Update on the association between alpha‐synuclein and tau with mitochondrial dysfunction: Implications for Parkinson's disease

Clinical and neuropathological differences between Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies – current issues and future directions

(2019) Lauren Walker et al.   JOURNAL OF NEUROCHEMISTRY

RNAi-mediated knockdown of DJ-1 leads to mitochondrial dysfunction via Akt/GSK-3ß and JNK signaling pathways in dopaminergic neuron-like cells

(2019) Xiao-Ling Zhang et al.   BRAIN RESEARCH BULLETIN

Parkinson’s disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes

(2019) Jee Hoon Lee et al.   Acta Neuropathologica Communications

Mangiferin: A multipotent natural product preventing neurodegeneration in Alzheimer’s and Parkinson’s disease models

(2019) Si-Tong Feng et al.   PHARMACOLOGICAL RESEARCH

Dynamin-related protein 1: A protein critical for mitochondrial fission, mitophagy, and neuronal death in Parkinson’s disease

(2019) Si-Tong Feng et al.   PHARMACOLOGICAL RESEARCH

α-Synuclein Oligomers Induce a Unique Toxic Tau Strain

(2018) Diana L. Castillo-Carranza et al.   BIOLOGICAL PSYCHIATRY

Synergistic Amyloid Switch Triggered by Early Heterotypic Oligomerization of Intrinsically Disordered α-Synuclein and Tau

(2018) Karishma Bhasne et al.   JOURNAL OF MOLECULAR BIOLOGY

Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy

(2018) Julia E. Gerson et al.   Molecular Neurodegeneration

α-synuclein Induces Mitochondrial Dysfunction through Spectrin and the Actin Cytoskeleton

(2018) Dalila G. Ordonez et al.   NEURON

α-Synuclein and Tau: Mitochondrial Kill Switches

(2018) Ulrike Pech et al.   NEURON

Cyclin-dependent kinase 5-mediated phosphorylation of CHIP promotes the tAIF-dependent death pathway in rotenone-treated cortical neurons

(2018) Chiho Kim et al.   NEUROSCIENCE LETTERS

Unlocking the mystery of biomarkers: A brief introduction, challenges and opportunities in Parkinson Disease

(2018) Thomas F. Tropea et al.   PARKINSONISM & RELATED DISORDERS

α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies

(2018) Iryna Prots et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Insulin/IGF-1/PI3K/Akt/GSK3β Signaling in Parkinson's Disease Dementia

(2018) Liying Yang et al.   Frontiers in Neuroscience

Ablation of tau causes an olfactory deficit in a murine model of Parkinson’s disease

(2018) Leah C. Beauchamp et al.   Acta Neuropathologica Communications

Lifestyles of a Toxic Twosome: A Novel Tau Strain Induced by α-Synuclein Oligomers

(2018) George R. Jackson   BIOLOGICAL PSYCHIATRY

Parkinson’s disease research: adopting a more human perspective to accelerate advances

(2018) Lindsay J. Marshall et al.   DRUG DISCOVERY TODAY

Genetic background and outcome of Deep Brain Stimulation in Parkinson's disease

(2018) Mario Giorgio Rizzone et al.   PARKINSONISM & RELATED DISORDERS

Heterogeneity in α-synuclein subtypes and their expression in cortical brain tissue lysates from Lewy body diseases and Alzheimer's disease

(2018) N. N. Vaikath et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Parkinson's disease: Evolution of the scientific literature from 1983 to 2017 by countries and journals

(2018) C. Robert et al.   PARKINSONISM & RELATED DISORDERS

Da-Bu-Yin-Wan Improves the Ameliorative Effect of DJ-1 on Mitochondrial Dysfunction Through Augmenting the Akt Phosphorylation in a Cellular Model of Parkinson’s Disease

(2018) Yi Zhang et al.   Frontiers in Pharmacology

The M458L missense mutation disrupts the catalytic properties of Parkin

(2017) Yun-Ju Do et al.   FEBS LETTERS

Mdivi-1 ameliorates early brain injury after subarachnoid hemorrhage via the suppression of inflammation-related blood–brain barrier disruption and endoplasmic reticulum stress-based apoptosis

(2017) Lin-feng Fan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial Calcium Dysregulation Contributes to Dendrite Degeneration Mediated by PD/LBD-Associated LRRK2 Mutants

