISEASES
- A Cationic Nanoemulsion for the Delivery of Next-generation RNA Vaccines
- (2014) Luis A Brito et al. MOLECULAR THERAPY
- mRNA-based therapeutics — developing a new class of drugs
- (2014) Ugur Sahin et al. NATURE REVIEWS DRUG DISCOVERY
- Diversity and clonal selection in the human T-cell repertoire
- (2014) Q. Qi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity
- (2014) Kathryn A. Whitehead et al. Nature Communications
- The accelerated blood clearance (ABC) phenomenon: Clinical challenge and approaches to manage
- (2013) Amr S. Abu Lila et al. JOURNAL OF CONTROLLED RELEASE
- Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling
- (2013) Gaurav Sahay et al. NATURE BIOTECHNOLOGY
- Delivery materials for siRNA therapeutics
- (2013) Rosemary Kanasty et al. NATURE MATERIALS
- Multiparametric approach for the evaluation of lipid nanoparticles for siRNA delivery
- (2013) C. A. Alabi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody
- (2013) J. S. McLellan et al. SCIENCE
- Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus
- (2013) J. S. McLellan et al. SCIENCE
- A novel, disruptive vaccination technology
- (2013) Karl-Josef Kallen et al. Human Vaccines & Immunotherapeutics
- Rapidly produced SAM® vaccine against H7N9 influenza is immunogenic in mice
- (2013) Armin Hekele et al. Emerging Microbes & Infections
- The Effect of Age on Thymic Function
- (2013) Donald B. Palmer Frontiers in Immunology
- Cationic lipids activate intracellular signaling pathways
- (2012) Caroline Lonez et al. ADVANCED DRUG DELIVERY REVIEWS
- Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo
- (2012) Muthusamy Jayaraman et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Silent Substitutions Predictably Alter Translation Elongation Rates and Protein Folding Efficiencies
- (2012) Paige S. Spencer et al. JOURNAL OF MOLECULAR BIOLOGY
- Type I IFN Counteracts the Induction of Antigen-Specific Immune Responses by Lipid-Based Delivery of mRNA Vaccines
- (2012) Charlotte Pollard et al. MOLECULAR THERAPY
- Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection
- (2012) Benjamin Petsch et al. NATURE BIOTECHNOLOGY
- A Plasmodium-encoded cytokine suppresses T-cell immunity during malaria
- (2012) T. Sun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Nonviral delivery of self-amplifying RNA vaccines
- (2012) A. J. Geall et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The mechanism of action of MF59 – An innately attractive adjuvant formulation
- (2012) D.T. O’Hagan et al. VACCINE
- Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA
- (2012) Nathan M Belliveau et al. Molecular Therapy-Nucleic Acids
- Mechanism of Neutralization by the Broadly Neutralizing HIV-1 Monoclonal Antibody VRC01
- (2011) Y. Li et al. JOURNAL OF VIROLOGY
- Endocytosis of nanomedicines
- (2010) Gaurav Sahay et al. JOURNAL OF CONTROLLED RELEASE
- Lipid-like materials for low-dose, in vivo gene silencing
- (2010) K. T. Love et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Direct Injection of Protamine-protected mRNA: Results of a Phase 1/2 Vaccination Trial in Metastatic Melanoma Patients
- (2009) Benjamin Weide et al. JOURNAL OF IMMUNOTHERAPY
- Development of Lipidoid–siRNA Formulations for Systemic Delivery to the Liver
- (2009) Akin Akinc et al. MOLECULAR THERAPY
- Nonviral Vectors for Gene Delivery
- (2008) Meredith A. Mintzer et al. CHEMICAL REVIEWS
- Molecular and cellular signatures of human vaccine adjuvants
- (2008) F. Mosca et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Vaccination and antigenic drift in influenza
- (2008) Maciej F. Boni VACCINE
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started