Gasdermin and Gasdermin-Like Pore-Forming Proteins in Invertebrates, Fungi and Bacteria

Oligomerization of Sticholysins from Förster Resonance Energy Transfer

(2021) Juan Palacios-Ortega et al.   BIOCHEMISTRY

Breaching the Bacterial Envelope: The Pivotal Role of Perforin-2 (MPEG1) Within Phagocytes

(2021) Leidy C. Merselis et al.   Frontiers in Immunology

Gasdermin D pore structure reveals preferential release of mature interleukin-1

(2021) Shiyu Xia et al.   NATURE

Pathogenic ubiquitination of GSDMB inhibits NK cell bactericidal functions

(2021) Justin M. Hansen et al.   CELL

Seneca Valley Virus 3C Protease Induces Pyroptosis by Directly Cleaving Porcine Gasdermin D

(2021) Wei Wen et al.   JOURNAL OF IMMUNOLOGY

Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis

(2020) Kun Wang et al.   CELL

Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity

(2020) Tao Ni et al.   Science Advances

The Bcl-2 Family: Ancient Origins, Conserved Structures, and Divergent Mechanisms

(2020) Suresh Banjara et al.   Biomolecules

Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

(2020) Zhiwei Zhou et al.   SCIENCE

Conflict, Competition, and Cooperation Regulate Social Interactions in Filamentous Fungi

(2020) A. Pedro Gonçalves et al.   Annual Review of Microbiology

Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage

(2020) Zhonghua Liu et al.   IMMUNITY

NLRC4 biology in immunity and inflammation

(2020) Warrison A. Andrade et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Molecular characterization of a fungal gasdermin-like protein

(2020) Asen Daskalov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis

(2020) Andre L. Samson et al.   Nature Communications

Identification of NLR-associated amyloid signaling motifs in bacterial genomes

(2020) Witold Dyrka et al.   JOURNAL OF MOLECULAR BIOLOGY

Prokaryotic viperins produce diverse antiviral molecules

(2020) Aude Bernheim et al.   NATURE

Diverse enzymatic activities mediate antiviral immunity in prokaryotes

(2020) Linyi Gao et al.   SCIENCE

Plasma Membrane Pores Drive Inflammatory Cell Death

(2020) Benedikt Kolbrink et al.   Frontiers in Cell and Developmental Biology

Lighting a fire on the reef

(2020) Zhibin Zhang et al.   Science Immunology

Coral gasdermin triggers pyroptosis

(2020) Shuai Jiang et al.   Science Immunology

Bacterial cGAS-like enzymes synthesize diverse nucleotide signals

(2019) Aaron T. Whiteley et al.   NATURE

The molecular machinery of regulated cell death

(2019) Daolin Tang et al.   CELL RESEARCH

Reconstitution and structure of a plant NLR resistosome conferring immunity

(2019) Jizong Wang et al.   SCIENCE

Long-term balancing selection drives evolution of immunity genes in Capsella

(2019) Daniel Koenig et al.   eLife

RPW8/HR repeats control NLR activation in Arabidopsis thaliana

(2019) Cristina A. Barragan et al.   PLoS Genetics

Pore-Forming Proteins from Cnidarians and Arachnids as Potential Biotechnological Tools

(2019) Esperanza Rivera-de-Torre et al.   Toxins

Teleost Gasdermin E Is Cleaved by Caspase 1, 3, and 7 and Induces Pyroptosis

(2019) Shuai Jiang et al.   JOURNAL OF IMMUNOLOGY

Cyclic GMP–AMP signalling protects bacteria against viral infection

(2019) Daniel Cohen et al.   NATURE

The Rise of Plant Resistosomes

(2019) Glykeria Mermigka et al.   TRENDS IN IMMUNOLOGY

Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3

(2019) Emma J. Petrie et al.   Cell Reports

Programmed Cell Death in Neurospora crassa Is Controlled by the Allorecognition Determinant rcd-1

(2019) Asen Daskalov et al.   GENETICS

The Diversification of Cell Death and Immunity: Memento Mori

(2019) Arnaud J. Legrand et al.   MOLECULAR CELL

The pan-immune system of bacteria: antiviral defence as a community resource

(2019) Aude Bernheim et al.   NATURE REVIEWS MICROBIOLOGY

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Mechanism of membrane pore formation by human gasdermin‐D

(2018) Estefania Mulvihill et al.   EMBO JOURNAL

Balancing selection at nonself recognition loci in the chestnut blight fungus, Cryphonectria parasitica, demonstrated by trans-species polymorphisms, positive selection, and even allele frequencies

(2018) Michael G. Milgroom et al.   HEREDITY

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis

(2018) Emma J. Petrie et al.   Nature Communications

Signatures of balancing selection in toll-like receptor (TLRs) genes – novel insights from a free-living rodent

(2018) Agnieszka Kloch et al.   Scientific Reports

Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death

(2018) Hiroto Kambara et al.   Cell Reports

Advances in cryoEM and its impact on β-pore forming proteins

(2018) Courtney M Boyd et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Cryo-EM structure of the gasdermin A3 membrane pore

(2018) Jianbin Ruan et al.   NATURE

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

(2018) Joseph Sarhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

(2018) Pontus Orning et al.   SCIENCE

Bax, Bak and beyond - mitochondrial performance in apoptosis

(2017) Aida Peña-Blanco et al.   FEBS Journal

The Membrane Attack Complex/Perforin Superfamily

(2017) Gabriel Moreno-Hagelsieb et al.   JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY

