Article
Plant Sciences
Ka-Ying Wong, Liping Zhou, Wenxuan Yu, Christina Chui-Wa Poon, Huihui Xiao, Chi-On Chan, Daniel Kam-Wah Mok, Man-Sau Wong
Summary: The study found that EXD selectively exerted estrogenic effects in a tissue-selective manner and interacted with SERMs. The combined treatment of EXD and SERMs did not affect the beneficial effects of SERMs on bone or brain, but appeared to moderate the estrogenic effect of SERMs in the uterus.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Ming-Shi Ren, Hui-Hui Xie, Yu Ding, Zi-Han Li, Bo Liu
Summary: This study aimed to determine whether the serum containing EXD promotes the proliferation and differentiation of osteoblasts through the regulation of BK channel.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Integrative & Complementary Medicine
Zhang Xiaoli, Li Jing, Zhou Xiaolin, Chen Qiaoli
Summary: Er-Xian decoction has therapeutic effects on ZP3-induced autoimmune premature ovarian failure in mice, possibly through regulating hormone levels, immune cell subtypes, follicular structure, and the expression of molecules such as BMP15 and Akt.
JOURNAL OF TRADITIONAL CHINESE MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Lu Qiu, Min Zhang, Chenghao Li, Yehu Hou, Hao Liu, Jia Lin, Juan Yao, Dong Zhu Duan, Yi Xi Zhang, Mi Li, Ya Ling Li, Peng Wang, Jin Tian Li, Xiao Jie Jin, Yong Qi Liu
Summary: This study demonstrates that the active constituents from Dabushen decoction (alisol A, emodin, taxifolin, isoliquiritigenin, and schisandrin C) can ameliorate osteoarthritis by targeting DNMT1 to preserve PPAR gamma, providing a valuable strategy for developing natural epigenetic modulators from Chinese herbal formulas.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Jing-Ze Lu, Dan Ye, Bing-Liang Ma
Summary: Gegen-Qinlian decoction (GQD) is a classic traditional Chinese medicine formula that is effective in treating inflammatory intestinal diseases, metabolic diseases, and lung injury. The main constituents of GQD can be classified into eight groups, with parent constituents including puerarin, baicalin, berberine, and glycyrrhetinic acid. Issues such as effective constituents, interactions, pharmacokinetics, drug interactions, and pharmacological effects of GQD were discussed in this review, with prospects for future research.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Mei Ye, Guangxian Liu, Yujun Yang, Hongyu Yang, Juan Ren, Wenfei Chen, Zeli Gao
Summary: This study investigated the potential mechanism of action of Er-Xian decoction in treating aplastic anemia. By screening the active components and targets, constructing networks, and analyzing pathways, the study found that Er-Xian decoction regulates the PI3K-Akt pathway and JAK-STAT pathway to exert its therapeutic effect on aplastic anemia.
SCIENTIFIC REPORTS
(2023)
Article
Physiology
S. -M. Liu, W. -L. Yao, C. -X. Li, H. -Q. Li, G. -Z. Qin
Summary: This study demonstrated the protective effects of Er-Xian decoction (EXD) on sperm motility and DJ-1 expression in rats with asthenozoospermia. EXD significantly improved oxidative stress levels and sperm motility, with higher doses showing more significant improvements. The protective effect of EXD on sperm motility is associated with enhanced DJ-1 expression in testis and epididymis tissues.
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Mingmin Qiang, Jiping Hao, Huihui Liu, Jia Yin, Hui Zhang, Jinxin Yang, Hudie Meng, Yuqing Chen, Yuqin Gao
Summary: Curculigo orchioides and Epimedium are traditional Chinese medicines with estrogen-like activity. This study found that Curculigo orchioides can protect against myocardial ischemia-reperfusion injury by reducing tissue damage, infarct size, and cardiomyocyte apoptosis. The cardioprotective effects are mediated through the RISK signaling pathway and the involvement of estrogen receptors.
CHINESE JOURNAL OF NATURAL MEDICINES
(2022)
Article
Medicine, General & Internal
Xue Zhao, Jie Xu, Ming-Yue Wang, Zi-Wei Hou, Hui-Shan Shi, Xiao-Xia Zhang
Summary: This study aimed to observe the clinical effects of Xiao-xian decoction combined with acupoint application therapy for treating pediatric adenoid hypertrophy. The results showed that this combination therapy significantly improved the major and secondary symptoms of patients and had better efficacy compared to the control and AAT alone groups.
Article
Plant Sciences
Yaosheng Xiao, Qun Ren, Yizhou Zheng, Shanshan Zhang, Jing Ouyang, Linhui Jiao, Chunfang Tang, Linfu Li, Weimei Shi, Miaofei Wang, Sainan Zhang, Di Zhang, Bin Zhong, Fang Peng, Zhixi Chen, Longhuo Wu
Summary: The study showed that GEN effectively alleviated the pathological changes of trabecular bone induced by DEX in rats, and reduced the expression levels of ATF4/CHOP. In MC3T3-E1 cells, DEX triggered ER stress and mitochondrial apoptosis, which could be alleviated by inhibiting ER stress.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Ajay Rana, Shalika Rana, Sanjay Kumar
Summary: Tea, a widely recognized functional beverage, has many health benefits due to its constituents such as catechins, caffeine, and theanine. These components exhibit properties like antioxidant, anti-inflammatory, and anticancer effects. Techniques like micro- and nanoencapsulation can enhance the efficacy and applicability of active tea constituents.