(2017) Manish Verma et al.   JOURNAL OF NEUROSCIENCE

Alpha-Synuclein Suppresses Retinoic Acid-Induced Neuronal Differentiation by Targeting the Glycogen Synthase Kinase-3β/β-Catenin Signaling Pathway

(2017) Sasuk Kim et al.   MOLECULAR NEUROBIOLOGY

The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity

(2017) Maya Ando et al.   Molecular Neurodegeneration

Neuropathology of genetic synucleinopathies with parkinsonism: Review of the literature

(2017) Susanne A. Schneider et al.   MOVEMENT DISORDERS

Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy

(2017) J.A. Obeso et al.   MOVEMENT DISORDERS

β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson’s disease

(2017) Shuchi Mittal et al.   SCIENCE

Mitochondrial hyperpolarization in iPSC-derived neurons from patients of FTDP-17 with 10+16 MAPT mutation leads to oxidative stress and neurodegeneration

(2017) Noemí Esteras et al.   Redox Biology

Mitochondrial division inhibitor-1 is neuroprotective in the A53T-α-synuclein rat model of Parkinson’s disease

(2017) Simone Bido et al.   Scientific Reports

The Essential Role of Drp1 and Its Regulation by S-Nitrosylation of Parkin in Dopaminergic Neurodegeneration: Implications for Parkinson's Disease

(2016) Zhenzhen Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Back to the tubule: microtubule dynamics in Parkinson’s disease

(2016) Laura Pellegrini et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitochondrial Dysfunction and Biogenesis in Neurodegenerative diseases: Pathogenesis and Treatment

(2016) Mojtaba Golpich et al.   CNS Neuroscience & Therapeutics

Overexpression of DJ-1/PARK7, the Parkinson's disease-related protein, improves mitochondrial function via Akt phosphorylation on threonine 308 in dopaminergic neuron-like cells

(2016) Yi Zhang et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Functional role of mitochondrial reactive oxygen species in physiology

(2016) Plamena R. Angelova et al.   FREE RADICAL BIOLOGY AND MEDICINE

α-Synuclein Fibrils Exhibit Gain of Toxic Function, Promoting Tau Aggregation and Inhibiting Microtubule Assembly

(2016) Takayuki Oikawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DJ-1 protects the heart against ischemia–reperfusion injury by regulating mitochondrial fission

(2016) Yuuki Shimizu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance

(2016) Dena G. Hernandez et al.   JOURNAL OF NEUROCHEMISTRY

The epidemiology of Parkinson's disease: risk factors and prevention

(2016) Alberto Ascherio et al.   LANCET NEUROLOGY

Early alterations of mitochondrial morphology in dopaminergic neurons from Parkinson's disease-like pathology and time-dependent neuroprotection with D2 receptor activation

(2016) Lyle Wiemerslage et al.   MITOCHONDRION

Co-expression of truncated and full-length tau induces severe neurotoxicity

(2016) S Ozcelik et al.   MOLECULAR PSYCHIATRY

Parkinson-Related LRRK2 Mutation R1628P Enables Cdk5 Phosphorylation of LRRK2 and Upregulates Its Kinase Activity

(2016) Yang Shu et al.   PLoS One

LRRK2 Facilitates tau Phosphorylation through Strong Interaction with tau and cdk5

(2015) Mary R. Shanley et al.   BIOCHEMISTRY

Pathological Interface Between Oligomeric Alpha-Synuclein and Tau in Synucleinopathies

(2015) Urmi Sengupta et al.   BIOLOGICAL PSYCHIATRY

Elevated Mitochondrial Bioenergetics and Axonal Arborization Size Are Key Contributors to the Vulnerability of Dopamine Neurons

(2015) Consiglia Pacelli et al.   CURRENT BIOLOGY

Parkinson's disease-associated PINK1G309D mutation increases abnormal phosphorylation of Tau

(2015) Ming Ye et al.   IUBMB LIFE

Cdk5 at crossroads of protein oligomerization in neurodegenerative diseases: facts and hypotheses

(2015) Anna Wilkaniec et al.   JOURNAL OF NEUROCHEMISTRY

A53T Human  -Synuclein Overexpression in Transgenic Mice Induces Pervasive Mitochondria Macroautophagy Defects Preceding Dopamine Neuron Degeneration

(2015) L. Chen et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial Quality Control via the PGC1 -TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by Rapamycin

(2015) A. Siddiqui et al.   JOURNAL OF NEUROSCIENCE

LRRK2 Promotes Tau Accumulation, Aggregation and Release

(2015) Patrícia Silva Guerreiro et al.   MOLECULAR NEUROBIOLOGY

A new role for α-synuclein in Parkinson's disease: Alteration of ER-mitochondrial communication

(2015) Cristina Guardia-Laguarta et al.   MOVEMENT DISORDERS

Tau Hyperphosphorylation and Oxidative Stress, a Critical Vicious Circle in Neurodegenerative Tauopathies?

