Epimedii Folium and Curculiginis Rhizoma ameliorate lipopolysaccharides-induced cognitive impairment by regulating the TREM2 signaling pathway

Banhasasim-Tang Attenuates Lipopolysaccharide-Induced Cognitive Impairment by Suppressing Neuroinflammation in Mice

(2020) You-Chang Oh et al.   Nutrients

Ganoderic acid A alleviates hypoxia-induced apoptosis, autophagy, and inflammation in rat neural stem cells through the PI3K/AKT/mTOR pathways

(2019) Yanhua Chang et al.   PHYTOTHERAPY RESEARCH

Nobiletin Protects against Systemic Inflammation-Stimulated Memory Impairment via MAPK and NF-κB Signaling Pathways

(2019) Guoyuan Qi et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Icariside II inhibits lipopolysaccharide-induced inflammation and amyloid production in rat astrocytes by regulating IKK/IκB/NF-κB/BACE1 signaling pathway

(2019) Yong Zheng et al.   ACTA PHARMACOLOGICA SINICA

TREM2 — a key player in microglial biology and Alzheimer disease

(2018) Tyler K. Ulland et al.   Nature Reviews Neurology

Effective Knockdown of Gene Expression in Primary Microglia With siRNA and Magnetic Nanoparticles Without Cell Death or Inflammation

(2018) Alejandro Carrillo-Jimenez et al.   Frontiers in Cellular Neuroscience

Icariside II attenuates lipopolysaccharide-induced neuroinflammation through inhibiting TLR4/MyD88/NF-κB pathway in rats

(2018) Jiayin Zhou et al.   BIOMEDICINE & PHARMACOTHERAPY

A Tale of Two Genes: Microglial Apoe and Trem2

(2017) Anna A. Pimenova et al.   IMMUNITY

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

The protective effect of Epimedii Folium and Curculiginis Rhizoma on Alzheimer’s disease by the inhibitions of NF-κB/MAPK pathway and NLRP3 inflammasome

(2017) Zhou Lan et al.   Oncotarget

Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy

(2017) Kevin A. Clayton et al.   Frontiers in Neuroscience

Salidroside suppresses inflammation in a D-galactose-induced rat model of Alzheimer’s disease via SIRT1/NF-κB pathway

(2016) Jin Gao et al.   METABOLIC BRAIN DISEASE

TREM2 variants: new keys to decipher Alzheimer disease pathogenesis

(2016) Marco Colonna et al.   NATURE REVIEWS NEUROSCIENCE

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

(2016) Felix L. Yeh et al.   NEURON

Salidroside ameliorates arthritis-induced brain cognition deficits by regulating Rho/ROCK/NF-κB pathway

(2016) Lingpeng Zhu et al.   NEUROPHARMACOLOGY

Microglia development follows a stepwise program to regulate brain homeostasis

(2016) O. Matcovitch-Natan et al.   SCIENCE

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

(−)-Epigallocatechin-3-gallate attenuates cognitive deterioration in Alzheimer׳s disease model mice by upregulating neprilysin expression

(2015) Xiang Chang et al.   EXPERIMENTAL CELL RESEARCH

Effects of esculetin on lipopolysaccharide (LPS)-induced acute lung injury via regulation of RhoA/Rho Kinase/NF-кB pathways in vivo and in vitro

(2015) Tong Chen et al.   FREE RADICAL RESEARCH

Ginsenoside Rg5 improves cognitive dysfunction and beta-amyloid deposition in STZ-induced memory impaired rats via attenuating neuroinflammatory responses

(2014) Shenghui Chu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Orcinol glucoside produces antidepressant effects by blocking the behavioural and neuronal deficits caused by chronic stress

(2013) Jin-Fang Ge et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Molecular Basis of Etiological Implications in Alzheimer’s Disease: Focus on Neuroinflammation

(2013) Rituraj Niranjan   MOLECULAR NEUROBIOLOGY

Triggering receptor expressed on myeloid cells 2 knockdown exacerbates aging-related neuroinflammation and cognitive deficiency in senescence-accelerated mouse prone 8 mice

(2013) Teng Jiang et al.   NEUROBIOLOGY OF AGING

Danggui-Shaoyao-San ameliorates cognition deficits and attenuates oxidative stress-related neuronal apoptosis in d-galactose-induced senescent mice

(2012) Zhou Lan et al.   JOURNAL OF ETHNOPHARMACOLOGY

Icariin attenuates LPS-induced acute inflammatory responses: Involvement of PI3K/Akt and NF-κB signaling pathway

(2010) Chang-Qing Xu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria

(2009) Elsa-Noah N'Diaye et al.   JOURNAL OF CELL BIOLOGY

A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia

(2009) Christine L. Hsieh et al.   JOURNAL OF NEUROCHEMISTRY

Antiosteoporotic chemical constituents from Er-Xian Decoction, a traditional Chinese herbal formula

(2008) Luping Qin et al.   JOURNAL OF ETHNOPHARMACOLOGY