Approaching Neutrophil Pyroptosis

NINJ1 mediates plasma membrane rupture during lytic cell death

(2021) Nobuhiko Kayagaki et al.   NATURE

Substrate stiffness induces neutrophil extracellular trap (NET) formation through focal adhesion kinase activation

(2021) Jefferson O. Abaricia et al.   BIOMATERIALS

The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments

(2021) Ricardo Grieshaber-Bouyer et al.   Nature Communications

β-Glucan-stimulated neutrophil secretion of IL-1α is independent of GSDMD and mediated through extracellular vesicles

(2021) Bridget Ratitong et al.   Cell Reports

Hierarchical cell-type-specific functions of caspase-11 in LPS shock and antibacterial host defense

(2021) Puja Kumari et al.   Cell Reports

Gasdermin D inhibition prevents multiple organ dysfunction during sepsis by blocking NET formation

(2021) Camila Meirelles Silva et al.   BLOOD

Selective activation of PFKL suppresses the phagocytic oxidative burst

(2021) Neri Amara et al.   CELL

Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway

(2021) Charles L. Evavold et al.   CELL

Pathogenic ubiquitination of GSDMB inhibits NK cell bactericidal functions

(2021) Justin M. Hansen et al.   CELL

Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome

(2021) Julien Stackowicz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Programmed ‘disarming’ of the neutrophil proteome reduces the magnitude of inflammation

(2020) Jose M. Adrover et al.   NATURE IMMUNOLOGY

Cytokine Production and NET Formation by Monosodium Urate-Activated Human Neutrophils Involves Early and Late Events, and Requires Upstream TAK1 and Syk

(2020) Olga Tatsiy et al.   Frontiers in Immunology

Neutrophil Extracellular Traps Participate in Cardiovascular Diseases

(2020) Yvonne Döring et al.   CIRCULATION RESEARCH

Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

(2020) Zhiwei Zhou et al.   SCIENCE

N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis

(2020) Mausita Karmakar et al.   Nature Communications

Histones, DNA, and Citrullination Promote Neutrophil Extracellular Trap Inflammation by Regulating the Localization and Activation of TLR4

(2020) Theodora-Dorita Tsourouktsoglou et al.   Cell Reports

Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)

(2020) Shelbi Christgen et al.   Frontiers in Cellular and Infection Microbiology

Nuclear envelope rupture and NET formation is driven by PKCα‐mediated lamin B disassembly

(2020) Yubin Li et al.   EMBO REPORTS

NLRP3 inflammasome priming: A riddle wrapped in a mystery inside an enigma

(2020) Chloe M. McKee et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium

(2020) Stephen B. Kovacs et al.   Cell Reports

Inflammasome activation and regulation: toward a better understanding of complex mechanisms

(2020) Danping Zheng et al.   Cell Discovery

Co-option of Neutrophil Fates by Tissue Environments

(2020) Iván Ballesteros et al.   CELL

NET formation – mechanisms and how they relate to other cell death pathways

(2020) Thibault Rosazza et al.   FEBS Journal

NETosis Occurs Independently of Neutrophil Serine Proteases

(2020) Paulina Kasperkiewicz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Staphylococcus aureus Panton‐Valentine Leukocidin triggers an alternative NETosis process targeting mitochondria

(2020) Viola Mazzoleni et al.   FASEB JOURNAL

Proteome analysis of human neutrophil granulocytes from patients with monogenic disease using data-independent acquisition

(2019) Piotr Grabowski et al.   MOLECULAR & CELLULAR PROTEOMICS

A Neutrophil Timer Coordinates Immune Defense and Vascular Protection

(2019) José M. Adrover et al.   IMMUNITY

Neutrophil Extracellular Traps Confine Pseudomonas aeruginosa Ocular Biofilms and Restrict Brain Invasion

(2019) Ajitha Thanabalasuriar et al.   Cell Host & Microbe

Neutrophils and NETS in modulating acute and chronic inflammation

(2019) Fernanda Vargas e Silva Castanheira et al.   BLOOD

Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM

(2019) Michael Carty et al.   IMMUNITY

The Neutrophil Life Cycle

(2019) Andrés Hidalgo et al.   TRENDS IN IMMUNOLOGY

Neutrophil extracellular traps (NET) induced by different stimuli: A comparative proteomic analysis