Enterovirus 71 Inhibits Pyroptosis through Cleavage of Gasdermin D

(2017) Xiaobo Lei et al.   JOURNAL OF VIROLOGY

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Apoptotic foci at mitochondria: in and around Bax pores

(2017) Begoña Ugarte-Uribe et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Pore-forming toxins in Cnidaria

(2017) Marjetka Podobnik et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Gasdermins: Effectors of Pyroptosis

(2017) Stephen B. Kovacs et al.   TRENDS IN CELL BIOLOGY

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

Gasdermin: A new player to the inflammasome game

(2017) Erivan S. Ramos-Junior et al.   Biomedical Journal

Bax assembly into rings and arcs in apoptotic mitochondria is linked to membrane pores

(2016) R. Salvador-Gallego et al.   EMBO JOURNAL

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

(2016) Lorenzo Sborgi et al.   EMBO JOURNAL

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Engineering super mycovirus donor strains of chestnut blight fungus by systematic disruption of multilocusvicgenes

(2016) Dong-Xiu Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

(2016) Robin A. Aglietti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a novel cell death-inducing domain reveals that fungal amyloid-controlled programmed cell death is related to necroptosis

(2016) Asen Daskalov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular innate immune surveillance devices in plants and animals

(2016) J. D. G. Jones et al.   SCIENCE

An evolutionary perspective on the necroptotic pathway

(2016) Yves Dondelinger et al.   TRENDS IN CELL BIOLOGY

Structure of the poly-C9 component of the complement membrane attack complex

(2016) Natalya V. Dudkina et al.   Nature Communications

Experimental evolution reveals that high relatedness protects multicellular cooperation from cheaters

(2016) Eric Bastiaans et al.   Nature Communications

Evolution of the Cytolytic Pore-Forming Proteins (Actinoporins) in Sea Anemones

(2016) Jason Macrander et al.   Toxins

Vegetative incompatibility in fungi: From recognition to cell death, whatever does the trick

(2016) Mathieu Paoletti   Fungal Biology Reviews

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

More Than a Pore: The Interplay of Pore-Forming Proteins and Lipid Membranes

(2015) Uris Ros et al.   JOURNAL OF MEMBRANE BIOLOGY

Identification of Allorecognition Loci inNeurospora crassaby Genomics and Evolutionary Approaches

(2015) Jiuhai Zhao et al.   MOLECULAR BIOLOGY AND EVOLUTION

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Pore-forming toxins: ancient, but never really out of fashion

(2015) Matteo Dal Peraro et al.   NATURE REVIEWS MICROBIOLOGY

As a toxin dies a prion comes to life: A tentative natural history of the [Het-s] prion

(2015) Asen Daskalov et al.   Prion

Necroptosis: Pathway diversity and characteristics

(2015) M. Cristina de Almagro et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin

(2015) Natalya Lukoyanova et al.   PLOS BIOLOGY

Signal Transduction by a Fungal NOD-Like Receptor Based on Propagation of a Prion Amyloid Fold

(2015) Asen Daskalov et al.   PLOS BIOLOGY

Trans-Species Polymorphism in Immune Genes: General Pattern or MHC-Restricted Phenomenon?

(2015) Martin Těšický et al.   Journal of Immunology Research

Tandem-repeat protein domains across the tree of life

(2015) Kristin K. Jernigan et al.   PeerJ

The Bcl-2 family: structures, interactions and targets for drug discovery

(2014) Marc Kvansakul et al.   APOPTOSIS

Vegetative Incompatibility Loci with Dedicated Roles in Allorecognition Restrict Mycovirus Transmission in Chestnut Blight Fungus

(2014) Dong-Xiu Zhang et al.   GENETICS

Diversity and Variability of NOD-Like Receptors in Fungi

(2014) Witold Dyrka et al.   Genome Biology and Evolution

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

(2014) Joanne M. Hildebrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

(2014) Yves Dondelinger et al.   Cell Reports

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pathogenic Pore-Forming Proteins: Function and Host Response

(2012) Mirko Bischofberger et al.   Cell Host & Microbe

Heterokaryon Incompatibility Is Suppressed Following Conidial Anastomosis Tube Fusion in a Fungal Plant Pathogen

(2012) Francine H. Ishikawa et al.   PLoS One

Genomic Clustering and Homology between HET-S and the NWD2 STAND Protein in Various Fungal Genomes

(2012) Asen Daskalov et al.   PLoS One

Structural and Functional Discussion of the Tetra-Trico-Peptide Repeat, a Protein Interaction Module

(2012) Natalie Zeytuni et al.   STRUCTURE

The Mechanism of Toxicity in HET-S/HET-s Prion Incompatibility

(2012) Carolin Seuring et al.   PLOS BIOLOGY

Structure and assembly of pore-forming proteins

(2010) Ioan Iacovache et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The structural basis for membrane binding and pore formation by lymphocyte perforin

(2010) Ruby H. P. Law et al.   NATURE

WD40 proteins propel cellular networks

(2010) Christian U. Stirnimann et al.   TRENDS IN BIOCHEMICAL SCIENCES

Complement and its role in innate and adaptive immune responses

(2009) Jason R Dunkelberger et al.   CELL RESEARCH

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

MEROPS: the peptidase database

(2009) Neil D. Rawlings et al.   NUCLEIC ACIDS RESEARCH

Caspases in apoptosis and beyond

(2008) J Li et al.   ONCOGENE