Article
Nutrition & Dietetics
Miquel Martin, Matteo M. M. Pusceddu, Joan Teichenne, Teresa Negra, Alan Connolly, Xavier Escote, Helena Torrell Galceran, Adria Cereto Massague, Iris Samarra Mestre, Antoni del Pino Rius, Jordi Romero-Gimenez, Cristina Egea, Juan Maria Alcaide-Hidalgo, Josep Maria del Bas
Summary: Cognitive alterations, triggered by microglia activation and oxidative/inflammatory processes, are a major health concern worldwide. Consuming bioactive compounds like astaxanthin and spirulina can help prevent the development of these diseases. In this study, the neuroprotective effects of a low dose of astaxanthin microencapsulated within spirulina (ASXSP) were investigated in female rats with LPS-induced cognitive deficits. The results showed that ASXSP improved cognitive alterations, reduced microglia activation, and partially restored gut dysbiosis caused by LPS.
Article
Food Science & Technology
Chi Heung Cho, Young Sung Jung, Jong Min Kim, Tae Gyu Nam, Sang-Hoon Lee, Hye Sung Cho, Myoung Chong Song, Ho Jin Heo, Dae-Ok Kim
Summary: The Actinidia eriantha cv. Bidan extract (AEE) showed neuroprotective effects by reducing reactive oxygen species levels and suppressing apoptotic cell death, resulting in improvements in learning and spatial memory in Aβ1-42-treated mice. AEE also increased endogenous antioxidant systems in mouse brain tissue and contained caffeic acid derivatives, suggesting its potential to improve cognitive function as a source of antioxidant phenolics.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Multidisciplinary Sciences
Chao Chen, Xiaoxin Zhang, Hao Huang, Hongyi Bao, Xiaodong Li, Ye Cheng, Jing Zhang, Yin Ding, Yanguang Yang, Haiying Gu, Donglin Xia
Summary: The study showed that poly(lactic-co-glycolic acid) meso-particles containing superoxide dismutase and catalase were effective in attenuating lead-induced cognitive impairment by inhibiting oxidative stress. The bi-enzymes platform displayed a remarkable protective mechanism in preventing memory impairment and reversing lead-induced cognitive impairments.
ROYAL SOCIETY OPEN SCIENCE
(2021)
Article
Engineering, Biomedical
Aria W. Tarudji, Connor C. Gee, Sarah M. Romereim, Anthony J. Convertine, Forrest M. Kievit
Summary: Utilizing antioxidant nanoparticles NP1, this study demonstrates a potential treatment strategy to reduce secondary spread of traumatic brain injury. The NP1 treatment protected mice from learning and memory deficits induced by injury, likely through reduction of oxidative stress and spread of neuroinflammation. These findings suggest that NP1-mediated reduction in post-traumatic oxidative stress correlates with protection of spatial memory and learning, offering an improved therapeutic approach for TBI.
Article
Pharmacology & Pharmacy
Zahra Gholami Mahmoudian, Ali Ghanbari, Iraj Rashidi, Iraj Amiri, Alireza Komaki
Summary: This study investigated the effects of minocycline on cognitive abilities, antioxidant enzyme activities, neuronal loss, and plaque number in rats with Alzheimer's disease induced by Aβ. The results showed that minocycline improved anxiety behavior, restored learning and memory deficits, and had antioxidant and anti-apoptotic effects.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Leila Karimi-Zandi, Maryam Zahmatkesh, Gholamreza Hassanzadeh, Soheila Hosseinzadeh
Summary: This study found an increase in fractalkine-positive microvesicles in the early stages of Alzheimer's disease, suggesting their potential as a biomarker for early diagnosis.
Review
Behavioral Sciences
Lilian Juliana Lissner, Krista Mineia Wartchow, Ana Paula Toniazzo, Carlos-Alberto Goncalves, Leticia Rodrigues
Summary: Object recognition (OR) and the Morris water maze (MWM) are classical tasks used to assess memory parameters in rodents, involving hippocampus and prefrontal cortex connections. Despite controversy, these tests offer practical tools for evaluating hippocampal-related memory deficits in rats, with minimal manageable stressful conditions.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Food Science & Technology
Long Sun, Xian Li, Chenjing Ma, Zhao He, Xin Zhang, Chengye Wang, Min Zhao, Jin Gan, Ying Feng
Summary: The study found that Policosanol (PC) from Ericerus pela wax can enhance learning and memory in mice by promoting the cholinergic system and attenuating oxidative stress.
Article
Neurosciences
Ru Jin, Xiaoqiao Ning, Xiang Liu, Yueyang Zhao, Guo Ye
Summary: This study found that infection by P. gingivalis and activation of the P38 MAPK signaling pathway can lead to memory and cognitive impairment. Furthermore, it was discovered that periodontitis can induce neuroinflammatory response and alterations in APP processing. Therefore, P38 MAPK may serve as a linking pathway between periodontitis and cognitive impairment.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Endocrinology & Metabolism
Maryam Sajjadi, Ehsan Oskoueian, Ehsan Karimi, Mahdi Ebrahimi
Summary: The root extract of Amygdalus spinosissima plant contains bioactive phenolic and flavonoid compounds with antioxidant and anti-inflammatory properties, improving learning and memory function in mice. This extract shows promising potential in retarding the development of neurodegenerative diseases such as Alzheimer's disease.
METABOLIC BRAIN DISEASE
(2021)
Article
Agriculture, Multidisciplinary
Zuchen Wei, Yuanji Wang, Zhenxing Shi, Nong Zhou, Guixing Ren, Xiyu Hao, Liang Zou, Yang Yao
Summary: Early undernutrition is associated with neurodevelopmental deficits, but a mung bean protein diet (MBPD) has been shown to reverse these effects by modulating gut microbiota and improving central nervous system functions. MBPD supplementation upregulates key neurotrophic factors and synaptic proteins while downregulating inflammatory pathways, indicating its potential therapeutic value for cognitive dysfunction.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Pediatrics
Claudia Fernandez-Alarcon, Lucy E. Meyer, Michael A. McVoy, James R. Lokensgard, Shuxian Hu, Michael A. Benneyworth, Kaitlyn M. Anderholm, Bradley C. Janus, Mark R. Schleiss
Summary: The study showed that neonatal guinea pig infection with GPCMV results in cognitive defects demonstrable by the MWM, including spatial learning and memory. This model can be exploited for studying antiviral interventions.
PEDIATRIC RESEARCH
(2021)
Article
Multidisciplinary Sciences
Seema Gul, Sobia Attaullah, Mahdi H. Alsugoor, Sami Bawazeer, Shahid Ali Shah, Sanaullah Khan, Hafiza Sara Salahuddin, Mujeeb Ullah
Summary: This study evaluated the neuroprotective capability of folicitin against scopolamine-induced Alzheimer's disease neuropathology in mice. The results showed that folicitin could reduce oxidative stress, improve memory impairment and synaptic dysfunction, and inhibit hyperglycemia and hyperlipidemia caused by scopolamine. These findings suggest that folicitin has potential in treating Alzheimer's disease.
Article
Pharmacology & Pharmacy
Wen-qiang Ren, Nuo Liu, Yan Shen, Xian-yan Wang, Qiong Zhou, Chen Rui, Xiao-han Yang, Sheng-long Cao, Ling-yu Li, Yan Wang, Qu-nan Wang
Summary: Subchronic exposure to DEHP may cause neurotoxicity by disrupting blood brain barrier function and inducing neuroinflammatory responses.