(2019) Andrea Petretto et al.   PLoS One

Alternative splicing regulates stochastic NLRP3 activity

(2019) Florian Hoss et al.   Nature Communications

Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation

(2019) Sabrina Sofia Burgener et al.   Cell Reports

Dynamic Transcriptome-Proteome Correlation Networks Reveal Human Myeloid Differentiation and Neutrophil-Specific Programming

(2019) Arie J. Hoogendijk et al.   Cell Reports

Caspase-11 Mediates Neutrophil Chemotaxis and Extracellular Trap Formation During Acute Gouty Arthritis Through Alteration of Cofilin Phosphorylation

(2019) Kyle Caution et al.   Frontiers in Immunology

Neutrophil extracellular traps drive inflammatory pathogenesis in malaria

(2019) Sebastian Lorenz Knackstedt et al.   Science Immunology

Deadliest catch

(2019) Rishi R. Goel et al.   CURRENT OPINION IN RHEUMATOLOGY

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions

(2018) Maximilien Evrard et al.   IMMUNITY

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

(2018) Charles L. Evavold et al.   IMMUNITY

The bacterial pigment pyocyanin inhibits the NLRP3 inflammasome through intracellular reactive oxygen and nitrogen species

(2018) Sebastian Virreira Winter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Staphylococcus aureusbiofilms release leukocidins to elicit extracellular trap formation and evade neutrophil-mediated killing

(2018) Mohini Bhattacharya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death

(2018) Hiroto Kambara et al.   Cell Reports

Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion

(2018) Mercedes Monteleone et al.   Cell Reports

Neutrophils instruct homeostatic and pathological states in naive tissues

(2018) Maria Casanova-Acebes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Staphylococcus aureus promotes receptor‐interacting protein kinase 3‐ and protease‐dependent production of IL‐1β in human neutrophils

(2018) Silvie Kremserova et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

(2018) Pontus Orning et al.   SCIENCE

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation

(2018) Sebastian Rühl et al.   SCIENCE

Reactive Oxygen Species Localization Programs Inflammation to Clear Microbes of Different Size

(2017) Annika Warnatsch et al.   IMMUNITY

Severe glucose-6-phosphate dehydrogenase deficiency leads to susceptibility to infection and absent NETosis

(2017) Ulrich Siler et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Necroptosis controls NET generation and mediates complement activation, endothelial damage, and autoimmune vasculitis

(2017) Adrian Schreiber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Host DNases prevent vascular occlusion by neutrophil extracellular traps

(2017) Miguel Jiménez-Alcázar et al.   SCIENCE

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares

(2017) Emily L. Goldberg et al.   Cell Reports

Diverse stimuli engage different neutrophil extracellular trap pathways

(2017) Elaine F Kenny et al.   eLife

Inflammasome Complexes: Emerging Mechanisms and Effector Functions

(2016) Vijay A.K. Rathinam et al.   CELL

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

(2016) Lorenzo Sborgi et al.   EMBO JOURNAL

The murine neutrophil NLRP3 inflammasome is activated by soluble but not particulate or crystalline agonists

(2016) Kaiwen W. Chen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Oxidized LDL induced extracellular trap formation in human neutrophils via TLR-PKC-IRAK-MAPK and NADPH-oxidase activation

(2016) Deepika Awasthi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Human Monocytes Engage an Alternative Inflammasome Pathway

(2016) Moritz M. Gaidt et al.   IMMUNITY

Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity

(2016) Andrew Hollands et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutrophil pyroptosis mediates pathology of P. aeruginosa lung infection in the absence of the NADPH oxidase NOX2

(2016) J-C Ryu et al.   Mucosal Immunology

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

(2016) Robin A. Aglietti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells

(2016) Ivan Zanoni et al.   SCIENCE

Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP

(2016) Mausita Karmakar et al.   Nature Communications

Neutrophils Discriminate between Lipopolysaccharides of Different Bacterial Sources and Selectively Release Neutrophil Extracellular Traps

(2016) Elmar Pieterse et al.   Frontiers in Immunology

Transforming Growth Factor-β-Activated Kinase 1 Is Required for Human FcγRIIIb-Induced Neutrophil Extracellular Trap Formation

(2016) Omar Rafael Alemán et al.   Frontiers in Immunology

Neutrophil Extracellular Trap Formation Is Independent of De Novo Gene Expression

(2016) Gabriel Sollberger et al.   PLoS One

Neutrophil oxidative burst activates ATM to regulate cytokine production and apoptosis

