Bax, Bak and beyond - mitochondrial performance in apoptosis

The membrane activity of BOK involves formation of large, stable toroidal pores and is promoted by cBID

(2017) Yuniel Fernández-Marrero et al.   FEBS Journal

PARL mediates Smac proteolytic maturation in mitochondria to promote apoptosis

(2017) Shotaro Saita et al.   NATURE CELL BIOLOGY

BAK α6 permits activation by BH3-only proteins and homooligomerization via the canonical hydrophobic groove

(2017) Mark Xiang Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bax and Bak Pores: Are We Closing the Circle?

(2017) Katia Cosentino et al.   TRENDS IN CELL BIOLOGY

Quantitative interactome of a membrane Bcl-2 network identifies a hierarchy of complexes for apoptosis regulation

(2017) Stephanie Bleicken et al.   Nature Communications

Disordered clusters of Bak dimers rupture mitochondria during apoptosis

(2017) Rachel T Uren et al.   eLife

BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation

(2016) Fabien Llambi et al.   CELL

Bax assembly into rings and arcs in apoptotic mitochondria is linked to membrane pores

(2016) R. Salvador-Gallego et al.   EMBO JOURNAL

Bax assembles into large ring-like structures remodeling the mitochondrial outer membrane in apoptosis

(2016) L. Grosse et al.   EMBO JOURNAL

Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane

(2016) Katelyn L. O'Neill et al.   GENES & DEVELOPMENT

Drp1-dependent mitochondrial fission via MiD49/51 is essential for apoptotic cristae remodeling

(2016) Hidenori Otera et al.   JOURNAL OF CELL BIOLOGY

Diverting CERT-mediated ceramide transport to mitochondria triggers Bax-dependent apoptosis

(2016) Amrita Jain et al.   JOURNAL OF CELL SCIENCE

Bok is a genuine multi-BH-domain protein that triggers apoptosis in the absence of Bax and Bak

(2016) Stephanie Einsele-Scholz et al.   JOURNAL OF CELL SCIENCE

An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway

(2016) Thomas P. Garner et al.   MOLECULAR CELL

cBid, Bax and Bcl-xL exhibit opposite membrane remodeling activities

(2016) S Bleicken et al.   Cell Death & Disease

Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies

(2016) Sweta Iyer et al.   Nature Communications

Assembly of Bak homodimers into higher order homooligomers in the mitochondrial apoptotic pore

(2016) Tirtha Mandal et al.   Scientific Reports

Pro-apoptotic Bax molecules densely populate the edges of membrane pores

(2016) Tomomi Kuwana et al.   Scientific Reports

In Situ Characterization of Bak Clusters Responsible for Cell Death Using Single Molecule Localization Microscopy

(2016) Yusuke Nasu et al.   Scientific Reports

BH3-in-groove dimerization initiates and helix 9 dimerization expands Bax pore assembly in membranes

(2015) Z. Zhang et al.   EMBO JOURNAL

Mitochondrial Shape Governs BAX-Induced Membrane Permeabilization and Apoptosis

(2015) Thibaud T. Renault et al.   MOLECULAR CELL

MAPL SUMOylation of Drp1 Stabilizes an ER/Mitochondrial Platform Required for Cell Death

(2015) Julien Prudent et al.   MOLECULAR CELL

An interconnected hierarchical model of cell death regulation by the BCL-2 family

(2015) Hui-Chen Chen et al.   NATURE CELL BIOLOGY

Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax and show no preference for Bak versus Bax

(2015) C Hockings et al.   Cell Death & Disease

Bax monomers form dimer units in the membrane that further self-assemble into multiple oligomeric species

(2015) Yamunadevi Subburaj et al.   Nature Communications

Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

(2014) Michael J. White et al.   CELL

Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA

(2014) Anthony Rongvaux et al.   CELL

Mitochondrial alterations in apoptosis

(2014) Katia Cosentino et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Differential retrotranslocation of mitochondrial Bax and Bak