Review
Behavioral Sciences
Lucia Amendola, Daniel Weary, Gosia Zobel
Summary: Individual variation in responses to anxiety and spatial memory tests is often reported. These variations are related to consistent individual differences in behavior (personality). However, personality differences are rarely considered in anxiety treatment studies. This article focuses on rat literature to describe principles in anxiety and spatial memory tests and discusses the influence of personality and housing conditions on behavioral responses. The authors propose that environmental enrichment can enhance stress resiliency in environmentally sensitive individuals. Incorporating personality measures into study design and analysis can improve research reproducibility.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Immunology
Kwang-Youn Kim, Tae-Woo Oh, Hyun Ju Do, Ju-Hye Yang, In Jun Yang, Yong Hyun Jeon, Young-Hoon Go, Soon-Cheol Ahn, Jin-Yeul Ma, Kwang-Il Park
JOURNAL OF IMMUNOLOGY RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
You-Chang Oh, Yun Hee Jeong, Wei Li, Younghoon Go
Article
Biochemistry & Molecular Biology
Changyeol Lee, Wei Li, Sunghee Bang, Sun Joo Lee, Nam-young Kang, Soonok Kim, Tae In Kim, Younghoon Go, Sang Hee Shim
Article
Biochemistry & Molecular Biology
Hong Xu Li, Myungsook Heo, Younghoon Go, Young Soo Kim, Young Ho Kim, Seo Young Yang, Wei Li
Article
Plant Sciences
Yu Juan Chai, Younghoon Go, Hai Qi Zhou, Hong Xu Li, Sun Joo Lee, Yeo Jin Park, Wahyu Widowatib, Rizal Rizal, Young Ho Kim, Seo Young Yang, Wei Li
Summary: Three undescribed bicyclo[3.2.1]octanoid neolignan glucosides, along with a known neolignan, were isolated from Piper crocatum leaves. Their chemical structures were elucidated through spectroscopic analyses and compared with previous data. Two compounds showed strong inhibitory effects against pyruvate dehydrogenase E1 alpha S300 phosphorylation in comparison to the positive control.
Article
Cell Biology
Malk Eun Pak, You-Chang Oh, Yeo Jin Park, Jae Kwang Kim, Min-Gyeong Shin, Jong Hyuk Yoon, Younghoon Go
Summary: Banhasasim-tang (BHS) has been traditionally used to treat functional dyspepsia in East Asia, and this study found that BHS administration can protect hippocampal neurons against oxidative stress, improve memory dysfunction, increase neuronal survival, and regulate multiple signaling pathways. This suggests that BHS may have therapeutic potential for reducing neuronal damage and improving memory in neurodegenerative diseases.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Biochemistry & Molecular Biology
Buyun Kim, Young Soo Kim, Youn-Hwan Hwang, Hye Jin Yang, Wei Li, Eun-Bin Kwon, Tae In Kim, Younghoon Go, Jang-Gi Choi
Summary: This study demonstrates that Quercus acuta has antiviral effects against HSV-1 infection, with its main components including chlorogenic acid and isoquercitrin. Through inhibition of ROS expression and NF-kB activity, as well as promotion of IRF3 phosphorylation activity, QA can effectively prevent the replication and spread of HSV-1 virus.
Article
Biochemistry & Molecular Biology
Yeo Jin Park, Hye Jin Yang, Wei Li, You-Chang Oh, Younghoon Go
Summary: In this study, the effects of Menthae Herba (MH) on the inflammatory response and molecular mechanisms in activated microglia were evaluated. The results showed that MH inhibited the production of proinflammatory enzymes and mediators, reduced reactive oxygen species (ROS) levels, and activated antioxidant signaling pathways. These findings suggest the potential therapeutic use of MH in neuroinflammatory diseases.
Article
Biochemistry & Molecular Biology
Buyun Kim, Eun-Bin Kwon, Hye Jin Yang, Wei Li, Youn-Hwan Hwang, Young Soo Kim, Malk Eun Pak, Younghoon Go, Jang-Gi Choi
Summary: HSV-1 is a neurotropic virus that infects the peripheral and central nervous system. VBT, as Vaccinium bracteatum Thunb., shows anti-inflammatory, antioxidant, and antidiabetic activity. Research indicates that VBT has antiviral effects against HSV-1 infection.