(2015) C. J. Harbort et al.   BLOOD

NADPH oxidase, MPO, NE, ERK1/2, p38 MAPK and Ca2+ influx are essential for Cryptosporidium parvum-induced NET formation

(2015) Tamara Muñoz-Caro et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

PMA and crystal-induced neutrophil extracellular trap formation involves RIPK1-RIPK3-MLKL signaling

(2015) Jyaysi Desai et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

NET formation can occur independently of RIPK3 and MLKL signaling

(2015) Poorya Amini et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A Metabolic Shift toward Pentose Phosphate Pathway Is Necessary for Amyloid Fibril- and Phorbol 12-Myristate 13-Acetate-induced Neutrophil Extracellular Trap (NET) Formation

(2015) Estefania P. Azevedo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Src Family Kinases and Syk Are Required for Neutrophil Extracellular Trap Formation in Response to �-Glucan Particles

(2015) Sara Nanì et al.   Journal of Innate Immunity

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Diabetes primes neutrophils to undergo NETosis, which impairs wound healing

(2015) Siu Ling Wong et al.   NATURE MEDICINE

SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx

(2015) David Nobuhiro Douda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis

(2015) A. Warnatsch et al.   SCIENCE

Translocation of interleukin-1β into a vesicle intermediate in autophagy-mediated secretion

(2015) Min Zhang et al.   eLife

Localization and Functionality of the Inflammasome in Neutrophils

(2014) Martina Bakele et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens

(2014) Nora Branzk et al.   NATURE IMMUNOLOGY

Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines

(2014) Christine Schauer et al.   NATURE MEDICINE

A Myeloperoxidase-Containing Complex Regulates Neutrophil Elastase Release and Actin Dynamics during NETosis

(2014) Kathleen D. Metzler et al.   Cell Reports

The Neutrophil NLRC4 Inflammasome Selectively Promotes IL-1β Maturation without Pyroptosis during Acute Salmonella Challenge

(2014) Kaiwen W. Chen et al.   Cell Reports

NETosis: how vital is it?

(2013) B. G. Yipp et al.   BLOOD

Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance

(2013) María Casanova-Acebes et al.   CELL

Staphylococcus aureus Leukotoxin GH Promotes Formation of Neutrophil Extracellular Traps

(2013) N. Malachowa et al.   JOURNAL OF IMMUNOLOGY

Activation of conventional protein kinase C (PKC) is critical in the generation of human neutrophil extracellular traps

(2013) Robert D Gray et al.   Journal of Inflammation-London

Pyocyanin-Enhanced Neutrophil Extracellular Trap Formation Requires the NADPH Oxidase

(2013) Balázs Rada et al.   PLoS One

Opposition between PKC isoforms regulates histone deimination and neutrophil extracellular chromatin release

(2013) Indira Neeli et al.   Frontiers in Immunology

Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality

(2011) Q Remijsen et al.   CELL DEATH AND DIFFERENTIATION

Toxoplasma gondii Triggers Release of Human and Mouse Neutrophil Extracellular Traps

(2011) Delbert S. Abi Abdallah et al.   INFECTION AND IMMUNITY

Neutrophil extracellular traps promote deep vein thrombosis in mice

(2011) A. BRILL et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Rapid Immunomagnetic Negative Enrichment of Neutrophil Granulocytes from Murine Bone Marrow for Functional Studies In Vitro and In Vivo

(2011) Mike Hasenberg et al.   PLoS One

Neutrophil Extracellular Trap Formation Is Associated with IL-1β and Autophagy-Related Signaling in Gout

(2011) Ioannis Mitroulis et al.   PLoS One

Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease

(2010) F. Meissner et al.   BLOOD

Neutrophils, from Marrow to Microbes

(2010) Niels Borregaard   IMMUNITY

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation

(2010) Abdul Hakkim et al.   Nature Chemical Biology

Restoration of NET formation by gene therapy in CGD controls aspergillosis

(2009) M. Bianchi et al.   BLOOD

Inflammasome-Mediated Disease Animal Models Reveal Roles for Innate but Not Adaptive Immunity

(2009) Susannah D. Brydges et al.   IMMUNITY

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

(2009) Yanming Wang et al.   JOURNAL OF CELL BIOLOGY

Active Caspase-1 Is a Regulator of Unconventional Protein Secretion

(2008) Martin Keller et al.   CELL

Superoxide dismutase 1 regulates caspase-1 and endotoxic shock

(2008) Felix Meissner et al.   NATURE IMMUNOLOGY