(2014) F. Todt et al.   EMBO JOURNAL

Conformational Rearrangements in the Pro-apoptotic Protein, Bax, as It Inserts into Mitochondria

(2014) Robert F. Gahl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bak Core and Latch Domains Separate during Activation, and Freed Core Domains Form Symmetric Homodimers

(2014) Jason M. Brouwer et al.   MOLECULAR CELL

Structural Model of Active Bax at the Membrane

(2014) Stephanie Bleicken et al.   MOLECULAR CELL

Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane

(2014) Dana Westphal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bcl2L13 is a ceramide synthase inhibitor in glioblastoma

(2014) S. A. Jensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane pore formation at protein–lipid interfaces

(2014) Robert J.C. Gilbert et al.   TRENDS IN BIOCHEMICAL SCIENCES

BAK activation is necessary and sufficient to drive ceramide synthase-dependent ceramide accumulation following inhibition of BCL2-like proteins

(2013) Levi J. Beverly et al.   BIOCHEMICAL JOURNAL

Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis

(2013) Peter E. Czabotar et al.   CELL

Intracellular localization of the BCL-2 family member BOK and functional implications

(2013) N Echeverry et al.   CELL DEATH AND DIFFERENTIATION

Assembly of the Bak Apoptotic Pore

(2013) Stephen Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Organization of the Mitochondrial Apoptotic BAK Pore

(2013) Sreevidya Aluvila et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proapoptotic Bax and Bak Proteins Form Stable Protein-permeable Pores of Tunable Size

(2013) Stephanie Bleicken et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingomyelin synthase-related protein SMSr is a suppressor of ceramide-induced mitochondrial apoptosis

(2013) F. G. Tafesse et al.   JOURNAL OF CELL SCIENCE

BID Preferentially Activates BAK while BIM Preferentially Activates BAX, Affecting Chemotherapy Response

(2013) Kristopher A. Sarosiek et al.   MOLECULAR CELL

Bax Exists in a Dynamic Equilibrium between the Cytosol and Mitochondria to Control Apoptotic Priming

(2013) Barbara Schellenberg et al.   MOLECULAR CELL

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

(2013) Andrew J Souers et al.   NATURE MEDICINE

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Direct activation of full-length proapoptotic BAK

(2013) Elizaveta S. Leshchiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-dimensional structure of Bax-mediated pores in membrane bilayers

(2013) X-P Xu et al.   Cell Death & Disease

Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis

(2012) Jerry E. Chipuk et al.   CELL

The secrets of the Bcl-2 family

(2012) A J García-Sáez   CELL DEATH AND DIFFERENTIATION

Differences in the Mechanisms of Proapoptotic BH3 Proteins Binding to Bcl-XL and Bcl-2 Quantified in Live MCF-7 Cells

(2012) Alexander Aranovich et al.   MOLECULAR CELL

Endoplasmic reticulum–mitochondria contacts: function of the junction

(2012) Ashley A. Rowland et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Bak Conformational Changes Induced by Ligand Binding: Insight into BH3 Domain Binding and Bak Homo-Oligomerization

(2012) Yuan-Ping Pang et al.   Scientific Reports

Bcl-xL Retrotranslocates Bax from the Mitochondria into the Cytosol

(2011) Frank Edlich et al.   CELL

Bax dimerizes via a symmetric BH3:groove interface during apoptosis

(2011) G Dewson et al.   CELL DEATH AND DIFFERENTIATION

Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial Dynamics

(2011) Jean-Claude Martinou et al.   DEVELOPMENTAL CELL

Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases

(2011) Andreas Strasser et al.   EMBO JOURNAL

Reconstitution of Proapoptotic BAK Function in Liposomes Reveals a Dual Role for Mitochondrial Lipids in the BAK-driven Membrane Permeabilization Process