(2015) Seyedeh Maryam Alavi Naini et al.   Oxidative Medicine and Cellular Longevity

Glycogen synthase kinase-3 beta (GSK-3β) signaling: Implications for Parkinson's disease

(2015) Mojtaba Golpich et al.   PHARMACOLOGICAL RESEARCH

Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease

(2015) Brent J. Ryan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Novel subcellular localization for α-synuclein: possible functional consequences

(2015) Cristina Guardia-Laguarta et al.   Frontiers in Neuroanatomy

Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization

(2014) Judith Eschbach et al.   ANNALS OF NEUROLOGY

A Mitocentric View of Parkinson's Disease

(2014) Nele A. Haelterman et al.   Annual Review of Neuroscience

Interactions between Tau and α-synuclein augment neurotoxicity in a Drosophila model of Parkinson's disease

(2014) Bidisha Roy et al.   HUMAN MOLECULAR GENETICS

Soluble, Prefibrillar α-Synuclein Oligomers Promote Complex I-dependent, Ca2+-induced Mitochondrial Dysfunction

(2014) Eric S. Luth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LRRK2 pathobiology in Parkinson's disease

(2014) Ian Martin et al.   JOURNAL OF NEUROCHEMISTRY

 -Synuclein Is Localized to Mitochondria-Associated ER Membranes

(2014) C. Guardia-Laguarta et al.   JOURNAL OF NEUROSCIENCE

Wnt/β-Catenin Signaling Is Required to Rescue Midbrain Dopaminergic Progenitors and Promote Neurorepair in Ageing Mouse Model of Parkinson's Disease

(2014) Francesca L'Episcopo et al.   STEM CELLS

The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling

(2014) S Saez-Atienzar et al.   Cell Death & Disease

LRRK2 phosphorylates novel tau epitopes and promotes tauopathy

(2013) Rachel M. Bailey et al.   ACTA NEUROPATHOLOGICA

A meta-analysis of the relationship of the Parkin p.Val380Leu polymorphism to Parkinson's disease

(2013) Yi Zhang et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Parkinson's Disease-Associated Dj-1 Mutations Increase Abnormal Phosphorylation of Tau Protein through Akt/Gsk-3β Pathways

(2013) Yangang Wang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Mitochondrial dynamics modulate the expression of pro-inflammatory mediators in microglial cells

(2013) Junghyung Park et al.   JOURNAL OF NEUROCHEMISTRY

Redox regulation of protein misfolding, mitochondrial dysfunction, synaptic damage, and cell death in neurodegenerative diseases

(2012) Tomohiro Nakamura et al.   EXPERIMENTAL NEUROLOGY

LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1

(2012) X. Wang et al.   HUMAN MOLECULAR GENETICS

A New Link to Mitochondrial Impairment in Tauopathies

(2012) Kathrin L. Schulz et al.   MOLECULAR NEUROBIOLOGY

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

Tau Promotes Neurodegeneration via DRP1 Mislocalization In Vivo

(2012) Brian DuBoff et al.   NEURON

Meta-analysis of the influence of Parkin p.Asp394Asn variant on the susceptibility of Parkinson's disease

(2012) Yi Zhang et al.   NEUROSCIENCE LETTERS

Parkin, PINK1 and mitochondrial integrity: emerging concepts of mitochondrial dysfunction in Parkinson’s disease

(2011) Anna Pilsl et al.   ACTA NEUROPATHOLOGICA

PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease

(2011) Joo-Ho Shin et al.   CELL

The regulation of mitochondrial morphology: Intricate mechanisms and dynamic machinery

(2011) Catherine S. Palmer et al.   CELLULAR SIGNALLING

Seeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles

(2011) Jing L. Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of Intracellular Tau Aggregation Is Promoted by  -Synuclein Seeds and Provides Novel Insights into the Hyperphosphorylation of Tau

