期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 111, 期 25, 页码 9058-9063出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1402858111
关键词
synthetic membranes; biomembrane mimics; multibilayer vesicles
资金
- National Science Foundation [DMR-1066116, DMR-1120901]
- P. Roy Vagelos Chair at the University of Pennsylvania
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1066116] Funding Source: National Science Foundation
A constitutional isomeric library synthesized by a modular approach has been used to discover six amphiphilic Janus dendrimer primary structures, which self-assemble into uniform onion-like vesicles with predictable dimensions and number of internal bilayers. These vesicles, denoted onion-like dendrimersomes, are assembled by simple injection of a solution of Janus dendrimer in a water-miscible solvent into water or buffer. These dendrimersomes provide mimics of double-bilayer and multibilayer biological membranes with dimensions and number of bilayers predicted by the Janus compound concentration in water. The simple injection method of preparation is accessible without any special equipment, generating uniform vesicles, and thus provides a promising tool for fundamental studies as well as technological applications in nanomedicine and other fields.
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