(2011) Olatz Landeta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization

(2011) Haiming Dai et al.   JOURNAL OF CELL BIOLOGY

A Unified Model of Mammalian BCL-2 Protein Family Interactions at the Mitochondria

(2011) Fabien Llambi et al.   MOLECULAR CELL

ER Tubules Mark Sites of Mitochondrial Division

(2011) J. R. Friedman et al.   SCIENCE

Ceramide and activated Bax act synergistically to permeabilize the mitochondrial outer membrane

(2010) Vidyaramanan Ganesan et al.   APOPTOSIS

Mathematical modelling of the mitochondrial apoptosis pathway

(2010) Heinrich J. Huber et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Pores Formed by Baxα5 Relax to a Smaller Size and Keep at Equilibrium

(2010) Gustavo Fuertes et al.   BIOPHYSICAL JOURNAL

Membrane Remodeling Induced by the Dynamin-Related Protein Drp1 Stimulates Bax Oligomerization

(2010) Sylvie Montessuit et al.   CELL

The BCL-2 Protein BAK Is Required for Long-chain Ceramide Generation during Apoptosis

(2010) Leah J. Siskind et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The BCL-2 Family Reunion

(2010) Jerry E. Chipuk et al.   MOLECULAR CELL

BH3-Triggered Structural Reorganization Drives the Activation of Proapoptotic BAX

(2010) Evripidis Gavathiotis et al.   MOLECULAR CELL

MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria

(2010) Yehudit Zaltsman et al.   NATURE CELL BIOLOGY

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Still embedded together binding to membranes regulates Bcl-2 protein interactions

(2010) B Leber et al.   ONCOGENE

Computational Analysis of Dynamical Responses to the Intrinsic Pathway of Programmed Cell Death

(2009) Tongli Zhang et al.   BIOPHYSICAL JOURNAL

Dynamics of outer mitochondrial membrane permeabilization during apoptosis

(2009) M Rehm et al.   CELL DEATH AND DIFFERENTIATION

Single-cell quantification of Bax activation and mathematical modelling suggest pore formation on minimal mitochondrial Bax accumulation

(2009) H Düssmann et al.   CELL DEATH AND DIFFERENTIATION

Molecular Details of Bax Activation, Oligomerization, and Membrane Insertion

(2009) Stephanie Bleicken et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Outer Membrane Proteins Assist Bid in Bax-mediated Lipidic Pore Formation

(2009) Blanca Schafer et al.   MOLECULAR BIOLOGY OF THE CELL

Bak Activation for Apoptosis Involves Oligomerization of Dimers via Their α6 Helices

(2009) Grant Dewson et al.   MOLECULAR CELL

Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis

(2009) Hyungjin Kim et al.   MOLECULAR CELL

Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice

(2009) Naotada Ishihara et al.   NATURE CELL BIOLOGY

Membrane promotes tBID interaction with BCLXL

(2009) Ana J García-Sáez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax

(2008) Jonathan F. Lovell et al.   CELL

Chemical Inhibition of the Mitochondrial Division Dynamin Reveals Its Role in Bax/Bak-Dependent Mitochondrial Outer Membrane Permeabilization

(2008) Ann Cassidy-Stone et al.   DEVELOPMENTAL CELL

Cardiolipin provides an essential activating platform for caspase-8 on mitochondria

(2008) Francois Gonzalvez et al.   JOURNAL OF CELL BIOLOGY

To Trigger Apoptosis, Bak Exposes Its BH3 Domain and Homodimerizes via BH3:Groove Interactions

(2008) Grant Dewson et al.   MOLECULAR CELL

Bax- or Bak-Induced Mitochondrial Fission Can Be Uncoupled from Cytochrome c Release

(2008) Clare Sheridan et al.   MOLECULAR CELL

BAX activation is initiated at a novel interaction site

(2008) Evripidis Gavathiotis et al.   NATURE

Structure of transmembrane pore induced by Bax-derived peptide: Evidence for lipidic pores

(2008) S. Qian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY