FRET‐based assay for intracellular evaluation of α‐synuclein aggregation inhibitors

Fluorescent Probe for Selective Imaging of α-Synuclein Fibrils in Living Cells

(2021) Pankaj Gaur et al.   ACS Chemical Neuroscience

Rationally Designed Protein-Based Inhibitor of α-Synuclein Fibrillization in Cells

(2021) Anastasiia Priss et al.   JOURNAL OF MEDICINAL CHEMISTRY

Update on the association between alpha‐synuclein and tau with mitochondrial dysfunction: Implications for Parkinson's disease

(2020) Si‐Tong Feng et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Initiation and propagation of α-synuclein aggregation in the nervous system

(2020) Baraa A. Hijaz et al.   Molecular Neurodegeneration

Inhibition of synucleinopathic seeding by rationally designed inhibitors

(2020) Smriti Sangwan et al.   eLife

Monitoring alpha‐synuclein oligomerization and aggregation using bimolecular fluorescence complementation assays: what you see is not always what you get

(2020) Bryan Frey et al.   JOURNAL OF NEUROCHEMISTRY

Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization

(2020) Antonio Dominguez-Meijide et al.   Scientific Reports

Alpha-Synuclein FRET Biosensors Reveal Early Alpha-Synuclein Aggregation in the Endoplasmic Reticulum

(2020) Fabiana Miraglia et al.   Life-Basel

Distinct alpha‐Synuclein species induced by seeding are selectively cleared by the Lysosome or the Proteasome in neuronally differentiated SH‐SY5Y cells

(2020) Marina Pantazopoulou et al.   JOURNAL OF NEUROCHEMISTRY

Alpha‐Synuclein oligomerization and aggregation: All models are useful but only if we know what they model

(2020) Hilal A. Lashuel   JOURNAL OF NEUROCHEMISTRY

How specific are the conformation-specific α-synuclein antibodies? Characterization and validation of 16 α-synuclein conformation-specific antibodies using well-characterized preparations of α-synuclein monomers, fibrils and oligomers with distinct structures and morphology

(2020) Senthil T. Kumar et al.   NEUROBIOLOGY OF DISEASE

Different Effects of α-Synuclein Mutants on Lipid Binding and Aggregation Detected by Single Molecule Fluorescence Spectroscopy and ThT Fluorescence-Based Measurements

(2019) Viktoria C. Ruf et al.   ACS Chemical Neuroscience

The prion-like spreading of α-synuclein: From in vitro to in vivo models of Parkinson’s disease

(2019) Jessica Y. Vargas et al.   AGEING RESEARCH REVIEWS

Quantitative Characterization of α-Synuclein Aggregation in Living Cells through Automated Microfluidics Feedback Control

(2019) Giansimone Perrino et al.   Cell Reports

An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils

(2019) Emil Dandanell Agerschou et al.   eLife

α-Synuclein Dimers as Potent Inhibitors of Fibrillization

(2019) Yevhenii A. Kyriukha et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Optimization of Inhibitors of α-Synuclein Fibril Growth: Affinity to the Fibril End as a Crucial Factor

(2019) Kseniia Afitska et al.   JOURNAL OF MOLECULAR BIOLOGY

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine

(2018) Michele Perni et al.   ACS Chemical Biology

Inhibition of α-Synuclein Amyloid Fibril Elongation by Blocking Fibril Ends

(2018) Volodymyr V. Shvadchak et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Extracellular α-Synuclein Disrupts Membrane Nanostructure and Promotes S-Nitrosylation-Induced Neuronal Cell Death

(2018) Roshan Kumar et al.   BIOMACROMOLECULES

Alpha-synuclein, Proteotoxicity and Parkinson's Disease: Search for Neuroprotective Therapy

(2018) Upasana Ganguly et al.   Current Neuropharmacology

Exogenous α-synuclein hinders synaptic communication in cultured cortical primary rat neurons

(2018) G. C. Hassink et al.   PLoS One

Novel DNA Aptamers for Parkinson’s Disease Treatment Inhibit α-Synuclein Aggregation and Facilitate its Degradation

(2018) Yuan Zheng et al.   Molecular Therapy-Nucleic Acids

Propagation and spread of pathogenic protein assemblies in neurodegenerative diseases

(2018) Mathias Jucker et al.   NATURE NEUROSCIENCE

Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons

(2018) Jordi Pujols et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Review on Electroporation-Based Intracellular Delivery

(2018) Junfeng Shi et al.   MOLECULES

Opposed Effects of Dityrosine Formation in Soluble and Aggregated α-Synuclein on Fibril Growth

(2017) Michael M. Wördehoff et al.   JOURNAL OF MOLECULAR BIOLOGY

Epidemiology of Parkinson’s disease

(2017) Ole-Bjørn Tysnes et al.   JOURNAL OF NEURAL TRANSMISSION

The SH-SY5Y cell line in Parkinson’s disease research: a systematic review

(2017) Helena Xicoy et al.   Molecular Neurodegeneration

Novel conformation-selective alpha-synuclein antibodies raised against different in vitro fibril forms show distinct patterns of Lewy pathology in Parkinson's disease

(2017) D. J. Covell et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Nanoscopic insights into seeding mechanisms and toxicity of α-synuclein species in neurons

(2016) Dorothea Pinotsi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-Synuclein and Lewy pathology in Parkinsonʼs disease

(2015) Lorraine V. Kalia et al.   CURRENT OPINION IN NEUROLOGY

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons

(2015) Emily M. Rocha et al.   NEUROBIOLOGY OF DISEASE

The Unreliability of MTT Assay in the Cytotoxic Test of Primary Cultured Glioblastoma Cells

(2015) Hwa Yeon Jo et al.   Experimental Neurobiology

Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice

(2014) J. Mark Cooper et al.   MOVEMENT DISORDERS

Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite–like aggregates

(2014) Laura A Volpicelli-Daley et al.   Nature Protocols

Solution conditions determine the relative importance of nucleation and growth processes in  -synuclein aggregation

(2014) A. K. Buell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease

(2013) Jens Wagner et al.   ACTA NEUROPATHOLOGICA

Lewy Body-like α-Synuclein Aggregates Resist Degradation and Impair Macroautophagy

(2013) Selcuk A. Tanik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A prolyl oligopeptidase inhibitor, KYP-2047, reduces α-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease

(2012) TT Myöhänen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Exocytosis of MTT formazan could exacerbate cell injury

(2012) Lanhai Lü et al.   TOXICOLOGY IN VITRO

ER stress response plays an important role in aggregation of α-synuclein

(2011) Peizhou Jiang et al.   Molecular Neurodegeneration

EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity

(2010) Jan Bieschke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aβ Mediated Diminution of MTT Reduction—An Artefact of Single Cell Culture?

(2008) Raik Rönicke et al.   PLoS One