(2011) E. A. Waxman et al.   JOURNAL OF NEUROSCIENCE

A Wnt1 regulated Frizzled-1/β-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection

(2011) Francesca L'Episcopo et al.   Molecular Neurodegeneration

Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's disease

(2011) Alan S. L. Wong et al.   NATURE CELL BIOLOGY

Mitochondria: The Next (Neurode)Generation

(2011) Eric A. Schon et al.   NEURON

Animal models of Parkinson's disease

(2011) Vernice Jackson-Lewis et al.   PARKINSONISM & RELATED DISORDERS

Insulin-like growth factor 1 protects human neuroblastoma cells SH-EP1 against MPP+-induced apoptosis by AKT/GSK-3β/JNK signaling

(2010) Lei Wang et al.   APOPTOSIS

Protein aggregation containing beta-amyloid, alpha-synuclein and hyperphosphorylated tau in cultured cells of hippocampus, substantia nigra and locus coeruleus after rotenone exposure

(2010) Rodrigo S Chaves et al.   BMC NEUROSCIENCE

Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1

(2010) Frits Kamp et al.   EMBO JOURNAL

SNCA,MAPT, andGSK3Bin Parkinson disease: a gene-gene interaction study

(2010) C. Wider et al.   EUROPEAN JOURNAL OF NEUROLOGY

Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia

(2010) Jonathan Wills et al.   EXPERIMENTAL NEUROLOGY

DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy

(2010) Kelly Jean Thomas et al.   HUMAN MOLECULAR GENETICS

Parkinsonian Neurotoxin 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and α-Synuclein Mutations Promote Tau Protein Phosphorylation at Ser262and Destabilize Microtubule Cytoskeletonin Vitro

(2010) Hamid Y. Qureshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LRRK2 G2019S Mutation Induces Dendrite Degeneration through Mislocalization and Phosphorylation of Tau by Recruiting Autoactivated GSK3 

(2010) C.-H. Lin et al.   JOURNAL OF NEUROSCIENCE

Redox Reactions Induced by Nitrosative Stress Mediate Protein Misfolding and Mitochondrial Dysfunction in Neurodegenerative Diseases

(2010) Zezong Gu et al.   MOLECULAR NEUROBIOLOGY

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

(2010) Jaime N. Guzman et al.   NATURE

Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2

(2010) H. Mortiboys et al.   NEUROLOGY

Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo

(2010) Shankar J. Chinta et al.   NEUROSCIENCE LETTERS

DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function

(2010) L.-Y. Hao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Commitment of 1-Methyl-4-phenylpyrinidinium Ion-induced Neuronal Cell Death by Proteasome-mediated Degradation of p35 Cyclin-dependent Kinase 5 Activator

(2009) Ryo Endo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of Parkin or PINK1 Function Increases Drp1-dependent Mitochondrial Fragmentation

(2009) A. Kathrin Lutz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission

(2009) Ruben K. Dagda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport

(2009) Will Stoothoff et al.   JOURNAL OF NEUROCHEMISTRY

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

(2009) Wataru Satake et al.   NATURE GENETICS

Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson's-Disease-Related Mutant α-synuclein

(2009) Xian Lin et al.   NEURON

Tau pathophysiology in neurodegeneration: a tangled issue

(2009) Tara L. Spires-Jones et al.   TRENDS IN NEUROSCIENCES

Parkin Attenuates Wild-Type τ Modification in the Presence of β-Amyloid and α-Synuclein

(2008) Charbel E.-H. Moussa   JOURNAL OF MOLECULAR NEUROSCIENCE

Proteomics Analysis Identifies Phosphorylation-dependent α-Synuclein Protein Interactions

(2008) Melinda A. McFarland et al.   MOLECULAR & CELLULAR PROTEOMICS

Haplotypes and gene expression implicate the MAPT region for Parkinson disease: The GenePD Study

(2008) J. E. Tobin et al.   NEUROLOGY

Phosphorylation of tau and α-synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer’s disease, and in Parkinson’s disease and related α-synucleinopathies

(2008) G. Muntané et al.   NEUROSCIENCE

Early α-synuclein lipoxidation in neocortex in Lewy body diseases

(2006) Esther Dalfó et al.   NEUROBIOLOGY OF AGING