ENVIRONMENTAL CHEMISTRY LETTERS
(2021)
Article
Pharmacology & Pharmacy
Qun Wang, Ya Shi, Zengguang Wu, Xinli Song, Jinfang Luo, Hong Yang, Xiaolan Chen, Xingde Liu
Summary: The study aimed to investigate the effects of HOD on diabetic nephropathy and the tissue distribution of its active ingredients in normal and DN mouse models. Treatment with HOD in DN mice led to improved renal function and decreased key markers of DN. The tissue distribution of HOD active ingredients differed in mice with DN compared to normal mice, indicating a potential impact of the pathological state of diabetic nephropathy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Zheng Li, Biao Qu, Xiaowen Wu, Hongwei Chen, Jue Wang, Lei Zhou, Xiaoyi Wu, Wei Zhang
Summary: This study investigates the limitations of conventional network pharmacology and proposes strategies for improvement using XLGB as a representative. The results highlight the necessity of improving the methodology and provide promising directions for future research on XLGB.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Hongya Guo, Yunxing Li, Lingyan Qiu, Jianyin Li, Xiaochun Guo, Yujing Zhang, Jian Wang
Summary: This study aims to investigate whether Gua Lou Er Chen decoction (GED) can attenuate atherosclerosis (AS) by reducing chondroitin sulphate proteoglycan (CSPG) expressions and alleviating inflammation. The results demonstrate that GED significantly improves hyperlipidemia, reduces lipid plaque deposition, and increases plaque stability in AS mice. Moreover, GED decreases CSPG and versican levels, down-regulates CS synthetase and inflammatory factor expressions, and inhibits cell proliferation. Overall, GED attenuates AS by reducing hyperlipidemia, hyper-expression of CSPG, and inflammation.
Review
Biochemistry & Molecular Biology
Vivek P. Chavda, Amit Z. Chaudhari, Divya Teli, Pankti Balar, Lalitkumar Vora
Summary: Propolis is a chemically diverse substance produced by honeybees from plant resins, and has been used as a traditional remedy for various purposes. It has gained recognition in pharmaceutical and nutraceutical areas due to its diverse chemical composition and potential health benefits. Over 300 molecular structures have been discovered in propolis, and it has been found to have various pharmacological activities. Abundant research has been conducted to explore propolis as an alternative therapy for chronic diseases, and clinical trials have shown its potency in preventing and curing certain conditions.
Article
Chemistry, Analytical
Yongjing He, Xin Dong, Xiaoxuan Jia, Mei Li, Tingting Yuan, Hongtao Xu, Luping Qin, Ting Han, Qiaoyan Zhang
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2015)
Article
Chemistry, Medicinal
Zhiguo Zhang, Qiaoyan Zhang, Hua Yang, Wei Liu, Naidan Zhang, Luping Qin, Hailiang Xin
Article
Plant Sciences
Liming Xue, Yiping Jiang, Ting Han, Naidan Zhang, Luping Qin, Hailiang Xin, Qiaoyan Zhang
JOURNAL OF ETHNOPHARMACOLOGY
(2016)
Article
Oncology
Weiyue Zhang, Qiaoyan Zhang, Yiping Jiang, Feng Li, Hailiang Xin
MOLECULAR MEDICINE REPORTS
(2016)
Article
Chemistry, Analytical
Nani Wang, Qiaoyan Zhang, Hailiang Xin, Dan Shou, Luping Qin
JOURNAL OF SEPARATION SCIENCE
(2017)
Article
Chemistry, Analytical
Nani Wang, Hailiang Xin, Qiaoyan Zhang, Yiping Jiang, Xuping Wang, Dan Shou, Luping Qin
Article
Chemistry, Analytical
Nani Wang, Xuping Wang, Yang Zhang, Qiaoyan Zhang, Pingcui Xu, Hailiang Xin, Renjie Wu, Dan Shou, Luping Qin
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2018)
Article
Medicine, Legal
Quanlong Zhang, Zhujun Mao, Qiaoyan Zhang, Jianguo Qiu, Zhengping Jia, Luping Qin
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Ying Wang, Lu Zhao, Yin Wang, Jinlong Xu, Yan Nie, Yuanhui Guo, Yongtao Tong, Luping Qin, Qiaoyan Zhang
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2012)
Article
Integrative & Complementary Medicine
Liming Xue, Yin Wang, Yiping Jiang, Ting Han, Yan Nie, Lu Zhao, Qiaoyan Zhang, Luping Qin
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2012)
Article
Biochemistry & Molecular Biology
Liming Xue, Yin Wang, Lei Liu, Lu Zhao, Ting Han, Qiaoyan Zhang, Luping Qin
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2011)
Review
Plant Sciences
Yan Nie, Xin Dong, Yongjing He, Tingting Yuan, Ting Han, Khalid Rahman, Luping Qin, Qiaoyan Zhang
JOURNAL OF ETHNOPHARMACOLOGY
(2013)
Article
Plant Sciences
Qianliang Ming, Chunyan Su, Chengjian Zheng, Min Jia, Qiaoyan Zhang, Hong Zhang, Khalid Rahman, Ting Han, Luping Qin
JOURNAL OF EXPERIMENTAL BOTANY
(2013)
Article
Chemistry, Analytical
Jinlong Xu, Qiaoyan Zhang, Liang Zhao, Ying Wang, Liming Xue, Ting Han, Chengjian Zheng, Luping Qin
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2012)
Article
Plant Sciences
Qianliang Ming, Ting Han, Wenchao Li, Qiaoyan Zhang, Hong Zhang, Chengjian Zheng, Fang Huang, Khalid Rahman, Luping Qin
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)